Surgery

• Pancreatic disease
• Shock, Sepsis and Intestinal Permeability
• Surgery for Obesity
• Minimally Invasive Therapy
• Cancer Cachexia
• Distance and e-Learning
• Evidence based medicine
• Meta-analysis and Systematic Reviews (Editor, Cochrane Collaboration: UGI & Pancreatic Disease Group)
• Non surgical treatments for benign anal disease, especially anal fissure and pilonidal sinus disease
• Smooth muscle physiology of the gallbladder
• Myoglobin as a predictor of surgical outcome
• Epigenetics of colorectal cancer
• Micro RNA expression and function in cancers
• Molecular mechanisms of gene silencing during development/differentiation and in disease
• Identification of novel biomarkers for cancer diagnosis and prognosis
• Development of cancer therapies targeting functional biomarkers

Projects- Current

• Intestinal permeability measurement in vivo and in vitro (PhD student: Dr Abdul Alhamoruni)
• Visceral and peripheral adipocytokines in severely obese NAFLD patients (with Dr Garry Tan, CISBM, and Dr Guru Aithal, WDDC)
• Cochrane Systematic Review of antibiotic therapy in pancreatic necrosis
• Randomised trial of fibrin glue in the treatment of pilonidal sinus disease
• Epigenetics of colorectal cancer (in collaboration with Dr. Cristina Tufarelli, Wolfson Centre for Stem cells, Tissue Engineering and Modelling (STEM) University of Nottingham Centre for Biomolecular Sciences)
• Micro RNA expression and function in cancers
• Myoglobin as a predictor of operative outcomes (with Dr John Williams, Derby Hospitals and Prof Mike Rennie)
• An online learning resource featuring text, pictures, audio and video podcasts relating to colorectal surgery and also featuring videos of abdominal anatomy is now available here:  http://www.learncolorectalsurgery.com

Projects- Recent

• Intestinal fatty acid binding protein (iFABP) as a marker for shock
• High mobility Group Box 1 (HMGB1) in acute pancreatitis
• Prehab or rehab for cancer cachexia? (collaboration between Prof Mike Rennie, CISBM, Mr Jon Lund, WDDC.)
• MCP-1 dimerisation in acute pancreatitis 

Techniques

• Intestinal Permeability measurement in vivo and in vitro
• Western Blotting
• Tissue Culture
• Real-time PCR
• PCR and genetic analysis
• ELISA
• Immunofluorescence
• Molecular Cloning
• RNA interference