David Humes

Contact

• workRoom W.E/1332 QMC West Block
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 82 31143
• fax0115 82 31160
• david.humes@nottingham.ac.uk

Research Summary

I am currently using linked GPRD and HES data to study the epidemiology of diverticular bleeding and femoral hernia.

Recent Publications

• HUMES DJ, SIMPSON J, SMITH J, SUTTON P, ZAITOUN A, BUSH D, BENNETT A, SCHOLEFIELD JH and SPILLER RC, 2012. Visceral Hypersensitivity In Symptomatic Diverticular Disease And The Role Of Neuropeptides And Low Grade Inflammation. Neurogastroenterology And Motility : The Official Journal Of The European Gastrointestinal Motility Society. (In Press.)
• HUMES, DAVID J, FLEMING, KATE M, SPILLER, ROBIN C and WEST, JOE, 2011. Concurrent drug use and the risk of perforated colonic diverticular disease: a population-based case-control study. Gut. 60(2), 219-24
• HUMES, DAVID J and WEST, JOE, 2011. Diet and risk of diverticular disease. BMJ (Clinical research ed.). 343, d4115
• HUMES, DAVID J and WEST, JOE, 2011. Role of acute diverticulitis in the development of complicated colonic diverticular disease and 1-year mortality after diagnosis in the UK: population-based cohort study. Gut.

• View all publications

Past Research

My main research focus has been on the epidemiology and treatment of patients with diverticular disease. I completed my PhD on symptom aetiology in diverticular disease and the epidemiology of perforated diverticular disease. Since completion of my PhD my post doctoral work has focused on the epidemiology of complicated diverticular disease with a focus on using routinely collected data to answer clinically important questions regarding the aetiology of symptoms.

Future Research

I plan to use routinely collected health care data to study the epidemiology of various surgical conditions.

• HUMES DJ, SIMPSON J, SMITH J, SUTTON P, ZAITOUN A, BUSH D, BENNETT A, SCHOLEFIELD JH and SPILLER RC, 2012. Visceral Hypersensitivity In Symptomatic Diverticular Disease And The Role Of Neuropeptides And Low Grade Inflammation. Neurogastroenterology And Motility : The Official Journal Of The European Gastrointestinal Motility Society. (In Press.)
• HUMES, DAVID J, FLEMING, KATE M, SPILLER, ROBIN C and WEST, JOE, 2011. Concurrent drug use and the risk of perforated colonic diverticular disease: a population-based case-control study. Gut. 60(2), 219-24
• HUMES, DAVID J and WEST, JOE, 2011. Diet and risk of diverticular disease. BMJ (Clinical research ed.). 343, d4115
• HUMES, DAVID J and WEST, JOE, 2011. Role of acute diverticulitis in the development of complicated colonic diverticular disease and 1-year mortality after diagnosis in the UK: population-based cohort study. Gut.
• SMITH, J K, HUMES, D J, HEAD, K E, BUSH, D, WHITE, T P, STEVENSON, C M, BROOKES, M J, MARCIANI, L, SPILLER, R C, GOWLAND, P A and FRANCIS, S T, 2011. fMRI and MEG analysis of visceral pain in healthy volunteers. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
• CHOWDHURY AH, HUMES DJ, PRITCHARD SE, MARCIANI L, GOWLAND PA, SIMPSON J and LOBO DN, 2011. The Effects Of Morphine-Neostigmine And Secretin Provocation On Pancreaticobiliary Morphology In Healthy Subjects: A Randomized, Double-Blind Crossover Study Using Serial Mrcp. World Journal Of Surgery. 35(9), 2102-9
• SMITH J, HUMES DJ and SPILLER RC, 2011. Should We Treat Uncomplicated Symptomatic Diverticular Disease With Fibre? Bmj (Clinical Research Ed.). 342, d2951
• HUMES D, SMITH JK and SPILLER RC, 2011. Colonic Diverticular Disease. American Family Physician. 84(10), 1163-4
• HUMES D, SMITH JK and SPILLER RC, 2011. Colonic Diverticular Disease. Clinical Evidence. 2011,
• SPILLER RC, HUMES DJ, CAMPBELL E, HASTINGS M, NEAL KR, DUKES GE and WHORWELL PJ, 2010. The Patient Health Questionnaire 12 Somatic Symptom Scale As A Predictor Of Symptom Severity And Consulting Behaviour In Patients With Irritable Bowel Syndrome And Symptomatic Diverticular Disease. Alimentary Pharmacology & Therapeutics. 32(6), 811-20
• HUMES DJ, AHMED I and LOBO DN, 2010. The Pedicle Effect And Direct Coupling: Delayed Thermal Injuries To The Bile Duct After Laparoscopic Cholecystectomy. Archives Of Surgery (Chicago, Ill. : 1960). 145(1), 96-8
• VARADHAN KK, HUMES DJ, NEAL KR and LOBO DN, 2010. Antibiotic Therapy Versus Appendectomy For Acute Appendicitis: A Meta-Analysis. World Journal Of Surgery. 34(2), 199-209
• HUMES, DAVID J, SOLAYMANI-DODARAN, MASOUD, FLEMING, KATE M, SIMPSON, JOHN, SPILLER, ROBIN C and WEST, JOE, 2009. A population-based study of perforated diverticular disease incidence and associated mortality. Gastroenterology. 136(4), 1198-205
• SIMPSON,, SUNDLER,, HUMES,, JENKINS,, SCHOLEFIELD, and SPILLER,, 2009. Post inflammatory damage to the enteric nervous system in diverticular disease and its relationship to symptoms. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
• MACAFEE DAL, HUMES DJ, BOULIOTIS G, BECKINGHAM IJ, WHYNES DK and LOBO DN, 2009. Prospective Randomized Trial Using Cost-Utility Analysis Of Early Versus Delayed Laparoscopic Cholecystectomy For Acute Gallbladder Disease. The British Journal Of Surgery. 96(9), 1031-40
• SUTTON PA, HUMES DJ, PURCELL G, SMITH JK, WHITING F, WRIGHT T, MORGAN L and LOBO DN, 2009. The Role Of Routine Assays Of Serum Amylase And Lipase For The Diagnosis Of Acute Abdominal Pain. Annals Of The Royal College Of Surgeons Of England. 91(5), 381-4
• HUMES DJ, SIMPSON J, NEAL K, SCHOLEFIELD JH, SPILLER RC., 2008. Psychological and colonic factors in painful diverticulosis. Br J Surg. 95(2), 195-8
• J SIMPSON, F SUNDLER, DJ HUMES, D JENKINS, D WAKELIN JH SCHOLEFIELD, RC SPILLER., 2008. Prolonged elevation of galanin and tachykinin expression in mucosal and myenteric enteric nerves following acute colitis Neurogastroenterology and Motility. 20(4), 392-406
• SIMPSON J, HUMES DJ, O'ROURKE EJ, JAMES PD and ACHESON AG, 2008. Rigler On The Roof. Rigler's Sign. Gut. 57(6), 798, 836
• HUMES D, SIMPSON J and SPILLER RC, 2007. Colonic Diverticular Disease. Clinical Evidence. 2007,
• HUMES D, SPEAKE WJ and SIMPSON J, 2007. Appendicitis. Clinical Evidence. 2007,
• HUMES, D.J. and SIMPSON, J., 2006. Acute appendicitis BMJ. 333(7567), 530-534
• HUMES, DAVID and LOBO, DILEEP N, 2005. Removal of a rectal foreign body by using a Foley catheter passed through a rigid sigmoidoscope. Gastrointestinal Endoscopy. 62(4), 610
• HUMES D, JÄHNICH H, REHM A and COMPSON JP, 2004. The Osteology Of The Trapezium. Journal Of Hand Surgery (Edinburgh, Scotland). 29(1), 42-5