Stephen Hill

Contact

• workRoom D12 The University of Nottingham Medical School
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 82 30082 82 30100
• fax0115 82 30081
• steve.hill@nottingham.ac.uk

Expertise Summary

Stephen Hill studied Pharmacology in Bristol (BSc, 1976) and then undertook PhD studies in the Department of Pharmacology in Cambridge (PhD 1979, first demonstration of 3H-mepyramine binding to histamine H1-receptors). After postdoctoral studies in Cambridge (1979-1981) he was appointed to a lecturer position in the Department of Pharmacy at the University of Nottingham.

He joined the Department of Physiology and Pharmacology (now the School of Biomedical Sciences) in 1984 and was subsequently promoted to Reader (1989) and Professor of Molecular Pharmacology (1995). In 1997 he became Director of the Institute of Cell Signalling.

He has published over 150 papers and his research has concentrated mainly on the molecular pharmacology of G protein-coupled receptors and cross-talk between intracellular signaling cascades. Currently, the emphasis of his work is on the study of single ligand-receptor interactions in membrane microdomains using fluorescence correlation spectroscopy. His work also concentrates on the analysis of ligand-directed signaling from GPCRs.

He is a founding director of the University of Nottingham spin-out company CellAura Technologies Ltd that provides fluorescent ligands to the scientific community. He has served on the Editorial Boards of the British Journal of Pharmacology and Current Opinion on Pharmacology. He was Vice-President (Meetings) of the British Pharmacological Society (2004-2006) and was the BPS Sandoz (Novartis) Prize winner in 1987 and the BPS Australasian Lecturer in 2006.

He was elected a Fellow of the British Pharmacological Society in 2004. According to ISI, he is one of the top 250 pre-eminent individual researchers in pharmacology as measured by citations to their work. He is currently a member of the MRC Molecular & Cellular Medicine Research Board and has previously served on the Wellcome Trust Physiology & Pharmacology Panel and the Wellcome Trust Career Development Interview Panel.

Selected Publications

• MAY, L.T., BRIDGE, L.J., STODDART, L.A., BRIDDON, S.J. and HILL, S.J., 2011. Allosteric interactions across native adenosine-A₃ receptor homodimers: quantification using single-cell ligand-binding kinetics FASEB Journal. 25(10), 3465-3476
• BAKER, J.G., MIDDLETON, R., ADAMS, L., MAY, L.T., BRIDDON, S.J., KELLAM, B. and HILL, S.J., 2010. Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A₁ receptor ligands British Journal of Pharmacology. 159(4), 772-786
• MAY, L T, BRIDDON, S J and HILL, S J, 2010. Antagonist selective modulation of adenosine A1 and A3 receptor pharmacology by the food dye Brilliant Black BN: evidence for allosteric interactions. Molecular Pharmacology. 77(4), 678-86
• BAKER, J.G., KEMP, P., MARCH, J., FRETWELL, L., HILL, S.J. and GARDINER, S.M., 2011. Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses FASEB Journal. 25(12), 4486-4497

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• ROSE, R.H., BRIDDON, S.J. and HILL, S.J., 2012. A novel fluorescent histamine H₁ receptor antagonist demonstrates the advantage of using fluorescence correlation spectroscopy to study the binding of lipophilic ligands British Journal of Pharmacology. 165(6), 1789-1800
• VERNALL, A.J., STODDART, L.A., BRIDDON, S.J., HILL, S.J. and KELLAM, B., 2012. Highly potent and selective fluorescent antagonists of the human adenosine A₃ receptor based on the 1,2,4-triazolo[4,3-α]quinoxalin-1-one scaffold Journal of Medicinal Chemistry. 55(4), 1771-1782
• AYLING, L.J., BRIDDON, S.J., HALLS, M.L., HAMMOND, G.R.V., VACA, L., PACHECO, J., HILL, S.J. and COOPER, D.M.F., 2012. Adenylyl cyclase AC8 directly controls its micro-environment by recruiting the actin cytoskeleton in a cholesterol-rich milieu Journal of Cell Science. 125(4), 869-886
• STODDART, L.A., VERNALL, A.J., DENMAN, J.L., BRIDDON, S.J., KELLAM, B. and HILL, S.J., 2012. Fragment screening at adenosine-A₃ receptors in living cells using a fluorescence-based binding assay Chemistry & Biology. 19(9), 1105-1115
• BRIDDON, STEPHEN J, KELLAM, BARRIE and HILL, STEPHEN J, 2011. Design and use of fluorescent ligands to study ligand-receptor interactions in single living cells. Methods in Molecular Biology. 746, 211-36
• BAKER, J.G., ADAMS, L.A., SALCHOW, K., MISTRY, S.N., MIDDLETON, R.J., HILL, S.J. and KELLAM, B., 2011. Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3A,4A-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors Journal of Medicinal Chemistry. 54(19), 6874-6887
• MAY, L.T., BRIDGE, L.J., STODDART, L.A., BRIDDON, S.J. and HILL, S.J., 2011. Allosteric interactions across native adenosine-A₃ receptor homodimers: quantification using single-cell ligand-binding kinetics FASEB Journal. 25(10), 3465-3476
• BAKER JG, HILL SJ and SUMMERS RJ, 2011. Evolution Of Β-Blockers: From Anti-Anginal Drugs To Ligand-Directed Signalling. Trends In Pharmacological Sciences. 32(4), 227-34
• BAKER, J.G., KEMP, P., MARCH, J., FRETWELL, L., HILL, S.J. and GARDINER, S.M., 2011. Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses FASEB Journal. 25(12), 4486-4497
• BAKER, J.G., MIDDLETON, R., ADAMS, L., MAY, L.T., BRIDDON, S.J., KELLAM, B. and HILL, S.J., 2010. Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A₁ receptor ligands British Journal of Pharmacology. 159(4), 772-786
• KILPATRICK, L.E., BRIDDON, S.J., HILL, S.J. and HOLLIDAY, N.D., 2010. Quantitative analysis of neuropeptide Y receptor association with β-arrestin2 measured by bimolecular fluorescence complementation British Journal of Pharmacology. 160(4), 892-906
• MAY, L T, BRIDDON, S J and HILL, S J, 2010. Antagonist selective modulation of adenosine A1 and A3 receptor pharmacology by the food dye Brilliant Black BN: evidence for allosteric interactions. Molecular Pharmacology. 77(4), 678-86
• WOODROFFE, P J, BRIDGE, L J, KING, J R, CHEN, C Y and HILL, S J, 2010. Modelling of the activation of G-protein coupled receptors: drug free constitutive receptor activity. Journal of mathematical biology. 60(3), 313-46
• ALCOCK, J., WARREN, A.Y., GOODSON, Y.J., HILL, S.J., KHAN, R.N. and LYMN, J.S., 2010. Inhibition of tissue transglutaminase 2 attenuates contractility of pregnant human myometrium Biology of Reproduction. 84(4), 646-653
• MAY, L.T., SELF, T.J., BRIDDON, S.J. and HILL, S.J., 2010. The effect of allosteric modulators on the kinetics of agonist-G protein-coupled receptor interactions in single living cells Molecular Pharmacology. 78(3), 511-523
• HILL, SJ, WILLIAMS, C and MAY, LT, 2010. Insights Into Gpcr Pharmacology From The Measurement Of Changes In Intracellular Cyclic Amp; Advantages And Pitfalls Of Differing Methodologies
• BRIDGE, L J, KING, J R, HILL, S J and OWEN, M R, 2009. Mathematical modelling of signalling in a two-ligand G-protein coupled receptor system: Agonist-antagonist competition. Mathematical biosciences.
• WILLIAMS, CHRISTINE and HILL, STEPHEN J, 2009. GPCR signaling: understanding the pathway to successful drug discovery. Methods in molecular biology (Clifton, N.J.). 552, 39-50
• WOODROFFE, P J, BRIDGE, L J, KING, J R and HILL, S J, 2009. Modelling the activation of G-protein coupled receptors by a single drug. Mathematical biosciences. 219(1), 32-55
• WOODROFFE, PJ, BRIDGE, LJ, KING, JR and HILL, SJ, 2009. Modelling The Activation Of G-Protein Coupled Receptors By A Single Drug Mathematical Biosciences. 219(1), 32-55
• CORDEAUX, Y., BRIDDON, S.J., ALEXANDER, S.P.H., KELLAM, B. and HILL, S.J., 2008. Agonist-occupied A₃ adenosine receptors exist within heterogeneous complexes in membrane microdomains of individual living cells FASEB Journal. 22(3), 850-860
• CORDELL, REBECCA L, HILL, STEPHEN J, ORTORI, CATHARINE A and BARRETT, DAVID A, 2008. Quantitative profiling of nucleotides and related phosphate-containing metabolites in cultured mammalian cells by liquid chromatography tandem electrospray mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 871(1), 115-24
• BAKER, J.G., PROUDMAN, R.G.W., HAWLEY, N.C., FISCHER, P.M. and HILL, S.J., 2008. Role of key transmembrane residues in agonist and antagonist actions at the two conformations of the human β1-adrenoceptor Molecular Pharmacology. 74(5), 1246-1260
• LONGDEN, J, COOKE, E-L and HILL, S J, 2008. Effect of CCR5 receptor antagonists on endocytosis of the human CCR5 receptor in CHO-K1 cells. British Journal of Pharmacology. 153(7), 1513-27
• MAY, LAUREN T and HILL, STEPHEN J, 2008. ERK phosphorylation: Spatial and temporal regulation by G protein-coupled receptors. International Journal of Biochemistry and Cell Biology. 40(10), 2013-7
• BRIDDON, S.J., GANDÍA, J., AMARAL, O.B., FERRÉ, S., LLUÍS, C., FRANCO, R., HILL, S.J. and CIRUELA, F., 2008. Plasma membrane diffusion of g protein-coupled receptor oligomers Biochimica et Biophysica Acta: Molecular Cell Research. 1783(12), 2262-2268
• MIDDLETON,R, BRIDDON,S.J., CORDEAUX,Y., YATES,A.S., DALE,C.L., GEORGE,M., BAKER,J.G., HILL,S.J. and KELLAM,B., 2007. New Fluorescent Adenosine A(1)-Receptor Agonists That Allow Quantification of Ligand-Receptor Interactions in Microdomains of Single Living Cells. Journal of Medicinal Chemistry. 50(4), 782-793
• BAKER, J.G. and HILL, S.J., 2007. A comparison of the antagonist affinities for the Gi and Gs-coupled states of the human adenosine A1 receptor Journal of Pharmacology and Experimental Therapeutics. 320(1), 218-228
• ANDERSON, D., SELF, T., MELLOR, I.R., GOH, G., HILL, S.J. and DENNING, C., 2007. Transgenic enrichment of cardiomyocytes from human embryonic stem cells. Molecular Therapy. 15(11), 2027-2036
• BAKER, JILLIAN G and HILL, STEPHEN J, 2007. Multiple GPCR conformations and signalling pathways: implications for antagonist affinity estimates. Trends in Pharmacological Sciences. 28(8), 374-81
• BRIDDON, and HILL,, 2007. Pharmacology under the microscope: the use of fluorescence correlation spectroscopy to determine the properties of ligand-receptor complexes. Trends in Pharmacological Sciences. 28, 637-645
• HILL, S.J., 2006. G-protein-coupled receptors: past, present and future British Journal of Pharmacology. 147(Supplement 1), S27-37
• LIU, B., HILL, S.J. and KHAN, R.N., 2005. Oxytocin inhibits T-type calcium current of human decidual stromal cells. Journal of Clinical Endocrinology & Metabolism. 90(7), 4191-4197
• SELF, T.J., OAKLEY, S.M. and HILL, S.J., 2005. Clathrin-independent internalization of the human histamine H1-receptor in CHO-K1 cells British Journal of Pharmacology. 146(4), 612-24
• MYATT, A. and HILL, S.J., 2005. Trypsin stimulates the phosphorylation of p42,44 mitogen-activated protein kinases via the proteinase-activated receptor-2 and protein kinase C epsilon in human cultured prostate stromal cells The Prostate. 64(2), 175-85
• CARTER, A.A. and HILL, S.J., 2005. Characterization of isoprenaline- and salmeterol-stimulated interactions between beta2-adrenoceptors and beta-arrestin 2 using beta-galactosidase complementation in C2C12 cells Journal of Pharmacology and Experimental Therapeutics. 315(2), 839-48
• BRIDDON, S.J., MIDDLETON, R.J., CORDEAUX, Y., FLAVIN, F.M., WEINSTEIN, J.A., GEORGE, M.W., KELLAM, B. and HILL, S.J., 2004. Quantitative analysis of the formation and diffusion of A1-adenosine receptor-antagonist complexes in single living cells Proceedings of the National Academy of Sciences of the United States of America. 101(13), 4673-4678
• BRIDDON, S.J., MIDDLETON, R.J., YATES, A.S., GEORGE, M.W., KELLAM, B. and HILL, S.J., 2004. Application of fluorescence correlation spectroscopy to the measurement of agonist binding to a G-protein coupled receptor at the single cell level Faraday Discussions. 126, 197-207
• BAKER, J.G., HALL, I.P. and HILL, S.J., 2004. Temporal characteristics of cAMP response element-mediated gene transcription: requirement for sustained cAMP production Molecular Pharmacology. 65(4), 986-998
• CORDEAUX, Y., IJZERMAN, A.P and HILL, S.J., 2004. Coupling of the human A1 adenosine receptor to different heterotrimeric G proteins: evidence for agonist-specific G protein activation British Journal of Pharmacology. 143(6), 705-14
• BAKER, J.G, HALL, I.P. and HILL, S.J., 2003. Agonist actions of "beta-blockers" provide evidence for two agonist activation sites or conformations of the human beta1-adrenoceptor Molecular Pharmacology. 63(6), 1312-1321
• BAKER, J.G., HALL, I.P. and HILL, S.J., 2003. Agonist and inverse agonist actions of beta-blockers at the human beta 2-adrenoceptor provide evidence for agonist-directed signaling Molecular Pharmacology. 64(6), 1357-1369
• BAKER, J.G., HALL, I.P. and HILL, S.J., 2003. Influence of agonist efficacy and receptor phosphorylation on antagonist affinity measurements: differences between second messenger and reporter gene responses Molecular Pharmacology. 64(3), 679-688
• LIU, B., ARULKUMARAN, S., HILL, S.J. and KHAN, R.N., 2003. Comparison of potassium currents in human decidua before and after the onset of labor Biology of Reproduction. 68(6), 2281-2288
• BAKER, J.G., HALL, I.P. and HILL, S.J., 2003. Pharmacology and direct visualisation of BODIPY-TMR-CGP: a long-acting fluorescent beta2-adrenoceptor agonist British Journal of Pharmacology. 139(2), 232-42
• HILL, S.J. and BAKER, J.G., 2003. The ups and downs of Gs- to Gi-protein switching British Journal of Pharmacology. 138(7), 1188-1190
• HILL, K.J., WEBBER, A.C. and HILL, S.J., 2003. A role of protein kinase C mu in signalling from the human adenosine A1 receptor to the nucleus British Journal of Pharmacology. 139(4), 721-32
• CHEN, C.Y., CORDEAUX, Y., HILL, S.J. and KING, J.R., 2003. Modelling of signalling via G-protein coupled receptors: pathway-dependent agonist potency and efficacy Bulletin of Mathematical Biology. 65(5), 933-58
• BAKER, J.G, HALL, I.P and HILL, S.J., 2002. Pharmacological characterization of CGP 12177 at the human beta(2)-adrenoceptor British Journal of Pharmacology. 137(3), 400-8
• CORDEAUX, Y. and HILL, S.J., 2002. Mechanisms of cross-talk between G-protein-coupled receptors Neuro-Signals. 11(1), 45-57
• BURTON, C.L., CHHABRA, S.R., SWIFT, S., BALDWIN, T.J., WITHERS, H., HILL, S.J. and WILLIAMS, P., 2002. The growth response of Escherichia coli to neurotransmitters and related catecholamine drugs requires a functional enterobactin biosynthesis and uptake system Infection and Immunity. 70(11), 5913-5923
• MEGSON, A.C., WALKER, E.M. and HILL, S.J., 2001. Role of protein kinase Calpha in signaling from the histamine H(1) receptor to the nucleus Molecular Pharmacology. 59(5), 1012-1021
• HILL, S J, BAKER, J G and REES, S, 2001. Reporter-gene systems for the study of G-protein-coupled receptors. Current Opinion in Pharmacology. 1(5), 526-32
• MIDDLETON, A., NURY, D., WILLINGTON, S. J., LATIF, L., HILL, S. J. and MIDDLETON, B., 2001. Modulation by cellular cholesterol of gene transcription via the cyclic AMP response element Biochemical Pharmacology. VOL 62(NUMBER 2), 171-181
• CORDEAUX, Y, BRIDDON, S J, MEGSON, A E, MCDONNELL, J, DICKENSON, J M and HILL, S J, 2000. Influence of receptor number on functional responses elicited by agonists acting at the human adenosine A(1) receptor: evidence for signaling pathway-dependent changes in agonist potency and relative intrinsic activity. Molecular Pharmacology. 58(5), 1075-84
• HOPKINSON, H E, LATIF, M L and HILL, S J, 2000. Non-competitive antagonism of beta(2)-agonist-mediated cyclic AMP accumulation by ICI 118551 in BC3H1 cells endogenously expressing constitutively active beta(2)-adrenoceptors. British Journal of Pharmacology. 131(1), 124-30
• HAYNES, J M, SELBIE, L A and HILL, S J, 1999. Gi-Protein alpha-subunit mRNA antisense oligonucleotide inhibition of Gi-coupled receptor contractile activity in the epididymis of the guinea-pig. British Journal of Pharmacology. 127(1), 85-90
• HAYNES, J M, ALEXANDER, S P and HILL, S J, 1998. A1 and A2 adenosine receptor modulation of contractility in the cauda epididymis of the guinea-pig. British Journal of Pharmacology. 125(3), 570-6
• HAYNES, J M, ALEXANDER, S P and HILL, S J, 1998. A1 adenosine receptor modulation of electrically-evoked contractions in the bisected vas deferens and cauda epididymis of the guinea-pig. British Journal of Pharmacology. 124(5), 964-70
• WALKER, E M, BISPHAM, J R and HILL, S J, 1998. Nonselective effects of the putative phospholipase C inhibitor, U73122, on adenosine A1 receptor-mediated signal transduction events in Chinese hamster ovary cells. Biochemical Pharmacology. 56(11), 1455-62
• DICKENSON, J M and HILL, S J, 1998. Human 5-HT1B receptor stimulated inositol phospholipid hydrolysis in CHO cells: synergy with Gq-coupled receptors. European Journal of Pharmacology. 348(2-3), 279-85
• DICKENSON, J M and HILL, S J, 1998. Involvement of G-protein betagamma subunits in coupling the adenosine A1 receptor to phospholipase C in transfected CHO cells. European Journal of Pharmacology. 355(1), 85-93
• SELBIE, L A and HILL, S J, 1998. G protein-coupled-receptor cross-talk: the fine-tuning of multiple receptor-signalling pathways. Trends in Pharmacological Sciences. 19(3), 87-93
• DICKENSON, J M and HILL, S J, 1998. Potentiation of adenosine A1 receptor-mediated inositol phospholipid hydrolysis by tyrosine kinase inhibitors in CHO cells. British Journal of Pharmacology. 125(5), 1049-57
• MCDONNELL, J, LATIF, M L, REES, E S, BEVAN, N J and HILL, S J, 1998. Influence of receptor number on the stimulation by salmeterol of gene transcription in CHO-K1 cells transfected with the human beta2-adrenoceptor. British Journal of Pharmacology. 125(4), 717-26
• DICKENSON, J M, BLANK, J L and HILL, S J, 1998. Human adenosine A1 receptor and P2Y2-purinoceptor-mediated activation of the mitogen-activated protein kinase cascade in transfected CHO cells. British Journal of Pharmacology. 124(7), 1491-9
• MARSH, K A, DRAPER, L M, RUBIN, P C and HILL, S J, 1997. Receptor-stimulated phospholipase C activity in human umbilical artery cultured endothelial cells grown in a low oxygen environment. Biochemical Pharmacology. 54(12), 1351-9
• COOPER, J, HILL, S J and ALEXANDER, S P, 1997. An endogenous A2B adenosine receptor coupled to cyclic AMP generation in human embryonic kidney (HEK 293) cells. British Journal of Pharmacology. 122(3), 546-50
• HILL, S J, GANELLIN, C R, TIMMERMAN, H, SCHWARTZ, J C, SHANKLEY, N P, YOUNG, J M, SCHUNACK, W, LEVI, R and HAAS, H L, 1997. International Union of Pharmacology. XIII. Classification of histamine receptors. Pharmacological Reviews. 49(3), 253-78
• HAYNES, J M, HILL, S J and SELBIE, L A, 1997. Neuropeptide Y (NPY) and peptide YY (PYY) effects in the epididymis of the guinea-pig: evidence of a pre-junctional PYY-selective receptor. British Journal of Pharmacology. 122(7), 1530-6
• SELBIE, L A, KING, N V, DICKENSON, J M and HILL, S J, 1997. Role of G-protein beta gamma subunits in the augmentation of P2Y2 (P2U)receptor-stimulated responses by neuropeptide Y Y1 Gi/o-coupled receptors. Biochemical Journal. 328 ( Pt 1), 153-8
• DICKENSON, J M and HILL, S J, 1997. Transfected adenosine A1 receptor-mediated modulation of thrombin-stimulated phospholipase C and phospholipase A2 activity in CHO cells. European Journal of Pharmacology. 321(1), 77-86
• HAYNES, J M and HILL, S J, 1997. Beta-adrenoceptor-mediated inhibition of alpha 1-adrenoceptor-mediated and field stimulation-induced contractile responses in the prostate of the guinea pig. British Journal of Pharmacology. 122(6), 1067-74
• MARSH, K A, HARRISSS, D R and HILL, S J, 1996. Desensitization of muscarinic receptor-coupled inositol phospholipid hydrolysis in human detrusor cultured smooth cells. The Journal of urology. 155(4), 1439-43
• PEAKMAN, M C and HILL, S J, 1996. Adenosine A1 receptor-mediated inhibition of cyclic AMP accumulation in type-2 but not type-1 rat astrocytes. European Journal of Pharmacology. 306(1-3), 281-9
• CLARK, E A and HILL, S J, 1996. Sensitivity of histamine H3 receptor agonist-stimulated [35S]GTP gamma[S] binding to pertussis toxin. European Journal of Pharmacology. 296(2), 223-5
• ALEXANDER, S P, COOPER, J, SHINE, J and HILL, S J, 1996. Characterization of the human brain putative A2B adenosine receptor expressed in Chinese hamster ovary (CHO.A2B4) cells. British Journal of Pharmacology. 119(6), 1286-90
• MCCREA, K E and HILL, S J, 1996. Comparison of duration of agonist action at beta 1- and beta 2- adrenoceptors in C6 glioma cells: evidence that the long duration of action of salmeterol is specific to the beta 2-adrenoceptor. Molecular Pharmacology. 49(5), 927-37
• DICKENSON, J M and HILL, S J, 1996. Synergistic interactions between human transfected adenosine A1 receptors and endogenous cholecystokinin receptors in CHO cells. European Journal of Pharmacology. 302(1-3), 141-51
• HAYNES, J M and HILL, S J, 1996. Alpha-adrenoceptor mediated responses of the cauda epididymis of the guinea-pig. British Journal of Pharmacology. 119(6), 1203-10
• IREDALE, P A, ALEXANDER, S P and HILL, S J, 1994. Coupling of a transfected human brain A1 adenosine receptor in CHO-K1 cells to calcium mobilisation via a pertussis toxin-sensitive mechanism. British Journal of Pharmacology. 111(4), 1252-6
• ALEXANDER, S P, CURTIS, A R, KENDALL, D A and HILL, S J, 1994. A1 adenosine receptor inhibition of cyclic AMP formation and radioligand binding in the guinea-pig cerebral cortex. British Journal of Pharmacology. 113(4), 1501-7
• ALEXANDER, S P, LOSINSKI, A, KENDALL, D A and HILL, S J, 1994. A comparison of A2 adenosine receptor-induced cyclic AMP generation in cerebral cortex and relaxation of pre-contracted aorta. British Journal of Pharmacology. 111(1), 185-90
• DICKENSON, J M and HILL, S J, 1994. Characteristics of [3H]mepyramine binding in DDT1MF-2 cells: evidence for high affinity binding to a functional histamine H1 receptor. European Journal of Pharmacology. 268(2), 257-62
• MCCREATH, G, HALL, I P and HILL, S J, 1994. Agonist-induced desensitization of histamine H1 receptor-mediated inositol phospholipid hydrolysis in human umbilical vein endothelial cells. British Journal of Pharmacology. 113(3), 823-30
• DICKENSON, J M and HILL, S J, 1994. Interactions between adenosine A1- and histamine H1-receptors. The International journal of biochemistry. 26(8), 959-69
• MARSH, K A and HILL, S J, 1994. Des-Arg9-bradykinin-induced increases in intracellular calcium ion concentration in single bovine tracheal smooth muscle cells. British Journal of Pharmacology. 112(3), 934-8
• PEAKMAN, M C and HILL, S J, 1994. Endogenous expression of histamine H1 receptors functionally coupled to phosphoinositide hydrolysis in C6 glioma cells: regulation by cyclic AMP. British Journal of Pharmacology. 113(4), 1554-60
• PEAKMAN, M C and HILL, S J, 1994. Adenosine A2B-receptor-mediated cyclic AMP accumulation in primary rat astrocytes. British Journal of Pharmacology. 111(1), 191-8
• DICKENSON, J M and HILL, S J, 1994. Selective potentiation of histamine H1-receptor stimulated calcium responses by 1,4-dithiothreitol in DDT1MF-2 cells. Biochemical Pharmacology. 48(9), 1721-8
• DICKENSON, J M, BULMER, S, WHITTAKER, A, SALWEY, M, HAWLEY, J and HILL, S J, 1994. Bradykinin B2- and 5-hydroxytryptamine (5-HT2)-receptor stimulated increases in intracellular calcium in cultured guinea-pig aortic smooth muscle cells. Biochemical Pharmacology. 47(6), 947-52