Ive De Smet

BBSRC David Philips Research Fellow, Faculty of Science

Personal Details
Research
Publications

Contact

workRoom C30 Plant Sciences
Sutton Bonington Campus
Sutton Bonington
Leicestershire
LE12 5RD
UK
work0115 951 6681
Ive.De_Smet@nottingham.ac.uk

Research Summary

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http://rstb.royalsocietypublishing.org/site/2012/root_growth_branching.xhtml

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***PhD Studentship Options***

http://www.nottingham.ac.uk/biosciences/documents/vacancies/2012/receptor-kinase-signalling-complexes-in-root-development-2012.pdf

Optimized root architecture is crucial for efficient water and nutrient uptake, and strongly affects plant growth and seed yield. Our group is interested in the involvement of membrane-associated receptor-like kinases in registering and conveying (positional) information during plant (lateral) root development. Specifically, we are investigating the ACR4-dependent signalling cascade, which we recently showed to be important for root development (De Smet et al. 2008, Science 322:594-597). In the framework of a David Phillips BBSRC Fellowship, we will identify substrates and ligands for the membrane-associated receptor-like kinase ACR4. We will combine the expertise of our lab in genetics and root development with that of partner labs competent in proteome-wide analyses. The characterization of this homeostatic ligand/receptor signalling mechanism, that can integrate mobile signalling molecules to control formative cell divisions during organogenesis, provides an excellent tool to study short range, cell-to-cell communication during growth and development.

Lab members:

Ive De Smet - Group Leader

E. Leanne Williams - Postdoctoral Research Fellow

Zhefeng Lin - Research Technician

Stephanie Smith - PhD Student

Evan Murphy - PhD Student

Available positions:

PhD position :

http://www.nottingham.ac.uk/biosciences/documents/vacancies/2012/receptor-kinase-signalling-complexes-in-root-development-2012.pdf

Postdoctoral fellowship funding opportunities through: EMBO (http://www.embo.org/programmes/fellowships/long-term.html), FP7 (http://cordis.europa.eu/fp7/people/international-dimension_en.html), FEBS (http://www.febs.org/index.php?id=83), Royal Society (http://www.newtonfellowships.org/the-fellowships.aspx), HFSP (http://www.hfsp.org/funding/postdoctoral-fellowships), ...

Selected Publications

DE SMET, IVE and BEECKMAN, TOM, 2011. Asymmetric cell division in land plants and algae: the driving force for differentiation. Nature Reviews Molecular Cell Biology. 12(3), 177-188
DE SMET, IVE, LAU, STEFFEN, VOSS, UTE, VANNESTE, STEFFEN, BENJAMINS, RENE, RADEMACHER, EIKE H, SCHLERETH, ALEXANDRA, DE RYBEL, BERT, VASSILEVA, VALYA, GRUNEWALD, WIM, NAUDTS, MIRANDE, LEVESQUE, MITCHELL P, EHRISMANN, JASMIN S, INZE, DIRK, LUSCHNIG, CHRISTIAN, BENFEY, PHILIP N, WEIJERS, DOLF, VAN MONTAGU, MARC CE, BENNETT, MALCOLM J, JURGENS, GERD and BEECKMAN, TOM, 2010. Bimodular auxin response controls organogenesis in Arabidopsis. Proceedings of the National Academy of Sciences of the United States of America. 107(6), 2705-2710
DE SMET, IVE, VOSS, UTE, JURGENS, GERD and BEECKMAN, TOM, 2009. Receptor-like kinases shape the plant. Nature Cell Biology. 11(10), 1166-1173
DE SMET, IVE, VASSILEVA, VALYA, DE RYBEL, BERT, LEVESQUE, MITCHELL P, GRUNEWALD, WIM, VAN DAMME, DANIEL, VAN NOORDEN, GIEL, NAUDTS, MIRANDE, VAN ISTERDAEL, GERT, DE CLERCQ, REBECCA, WANG, JEAN Y, LEULI, NICHOLAS, VANNESTE, STEFFEN, FRIML, JIRI, HILSON, PIERRE, JURGENS, GERD, INGRAM, GWYNETH C, INZE, DIRK, BENFEY, PHILIP N and BEECKMAN, TOM, 2008. Receptor-like kinase ACR4 restricts formative cell divisions in the Arabidopsis root. Science. 322(5901), 594-597

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Past Research

Very early in my research career (1999-2000), investigating the anatomy of brown algae of the genus Dictyopteris triggered my interest in what controls the development of complex multicellular organisms and distinct cell types. Recently, this interest resulted in two manuscripts on the evolution of auxin signalling - a major control mechanism in land plant development (Lau et al., 2009, Trends Plant Sci 14:182-188; De Smet et al., Plant Phys, 155:209-221).

During my PhD training (2001-2006) at the University of Leeds (U.K.) and at the Ghent University / VIB Department of Plant Systems Biology (Belgium) with H. Zhang and T. Beeckman, respectively, I investigated the role of the phytohormones abscisic acid and auxin during lateral root development (Signora et al., 2001, Plant J 28:655-662; De Smet et al., 2003, Plant J 33:543-555; De Smet et al., 2007, Development 134:681-690; Swarup et al., 2008, Nat Cell Biol 10:946-954). However, my main achievement was to identify ACR4 as the first receptor-like kinase that plays a decisive role in formative cell division in the root (De Smet et al., 2008, Science 322:594-597; De Smet et al., 2009, Nat Cell Biol 11:1166-1173).

After obtaining my PhD degree in 2006, I joined the lab of G. Jürgens at the University of Tübingen and the Max Planck Institute for Developmental Biology (Germany) as a postdoctoral research fellow (2006-2010) funded by EMBO and a Marie Curie Fellowship. During this period I focused on the regulation of gene expression in early embryogenesis (Lau et al., Nat Cell Biol, submitted). But I also investigated to what extent the molecular mechanisms that have been identified in embryo development also play a role in (lateral) root development (De Smet et al., 2010, Proc Natl Acad Sci USA 107:2705-2710; Zhang et al., 2010, Plant J 64:764-774).

After rejoining the Plant Systems Biology Department (VIB) as an FWO-funded postdoctoral research fellow (2010), I again focused on the role of receptor-like kinases in root development and asymmetric cell division (De Smet and Beeckman, Nat Rev Mol Cell Biol, in press; Den Herder et al., 2010, Trends Plant Sci 15:600-607).

GRUNEWALD W, DE SMET I, LEWIS DR, LÖFKE C, JANSEN L, GOEMINNE G, VANDEN BOSSCHE R, KARIMI M, DE RYBEL B, VANHOLME B, TEICHMANN T, BOERJAN W, VAN MONTAGU MCE, GHEYSEN G, MUDAY GK, FRIML J and BEECKMAN T, 2012. Transcription Factor Wrky23 Assists Auxin Distribution Patterns During Arabidopsis Root Development Through Local Control On Flavonol Biosynthesis. Proceedings Of The National Academy Of Sciences Of The United States Of America. 109(5), 1554-9
DE SMET I, WHITE PJ, BENGOUGH AG, DUPUY L, PARIZOT B, CASIMIRO I, HEIDSTRA R, LASKOWSKI M, LEPETIT M, HOCHHOLDINGER F, DRAYE X, ZHANG H, BROADLEY MR, PÉRET B, HAMMOND JP, FUKAKI H, MOONEY S, LYNCH JP, NACRY P, SCHURR U, LAPLAZE L, BENFEY P, BEECKMAN T and BENNETT M, 2012. Analyzing lateral root development: how to move forward. The Plant Cell. (In Press.)
DE SMET I, 2012. Lateral Root Initiation: One Step At A Time. The New Phytologist. 193(4), 867-73
VAN DAMME D, DE RYBEL B, GUDESBLAT G, DEMIDOV D, GRUNEWALD W, DE SMET I, HOUBEN A, BEECKMAN T and RUSSINOVA E, 2011. Arabidopsis Α Aurora Kinases Function In Formative Cell Division Plane Orientation. The Plant Cell. 23(11), 4013-24
LAU, STEFFEN, DE SMET, IVE, KOLB, MARTINA, MEINHARDT, HANS and JÜRGENS, GERD, 2011. Auxin triggers a genetic switch. Nature Cell Biology. 13(5), 611-615
DE SMET, IVE and BEECKMAN, TOM, 2011. Asymmetric cell division in land plants and algae: the driving force for differentiation. Nature Reviews Molecular Cell Biology. 12(3), 177-188
DE SMET, IVE, VOSS, UTE, LAU, STEFFEN, WILSON, MICHAEL, SHAO, NING, TIMME, RUTH, SWARUP, RANJAN, KERR, IAN, HODGMAN, CHARLIE, BOCK, RALPH, BENNETT, MALCOLM, JÜRGENS, GERD and BEECKMAN, TOM, 2011. Unraveling the evolution of auxin signaling. Plant Physiology. 155, 209-221
DE SMET, IVE, LAU, STEFFEN, MAYER, ULRIKE and JÜRGENS, GERD, 2010. Embryogenesis - the humble beginnings of plant life. The Plant Journal. 61(6), 959-70
DEN HERDER, GRIET, VAN ISTERDAEL, GERT, BEECKMAN, TOM and DE SMET, IVE, 2010. The roots of a new green revolution. Trends in plant science. 15(11), 600-7
DE SMET, IVE, LAU, STEFFEN, VOSS, UTE, VANNESTE, STEFFEN, BENJAMINS, RENE, RADEMACHER, EIKE H, SCHLERETH, ALEXANDRA, DE RYBEL, BERT, VASSILEVA, VALYA, GRUNEWALD, WIM, NAUDTS, MIRANDE, LEVESQUE, MITCHELL P, EHRISMANN, JASMIN S, INZE, DIRK, LUSCHNIG, CHRISTIAN, BENFEY, PHILIP N, WEIJERS, DOLF, VAN MONTAGU, MARC CE, BENNETT, MALCOLM J, JURGENS, GERD and BEECKMAN, TOM, 2010. Bimodular auxin response controls organogenesis in Arabidopsis. Proceedings of the National Academy of Sciences of the United States of America. 107(6), 2705-2710
ZHANG, HANMA, HAN, WOONG, DE SMET, IVE, TALBOYS, PETER, LOYA, RAKESH, HASSAN, AMAAR, RONG, HONGLIN, JÜRGENS, GERD, PAUL KNOX, J and WANG, MYEONG-HYEON, 2010. ABA promotes quiescence of the quiescent centre and suppresses stem cell differentiation in the Arabidopsis primary root meristem. The Plant Journal. 64(5), 764-74
RAMON, MATTHEW, DE SMET, IVE, VANDESTEENE, LIES, NAUDTS, MIRANDE, LEYMAN, BARBARA, VAN DIJCK, PATRICK, ROLLAND, FILIP, BEECKMAN, TOM and THEVELEIN, JOHAN M, 2009. Extensive expression regulation and lack of heterologous enzymatic activity of the Class II trehalose metabolism proteins from Arabidopsis thaliana. Plant, cell & environment. 32(8), 1015-32
DE SMET, IVE, VOSS, UTE, JURGENS, GERD and BEECKMAN, TOM, 2009. Receptor-like kinases shape the plant. Nature Cell Biology. 11(10), 1166-1173
LAU, STEFFEN, SHAO, NING, BOCK, RALPH, JÜRGENS, GERD and DE SMET, IVE, 2009. Auxin signaling in algal lineages: fact or myth? Trends in plant science. 14(4), 182-8
LAU, STEFFEN, JÜRGENS, GERD and DE SMET, IVE, 2008. The evolving complexity of the auxin pathway. The Plant Cell. 20(7), 1738-46
DE SMET, IVE, VASSILEVA, VALYA, DE RYBEL, BERT, LEVESQUE, MITCHELL P, GRUNEWALD, WIM, VAN DAMME, DANIEL, VAN NOORDEN, GIEL, NAUDTS, MIRANDE, VAN ISTERDAEL, GERT, DE CLERCQ, REBECCA, WANG, JEAN Y, LEULI, NICHOLAS, VANNESTE, STEFFEN, FRIML, JIRI, HILSON, PIERRE, JURGENS, GERD, INGRAM, GWYNETH C, INZE, DIRK, BENFEY, PHILIP N and BEECKMAN, TOM, 2008. Receptor-like kinase ACR4 restricts formative cell divisions in the Arabidopsis root. Science. 322(5901), 594-597
PARIZOT, BORIS, LAPLAZE, LAURENT, RICAUD, LILIAN, BOUCHERON-DUBUISSON, ELODIE, BAYLE, VINCENT, BONKE, MARTIN, DE SMET, IVE, POETHIG, SCOTT R, HELARIUTTA, YKA, HASELOFF, JIM, CHRIQUI, DOMINIQUE and BEECKM, 2008. Diarch symmetry of the vascular bundle in Arabidopsis root encompasses the pericycle and is reflected in distich lateral root initiation. Plant physiology. 146(1), 140-8
SWARUP, R, BENKOVÁ, E, SWARUP, K, CASIMIRO, I, PÉRET, B, YANG, Y, PARRY, G, NIELSEN, E, DE SMET, I, VANNESTE, S, LEVESQUE, M, CARRIER, D, JAMES, N, CALVO, V, LJUNG, K, KRAMER, E, ROBERTS, R, GRAHAM, N, MARILLONNET, S, PATEL, K, JONES, J, TAYLOR, C, SCHACHTMAN, D, MAY, S, SANDBERG, G, BENFEY, P, FRIML, J, KERR, I, BEECKMAN, T, LAPLAZE, L and BENNETT, M., 2008. The auxin influx carrier LAX3 promotes lateral root emergence. Nature Cell Biology. 10(8), 946-954
DE SMET, IVE and JÜRGENS, GERD, 2007. Patterning the axis in plants--auxin in control. Current opinion in genetics & development. 17(4), 337-43
DE SMET, IVE, TETSUMURA, TAKUYA, DE RYBEL, BERT, FREY, NICOLAS FREI DIT, LAPLAZE, LAURENT, CASIMIRO, ILDA, SWARUP, RANJAN, NAUDTS, MIRANDE, VANNESTE, STEFFEN, AUDENAERT, DOMINIQUE, INZE, DIRK, BENNETT, MALCOLM J and BEECKMAN, TOM, 2007. Auxin-dependent regulation of lateral root positioning in the basal meristem of Arabidopsis. Development. 134(4), 681-690
DE SMET, IVE, VANNESTE, STEFFEN, INZÉ, DIRK and BEECKMAN, TOM, 2006. Lateral root initiation or the birth of a new meristem. Plant molecular biology. 60(6), 871-87
DE SMET, IVE, ZHANG, HANMA, INZÉ, DIRK and BEECKMAN, TOM, 2006. A novel role for abscisic acid emerges from underground. Trends in plant science. 11(9), 434-9
VANNESTE, STEFFEN, DE RYBEL, BERT, BEEMSTER, GERRIT T S, LJUNG, KARIN, DE SMET, IVE, VAN ISTERDAEL, GERT, NAUDTS, MIRANDE, IIDA, RYUSUKE, GRUISSEM, WILHELM, TASAKA, MASAO, INZÉ, DIRK and FUKAKI, HID, 2005. Cell cycle progression in the pericycle is not sufficient for SOLITARY ROOT/IAA14-mediated lateral root initiation in Arabidopsis thaliana. The Plant Cell. 17(11), 3035-50
DE SMET, I, CHAERLE, P, VANNESTE, S, DE RYCKE, R, INZÉ, D and BEECKMAN, T, 2004. An easy and versatile embedding method for transverse sections. Journal of microscopy. 213(Pt 1), 76-80
CARPENTIER, W, SANDRA, K, DE SMET, I, BRIGÉ, A, DE SMET, L and VAN BEEUMEN, J, 2003. Microbial reduction and precipitation of vanadium by Shewanella oneidensis. Applied and environmental microbiology. 69(6), 3636-9
DE SMET, IVE, SIGNORA, LAURENT, BEECKMAN, TOM, INZÉ, DIRK, FOYER, CHRISTINE H and ZHANG, HANMA, 2003. An abscisic acid-sensitive checkpoint in lateral root development of Arabidopsis. The Plant Journal. 33(3), 543-55
SIGNORA, L, DE SMET, I, FOYER, C H and ZHANG, H, 2001. ABA plays a central role in mediating the regulatory effects of nitrate on root branching in Arabidopsis. The Plant Journal. 28(6), 655-62

School of Biosciences

University of Nottingham
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