Reinhard Stoger

Contact

• workRoom Room 232 / 1st Floor South Laboratory
  Sutton Bonington Campus
  Sutton Bonington
  Leicestershire
  LE12 5RD
  UK
• work0115 951 6232
• fax0115 951 6302
• reinhard.stoger@nottingham.ac.uk
• http://stoegerlab.com/

Research Summary

Reinhard Stöger has long-standing experience and research interest in epigenetic phenomena. As a PhD student at the IMP/ Vienna (Austria), he worked with Denise Barlow to discover and describe an… read more

Selected Publications

• STÖGER, REINHARD, 2008. The thrifty epigenotype: an acquired and heritable predisposition for obesity and diabetes? BioEssays. 30(2), 156-66
• STÖGER, REINHARD, 2008. Epigenetics and obesity. Pharmacogenomics. 9(12), 1851-60
• GENEREUX, DIANE P, JOHNSON, WINSLOW C, BURDEN, ALICE F, STÖGER, REINHARD and LAIRD, CHARLES D, 2008. Errors in the bisulfite conversion of DNA: modulating inappropriate- and failed-conversion frequencies. Nucleic Acids Research. 36(22), e150
• STÖGER, REINHARD, 2006. In vivo methylation patterns of the leptin promoter in human and mouse. Epigenetics : official journal of the DNA Methylation Society. 1(4), 155-62

• View all publications

Current Research

Reinhard Stöger has long-standing experience and research interest in epigenetic phenomena. As a PhD student at the IMP/ Vienna (Austria), he worked with Denise Barlow to discover and describe an imprinted gene in mammals. Since then, Reinhard has worked in London and Seattle, focusing largely on molecular mechanisms in human syndromes and diseases that have strong epigenetic components. Over the past years Reinhard was involved in identifying a new subfamily of chromodomain helicases, contributed to the conception and development of new methods and research tools, and more recently advancing theoretical concepts.

Current Work

The role of epigenetic mechanisms in modulating gene-environment and developmental processes. Identification of genomic loci that are responsive to environmental stressors and stimuli such as under/overnutrition, human-produced compounds and hormones. The study of DNA methylation patterns and the fidelity of their mitotic and meiotic inheritance.

Leptin

Leptin is one of the important hormones that regulate weight and appetite. The

• FU AQ, GENEREUX DP, STÖGER R, BURDEN AF, LAIRD CD and STEPHENS M, 2012. Statistical Inference Of In Vivo Properties Of Human Dna Methyltransferases From Double-Stranded Methylation Patterns. Plos One. 7(3), e32225
• STÖGER R, GENEREUX DP, HAGERMAN RJ, HAGERMAN PJ, TASSONE F and LAIRD CD, 2011. Testing The Fmr1 Promoter For Mosaicism In Dna Methylation Among Cpg Sites, Strands, And Cells In Fmr1-Expressing Males With Fragile X Syndrome. Plos One. 6(8), e23648
• STÖGER, R, GENEREUX, DP, HAGERMAN, RJ, HAGERMAN, PJ, TASSONE, F and LAIRD, CD, 2011. Testing The Fmr1 Promoter For Mosaicism In Dna Methylation Among Cpg Sites, Strands, And Cells In Fmr1-Expressing Males With Fragile X Syndrome Plos One. 6(8), -
• LATHROP, MELISSA J, CHAKRABARTI, LISA, ENG, JEREMIAH, HARKER RHODES, C, LUTZ, THOMAS, NIETO, AMELIA, DENNY LIGGITT, H, WARNER, SANDRA, FIELDS, JENNIFER, STÖGER, REINHARD and FIERING, STEVEN, 2010. Deletion of the Chd6 exon 12 affects motor coordination. Mammalian genome : official journal of the International Mammalian Genome Society. 21(3-4), 130-142
• VOUTSINAS, GERASSIMOS E, STAVROU, ELEANA F, KAROUSOS, GERASSIMOS, DASOULA, AGGELIKI, PAPACHATZOPOULOU, ADAMANTIA, SYRROU, MARIA, VERKERK, ANNEMIEKE J M H, VAN DER SPEK, PETER, PATRINOS, GEORGE P, STÖGER, REINHARD and AND ATHANASSIADOU, AGLAIA, 2010. Allelic imbalance of expression and epigenetic regulation within the alpha-synuclein wild-type and p.Ala53Thr alleles in Parkinson disease. Human mutation. 31(6), 685-91
• FERTEY J, AMMERMANN I, WINKLER M, STÖGER R, IFTNER T and STUBENRAUCH F, 2010. Interaction Of The Papillomavirus E8--E2c Protein With The Cellular Chd6 Protein Contributes To Transcriptional Repression. Journal Of Virology. 84(18), 9505-15
• FU AQ, GENEREUX DP, STÖGER R, LAIRD CD and STEPHENS M, 2010. Statistical Inference Of Transmission Fidelity Of Dna Methylation Patterns Over Somatic Cell Divisions In Mammals. The Annals Of Applied Statistics. 4(2), 871-892
• GENEREUX, DP, JOHNSON, WC, BURDEN, AF, STOGER, R and LAIRD, CD, 2009. Errors In The Bisulfite Conversion Of Dna: Modulating Inappropriate- And Failed-Conversion Frequencies (Vol 37, Pg E150, 2008)
• GENEREUX, DIANE P, JOHNSON, WINSLOW C, BURDEN, ALICE F, STÖGER, REINHARD and LAIRD, CHARLES D, 2008. Errors in the bisulfite conversion of DNA: modulating inappropriate- and failed-conversion frequencies. Nucleic Acids Research. 36(22), e150
• STÖGER, REINHARD, 2008. The thrifty epigenotype: an acquired and heritable predisposition for obesity and diabetes? BioEssays. 30(2), 156-66
• STÖGER, REINHARD, 2008. Epigenetics and obesity. Pharmacogenomics. 9(12), 1851-60
• GENEREUX, DP, JOHNSON, WC, BURDEN, AF, STOGER, R and LAIRD, CD, 2008. Errors In The Bisulfite Conversion Of Dna: Modulating Inappropriate- And Failed-Conversion Frequencies Nucleic Acids Research. 36(22), -
• MCCLOSKEY, MEGAN L, STÖGER, REINHARD, HANSEN, R SCOTT and LAIRD, CHARLES D, 2007. Encoding PCR products with batch-stamps and barcodes. Biochemical Genetics. 45(11-12), 761-7
• LUTZ, THOMAS, STÖGER, REINHARD and NIETO, AMELIA, 2006. CHD6 is a DNA-dependent ATPase and localizes at nuclear sites of mRNA synthesis. FEBS Letters. 580(25), 5851-7
• STÖGER, REINHARD, 2006. In vivo methylation patterns of the leptin promoter in human and mouse. Epigenetics : official journal of the DNA Methylation Society. 1(4), 155-62
• TISCHKOWITZ, M D, MORGAN, N V, GRIMWADE, D, EDDY, C, BALL, S, VORECHOVSKY, I, LANGABEER, S, STÖGER, R, HODGSON, S V and MATHEW, C G, 2004. Deletion and reduced expression of the Fanconi anemia FANCA gene in sporadic acute myeloid leukemia. Leukemia. 18(3), 420-5
• LAIRD, CHARLES D, PLEASANT, NICOLE D, CLARK, AARON D, SNEEDEN, JESSICA L, HASSAN, K M ANWARUL, MANLEY, NATHAN C, VARY, JAY C, MORGAN, TODD, HANSEN, R SCOTT and STÖGER, REINHARD, 2004. Hairpin-bisulfite PCR: assessing epigenetic methylation patterns on complementary strands of individual DNA molecules. Proceedings of the National Academy of Sciences of the United States of America. 101(1), 204-9
• MINER, BROOKS E, STÖGER, REINHARD J, BURDEN, ALICE F, LAIRD, CHARLES D and HANSEN, R SCOTT, 2004. Molecular barcodes detect redundancy and contamination in hairpin-bisulfite PCR. Nucleic Acids Research. 32(17), e135
• SCHUSTER, EUGENE F and STÖGER, REINHARD, 2002. CHD5 defines a new subfamily of chromodomain-SWI2/SNF2-like helicases. Mammalian Genome. 13(2), 117-9
• HANSEN, R S, STÖGER, R, WIJMENGA, C, STANEK, A M, CANFIELD, T K, LUO, P, MATARAZZO, M R, D'ESPOSITO, M, FEIL, R, GIMELLI, G, WEEMAES, C M, LAIRD, C D and GARTLER, S M, 2000. Escape from gene silencing in ICF syndrome: evidence for advanced replication time as a major determinant. Human Molecular Genetics. 9(18), 2575-87
• KISPERT, A, STÖGER, R J, CAPARROS, M and HERRMANN, B G, 1999. The mouse Rsk3 gene maps to the Leh66 elements carrying the t-complex responder Tcr. Mammalian Genome. 10(8), 794-802
• TAPSCOTT, S J, KLESERT, T R, WIDROW, R J, STÖGER, R and LAIRD, C D, 1998. Fragile-X syndrome and myotonic dystrophy: parallels and paradoxes. Current Opinion in Genetics & Development. 8(2), 245-53
• STÖGER, R, KAJIMURA, T M, BROWN, W T and LAIRD, C D, 1997. Epigenetic variation illustrated by DNA methylation patterns of the fragile-X gene FMR1. Human Molecular Genetics. 6(11), 1791-801
• WONG, D J, BARRETT, M T, STÖGER, R, EMOND, M J and REID, B J, 1997. p16INK4a promoter is hypermethylated at a high frequency in esophageal adenocarcinomas. Cancer Research. 57(13), 2619-22
• SMRZKA, O W, FAÉ, I, STÖGER, R, KURZBAUER, R, FISCHER, G F, HENN, T, WEITH, A and BARLOW, D P, 1995. Conservation of a maternal-specific methylation signal at the human IGF2R locus. Human Molecular Genetics. 4(10), 1945-52
• STÖGER, R, KUBICKA, P, LIU, C G, KAFRI, T, RAZIN, A, CEDAR, H and BARLOW, D P, 1993. Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal. Cell. 73(1), 61-71
• BARLOW, D P, STÖGER, R, HERRMANN, B G, SAITO, K and SCHWEIFER, N, 1991. The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus. Nature. 349(6304), 84-7