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Marie Curie Fellow, Faculty of Science
My research focuses on uncovering the mechanisms regulating the decision of a seed to break dormancy and germinate. A systems-based experimental approach is utilized to identify the genetic,… read more
My research focuses on uncovering the mechanisms regulating the decision of a seed to break dormancy and germinate. A systems-based experimental approach is utilized to identify the genetic, biochemical and mechanical processes underlying this developmental phase transition. These data are ultimately being integrated into a predictive computational model. Recent work has identified the genome-wide transcriptional network underlying developmental fate in seeds. Two fundamentally different approaches towards this have been utilized: 1) Gene co-expression, and the resulting network SeedNet (Bassel et al. PNAS 2011) 2) Rule-based machine learning, or co-prediction, leading to SCoPNet (Bassel et al. 2011, submitted) Information from these genome-wide networks are being integrated into high resolution 3D images of germinating embryos leading to the development of comprehensive 3D computational models of seed germination.
University of NottinghamSutton Bonington Campus Loughborough, Leicestershire LE12 5RD
telephone: +44 (0) 115 951 6327 email: plantandcrop-enquiries@nottingham.ac.uk