TELFORD G, BROWN AP, RICH A, ENGLISH JSC and PRITCHARD DI, 2012. The wound debridement potential of maggot (Lucilia sericata) glycosidases. Medical and Veterinary Entomology. (In Press.)
TELFORD, G, BROWN, A P, KIND, A, ENGLISH, J S C and PRITCHARD, D I, 2011. Maggot chymotrypsin I from Lucilia sericata is resistant to endogenous wound protease inhibitors. The British Journal of Dermatology. 164(1), 192-6 BROWN A, HOROBIN A, BLOUNT DG, HILL PJ, ENGLISH J, RICH A, WILLIAMS PM and PRITCHARD DI, 2011. Lucilia sericata nuclease digests DNA associated with wound slough, and with Pseudomonas biofilm. Medical and Veterinary Entomology. (In Press.)
BRITLAND ST, SMITH AG, FINTER WF, VOWDEN K, VOWDEN P, TELFORD G, BROWN A, PRITCHARD DI and EAGLAND D, 2011. Recombinant Lucilia Sericata Chymotrypsin in a Tropical Hydrogel Formulation Degrades Human Wound Eschar Ex Vivo Biotechnology Progress. 27(3), 870-874 ELLIOTT DE, PRITCHARD DI, BROWN A and WEINSTOCK JV, 2011. Nematodes and human therapeutic trials. Book Chapter. In: Parasitic Nematodes: Molecular Biology, Biochemistry and Immunology
SOUADKIA, NAHED, BROWN, ALAN, LEACH, LOPA and PRITCHARD, DAVID I, 2010. Hookworm (Necator americanus) larval enzymes disrupt human vascular endothelium. The American Journal of Tropical Medicine and Hygiene. 83(3), 549-58 TELFORD, G, BROWN, A P, SEABRA, R A M, HOROBIN, A J, RICH, A, ENGLISH, J S C and PRITCHARD, D I, 2010. Degradation of eschar from venous leg ulcers using a recombinant chymotrypsin from Lucilia sericata. The British Journal of Dermatology. FEARY, JR, VENN, AJ, MORTIMER, K, BROWN, AP, HOOI, D, FALCONE, FH, PRITCHARD, DI and BRITTON, JR, 2010. Experimental hookworm infection: a randomized placebo-controlled trial in asthma Clinical & Experimental Allergy. 40(2), 299-306 FLOHR, C, TUYEN, LN, QUINNELL, RJ, LEWIS, S, MINH, TT, CAMPBELL, J, SIMMONS, C, TELFORD, G, BROWN, A, HIEN, TT, FARRAR, J, WILLIAMS, H, PRITCHARD, DI and BRITTON, J, 2010. Reduced helminth burden increases allergen skin sensitization but not clinical allergy: a randomized, double-blind, placebo-controlled trial in Vietnam Clin Exp Allergy. 40(1), 131-42 FEARY, J, VENN, A, BROWN, A, HOOI, D, FALCONE, FH, MORTIMER, K, PRITCHARD, DI and BRITTON, J, 2009. Safety of hookworm infection in individuals with measurable airway responsiveness: a randomized placebo-controlled feasibility study Clin Exp Allergy. 39(7), 1060-8 FALCONE, FH, TELFORD, G, HOOI, D, BROWN, AP, SEABRA, R, FEARY, J, VENN, A, BRITTON, J and PRITCHARD, DI, 2009. Antigen-driven basophil activation is indicative of early Necator americanus infection in IgE-seronegative patients J Allergy Clin Immunol. 124(6), 1343-50 BLOUNT, D, HOOI, D, FEARY, J, VENN, A, TELFORD, G, BROWN, A, BRITTON, J and PRITCHARD, D, 2009. Immunologic profiles of persons recruited for a randomized, placebo-controlled clinical trial of hookworm infection Am J Trop Med Hyg. 81(5), 911-6 GRIFFITHS, GARETH D, BROWN, ALAN P, HOOI, DOREEN S W, PEARCE, PETER C, HORNBY, REBECCA J, SCOTT, LEAH and PRITCHARD, DAVID I, 2008. Development of a model of hookworm infection exhibiting salient characteristics of human infection. The American Journal of Tropical Medicine and Hygiene. 78(6), 936-45
SEABRA, R., BROWN, A., HOOI, D., KERKHOFF, C., CHHABRA, S.R., HARTY, C., WILLIAMS, P. and PRITCHARD D.I., 2008. A eukaryotic binding protein for the immune modulatory bacterial quorum sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone Calcium Binding Proteins. 3(1), 31-37 PRITCHARD,D.I., HOOI, D.S.W., BROWN, A., BOCKARIE, M., CADDICK, R. and QUINNELL, R.J., 2007. Basophil Competence during Hookworm (Necator americanus) Infection. American Journal of Tropical Medicine and Hygiene. 77(5), 860-865
BROWN, A., HOOI, D.S., PRITCHARD, D.I., GRIFFITHS, D., PEARCE, P.C. and SCOTT, E.A.M., 2007. Human hookworm model and method for maintaining human hookworm in a non-human primate US07161059 01/01/2007 00:00:00
MORTIMER, K., BROWN, A., FEARY, J., JAGGER, C., LEWIS, S., ANTONIAK, M., PRITCHARD, D. and BRITTON, J., 2006. Dose-ranging study for trials of therapeutic infection with necator americanus in humans American Journal of Tropical Medicine and Hygiene. 75(5), 914-920
PRITCHARD, D.I., TODD, I., BROWN, A., BYCROFT, B.W., CHHABRA, S.R., WILLIAMS, P. and WOOD, P., 2005. Alleviation of insulitis and moderation of diabetes in NOD mice following treatment with a synthetic Pseudomonas aeruginosa signal molecule, N-(3-oxododecanoyl)-L-homoserine lactone Acta diabetologica.. 42(3), 119-22 QUINNELL, RUPERT J, PRITCHARD, DAVID I, RAIKO, ANDREW, BROWN, ALAN P and SHAW, MARIE-ANNE, 2004. Immune responses in human necatoriasis: association between interleukin-5 responses and resistance to reinfection. Journal of Infectious Diseases. 190(3), 430-8 CHAMBERS, L., WOODROW, S., BROWN, A.P., HARRIS, P.D., PHILLIPS, D., HALL, M., CHURCH, J.C.T. and PRITCHARD, D.I., 2003. Degradation of extracellular matrix components by defined proteinases from the greenbottle larva <i>Lucilia sericata</i> used for the clinical debridement of non-healing wounds British Journal of Dermatology. 148(1), 14-23 BROWN, ALAN, FARMER, KINLEY, MACDONALD, LOUISE, KALSHEKER, NOOR, PRITCHARD, DAVE, HASLETT, CHRIS, LAMB, JONATHAN and SALLENAVE, J-M, 2003. House dust mite Der p 1 downregulates defenses of the lung by inactivating elastase inhibitors. American Journal of Respiratory Cell and Molecular Biology. 29(3 Pt 1), 381-9 PRITCHARD, D.I., GIROD, N., BROWN, A.P., CADDICK, R., HOOI, D.S., QUINNELL, R.J., JOHNSON, S. and EGGLETON, P., 2003. The hookworm calreticulin conundrum. In: Calreticulin 2nd. Kluwer Academic Publishers BV, Dordrecht, NL. 238-247
CULLEY, FIONA J, BROWN, ALAN, GIROD, NADINE, PRITCHARD, DAVID I and WILLIAMS, TIMOTHY J, 2002. Innate and cognate mechanisms of pulmonary eosinophilia in helminth infection. European Journal of Immunology. 32(5), 1376-85 FALCONE, F.H., ROSSI, A.G., SHARKEY, R., BROWN, A.P., PRITCHARD, D.I. and MAIZELS, R.M., 2001. Ascaris suum-derived products induce human neutrophil activation via a G protein-coupled receptor that interacts with the interleukin-8 receptor pathway Infection and Immunity. 69(6), 4007-4018 CULLEY, F J, BROWN, A, CONROY, D M, SABROE, I, PRITCHARD, D I and WILLIAMS, T J, 2000. Eotaxin is specifically cleaved by hookworm metalloproteases preventing its action in vitro and in vivo. The Journal of Immunology. 165(11), 6447-53
PRITCHARD, D I, BROWN, A, KASPER, G, MCELROY, P, LOUKAS, A, HEWITT, C, BERRY, C, FüLLKRUG, R and BECK, E, 1999. A hookworm allergen which strongly resembles calreticulin. Parasite Immunology. 21(9), 439-50 BROWN, A, GIROD, N, BILLETT, E E and PRITCHARD, D I, 1999. Necator americanus (human hookworm) aspartyl proteinases and digestion of skin macromolecules during skin penetration. American Journal of Tropical Medicine and Hygiene. 60(5), 840-7
GRIFFITHS, G., BROPHY, P.M., PRITCHARD, D.I., FURMIDGE, B. and BROWN, A., 1997. The production and analysis of helminth excretory-secretory [ES] products 83-132