Luca Marciani

Contact

• workRoom E1416c, E Floor West Block, School of Clinical Sciences
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 82 31248
• fax0115 82 31409
• luca.marciani@nottingham.ac.uk

Biography

I graduated in Physics at the University of Genoa in Italy. I then worked in Milan and London before joining the University of Nottingham, where I was awarded my PhD in Physics. Following a series of multi-disciplinary research contracts and Fellowships (including a Wellcome Trust VIP Fellowship and a RCUK Academic Fellowship) held across the Sir Peter Mansfield Magnetic Resonance Centre and the Nottingham Digestive Diseases Centre (NDDC) I finally became Lecturer in Gastrointestinal MRI in the NDDC.

My research focuses on gastrointestinal physiology and pathology using magnetic resonance imaging (MRI) methods in combination with other physiological and behavioural techniques. My personal expertise is in imaging the human gastrointestinal tract using MRI. I have a particular interest in in-body imaging of food materials and in the GI response to factors in foods. I work within a team that has developed a unique cross-disciplinary collaboration between gastroenterologists, surgeons, physiologists, MRI physicists, food scientists, sensory scientists and industrial collaborators from the food and pharmaceutical industries in the UK and abroad.

I have published 39 research papers and 10 book chapters, I have been co-investigator on academic and commercial research grants worth £3.7 million, and I have been regular peer-reviewer for 2 MRI and 2 gastroenterology international journals and for the ISMRM international scientific meeting. I serve on the Nottingham NIHR Biomedical Research Unit in GI and Liver Disease's Executive Committee and Strategy Board and on the University's Human Research Scanners Management Committee. I was awarded the RinR/Wellcome/RCUK Communicator's Award for my science outreach work with secondary school pupils.

Research Summary

Our main current interests are in the physiopathology of the gastrointestinal tract (particularly fluid fluxes and the gastrocolonic response to feeding), the development of MRI tests of… read more

Selected Publications

• L MARCIANI, N HALL, SE PRITCHARD, EF COX, JJ TOTMAN, M LAD, CL HOAD, TJ FOSTER, PA GOWLAND and RC SPILLER, 2012. Preventing gastric sieving by blending a solid/water meal enhances satiation in healthy humans The Journal of Nutrition. (In Press.)
• ELDEGHAIDY S, MARCIANI L, MCGLONE F, HOLLOWOOD T, HORT J, HEAD K, TAYLOR AJ, BUSCH J, SPILLER RC, GOWLAND PA and FRANCIS ST, 2011. The Cortical Response To The Oral Perception Of Fat Emulsions And The Effect Of Taster Status. Journal Of Neurophysiology. 105(5), 2572-81
• MARCIANI, L., COX, E.F., HOAD, C.L., PRITCHARD, S., TOTMAN, J.J., FOLEY, S., MISTRY, A., EVANS, S., GOWLAND, P.A. and SPILLER, R.C., 2010. Postprandial changes in small bowel water content in healthy subjects and patients with irritable bowel syndrome Gastroenterology. 138, 469-477
• MARCIANI, L., WRIGHT, J., FOLEY, S., HOAD, C.L., TOTMAN, J.J., BUSH, D., HARTLEY, C., ARMSTRONG, A., MANBY, P., BLACKSHAW, E, PERKINS, P., GOWLAND, P.A. and SPILLER, R.C., 2010. Effects of a 5-HT3 antagonist, ondansetron, on fasting and postprandial small bowel water content assessed by magnetic resonance imaging Alimentary Pharmacology & Therapeutics. 32, 655-633

• View all publications

Papers published: 39

Book contributions: 10

Times cited: 646

ISI h-index: 15

PGR students supervised so far: 5

Research Funding: co-investigator on grants totalling £3.7 million (of which £350,000 as Principal Investigator)

Presentations: 62 oral (of which 23 invited, 9 internationally) and 21 poster presentations at national and international scientific meetings.

Abstracts: 130 of which 42 published in journals and 88 in conference proceedings

Patents: 1 filed

Current Research

Our main current interests are in the physiopathology of the gastrointestinal tract (particularly fluid fluxes and the gastrocolonic response to feeding), the development of MRI tests of gastrointestinal function (such as emptying, flow, motility and transit), physical factors in food influencing digestion and satiety, in-body imaging of foods (particularly fat), the definition of mechanisms of subtypes of Irritable Bowel Syndrome (particularly stress), the mode of action of gastrointestinal agents (such as ondansetron and mesalazine) and novel secretagogue and osmotic laxative formulations. We also investigate aspects of the gut brain axis pathways in terms of visceral perception and flavor perception, using functional brain MRI (fMRI).

• L MARCIANI, N HALL, SE PRITCHARD, EF COX, JJ TOTMAN, M LAD, CL HOAD, TJ FOSTER, PA GOWLAND and RC SPILLER, 2012. Preventing gastric sieving by blending a solid/water meal enhances satiation in healthy humans The Journal of Nutrition. (In Press.)
• SMITH, J K, HUMES, D J, HEAD, K E, BUSH, D, WHITE, T P, STEVENSON, C M, BROOKES, M J, MARCIANI, L, SPILLER, R C, GOWLAND, P A and FRANCIS, S T, 2011. fMRI and MEG analysis of visceral pain in healthy volunteers. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
• CHOWDHURY AH, HUMES DJ, PRITCHARD SE, MARCIANI L, GOWLAND PA, SIMPSON J and LOBO DN, 2011. The Effects Of Morphine-Neostigmine And Secretin Provocation On Pancreaticobiliary Morphology In Healthy Subjects: A Randomized, Double-Blind Crossover Study Using Serial Mrcp. World Journal Of Surgery. 35(9), 2102-9
• ELDEGHAIDY S, MARCIANI L, MCGLONE F, HOLLOWOOD T, HORT J, HEAD K, TAYLOR AJ, BUSCH J, SPILLER RC, GOWLAND PA and FRANCIS ST, 2011. The Cortical Response To The Oral Perception Of Fat Emulsions And The Effect Of Taster Status. Journal Of Neurophysiology. 105(5), 2572-81
• MARCIANI L, 2011. Assessment Of Gastrointestinal Motor Functions By Mri: A Comprehensive Review. Neurogastroenterology And Motility : The Official Journal Of The European Gastrointestinal Motility Society. 23(5), 399-407
• MARCIANI, L., WRIGHT, J., FOLEY, S., HOAD, C.L., TOTMAN, J.J., BUSH, D., HARTLEY, C., ARMSTRONG, A., MANBY, P., BLACKSHAW, E, PERKINS, P., GOWLAND, P.A. and SPILLER, R.C., 2010. Effects of a 5-HT3 antagonist, ondansetron, on fasting and postprandial small bowel water content assessed by magnetic resonance imaging Alimentary Pharmacology & Therapeutics. 32, 655-633
• MARCIANI, L., COX, E.F., HOAD, C.L., PRITCHARD, S., TOTMAN, J.J., FOLEY, S., MISTRY, A., EVANS, S., GOWLAND, P.A. and SPILLER, R.C., 2010. Postprandial changes in small bowel water content in healthy subjects and patients with irritable bowel syndrome Gastroenterology. 138, 469-477
• TOTMAN, J J, MARCIANI, L, FOLEY, S, CAMPBELL, E, HOAD, C L, MACDONALD, I A, SPILLER, R C and GOWLAND, P A, 2009. Characterization of the time course of the superior mesenteric, abdominal aorta, internal carotid and vertebral arteries blood flow response to the oral glucose challenge test using magnetic resonance imaging. Physiological Measurement. 30(10), 1117-36
• LOBO, D.N., HENDRY, P.O., RODRIGUES, G., MARCIANI, L., TOTMAN, J.J., WRIGHT, J.W., PRESTON, T., GOWLAND, P.A., SPILLER, R.C. and FEARON, K.C.H., 2009. Gastric emptying of three liquid oral preoperative metabolic preconditioning regimens measured by magnetic resonance imaging in healthy adult volunteers: A randomised double-blind, crossover study. Clinical Nutrition. 28, 636-641
• MARCIANI, L., FAULKS, R., WICKHAM, M.S.J., BUSH, D., PICK, B., WRIGHT, J., COX, E.F., FILLERY-TRAVIS A., , GOWLAND, P.A. and SPILLER, R.C., 2009. Effect of intragastric acid stability of fat emulsions on gastric emptying, plasma lipid profile and postprandial satiety British Journal of Nutrition. 101, 919-928
• HOLLOWOOD, T., BAYARRI, S., MARCIANI, L., BUSCH, J., FRANCIS, S., SPILLER, R., TAYLOR, A. and HORT, J., 2008. Modelling sweetness and texture perception in model emulsion systems European Food Research and Technology. 227, 537-545
• MITCHELL J.R., FERRY A.L., DESSE M., HILL S.E., HORT J., MARCIANI L. and WOLF B., 2008. Mixing hydrocolloids and water: polymers versus particles. In: Gums and stabilisers for the food industry The Royal Society of Chemistry. (In Press.)
• SPILLER, R.C., GOWLAND, P.A. and MARCIANI, L., 2008. Techniques for assessing the functional response to food of the stomach and small and large intestine. In: Designing functional foods Woodhead Publishing. (In Press.)
• HOAD, C L, MARCIANI, L, FOLEY, S, TOTMAN, J J, WRIGHT, J, BUSH, D, COX, E F, CAMPBELL, E, SPILLER, R C and GOWLAND, P A, 2007. Non-invasive quantification of small bowel water content by MRI: a validation study. Physics In Medicine And Biology. 52(23), 6909-22
• MARCIANI, L., WICKHAM, M., SINGH, G., BUSH, D., PICK, B., COX, E., FILLERY-TRAVIS, A., FAULKS, R., MARSDEN, C., GOWLAND, P.A. and SPILLER, R.C, 2007. Enhancement of intragastric acid stability of a fat emulsion meal delays gastric emptying and increases cholecystokinin release and gallbladder contraction. American Journal of Physiology: Gastrointestinal and Liver Physiology. 292(6), G1607-G1613
• DE CELIS ALONSO, B., MARCIANI, L., HEAD, K., CLARK, P., SPILLER, R. C., RAYMENT, P., ABLETT, S., FRANCIS, S. and GOWLAND, P. A., 2007. Functional magnetic resonance imaging assessmentof the cortical representation of oral viscosity Journal of Texture Studies. VOL 38(NUMBER 6), 725-737
• COX E., HOAD, C.L., MARCIANI, L., SPILLER R.C. and GOWLAND P.A., 2007. Functional MRI of food in the gastrointestinal tract. In: FARHAT, I.A., BELTON P.S. and WEBB, G.A., eds., Magnetic resonance in food science: from molecules to man The Royal Society of Chemistry. 15-25
• MARCIANI, L., WICKHAM, M.S.J., BUSH, D., FAULKS, R., WRIGHT, J., FILLERY-TRAVIS, A.J., SPILLER, R.C. and GOWLAND, P.A., 2006. Magnetic resonance imaging of the behaviour of oil-in-water emulsions in the gastric lumen of man British Journal of Nutrition. 95(2), 331-339
• MARCIANI, L., PFEIFFER, J.C., HORT, J., HEAD, K., BUSH, D., TAYLOR, A.J., SPILLER, R.C., FRANCIS, S. and GOWLAND, P.A., 2006. Improved methods for fMRI studies of combined taste and aroma stimuli. Journal of Neuroscience Methods. 158(2), 186-94
• MARCIANI, L., BUSH, D., WRIGHT, P., WICKHAM, M., PICK, B., WRIGHT, J., FAULKS, R., FILLERY-TRAVIS, A., SPILLER, R.C. and GOWLAND, P.A., 2005. Monitoring of gallbladder and gastric coordination by EPI Journal of Magnetic Resonance Imaging. 21(1), 82-85
• MARCIANI, L., COLEMAN, N. S., DUNLOP, S. P., SINGH, G., MARSDEN, C. A., HOLMES, G. K., SPILLER, R. C. and GOWLAND, P. A., 2005. Gallbladder Contraction, Gastric Emptying and Antral Motility: Single Visit Assessment of Upper GI Function in Untreated Celiac Disease Using Echo-Planar MRI Journal of Magnetic Resonance Imaging. VOL 22(NUMB 5), 634-638
• MARCIANI, L., WICKHAM, M., HILLS, B. P., WRIGHT, J., BUSH, D., FAULKS, R., FILLERY-TRAVIS, A., SPILLER, R. C. and GOWLAND, P. A., 2004. Intragastric Oil-in-Water Emulsion Fat Fraction Measured Using Inversion Recovery Echo-Planar Magnetic Resonance Imaging Journal of Food Science. VOL 69(NUMB 6), E290-E296
• TYLER, D. J., MOORE, R. J., MARCIANI, L. and GOWLAND, P. A., 2004. Rapid and accurate measurement of transverse relaxation times using a single shot multi-echo echo-planar imaging sequence Magnetic Resonance Imaging. VOL 22(NUMBER 7), 1031-1037
• HOAD, CAROLINE L, RAYMENT, PHILLIPPA, SPILLER, ROBIN C, MARCIANI, LUCA, ALONSO, BENITO DE CELIS, TRAYNOR, CATHERINE, MELA, DAVID J, PETERS, HARRY P F and GOWLAND, PENNY A, 2004. In vivo imaging of intragastric gelation and its effect on satiety in humans. The Journal of Nutrition. 134(9), 2293-300
• COLEMAN, N. S., MARCIANI, L., BLACKSHAW, E., WRIGHT, J., PARKER, M., YANO, T., YAMAZAKI, S., CHAN, P. Q., WILDE, K. and GOWLAND, P. A., 2003. Effect of a novel 5-HT3 receptor agonist MKC-733 on upper gastrointestinal motility in humans Alimentary Pharmacology and Therapeutics. VOL 18(NUMBER 10), 1039-1048
• MARCIANI, LUCA, LITTLE, SARAH L, SNEE, JANICE, COLEMAN, NICHOLAS S, TYLER, DAMIAN J, SYKES, JOHN, JOLLIFFE, IAN G, DETTMAR, PETER W, SPILLER, ROBIN C and GOWLAND, PENNY A, 2002. Echo-planar magnetic resonance imaging of Gaviscon alginate rafts in-vivo. Journal of Pharmacy and Pharmacology. 54(10), 1351-6
• FILLERY-TRAVIS, A., MARCIANI, L., GOWLAND P.A. and SPILLER R.C., 2002. The role of polysaccharides in the gastric processing of foods. In: WILLIAMS P.A. and PHILLIPS G.O., eds., Gums and stabilisers for the food industry The Royal Society of Chemistry. 342-348
• MARCIANI, L., GOWLAND, P. A., FILLERY-TRAVIS, A., MANOJ, P., WRIGHT, J., SMITH, A., YOUNG, P., MOORE, R. and SPILLER, R. C., 2001. Assessment of antral grinding of a model solid meal with echo-planar imaging American Journal of Physiology. 280(5), G844-G849
• MARCIANI, L., YOUNG, P., WRIGHT, J., MOORE, R., COLEMAN, N., GOWLAND, P. A. and SPILLER, R. C., 2001. Antral motility measurements by magnetic resonance imaging Neurogastroenterology and Motility. VOL 13(PART 5), 511-518
• MARCIANI, L., GOWLAND, P.A., SPILLER, R.C., MANOJ, P., MOORE, R.J., YOUNG, P. and FILLERY-TRAVIS, A.J., 2001. Effect of meal viscosity and nutrients on satiety, intragastric dilution, and emptying assessed by MRI American Journal of Physiology: Gastrointestinal and Liver Physiology. 280(6), 1227-1233
• MARCIANI, L, RAMANATHAN, C, TYLER, D J, YOUNG, P, MANOJ, P, WICKHAM, M, FILLERY-TRAVIS, A, SPILLER, R C and GOWLAND, P A, 2001. Fat emulsification measured using NMR transverse relaxation. Journal of Magnetic Resonance. 153(1), 1-6
• GOWLAND, P.A., MARCIANI, L., FILLERY-TRAVIS A. and SPILLER R.C., 2001. MRI of gastric function. In: WEBB, G.A., BELTON, P.S., GIL A.M. and DELGADILLO, I., eds., Magnetic resonance in food science, a view to the future The Royal Society of Chemistry. 85-97
• MARCIANI, L., GOWLAND, P. A., SPILLER, R. C., MANOJ, P., MOORE, R. J., YOUNG, P., AL-SAHAB, S., BUSH, D., WRIGHT, J. and FILLERY-TRAVIS, A. J., 2000. Gastric Response to Increased Meal Viscosity Assessed by Echo-Planar Magnetic Resonance Imaging in Humans Journal of Nutrition. VOL 130(PART 1), 122-127
• MARCIANI, L., YOUNG, P., WRIGHT, J., MOORE, R. J., EVANS, D. F., SPILLER, R. C. and GOWLAND, P. A., 2000. Echoplanar Imaging in GI Clinical Practice: Assessment of Gastric Emptying and Antral Motility in Four Patients Journal of Magnetic Resonance Imaging. VOL 12(PART 2), 343-346
• MARCIANI, L., MANOJ, P., HILLS, B.P., MOORE, R.P., YOUNG, P., FILLERY-TRAVIS, A., SPILLER R.C. and GOWLAND, P.A., 1998. Echo-planar imaging relaxometry to measure the viscosity of a model meal Journal of Magnetic Resonance. 135, 82-86
• BALESTRIERI, E., BELLUGI, L., BOICELLI, A., GIOMINI, M., GIULIANI, A.M., GIUSTINI, M., MARCIANI L. and SADLER, P.J., 1997. Interactions of tin(IV) with doxorubicin Journal of the Chemical Society, Dalton Transactions. 21, 4099-4106
• MARCIANI, L., BALDASSARRI, A.M., CAMMARATA G. and BOICELLI C.A., 1995. Metastatic hemangiosarcoma in canine eye: proton and sodium MRI with histological correlation Veterinary Comparative Ophtalmology. 5, 13-17