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School of Biomedical Sciences, Faculty of Medicine and Health Sciences, Queens Medical Centre, Nottingham NG7 2UH, UK. |
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Recent publications:
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Evans, E.L., Saxton, J., Shelton, S.J., Begitt, A., Holliday, N.D., Hipskind, R.A., Shaw, P.E. (2011) Dimer formation and conformational flexibility ensure cytoplasmic stability and nuclear accumulation of Elk-1. Nucl. Acids Res. 39 6390-402. | (PDF) |
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Hussain, A., Shaw, P.E., Hirst, J.D. (2011) Molecular dynamics simulations and in silico peptide ligand screening of the Elk-1 ETS domain. J. of Cheminformatics. 3: 49. | (PDF) |
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Foxler, D.E., James V., Shelton, S.J., Vallim, T.Q., Shaw, P.E., Sharp, T.V. (2011) PU.1 is a Major Transcriptional Activator of the Tumour Suppressor Gene LIMD1. FEBS Lett. 585 1089-96. | (PDF) |
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Shaw, P.E. (2010) Could STAT3 provide a link between respiration and cell cycle progression? Cell Cycle. 9 4294-6. |
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Li, L., Cheung, S.H., Evans, E., Shaw, P.E. (2010) Modulation of gene expression and tumor cell growth by redox modification of STAT3. Cancer Res. 70 8222-32. | (PDF) |
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Zhang, H.M., Vougier, S., Hodgson, G., Shaw, P.E. (2010) Integration of protein kinases into transcription complexes: identifying components of immobilised in vitro pre-initiation complexes. Methods Mol. Biol. 647: 291-203. | |
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Li, L., Saxton, J., Shaw, P.E. (2010) Post-translational control of ETS transcription factors: detection of modified factors at target gene promoters. Methods Mol. Biol. 647: 279-89. | |
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Zhang, H.M., Li, L., Papadopoulou, N., Hodgson, G., Evans, E., Galbraith, M., Dear, M., Vougier, S., Saxton, J., Shaw, P.E. (2008) Mitogen-induced recruitment of ERK and MSK to SRE promoter complexes by ternary complex factor Elk-1.Nucl. Acids Res. 36 2594-607. |
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Vougier S, Cheung SH, Li L, Hodgson G, Shaw PE. (2007) Anomalous behaviour of the STAT3 binding site in the human c-myc P2 promoter. Biochem Biophys Res Commun. 364 627-32. | (PDF) |
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Vincent, E., Saxton, J., Baker-Glenn, C., Moal, I., Hirst, J.D., Pattenden, G. and Shaw, P.E. (2007) Effects of ulapualide A and synthetic macrolide analogues on actin dynamics and gene regulation. Cell. Mol. Life Sci. 65, 487-497. | (PDF) |
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Shaw, P.E. (2007). Peptidyl-prolyl cis/trans isomerases
and transcription: is there a twist in the tail? EMBO Reports 8,
40-45. |
(PDF) |
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Melville, J.L., Moal, I.H., Baker-Glenn, C., Shaw, P.E., Pattenden, G., Hirst, J.D. (2007) The structural determinants of macrolide-actin binding: in silico insights. Biophys. J. 92. 3862-7. | (PDF) |
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Li, L. and Shaw, P.E. (2006). Elevated activity of STAT3C due to higher DNA-binding affinity of phosphotyrosine dimer rather than covalent dimer formation. J Biol Chem. 281, 33172-33181. | (PDF) |
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Li, L. and Shaw, P.E. (2004). A STAT3 dimer formed by inter-chain disulphide bridging during oxidative stress. Biochem. Biophys. Res. Com. 322, 1005-1011. | (PDF) |
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Li, L., Hooi, D., Chhabra, S, R., Pritchard, D., Shaw, P.E. (2004). Bacterial N-acylhomoserine lactone-induced apoptosis in breast carcinoma cells correlated with down-modulation of STAT3. Oncogene. 23, 4894-4902. | |
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Dhillon, A.S., Meikle, S., Grindlay, J., Kaiser, C., Steen, H., Shaw, P.E., Mischak, H. Eychene, A. and Kölch W. (2003). A Raf-1 mutant that dissociates MEK/ERK Activation from Malignant Transformation and Differentiation but not Differentiation. Mol. Cell. Biol. 23, 1983-1993. | (PDF) |
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Shaw, P.E., and Saxton, J. (2003) Ternary Complex Factors: Prime Nuclear Targets For Mitogen-Activated Protein Kinases. Int. J. Biochem. Cell Biol. 35, 1210-1226. | (PDF) |
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Brummer, T., Shaw, P.E., Reth, M. and Misawa, Y. (2002) Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling EMBO J. 21, 5611-5622. | (PDF) |
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Shaw, P.E. (2002). Peptidyl-Prolyl Isomerases: A New Twist to Transcription. EMBO Reports 3, 521-526. | (PDF) |
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Dhillon, A.S., Steen, H., Shaw, P.E., Mischak, H. and Kölch W. (2002). The cAMP Dependent Kinase Regulates the Raf-1 Kinase Mainly by Phosphorylation of Serine 259. Mol. Cell. Biol. 22, 3237-3246. | (PDF) |
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Li, L. and Shaw, P.E. (2002). Autocrine-mediated Activation of STAT3 Correlates with Cell Proliferation in Breast Carcinoma Lines. J. Biol Chem. 277, 17397-17405. | |
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Coles, L.C. and Shaw, P.E. (2002). PAK1 primes MEK1 for phosphorylation by Raf-1 kinase during cross-cascade activation of the ERK pathway. Oncogene 21, 2236-2244. | (PDF) |
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Drewett, V., Devitt, A., Saxton, J., Portman, N., Greaney, P., Cheong, N., Alnemri, T.F., Alnemri, E. and Shaw, P.E. (2001). Serum Response Factor (SRF) Cleavage by Caspases 3 and 7 Linked to Apoptosis in human BJAB Cells. J. Biol. Chem. 276, 33444-33451. | (PDF) |
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Okan, E., Drewett, V., Shaw, P.E. and Jones, P. (2001). The small-GTPase RalA activates transcription of the urokinase plasminogen activator receptor (uPAR) gene via an AP1-dependent mechanism. Oncogene 20, 1816-1824. | (PDF) |
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Drewett, V., Molina, H., Millar, A., Muller, S., von Hesler, F. and Shaw, P.E. (2001). DNA-bound transcription factor complexes analysed by mass-spectrometry: binding of novel proteins to the human c-fos promoter and related sequences. Nucl. Acids Res. 29, 479-487. | (PDF) |
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Drewett, V., Muller, S., Goodall, J. and Shaw, P.E. (2000) Dimer formation by Ternary Complex Factor Elk-1. J. Biol. Chem. 275, 1757-62. | (PDF) |
Last modified 03.02.12