Maria Marlow

Contact

• workRoom D05 Boots Science Building
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 8467045
• Maria.Marlow@nottingham.ac.uk

Biography

I am pharmacist with a PhD in drug delivery (University of Nottingham 1991) and post doctoral experience in tissue engineering (Massachusetts Institute of Technology 1991-1992) working with osteoblasts and biodegradable polymers. I have over 18 years experience in drug delivery in industry and have worked on many different drug delivery options and formulations throughout my career at Fisons, Astra and then AstraZeneca including oral, intravenous and inhaled dosage forms. Specifically I worked on AstraZeneca's metered dose inhaler SYMBICORT, for which I have a formulation patent. I have also developed formulations of poorly soluble candidate drugs. My industrial experience includes several scientific and line manager roles from 1996 leading multidisciplinary teams in product development and early development. My most recent industrial role in early development included the development of formulations for preclinical, toxicity and phase I/II studies. I have also project managed and led numerous technical improvement projects/teams including recently in 2010, the development of a new global process for suspension development and a global web based brochure for clinical supplies.

In May 2011, I made the transition back into academia and secured the first Gunn and Carter Senior Fellowship at De Montfort University working with Dr Geoff Smith on developing methodologies for studying bio-relevant physical form changes of drug substances and drug products using terahertz spectroscopy and pulsed imaging. In Jan 2012, I was appointed as Associate Professor in Formulation Science and Pharmaceutical Materials in the Drug Delivery and Tissue Engineering Group in the School of Pharmacy.

Research Summary

My research interests are focused on developing drug delivery systems or diagnostics that address an unmet clinical need in collaboration with clinicians. My initial research focus will be the self… read more

Selected Publications

• GOVIND NAYNA and MARLOW MARIA, 2010. The invention relates to a formulation comprising formoterol and budesonide: for use in the treatment of respiratory diseases 7,759,328 07/20/2010 00:00:00
• DAVIES, MJ, BRINDLEY, A, CHEN, XY, DOUGHTY, SW, MARLOW, M and ROBERTS, CJ, 2009. A Quantitative Assessment Of Inhaled Drug Particle-Pulmonary Surfactant Interaction By Atomic Force Microscopy Colloids And Surfaces B-Biointerfaces. 73(1), 97-102
• DAVIES, OR, MARLOW, M and STOLNIK, S, 2008. Macroporous Surface Modified Microparticles Soft Matter. 4(8), 1597-1601
• DAVIES, OR, HEAD, L, ARMITAGE, D, PEARSON, EA, DAVIES, MC, MARLOW, M and STOLNIK, S, 2008. Surface Modification Of Microspheres With Steric Stabilizing And Cationic Polymers For Gene Delivery Langmuir. 24(14), 7138-7146

• View all publications

Current Research

My research interests are focused on developing drug delivery systems or diagnostics that address an unmet clinical need in collaboration with clinicians. My initial research focus will be the self -assembly of prodrugs, hydrogels or microparticles particularly for localised or intratumoral delivery in cancer therapy, improving upon the therapeutic outcomes of existing drugs. The research will involve the physicochemical characterisation of these deliver systems to allow the prediction of their in vivo performance. I am also interested in collaborations where my industrial experience and formulation knowledge can be utilised in the formulation of inhaled therapeutics and poorly soluble drugs.

I will also maintain a collaboration with Dr Geoff Smith at De Montfort Univeristy on the development of terahertz spectroscopy and terahertz pulsed imaging methods for the material characterisation and skin including basal cell carcinoma and with Dr Huseyin Seker on using computational methods for formulation prediction.

• MAHBOUBIAN, A, STOLNIK, S, ARSHAD, S., MARLOW, ME and SIMTH, G, 2012. In: Drug Delivery: Through the ages. United Kingdom & Ireland Controlled Release Society: Birmingham, UK. p. 53.: Evaluating in-situ Gelation using Terahertz and Dielectric Spectroscopy,
• GOVIND NAYNA and MARLOW MARIA, 2010. The invention relates to a formulation comprising formoterol and budesonide: for use in the treatment of respiratory diseases 7,759,328 07/20/2010 00:00:00
• DAVIES, MJ, BRINDLEY, A, CHEN, XY, DOUGHTY, SW, MARLOW, M and ROBERTS, CJ, 2009. A Quantitative Assessment Of Inhaled Drug Particle-Pulmonary Surfactant Interaction By Atomic Force Microscopy Colloids And Surfaces B-Biointerfaces. 73(1), 97-102
• DAVIES, OR, MARLOW, M and STOLNIK, S, 2008. Macroporous Surface Modified Microparticles Soft Matter. 4(8), 1597-1601
• DAVIES, OR, HEAD, L, ARMITAGE, D, PEARSON, EA, DAVIES, MC, MARLOW, M and STOLNIK, S, 2008. Surface Modification Of Microspheres With Steric Stabilizing And Cationic Polymers For Gene Delivery Langmuir. 24(14), 7138-7146
• DAVIES, M, BRINDLEY, A, CHEN, XY, MARLOW, M, DOUGHTY, SW, SHRUBB, I and ROBERTS, CJ, 2005. Characterization Of Drug Particle Surface Energetics And Young's Modulus By Atomic Force Microscopy And Inverse Gas Chromatography Pharmaceutical Research. 22(7), 1158-1166
• PATEL, N, MARLOW, M and LAWRENCE, MJ, 2003. Formation Of Fluorinated Nonionic Surfactant Microemulsions In Hydrofluorocarbon 134A (Hfc 134A) Journal Of Colloid And Interface Science. 258(2), 345-353
• PATEL, N, MARLOW, M and LAWRENCE, MJ, 2003. Fluorinated Ionic Surfactant Microemulsions In Hydrofluorocarbon 134A (Hfc 134A) Journal Of Colloid And Interface Science. 258(2), 354-362
• HARPER, GR, DAVIS, SS, DAVIES, MC, NORMAN, ME, TADROS, TF, TAYLOR, DC, IRVING, MP, WATERS, JA and WATTS, JF, 1995. Influence Of Surface Coverage With Poly(Ethylene Oxide) On Attachment Of Sterically Stabilized Microspheres To Rat Kupffer Cells In-Vitro Biomaterials. 16(6), 427-439
• NORMAN ME, ELGENDY HM, SHORS EC, EL-AMIN SF and LAURENCIN CT, 1994. An In-Vitro Evaluation Of Coralline Porous Hydroxyapatite As A Scaffold For Osteoblast Growth. Clinical Materials. 17(2), 85-91
• NORMAN, ME, WILLIAMS, P and ILLUM, L, 1993. Invivo Evaluation Of Protein Adsorption To Sterically Stabilized Colloidal Carriers Journal Of Biomedical Materials Research. 27(7), 861-866
• LAURENCIN, CT, NORMAN, ME, ELGENDY, HM, ELAMIN, SF, ALLCOCK, HR, PUCHER, SR and AMBROSIO, AA, 1993. Use Of Polyphosphazenes For Skeletal Tissue Regeneration Journal Of Biomedical Materials Research. 27(7), 963-973
• DAVIS, SS, ILLUM, L, MOGHIMI, SM, DAVIES, MC, PORTER, CJH, MUIR, IS, BRINDLEY, A, CHRISTY, NM, NORMAN, ME, WILLIAMS, P and DUNN, SE, 1993. Microspheres For Targeting Drugs To Specific Body Sites
• ELGENDY, HM, NORMAN, ME, KEATON, AR and LAURENCIN, CT, 1993. Osteoblast-Like Cell (Mc3t3-E1) Proliferation On Bioerodible Polymers - An Approach Towards The Development Of A Bone Bioerodible Polymer Composite-Material Biomaterials. 14(4), 263-269
• NORMAN, ME, WILLIAMS, P and ILLUM, L, 1993. Influence Of Block Copolymers On The Adsorption Of Plasma-Proteins To Microspheres Biomaterials. 14(3), 193-202
• NORMAN, ME, WILLIAMS, P and ILLUM, L, 1992. Human Serum-Albumin As A Probe For Surface Conditioning (Opsonization) Of Block Copolymer-Coated Microspheres Biomaterials. 13(12), 841-849
• MARLOW, M, WOLLACOTT, J, FISK, J, BERRY, A and COOPER, A, Liposomes: a tool for extended release of drugs in preclinical development In: 1284-1284
• O'NEILL, AE, STOLNIK, S, HALL, IP and MARLOW, M, Drug targeting for pulmonary delivery In: S20-S20
• BOUGHELLAM, I, GARNETT, MC, MARLOW, M, MACIEWICZ, R, MITCHELL, J and STOLNIK, S, Biopolymer complexes for in situ formation of delivery systems In: S23-S23
• LAURENCIN, C, ELGENDY, H, KEATON, R and NORMAN, ME, BONE BIOERODIBLE POLYMER COMPOSITES - THE DEVELOPMENT OF AN INVITRO MODEL In: 18-PMSE