Xinyong Chen

Contact

• workRoom C05 Boots Science Building
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 8466269
• fax0115 9515110
• x.chen@nottingham.ac.uk
• http://www.nottingham.ac.uk/lbsa

Biography

• BSc in physics, 1982, Chongqing University, China.
• PhD in physics, 1987, Antwerp University (UIA), Belgium.
• 1982 - 1992, Teaching Assistant, Lecturer, Associate Professor, Department of Applied Physics, Chongqing University, China.
• Professor in physics, 1993, Chongqing University, China.
• Head, Department of Applied Physics, Chongqing University, 1988 - 1992.
• 1996 - Research Fellow, Research Officer, Senior Research Officer, Laboratory of Biophysics and Surface Analysis (LBSA), School of Pharmacy, University of Nottingham.

Research Summary

As a senior research officer, my duty is to provide scientific and technical support for research projects and PhD training undertaken in LBSA, in particular for those involving experiments with… read more

Selected Publications

• HOOK, AL, YANG, J, CHEN, XY, ROBERTS, CJ, MEI, Y, ANDERSON, DG, LANGER, R, ALEXANDER, MR and DAVIES, MC, 2011. Polymers With Hydro-Responsive Topography Identified Using High Throughput Afm Of An Acrylate Microarray Soft Matter. 7(16), 7194-7197
• EVANS, NICHOLAS D, GENTLEMAN, EILEEN, CHEN, XINYONG, ROBERTS, CLIVE J, POLAK, JULIA M and STEVENS, MOLLY M, 2010. Extracellular matrix-mediated osteogenic differentiation of murine embryonic stem cells. Biomaterials. 31(12), 3244-52
• COSGRIFF, SARAH, CHINTAKAYALA, KIRAN, CHIM, YA TSZ A, CHEN, XINYONG, ALLEN, STEPHANIE, LOVERING, ANDREW L and GRAINGER, DAVID C, 2010. Dimerization and DNA-dependent aggregation of the Escherichia coli nucleoid protein and chaperone CbpA. Molecular Microbiology. 77, 1289-1300
• EVANS, ND, MINELLI, C, GENTLEMAN, E, LAPOINTE, V, PATANKAR, SN, KALLIVRETAKI, M, CHEN, XY, ROBERTS, CJ and STEVENS, MM, 2009. Substrate Stiffness Affects Early Differentiation Events In Embryonic Stem Cells European Cells & Materials. 18, 1-14

• View all publications

Current Research

As a senior research officer, my duty is to provide scientific and technical support for research projects and PhD training undertaken in LBSA, in particular for those involving experiments with atomic force microscopy (AFM). My research interests are focused on AFM imaging mechanisms and AFM probe-sample interactions, as demonstrated in my recent publications.

• FERNANDES, AN, CHEN, XY, SCOTCHFORD, CA, WALKER, J, WELLS, DM, ROBERTS, CJ and EVERITT, NM, 2012. Mechanical Properties Of Epidermal Cells Of Whole Living Roots Of Arabidopsis Thaliana: An Atomic Force Microscopy Study Physical Review E. 85(2), -
• SEDMAN, VICTORIA L, KASOTAKIS, EMMANOUIL, CHEN, XINYONG, ALLEN, STEPHANIE, ROBERTS, CLIVE J, MITRAKI, ANNA and TENDLER, SAUL J B, 2011. Surface-templated fibril growth of peptide fragments from the shaft domain of the adenovirus fibre protein. Protein and peptide letters. 18(3), 268-74
• HOOK, AL, YANG, J, CHEN, XY, ROBERTS, CJ, MEI, Y, ANDERSON, DG, LANGER, R, ALEXANDER, MR and DAVIES, MC, 2011. Polymers With Hydro-Responsive Topography Identified Using High Throughput Afm Of An Acrylate Microarray Soft Matter. 7(16), 7194-7197
• GAO, N, YAN, YY, CHEN, XY and MEE, DJ, 2011. Superhydrophobic Surfaces With Hierarchical Structure Materials Letters. 65(19-20), 2902-2905
• EVANS, NICHOLAS D, GENTLEMAN, EILEEN, CHEN, XINYONG, ROBERTS, CLIVE J, POLAK, JULIA M and STEVENS, MOLLY M, 2010. Extracellular matrix-mediated osteogenic differentiation of murine embryonic stem cells. Biomaterials. 31(12), 3244-52
• COSGRIFF, SARAH, CHINTAKAYALA, KIRAN, CHIM, YA TSZ A, CHEN, XINYONG, ALLEN, STEPHANIE, LOVERING, ANDREW L and GRAINGER, DAVID C, 2010. Dimerization and DNA-dependent aggregation of the Escherichia coli nucleoid protein and chaperone CbpA. Molecular Microbiology. 77, 1289-1300
• N. GAO, Y. Y. YAN, X. Y. CHEN and X. F. ZHENG, 2010. Superhydrophobic Composite Films Based on THS and Nanoparticles Journal of Bionic Engineering. 7(Supplement), S59-S66
• SEDMAN, V.L., ALLEN, S., CHEN, X., ROBERTS, C.J. and TENDLER, S.J.B., 2009. Thermomechnaical Manipulation of Aromatic Peptide Nanotubes Langmuir. 25(13), 7256-7259
• DAVIES, M.J., BRINDLEY, A., CHEN, X., DOUGHTY, S.W., MARLOW, M. and ROBERTS, C.J., 2009. A quantitative assessment of inhaled drug particle–pulmonary surfactant interaction by atomic force microscopy Colloids and Surfaces B: Biointerfaces. 73, 97-102
• ZHANG, J., BUNKER, M., CHEN, X., PARKER, A.P., PATEL, N. and ROBERTS, C.J., 2009. Nanoscale thermal analysis of pharmaceutical solid dispersions International Journal of Pharmaceutics. 380, 170-173
• CREAN, B., CHEN, X., BANKS, S.R., COOK, W.G., MELIA, C.D. and ROBERTS, C.J., 2009. An Investigation into the Rheology of Pharmaceutical Inter-granular Material Bridges at High Shear Rates Pharmaceutical Research. 26(5), 1101-1111
• EVANS, ND, MINELLI, C, GENTLEMAN, E, LAPOINTE, V, PATANKAR, SN, KALLIVRETAKI, M, CHEN, XY, ROBERTS, CJ and STEVENS, MM, 2009. Substrate Stiffness Affects Early Differentiation Events In Embryonic Stem Cells European Cells & Materials. 18, 1-14
• INNGJERDINGEN, M., INNGJERDINGEN, K.T., PATEL, T.R., ALLEN, S., CHEN, X., ROLSTAD, B., MORRIS, G.A., HARDING, S.E., MICHAELSEN, T.E., DIALLO, D. and PAULSEN, B., 2008. Pectic polysaccharides from Biophytum petersianum Klotzsch, and their activation of macrophages and dendritic cells. Glycobiology. 18, 1074-184
• GADEGAARD N, CHEN X, RUTTEN F J M, ALEXANDER, M R, 2008. High-energy electron beam lithography of octadecylphosphonic acid monolayers on aluminum. Langmuir. 24(5), 2057-63
• INNGJERDINGEN, K.T., PATEL, T., CHEN, X., KENNE, L., ALLEN, S., MORRIS, G.A., HARDING, S.E., MATSUMOTO, T., DIALLO, D., YAMADA, H., MICHAELSEN, T.E., INNGJERDINGEN, M. and PAULSEN, B.S., 2007. Immunological and structural properties of a pectic polymer from Glinus oppositifolius. Glycobiology. 17, 1299-1310
• NIU, L., CHEN, X., ALLEN, S. and TENDLER, S.J.B., 2007. Using the Bending Beam Model to Estimate the Elasticity of Diphenylalanine Nanotubes Langmuir. 23(14), 7443-7446
• NIE, C.L, WEI, Y., CHEN, X., LIU, Y.Y., DUI, W., LIU, Y., DAVIES, M.C., TENDLER, S.J.B. and HE, R.Q., 2007. Formaldehyde at Low Concentration Induces Protein Tau into Globular Amyloid-Like Aggregates In Vitro and In Vivo PLoS ONE. 2(7), e629
• CREAN, B., PERKINS, M., CHEN, X., BANKS, S. R., COOK, W. G., MELIA, C. D. and ROBERTS, C. J., 2007. Properties of inter-granular binder bridges: making the nano to bulk formulation link JOURNAL OF PHARMACY AND PHARMACOLOGY. VOL 59(SUPP/1), A-21, 53
• WANG, Y. and CHEN, X., 2007. Carbon nanotubes: A promising standard for quantitative evaluation of AFM tip apex geometry Ultramicroscopy. VOL 107(NUMBER 4-5), 293-298
• ZHONG, S, LI, H, CHEN, X.Y., CAO, E.H., JIN, G and HU, K.S., 2007. Different interactions between the two sides of purple membrane with atomic force microscope tip Langmuir. 23(8), 4486-4493
• BUNKER, M.J., DAVIES, M.C., CHEN, X.Y., JAMES, M.B. and ROBERTS, C.J., 2006. Single particle friction on blister packaging materials used in dry powder inhalers European Journal of Pharmaceutical Sciences. 29(5), 405-413
• ZHANG, JIANXIN, EBBENS, STEPHEN, CHEN, XINYONG, JIN, ZHENG, LUK, SHEN, MADDEN, CLAIRE, PATEL, NIKIN and ROBERTS, CLIVE J, 2006. Determination of the surface free energy of crystalline and amorphous lactose by atomic force microscopy adhesion measurement. Pharmaceutical Research. 23(2), 401-7
• DAVIES, M., BRINDLEY, A., CHEN, X., MARLOW, M., DOUGHTY, S.W., SHRUBB, I. and ROBERTS, C.J., 2005. Characterization of drug particle surface energetics and Young's modulus by atomic force microscopy and inverse gas chromatography Pharmaceutical Research. 22(7), 1158-1166
• SEARLS, T., CHEN, X., ALLEN, S. and YUDKIN, M. D., 2004. Evaluation of the Kinetic Properties of the Sporulation Protein SpoIIE of Bacillus subtilis by Inclusion in a Model Membrane Journal of Bacteriology. VOL 186(PART 10), 3195-3201
• CUMPSON, P. J., HEDLEY, J., CLIFFORD, C. A., CHEN, X. and ALLEN, S., 2004. Microelectromechanical system device for calibration of atomic force microscope cantilever spring constants between 0.01 and 4 N/m Journal of Vacuum Science and Technology. Part A Vacuum, Surfaces and Films. VOL 22(PART 4), 1444-1449
• ZHANG, JUN, WANG, YUAN-LIANG, CHEN, XIN-YONG, HE, CHUANG-LONG, CHENG, CHAO and CAO, YANG, 2004. Preliminarily investigating the polymorphism of self-organized actin filament in vitro by atomic force microscope. Acta Biochimica Et Biophysica Sinica. 36(9), 637-43
• BURNHAM, N.A., CHEN, X., HODGES, C.S., MATEI, G.A., THORESON, E.J., ROBERTS, C.J., DAVIES, M.C. and TENDLER, S.J.B., 2003. Comparison of calibration methods for atomic-force microscopy cantilevers Nanotechnology. 14(1), 1-6
• CHEN, X., ROBERTS, C.J., DAVIES, M.C. and TENDLER, S.J.B., 2002. Phase contrast and attraction-repulsion transition in tapping mode atomic force microscopy Surface Science. 519(1-2), L593-L598
• ZHANG, J., BUSBY, A.J., ROBERTS, C.J., CHEN, X., DAVIES, M.C., TENDLER, S.J.B. and HOWDLE, S.M., 2002. Preparation of a poly(methyl methacrylate)/ultrahigh molecular weight polyethylene blend using supercritical carbon dioxide and the identification of a three-phase structure: an atomic force microscopy study Macromolecules. 35(23), 8869-8877
• ALLEN, S., CONNELL, S.D.A., CHEN, X., DAVIES, J., DAVIES, M.C., DAWKES, A.C., ROBERTS, C.J., TENDLER, S.J.B. and WILLIAMS, P.M., 2001. Mapping the surface characteristics of polystyrene microtiter wells by a multimode scanning force microscopy approach (Note) Journal of Colloid and Interface Science. 242(2), 470
• CHEN, X., DAVIES, M.C., ROBERTS, C.J., TENDLER, S.J.B. and WILLIAMS, P.M., 2000. Hydrodynamic damping of tip oscillation in pulsed-force atomic force microscopy Applied Physics Letters. 77(21), 3462-3464
• CHEN, X., DAVIES, M.C., ROBERTS, C.J., TENDLER, S.J.B., WILLIAMS, P.M. and BURNHAM, N.A., 2000. Optimizing phase imaging via dynamic force curves Surface Science. 460(1-3), 292-300
• DANESH, A., CHEN, X.Y., DAVIES, M.C., ROBERTS, C.J., SANDERS, G.H.W., TENDLER, S.J.B., WILLIAMS, P.M. and WILKINS, M.J., 2000. Polymorphic discrimination using atomic force microscopy: distinguishing between two polymorphs of the drug cimetidine Langmuir. 16(2), 866-870
• ERB, E M, CHEN, X, ALLEN, S, ROBERTS, C J, TENDLER, S J, DAVIES, M C and FORSÉN, S, 2000. Characterization of the surfaces generated by liposome binding to the modified dextran matrix of a surface plasmon resonance sensor chip. Analytical Biochemistry. 280(1), 29-35
• CHEN, X., DAVIES, M.C., ROBERTS, C.J., TENDLER, S.J.B., WILLIAMS, P.M., DAVIES, J. and DAWKES, A.C., 2000. Attractive tapping: a method to minimise topography distortions in tapping mode atomic force microscopy Probe Microscopy. 2(1), 21-29
• DANESH, A., CHEN, X. Y., DAVIES, M. C., ROBERTS, C. J., SANDERS, G. H. W., TENDLER, S. J. B., WILLIAMS, P. M. and WILKINS, M. J., 2000. The discrimination of drug polymorphic forms from single crystals using atomic force microscopy Pharmaceutical Research. 17(7), 887-890
• VANSTEENKISTE, S. O., CORNEILLIE, S. I., SCHACHT, E. H., CHEN, X., DAVIES, M. C., MOENS, M. and VAN VAECK, L., 2000. Direct measurement of protein adhesion at biomaterial surfaces by scanning force microscopy Langmuir. 16(7), 3330-3336
• CHEN, X., DAVIES, M.C., ROBERTS, C.J., TENDLER, S.J.B., WILLIAMS, P.M., DAVIES, J., DAWKES, A.C. and EDWARDS, J.C., 1998. Interpretation of tapping mode atomic force microscopy data using amplitude-phase-distance measurements Ultramicroscopy. 75(3), 171-181
• CHEN, X., MCGURK, S.L., DAVIES, M.C., ROBERTS, C.J., SHAKESHEFF, K.M., TENDLER, S.J.B., WILLIAMS, P.M., DAVIES, J., DAWKES, A.C. and DOMB, A., 1998. Chemical and morphological analysis of surface enrichment in a biodegradable polymer blend by phase-detection imaging atomic force microscopy Macromolecules. 31(7), 2278-2283
• CHEN, X., PATEL, N., DAVIES, M.C., ROBERTS, C.J., TENDLER, S.J.B., WILLIAMS, P.M., DAVIES, J., DAWKES, A.C. and EDWARDS, J.C., 1998. Application of protein-coated scanning force microscopy probes in measurements of surface affinity to protein adsorption Applied Physics A: materials science & processing. 66 SUPP/1, S631-S634
• ALLEN, S., CHEN, X., DAVIES, J., DAVIES, M.C., DAWKES, A.C., EDWARDS, J.C., ROBERTS, C.J., TENDLER, S.J.B. and WILLIAMS, P.M., 1998. The Application of Force Microscopy to Immunodiagnostic Systems: Imaging and Molecular Adhesion Measurements Applied Physics A. 66, S255-S261
• CHEN, X., DAVIES, M.C., ROBERTS, C.J., TENDLER, S.J.B. and WILLIAMS, P.M., 1997. Effect of scanning force microscope scanner geometry on probe-sample contact force Review of Scientific Instruments. 68(4), 1773-1775
• CHEN, X., DAVIES, M.C., ROBERTS, C.J., TENDLER, S.J.B., WILLIAMS, P.M., DAVIES, J., DAWKES, A.C. and EDWARDS, J.C., 1997. Recognition of protein adsorption onto polymer surfaces by scanning force microscopy and probe-surface adhesion measurements with protein-coated probes Langmuir. 13(15), 4106-4111
• CHEN, X., DAVIES, M.C., ROBERTS, C.J., SHAKESHEFF, K.M., TENDLER, S.J.B. and WILLIAMS, P.M., 1996. Dynamic surface events measured by simultaneous probe microscopy and surface plasmon detection Analytical Chemistry. 68(8), 1451-1455
• CHEN, X., DAVIES, M.C., ROBERTS, C.J., SHAKESHEFF, K.M., TENDLER, S.J.B., WILLIAMS, P.M. and DAVIES, J., 1996. Combined surface plasmon resonance and scanning force microscope instrument Journal of Vacuum Science and Technology. B, Microelectronics and Nanometer Structures. 14(3), 1582-1586
• CHEN, X., SHAKESHEFF, K.M., DVIES, M.C., HELLER, J., ROBERTS, C.J., TENDLER, S.J.B. and WILLIAMS, P.M., 1995. The degradation of a thin polymer film studied by simultaneous in situ atomic force microscopy and surface plasmon resonance analysis Journal of Physical Chemistry. 99, 11537-11542
• SHAKESHEFF, K.M., CHEN, X., DAVIES, M.C., DOMB, A., ROBERTS, C.J., TENDLER, S.J.B. and WILLIAMS, P.M., 1995. Relating phase morphology of a biodegradable polymer blend to erosion kinetics using in situ atomic force microscopy and surface plasmon resonance Langmuir. 11, 3921-3927
• CAI, C. Z., CHEN, X. Y., SHU, Q. Q. and ZHENG, X. L., Computer Correction For Distorted Stm Images Review Of Scientific Instruments. 63(12), 5649-5652