Matthew Elmes

Contact

• workRoom 53 North Lab Bldg
  Sutton Bonington Campus
  Sutton Bonington
  Leicestershire
  LE12 5RD
  UK
• work0115 951 6183
• fax0115 951 6122
• matthew.j.elmes@nottingham.ac.uk

Research Summary

Research Interests

My research interests include Nutritional programming, and the implications of dietary polyunsaturated fatty acids (PUFA's) on physiological processes. Nutritional Programming Epidemiological evidence suggests there is a strong relationship between impairment of foetal growth and risk of developing cardiovascular disease in adult life. My research involves manipulating maternal nutrition to alter foetal growth to programme cardiovascular disease in later life. Exposure of the developing foetus to a reduced nutrient supply throughout pregnancy has been demonstrated to lead to lifelong hypertension and physiological abnormalities in the offspring. Current research within this area now involves unravelling the key physiological mechanisms behind maternal nutrition and the associated development of cardiovascular disease in the adult offspring. PUFA's Cardiovascular disease is a major cause of premature death in the western world and saturated fat has been identified as a key factor. As a result dietary trends are changing, intakes of meat and diary products high in saturated fat are being reduced and consumption of vegetable protein and oils high in n-6 PUFA's are being increased. With reports that the UK population consumes ten times the requirement of n-6 PUFA I am interested in looking at the physiological consequences of this trend.

Recent Publications

• RYAN K, ELMES MJ and LANGLEY-EVANS SC, 2012. The effects of prenatal protein restriction on ß-adrenergic signalling of the adult rat heart during ischaemia reperfusion. Journal of Nutrition and Metabolism. (In Press.)
• CHENG, Z, ELMES, M, KIRKUP, S, ABAYASEKARA, D R E and WATHES, D C, 2011. Effects of n-6 polyunsaturated fatty acids on prostaglandin production in ovine fetal chorion cells in vitro in late gestation ewes. Placenta.
• ELMES, MJ, TAN, DSY, CHENG, Z, WATHES, DC and MCMULLEN, S, 2011. The Effects Of A High-Fat, High-Cholesterol Diet On Markers Of Uterine Contractility During Parturition In The Rat Reproduction. 141(2), 283-290
• KIRKUP, S E, CHENG, Z, ELMES, M, WATHES, D C and ABAYASEKARA, D R E, 2010. Polyunsaturated fatty acids modulate prostaglandin synthesis by ovine amnion cells in vitro. Reproduction (Cambridge, England). 140(6), 943-51

• View all publications

• RYAN K, ELMES MJ and LANGLEY-EVANS SC, 2012. The effects of prenatal protein restriction on ß-adrenergic signalling of the adult rat heart during ischaemia reperfusion. Journal of Nutrition and Metabolism. (In Press.)
• CHENG, Z, ELMES, M, KIRKUP, S, ABAYASEKARA, D R E and WATHES, D C, 2011. Effects of n-6 polyunsaturated fatty acids on prostaglandin production in ovine fetal chorion cells in vitro in late gestation ewes. Placenta.
• ELMES, MJ, TAN, DSY, CHENG, Z, WATHES, DC and MCMULLEN, S, 2011. The Effects Of A High-Fat, High-Cholesterol Diet On Markers Of Uterine Contractility During Parturition In The Rat Reproduction. 141(2), 283-290
• KIRKUP, S E, CHENG, Z, ELMES, M, WATHES, D C and ABAYASEKARA, D R E, 2010. Polyunsaturated fatty acids modulate prostaglandin synthesis by ovine amnion cells in vitro. Reproduction (Cambridge, England). 140(6), 943-51
• ELMES, MJ, HAASE, A, GARDNER, DS and LANGLEY-EVANS, SC., 2009. Sex differences in sensitivity to beta-adrenergic agonist isoproterenol in the isolated adult rat heart following prenatal protein restriction. British Journal of Nutrition. 101(5), 725-734
• MATTHEW J. ELMES, SARAH MCMULLEN, DAVID S. GARDNER & SIMON C. LANGLEY-EVANS,, 2008. Prenatal diet determines susceptibility to cardiac ischemia-reperfusion injury following treatment with diethylmaleic acid and N-acetylcysteine. Life Sciences. 82, 149-55
• ELMES, MATTHEW J, GARDNER, DAVID S and LANGLEY-EVANS, SIMON C, 2007. Fetal exposure to a maternal low-protein diet is associated with altered left ventricular pressure response to ischaemia-reperfusion injury. British Journal of Nutrition. 98(1), 93-100
• ELMES, M, GREEN, L R, POORE, K, NEWMAN, J, BURRAGE, D, ABAYASEKARA, D R E, CHENG, Z, HANSON, M A and WATHES, D C, 2005. Raised dietary n-6 polyunsaturated fatty acid intake increases 2-series prostaglandin production during labour in the ewe. Journal of Physiology. 562(Pt 2), 583-92
• CHENG, Z, ELMES, M, KIRKUP, S E, CHIN, E C, ABAYASEKARA, D R E and WATHES, D C, 2005. The effect of a diet supplemented with the n-6 polyunsaturated fatty acid linoleic acid on prostaglandin production in early- and late-pregnant ewes. Journal of Endocrinology. 184(1), 165-78
• ELMES, MATTHEW, TEW, PRIYA, CHENG, ZHANGRUI, KIRKUP, SUE E, ABAYASEKARA, D ROBERT E, CALDER, PHILIP C, HANSON, MARK A, WATHES, D CLAIRE and BURDGE, GRAHAM C, 2004. The effect of dietary supplementation with linoleic acid to late gestation ewes on the fatty acid composition of maternal and fetal plasma and tissues and the synthetic capacity of the placenta for 2-series prostaglandins. Biochimica et Biophysica Acta. 1686(1-2), 139-47
• CHENG, Z, ELMES, M, KIRKUP, S E, ABAYASEKARA, D R E and WATHES, D C, 2004. Alteration of prostaglandin production and agonist responsiveness by n-6 polyunsaturated fatty acids in endometrial cells from late-gestation ewes. Journal of Endocrinology. 182(2), 249-56
• MOSTYN, A., PEARCE, S., BUDGE, H., ELMES, M., FORHEAD, A. J., FOWDEN, A. L., STEPHENSON, T. and SYMONDS, M. E., 2003. Influence of cortisol on adipose tissue development in the fetal sheep during late gestation Journal of Endocrinology. 176(1), 23-30
• CHENG, Z, ELMES, M, ABAYASEKARA, D R E and WATHES, D C, 2003. Effects of conjugated linoleic acid on prostaglandins produced by cells isolated from maternal intercotyledonary endometrium, fetal allantochorion and amnion in late pregnant ewes. Biochimica et Biophysica Acta. 1633(3), 170-8
• WATHES, CD, CHENG, ZR, ELMES, M, KIRKUP, SE and ABAYASEKARA, RE, The effect of n-6 polyunsaturated fatty acids (PUFAS) on prostaglandin production by the endometrium of late pregnant ewes. In: 340-340