MALONEY, CHRISTOPHER A, HAY, SUSAN M, YOUNG, LORAINE E, SINCLAIR, KEVIN D and REES, WILLIAM D, 2011. A methyl-deficient diet fed to rat dams during the peri-conception period programs glucose homeostasis in adult male but not female offspring. The Journal of nutrition. 141(1), 95-100 FOWLER PA, BELLINGHAM M, SINCLAIR KD, EVANS NP, POCAR P, FISCHER B, SCHAEDLICH K, SCHMIDT J, AMEZAGA MR, BHATTACHARYA S, RHIND SM and O'SHAUGHNESSY PJ, 2011. Impact Of Endocrine-Disrupting Compounds (Edcs) On Female Reproductive Health. Molecular And Cellular Endocrinology. (In Press.)
TWIGT JM, HAMMICHE F, SINCLAIR KD, BECKERS NG, VISSER JA, LINDEMANS J, DE JONG FH, LAVEN JSE and STEEGERS-THEUNISSEN RP, 2011. Preconception Folic Acid Use Modulates Estradiol And Follicular Responses To Ovarian Stimulation. The Journal Of Clinical Endocrinology And Metabolism. 96(2), E322-9 MALONEY, CA, HAY, SM, YOUNG, LE, SINCLAIR, KD and REES, WD, 2011. A Methyl-Deficient Diet Fed To Rat Dams During The Peri-Conception Period Programs Glucose Homeostasis In Adult Male But Not Female Offspring Journal Of Nutrition. 141(1), 95-100 RHIND SM, EVANS NP, BELLINGHAM M, SHARPE RM, COTINOT C, MANDON-PEPIN B, LOUP B, SINCLAIR KD, LEA RG, POCAR P, FISCHER B, VAN DER ZALM E, HART K, SCHMIDT J, AMEZAGA MR and FOWLER PA, 2010. Effects Of Environmental Pollutants On The Reproduction And Welfare Of Ruminants. Animal : An International Journal Of Animal Bioscience. 4(7), 1227-1239 KWONG WY, ADAMIAK SJ, GWYNN A, SINGH R and SINCLAIR KD, 2010. Endogenous Folates And Single-Carbon Metabolism In The Ovarian Follicle, Oocyte And Pre-Implantation Embryo. Reproduction (Cambridge, England). 139(4), 705-15 SINCLAIR KD, KARAMITRI A and GARDNER DS, 2010. Dietary Regulation Of Developmental Programming In Ruminants: Epigenetic Modifications In The Germline. Society Of Reproduction And Fertility Supplement. 67, 59-72
WONNACOTT KE, KWONG WY, HUGHES J, SALTER AM, LEA RG, GARNSWORTHY PC and SINCLAIR KD, 2010. Dietary Omega-3 And -6 Polyunsaturated Fatty Acids Affect The Composition And Development Of Sheep Granulosa Cells, Oocytes And Embryos. Reproduction (Cambridge, England). 139(1), 57-69 GARDNER, D S, OZANNE, S E and SINCLAIR, K D, 2009. Effect of the early-life nutritional environment on fecundity and fertility of mammals. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 364(1534), 3419-27 FOULADI-NASHTA AA, WONNACOTT KE, GUTIERREZ CG, GONG JG, SINCLAIR KD, GARNSWORTHY PC and WEBB R, 2009. Oocyte Quality In Lactating Dairy Cows Fed On High Levels Of N-3 And N-6 Fatty Acids. Reproduction (Cambridge, England). 138(5), 771-81 ROOKE JA, AINSLIE A, WATT RG, ALINK FM, MCEVOY TG, SINCLAIR KD, GARNSWORTHY PC and WEBB R, 2009. Dietary Carbohydrates And Amino Acids Influence Oocyte Quality In Dairy Heifers. Reproduction, Fertility, And Development. 21(3), 419-27 KANAKKAPARAMBIL R, SINGH R, LI D, WEBB R and SINCLAIR KD, 2009. B-Vitamin And Homocysteine Status Determines Ovarian Response To Gonadotropin Treatment In Sheep. Biology Of Reproduction. 80(4), 743-52 THURSTON, ALEXANDRA, TAYLOR, JANE, GARDNER, JOHN, SINCLAIR, KEVIN D and YOUNG, LORRAINE E, 2008. Monoallelic expression of nine imprinted genes in the sheep embryo occurs after the blastocyst stage. Reproduction. 135(1), 29-40 SINCLAIR, K.D., LUNN, L.A., KWONG, W.Y., WONNACOTT, K., LINFORTH, R.S.T. and CRAIGON, J., 2008. Amino acid and fatty acid composition of follicular fluid as predictors of in-vitro embryo development Reproductive BioMedicine Online. 16, 859-868 GARNSWORTHY, P.C., SINCLAIR, K.D. and WEBB, R., 2008. Integration of physiological mechanisms that influence fertility in dairy cows Animal. VOL 2, 1144-1152 ROOKE, J.A, AINSLIE, A, WATT, R.G, ALINK, F.M, MCEVOY, T.G, SINCLAIR, K.D and GARNSWORTHY, P.C. AND WEBB, R., 2008. Feeding frequency has diet-dependant effects on plasma hormone concentrations but does not affect oocyte quality in dairy heifers fed fibre- or starch-based diets. Animal 2. (In Press.)
ROOKE, JA, AINSLIE, A, WATT, RG, ALINK, FM, MCEVOY, TG, SINCLAIR, KD, GARNSWORTHY, PC and WEBB, R, 2008. Feeding Frequency Has Diet-Dependent Effects On Plasma Hormone Concentrations But Does Not Affect Oocyte Quality In Dairy Heifers Fed Fibre- Or Starch-Based Diets Animal. 2(9), 1361-1370 GARNSWORTHY PC, GONG JG, ARMSTRONG DG, NEWBOLD JR, MARSDEN M, RICHARDS SE, MANN GE, SINCLAIR KD and WEBB R, 2008. Nutrition, Metabolism, And Fertility In Dairy Cows: 3. Amino Acids And Ovarian Function. Journal Of Dairy Science. 91(11), 4190-7 GARNSWORTHY PC, LOCK A, MANN GE, SINCLAIR KD and WEBB R, 2008. Nutrition, Metabolism, And Fertility In Dairy Cows: 2. Dietary Fatty Acids And Ovarian Function. Journal Of Dairy Science. 91(10), 3824-33 GARNSWORTHY PC, LOCK A, MANN GE, SINCLAIR KD and WEBB R, 2008. Nutrition, Metabolism, And Fertility In Dairy Cows: 1. Dietary Energy Source And Ovarian Function. Journal Of Dairy Science. 91(10), 3814-23 SINCLAIR KD, LUNN LA, KWONG WY, WONNACOTT K, LINFORTH RST and CRAIGON J, 2008. Amino Acid And Fatty Acid Composition Of Follicular Fluid As Predictors Of In-Vitro Embryo Development. Reproductive Biomedicine Online. 16(6), 859-68
SINCLAIR, KEVIN D, ALLEGRUCCI, CINZIA, SINGH, RAVINDER, GARDNER, DAVID S, SEBASTIAN, SONIA, BISPHAM, JAYSON, THURSTON, ALEXANDRA, HUNTLEY, JOHN F, REES, WILLIAM D, MALONEY, CHRISTOPHER A and LEA, RICHARD, 2007. DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. Proceedings of the National Academy of Sciences of the United States of America. 104(49), 19351-6
ROOKE, JA, MCEVOY, TG, ASHWORTH,CJ, ROBINSON,JJ, WILMUT,I, YOUNG,LE and SINCLAIR,KD, 2007. Ovine fetal development is more sensitive to perturbation by the presence of serum in embryo culture before rather than after compaction. Theriogenology. 67(3), 639-647 SINCLAIR,K.D, LEA,R.G, REES,W.D and YOUNG,L.E, 2007. The developmental origins of health and disease; current theories and epigenetic mechanisms Society for Reproduction and Fertility Supplement. 64, 425-443
SINGH, R and SINCLAIR, K D, 2007. Metabolomics: approaches to assessing oocyte and embryo quality. Theriogenology. 68 Suppl 1, S56-62 SINCLAIR, K D, LEA, R G, REES, W D and YOUNG, L E, 2007. The developmental origins of health and disease: current theories and epigenetic mechanisms. Society of Reproduction and Fertility supplement. 64, 425-43
SINGH, R, FOULADI-NASHTA, A A, LI, D, HALLIDAY, N, BARRETT, D A and SINCLAIR, K D, 2006. Methotrexate induced differentiation in colon cancer cells is primarily due to purine deprivation. Journal of cellular biochemistry. 99(1), 146-55 POWELL, K, ROOKE, J A, MCEVOY, T G, ASHWORTH, C J, ROBINSON, J J, WILMUT, I, YOUNG, L E and SINCLAIR, K D, 2006. Zygote donor nitrogen metabolism and in vitro embryo culture perturbs in utero development and IGF2R expression in ovine fetal tissues. Theriogenology. 66(8), 1901-12 ADAMIAK, S.J., POWELL, K., ROOKE, J.A., WEBB, R. and SINCLAIR, K.D., 2006. Body composition, dietary carbohydrates and fatty acids determine post-fertilisation development of bovine oocytes <i>in vitro</i>. Reproduction. 131(2), 247-58 STEELE, W, ALLEGRUCCI, C, SINGH, R, LUCAS, E, PRIDDLE, H, DENNING, C, SINCLAIR, K and YOUNG, L, 2005. Human embryonic stem cell methyl cycle enzyme expression: modelling epigenetic programming in assisted reproduction? Reproductive Biomedicine online. 10(6), 755-66 ALLEGRUCCI, C., DENNING, C.N., BURRIDGE, P., STEELE, W., SINCLAIR, K.D. and YOUNG, L.E., 2005. Human embryonic stem cells as a model for nutritional programming: an evaluation Reproductive Toxicology. 20(3), 353-367 ADAMIAK, S.J., MACKIE, K., WATT, R.G., WEBB, R. and SINCLAIR, K.D., 2005. Impact of nutrition on oocyte quality: cumulative effects of body composition and diet leading to hyperinsulinemia in cattle. Biology of Reproduction. 73(5), 918-926 YOUNG,L.E., REES,W.D. and SINCLAIR,K.D, 2004. Programming in the pre-implantation embryo. In: Fetal nutrition and Adult Disease: Programming of chronic disease through fetal exposure to undernutrition CAB International, Oxford.
QUINTANS, G., VINOLES, C. and SINCLAIR, K. D., 2004. Follicular growth and ovulation in postpartum beef cows following calf removal and GnRH treatment Animal Reproduction Science. VOL 80(NUMBER 1-2), 5-14 ROOKE, J A, EWEN, M, MACKIE, K, STAINES, M E, MCEVOY, T G and SINCLAIR, K D, 2004. Effect of ammonium chloride on the growth and metabolism of bovine ovarian granulosa cells and the development of ovine oocytes matured in the presence of bovine granulosa cells previously exposed to ammonium chloride. Animal Reproduction Science. 84(1-2), 53-71 QUINTANS, G, VIÑOLES, C and SINCLAIR, K D, 2004. Follicular growth and ovulation in postpartum beef cows following calf removal and GnRH treatment. Animal Reproduction Science. 80(1-2), 5-14
MANN, G.E., GREEN, M.P., SINCLAIR, K.D., DEMMERS, K.J., FRAY, M.D., GUTIERREZ, C.G., GARNSWORTHY, P.C. and WEBB, R., 2003. Effects of circulating progesterone and insulin on early embryo development in beef heifers Animal Reproduction Science. VOL 79(NUMBER 1-2), 71-79 SINCLAIR, K.D., GARNSWORTHY, P.C. and WEBB, R., 2003. Recent advances in reproductive technologies : implications for livestock production and animal nutrition. In: GARNSWORTHY, P.C. and WISEMAN, J., eds., Recent Advances in Animal Nutrition - 2003 Nottingham University Press. 89-113
MCEVOY, T. G., ASHWORTH, C. J., ROOKE, J. A. and SINCLAIR, K. D., 2003. Consequences of manipulating gametes and embryos of ruminant species Reproduction. Supplement. ISSU 61, 167-182
SINCLAIR, K. D., ROOKE, J. A. and MCEVOY, T. G., 2003. Regulation of nutrient uptake and metabolism in pre-elongation ruminant embryos Reproduction. Supplement. ISSU 61, 371-385
PUSHPAKUMARA, P.G.A., ROBINSON, R.S., DEMMERS, K.J., MANN, G.E., SINCLAIR, K.D., WEBB, R. and WATHES, D.C., 2002. Expression of the insulin-like growth factor (IGF) system in the bovine oviduct at oestrus and during early pregnancy Reproduction. VOL 123(PART 6), 859-868 DAWUDA, P. M., SCAIFE, J. R., HUTCHINSON, J. S. and SINCLAIR, K. D., 2002. Mechanisms linking under-nutrition and ovarian function in beef heifers Animal Reproduction Science. VOL 74(NUMBER 1-2), 11-26 SINCLAIR, K. D., MOLLE, G., REVILLA, R., ROCHE, J. F., QUINTANS, G., MARONGIU, L., SANZ, A., MACKEY, D. R. and DISKIN, M. G., 2002. Ovulation of the first dominant follicle arising after day 21 post partum in suckling beef cows Animal Science. VOL 75(PART 1), 115-126
ARMSTRONG, D.G., MCEVOY, T.G., BAXTER, G., ROBINSON, J.J., HOGG, C.O., WOAD, K.J., WEBB, R. and SINCLAIR, K.D., 2001. Effect of dietary energy and protein on bovine follicular dynamics and embryo production in vitro : associations with the ovarian insulin-like growth factor system Biology of Reproduction. 64(6), 1624-1632 YOUNG, L.E., FERNANDES, K., MCEVOY, T.G., BUTTERWITH, S.C., GUTIERREZ, C.G., CAROLAN, C., BROADBENT, P.J., ROBINSON, J.J., WILMUT, I. and SINCLAIR, K.D., 2001. Epigenetic change in <i>IGF2R</i> is associated with fetal overgrowth after sheep embryo culture Nature Genetics. 27(2), 153-154 ARMSTRONG, D G, MCEVOY, T G, BAXTER, G, ROBINSON, J J, HOGG, C O, WOAD, K J, WEBB, R and SINCLAIR, K D, 2001. Effect of dietary energy and protein on bovine follicular dynamics and embryo production in vitro: associations with the ovarian insulin-like growth factor system. Biology of Reproduction. 64(6), 1624-32 MALTIN, C A, DELDAY, M I, SINCLAIR, K D, STEVEN, J and SNEDDON, A A, 2001. Impact of manipulations of myogenesis in utero on the performance of adult skeletal muscle. Reproduction. 122(3), 359-74 MCEVOY, T., ROBINSON, J. J., ASHWORTH, C. J., ROOKE, J. A. and SINCLAIR, K. D., 2001. FEED AND FORAGE TOXICANTS AFFECTING EMBRYO SURVIVAL AND FETAL DEVELOPMENT Theriogenology. VOL 55(NO 1), 113-130 SINCLAIR, K. D., LOBLEY, G. E., HORGAN, G. W., KYLE, D. J., PORTER, A. D., MATTHEWS, K. R., WARKUP, C. C. and MALTIN, C. A., 2001. Factors influencing beef eating quality. 1. Effects of nutritional regimen and genotype on organoleptic properties and instrumental texture Animal Science. VOL 72(PART 2), 269-278
MALTIN,C.A., LOBLEY,G.E., GRANT,G.M., MILLER,L.A., KYLE,D.G., HORGAN,G.W., MATTHEWS,K.R. and SINCLAIR,K.D., 2001. Factors influencing beef eating quality. II. Effect of nutritional regimen and genotype on muscle fibre characteristics Animal Science. 72, 279
SINCLAIR, K.D., KURAN, M., GEBBIE, F.E., WEBB, R. and MCEVOY, T.G., 2000. Nitrogen metabolism and fertility in cattle: II. Development of oocytes recovered from heifers offered diets differing in their rate of nitrogen release in the rumen Journal of Animal Science. VOL 78(PART 10), 2670-2680
MCEVOY, T. G., SINCLAIR, K. D., YOUNG, L. E., WILMUT, I. and ROBINSON, J. J., 2000. Large offspring syndrome and other consequences of ruminant embryo culture in vitro: relevance to blastocyst culture in human ART Human Fertility. VOL 3(PART 4), 238-246
SINCLAIR, K. D., YOUNG, L. E., WILMUT, I. and MCEVOY, T. G., 2000. In-utero overgrowth in ruminants following embryo culture: lessons from mice and a warning to men Human Reproduction. VOL 15(SUPP/5), 68-86
MCEVOY,, SINCLAIR,, YOUNG,, WILMUT, and ROBINSON,, 2000. Large offspring syndrome and other consequences of ruminant embryo culture in vitro: relevance to blastocyst culture in human ART. Human Fertility. 3(4), 238-246
SINCLAIR, K D, SINCLAIR, L A and ROBINSON, J J, 2000. Nitrogen metabolism and fertility in cattle: I. Adaptive changes in intake and metabolism to diets differing in their rate of energy and nitrogen release in the rumen. Journal of Animal Science. 78(10), 2659-69
ARMSTRONG, D.G., BAXTER, G., HOGG, C.O. and WOAD, K.J., 1998. The effect of different energy and protein diets on the expression of mRNA encoding components of the ovarian IGF-system in cattle Journal of Reproduction and Fertility. Abstract Series. ISSUE 22, 13
SINCLAIR, K D, DUNNE, L D, MAXFIELD, E K, MALTIN, C A, YOUNG, L E, WILMUT, I, ROBINSON, J J and BROADBENT, P J, 1998. Fetal growth and development following temporary exposure of day 3 ovine embryos to an advanced uterine environment. Reproduction, Fertility and Development. 10(3), 263-9 ARMSTRONG, D.G., BAXTER, G., GUTIERREZ, C.G., WOAD, K.J., SINCLAIR, K.D., ROBINSON, J.J., MCEVOY, T.G. and WEBB, R., 1997. Ovarian IGF-II mRNA expression in cattle fed different energy and protein diets Journal of Reproduction and Fertility. Abstract Series. 19, 51
MCEVOY, T.G., SINCLAIR, K.D., STAINES, M.E., ROBINSON, J.J., ARMSTRONG, D. and WEBB, R., 1997. <I>In vitro</I> blastocyst production in relation to energy and protein intake prior to oocyte collection Journal of Reproduction and Fertility. Abstract Series. 19, 51