Robin Spiller

Professor of Gastroenterology. Head of Division of Gastroenterology, Lead Director of Biomedical Res, Faculty of Medicine & Health Sciences

Personal Details
Research
Publications

Contact

workRoom E1418 QMC West Block E Floor
Queen's Medical Centre
Nottingham
NG7 2UH
UK
work0115 823 1090
fax0115 823 1409
robin.spiller@nottingham.ac.uk
http://www.nottingham.ac.uk/SCS/BRU/NDDCBRU/index.aspx

Biography

Educated at Cambridge Unversity and University College Hospital London

SHO posts at Hammersmith, London Chest and Queens Square and West Middlesex. 1975-78 Registrar at Charing Cross,West and Central Middlesex 1978-1984.

MRC Travelling Fellowship to Mayo Clinic 1984-5

Senior Registrar Central Middlesex 1985-1988 Appointed Consultant Physician University Hospital Nottingham

!998 Reader and Honorary Consultant Physician University of Nottingham

2000 onwards Professor of Gastroenterology

2010 Lead Director of the Nottingham Digestive Diseases Centre Biomedical Research Unit at the University of Nottingham, UK.

2010 Elected Senior NIHR Investigator

Editor of Gut an international journal of Gastroenterology and Hepatology from 2003 -2009.

Expertise Summary

My main interest is in the pathophysiology of functional GI diseases, particularly focusing on the role of infection and inflammation and alterations in serotonin metabolism in the irritable bowel syndrome. I have twice edited the British Society of Gastroenterology ( BSG )Guidelines for the management of IBS and am a member of the Board of the Rome Foundation, an international group which produced the Rome III criteria for the classification of the functional GI diseases.

.I was the founding Chairman of the Neurogastroenterology and Motility Section of the British Society of Gastroenterology (BSG).

I am a member of MRC EME Board and National Institute for Health Research Senior Investigator. I am the author/co-author of more than 265 scientific reviews and original publications.

Research Summary

Busy GI practice with special interest in functional GI diseases, motility disorders.Research interests include pathology of post-infectious irritable bowel syndrome, neuropathology following gut… read more

Selected Publications

DUNLOP, S. P., JENKINS, D., NEAL, K. R. and SPILLER, R. C., 2003. Relative Importance of Enterochromaffin Cell Hyperplasia, Anxiety, and Depression in Postinfectious IBS Gastroenterology. 125(6), 1651-1659
DUNLOP, S.P, COLEMAN, N.S., BLACKSHAW, E., PERKINS, A.C., SINGH, G., MARSDEN, C.A. and SPILLER, R.C., 2005. Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome Clinical Gastroenterology and Hepatology. 3(4), 349-357
DUNLOP, S P, JENKINS, D, NEAL, K R, NAESDAL, J, BORGAONKER, M, COLLINS, S M and SPILLER, R C, 2003. Randomized, double-blind, placebo-controlled trial of prednisolone in post-infectious irritable bowel syndrome. Alimentary Pharmacology and Therapeutics. 18(1), 77-84
COLEMAN,N.S., MARCIANI,L., BLACKSHAW,P.E., GOWLAND,P.A., PERKINS,A.C. and SPILLER,R.C, 2001. MKC-733, a selective 5-HT3 receptor agonist, stimulates small bowel transit and relaxes the gastric fundus in man Gastroenterology. 120(5), 376

View all publications

Current Research

Techniques

Immunohistochemical assessment of mucosal nerves
Assessments of visceral hypersensitivity
Functional brain imaging
Intestinal motility assessment
Clinical trials and functional bowel disease

Projects

Inflammation in irritable bowel syndrome
Genetic basis of Irritable Bowel Syndrome
Abnormalities of serotonin metabolism in GI disease
Effects of inflammation on mucosal nerves and sensitivity
Functional magnetic resonance imaging of brain responses to oral fat
Effect of novel food substances on gastric motility
Effects of infection on visceral hypersensitivity

Past Research

Pathophysiology of functional GI diseases

Original description of postinfectious irritable bowel syndrome, particularly focusing on the role of inflammation and alterations in serotonin metabolism in the irritable bowel syndrome.

Development of MRI for studying gastric processing of complex meals

Future Research

Pathology of post-infectious Irritable bowel syndrome Functional brain imaging to explore pain pathways Neuropathology of post-inflammatory bowel disease Role of physical form of food in altering gastric and intestinal function, satiety . fMRI studies of taste and flavour pathways

HUMES, D. J., SIMPSON, J., SMITH, J., SUTTON, P., ZAITOUN, A., BUSH, D., BENNETT, A., SCHOLEFIELD, J. H. and SPILLER, R. C., 2012. Visceral hypersensitivity in symptomatic diverticular disease and the role of neuropeptides and low grade inflammation: Neurogastroenterol Motil
ELDEGHAIDY, S., MARCIANI, L., MCGLONE, F., HOLLOWOOD, T., HORT, J., HEAD, K., TAYLOR, A. J., BUSCH, J., SPILLER, R. C., GOWLAND, P. A. and FRANCIS, S. T., 2011. The cortical response to the oral perception of fat emulsions and the effect of taster status: J Neurophysiol 105(5), 2572-81
FOLEY, S., GARSED, K., SINGH, G., DUROUDIER, N. P., SWAN, C., HALL, I. P., ZAITOUN, A., BENNETT, A., MARSDEN, C., HOLMES, G., WALLS, A. and SPILLER, R. C., 2011. Impaired uptake of serotonin by platelets from patients with irritable bowel syndrome correlates with duodenal immune activation: Gastroenterology 140(5), 1434-43 e1
HUMES, D. J., FLEMING, K. M., SPILLER, R. C. and WEST, J., 2011. Concurrent drug use and the risk of perforated colonic diverticular disease: a population-based case-control study: Gut 60(2), 219-24
SMITH, J., HUMES, D. J. and SPILLER, R. C., 2011. Should we treat uncomplicated symptomatic diverticular disease with fibre?: BMJ 342, d2951
SMITH, J. K., HUMES, D. J., HEAD, K. E., BUSH, D., WHITE, T. P., STEVENSON, C. M., BROOKES, M. J., MARCIANI, L., SPILLER, R. C., GOWLAND, P. A. and FRANCIS, S. T., 2011. fMRI and MEG analysis of visceral pain in healthy volunteers: Neurogastroenterol Motil 23(7), 648-e260
SPILLER, R. C., 2011. Potential biomarkers: Gastroenterol Clin North Am 40(1), 121-39
SPILLER, R. C., 2011. Targeting the 5-HT(3) receptor in the treatment of irritable bowel syndrome: Curr Opin Pharmacol 11(1), 68-74
SPILLER, R. C., 2011. Irritable bowel syndrome: gender, infection, lifestyle or what else?: Dig Dis 29(2), 215-21
SPILLER, R. and LAM, C., 2011. The shifting interface between IBS and IBD: Curr Opin Pharmacol 11(6), 586-92
AWAD, S., STEPHENSON, M. C., PLACIDI, E., MARCIANI, L., CONSTANTIN-TEODOSIU, D., GOWLAND, P. A., SPILLER, R. C., FEARON, K. C., MORRIS, P. G., MACDONALD, I. A. and LOBO, D. N., 2010. The effects of fasting and refeeding with a 'metabolic preconditioning' drink on substrate reserves and mononuclear cell mitochondrial function: Clin Nutr 29(4), 538-44
DIZDAR, V., SPILLER, R., SINGH, G., HANEVIK, K., GILJA, O. H., EL-SALHY, M. and HAUSKEN, T., 2010. Relative importance of abnormalities of CCK and 5-HT (serotonin) in Giardia-induced post-infectious irritable bowel syndrome and functional dyspepsia: Aliment Pharmacol Ther 31(8), 883-91
DROSSMAN, D. A., CORAZZIARI, E., DELVAUX, M., SPILLER, R., TALLEY, N. J. and THOMPSON, W. G., 2010. [Appendix B: Rome III diagnostic criteria for functional gastrointestinal disorders.]: Rev Gastroenterol Mex 75(4), 511-516
MARCIANI, L., COX, E. F., HOAD, C. L., PRITCHARD, S., TOTMAN, J. J., FOLEY, S., MISTRY, A., EVANS, S., GOWLAND, P. A. and SPILLER, R. C., 2010. Postprandial changes in small bowel water content in healthy subjects and patients with irritable bowel syndrome: Gastroenterology 138(2), 469-77, 477 e1
MARCIANI, L., WRIGHT, J., FOLEY, S., HOAD, C. L., TOTMAN, J. J., BUSH, D., HARTLEY, C., ARMSTRONG, A., MANBY, P., BLACKSHAW, E., PERKINS, A. C., GOWLAND, P. A. and SPILLER, R. C., 2010. Effects of a 5-HT(3) antagonist, ondansetron, on fasting and postprandial small bowel water content assessed by magnetic resonance imaging: Aliment Pharmacol Ther 32(5), 655-63
PARKMAN, H. P., CAMILLERI, M., FARRUGIA, G., MCCALLUM, R. W., BHARUCHA, A. E., MAYER, E. A., TACK, J. F., SPILLER, R., HOROWITZ, M., VINIK, A. I., GALLIGAN, J. J., PASRICHA, P. J., KUO, B., SZARKA, L. A., MARCIANI, L., JONES, K., PARRISH, C. R., SANDRONI, P., ABELL, T., ORDOG, T., HASLER, W., KOCH, K. L., SANDERS, K., NORTON, N. J. and HAMILTON, F., 2010. Gastroparesis and functional dyspepsia: excerpts from the AGA/ANMS meeting: Neurogastroenterol Motil 22(2), 113-33
SPILLER, R. C. and THOMPSON, W. G., 2010. Bowel disorders: Am J Gastroenterol 105(4), 775-85
SPILLER, R. C., HUMES, D. J., CAMPBELL, E., HASTINGS, M., NEAL, K. R., DUKES, G. E. and WHORWELL, P. J., 2010. The Patient Health Questionnaire 12 Somatic Symptom scale as a predictor of symptom severity and consulting behaviour in patients with irritable bowel syndrome and symptomatic diverticular disease: Aliment Pharmacol Ther 32(6), 811-20
SPILLER, R. C. and GRANT THOMPSON, W., 2010. [Intestinal Disorders.]: Rev Gastroenterol Mex 75(4), 484-496
SPILLER, R., CAMILLERI, M. and LONGSTRETH, G. F., 2010. Do the symptom-based, Rome criteria of irritable bowel syndrome lead to better diagnosis and treatment outcomes?: Clin Gastroenterol Hepatol 8(2), 125-9; discussion 129-36
SPILLER, R., 2010. Postinfectious functional dyspepsia and postinfectious irritable bowel syndrome: different symptoms but similar risk factors: Gastroenterology 138(5), 1660-3
SPILLER, R., 2010. New insights into bloating and abdominal distension: is it all outlet obstruction?: Am J Gastroenterol 105(4), 888-9
HUMES, D. J., SOLAYMANI-DODARAN, M., FLEMING, K. M., SIMPSON, J., SPILLER, R. C. and WEST, J., 2009. A population-based study of perforated diverticular disease incidence and associated mortality: Gastroenterology 136(4), 1198-205
LOBO, D. N., HENDRY, P. O., RODRIGUES, G., MARCIANI, L., TOTMAN, J. J., WRIGHT, J. W., PRESTON, T., GOWLAND, P., SPILLER, R. C. and FEARON, K. C., 2009. Gastric emptying of three liquid oral preoperative metabolic preconditioning regimens measured by magnetic resonance imaging in healthy adult volunteers: a randomised double-blind, crossover study: Clin Nutr 28(6), 636-41
MARCIANI, L., FAULKS, R., WICKHAM, M. S., BUSH, D., PICK, B., WRIGHT, J., COX, E. F., FILLERY-TRAVIS, A., GOWLAND, P. A. and SPILLER, R. C., 2009. Effect of intragastric acid stability of fat emulsions on gastric emptying, plasma lipid profile and postprandial satiety: Br J Nutr 101(6), 919-28
SIMPSON, J., SUNDLER, F., HUMES, D. J., JENKINS, D., SCHOLEFIELD, J. H. and SPILLER, R. C., 2009. Post inflammatory damage to the enteric nervous system in diverticular disease and its relationship to symptoms: Neurogastroenterol Motil 21(8), 847-e58
TRAVIS, S. P., SPILLER, R. C., HOLZER, P. and COLOMBEL, J. F., 2009. IBD and IBS: novel mechanisms and future practice. Preface: Dig Dis 27 Suppl 1, 1-2
TOTMAN, J. J., MARCIANI, L., FOLEY, S., CAMPBELL, E., HOAD, C. L., MACDONALD, I. A., SPILLER, R. C. and GOWLAND, P. A., 2009. Characterization of the time course of the superior mesenteric, abdominal aorta, internal carotid and vertebral arteries blood flow response to the oral glucose challenge test using magnetic resonance imaging: Physiol Meas 30(10), 1117-36
SPILLER, R. C., 2009. Overlap between irritable bowel syndrome and inflammatory bowel disease: Dig Dis 27 Suppl 1, 48-54
SPILLER, R. and GARSED, K., 2009. Postinfectious irritable bowel syndrome: Gastroenterology 136(6), 1979-88
SPILLER, R. and GARSED, K., 2009. Infection, inflammation, and the irritable bowel syndrome: Dig Liver Dis 41(12), 844-9
BELTINGER, J., DEL BUONO, J., SKELLY, M. M., THORNLEY, J., SPILLER, R. C., STACK, W. A. and HAWKEY, C. J., 2008. Disruption of colonic barrier function and induction of mediator release by strains of Campylobacter jejuni that invade epithelial cells: World J Gastroenterol 14(48), 7345-52
HUMES, D. J., SIMPSON, J., NEAL, K. R., SCHOLEFIELD, J. H. and SPILLER, R. C., 2008. Psychological and colonic factors in painful diverticulosis: Br J Surg 95(2), 195-8
KEATING, C., BEYAK, M., FOLEY, S., SINGH, G., MARSDEN, C., SPILLER, R. and GRUNDY, D., 2008. Afferent hypersensitivity in a mouse model of post-inflammatory gut dysfunction: role of altered serotonin metabolism: J Physiol 586(Pt 18), 4517-30
PERKINS, A. C., BLACKSHAW, P. E., HAY, P. D., LAWES, S. C., ATHERTON, C. T., DANSEREAU, R. J., WAGNER, L. K., SCHNELL, D. J. and SPILLER, R. C., 2008. Esophageal transit and in vivo disintegration of branded risedronate sodium tablets and two generic formulations of alendronic acid tablets: a single-center, single-blind, six-period crossover study in healthy female subjects: Clin Ther 30(5), 834-44
SIMPSON, J., SUNDLER, F., HUMES, D. J., JENKINS, D., WAKELIN, D., SCHOLEFIELD, J. H. and SPILLER, R. C., 2008. Prolonged elevation of galanin and tachykinin expression in mucosal and myenteric enteric nerves in trinitrobenzene sulphonic acid colitis: Neurogastroenterol Motil 20(4), 392-406
WATERMEYER, G., EPSTEIN, D., HLATSHWAYO, S., GEORGE, D., LOCKETZ, M., OMAR, H. and SPILLER, R., 2008. Dysphagia and a skin rash: Gut 57(5), 672, 713
SPILLER, R. C., MEYERS, N. L. and HICKLING, R. I., 2008. Identification of patients with non-d, non-C irritable bowel syndrome and treatment with renzapride: an exploratory, multicenter, randomized, double-blind, placebo-controlled clinical trial: Dig Dis Sci 53(12), 3191-200
SPILLER, R., 2008. Review article: probiotics and prebiotics in irritable bowel syndrome: Aliment Pharmacol Ther 28(4), 385-96
SPILLER, R., 2008. Serotonergic agents and the irritable bowel syndrome: what goes wrong?: Curr Opin Pharmacol 8(6), 709-14
SPILLER, R., 2008. Serotonin and GI clinical disorders: Neuropharmacology 55(6), 1072-80
SPILLER, R., 2008. Irritable bowel syndrome--the new inflammatory bowel disease?: Clin Med 8(4), 417-9
AZPIROZ, F., BOUIN, M., CAMILLERI, M., MAYER, E. A., POITRAS, P., SERRA, J. and SPILLER, R. C., 2007. Mechanisms of hypersensitivity in IBS and functional disorders: Neurogastroenterol Motil 19(1 Suppl), 62-88
HOAD, C. L., MARCIANI, L., FOLEY, S., TOTMAN, J. J., WRIGHT, J., BUSH, D., COX, E. F., CAMPBELL, E., SPILLER, R. C. and GOWLAND, P. A., 2007. Non-invasive quantification of small bowel water content by MRI: a validation study: Phys Med Biol 52(23), 6909-22
HUMES, D., SIMPSON, J. and SPILLER, R. C., 2007. Colonic diverticular disease: Clin Evid (Online) 2007,
MARCIANI, L., WICKHAM, M., SINGH, G., BUSH, D., PICK, B., COX, E., FILLERY-TRAVIS, A., FAULKS, R., MARSDEN, C., GOWLAND, P. A. and SPILLER, R. C., 2007. Enhancement of intragastric acid stability of a fat emulsion meal delays gastric emptying and increases cholecystokinin release and gallbladder contraction: Am J Physiol Gastrointest Liver Physiol 292(6), G1607-13
SPILLER, R., 2007. Serotonin, inflammation, and IBS: fitting the jigsaw together?: J Pediatr Gastroenterol Nutr 45 Suppl 2, S115-9
SPILLER, R., 2007. Chronic diarrhoea: Gut 56(12), 1756-7
SPILLER, R., 2007. Gut in 2007: Gut 56(12), 1645
SPILLER, R., 2007. Recent advances in understanding the role of serotonin in gastrointestinal motility in functional bowel disorders: alterations in 5-HT signalling and metabolism in human disease: Neurogastroenterol Motil 19 Suppl 2, 25-31
SPILLER, R. C., 2007. Role of infection in irritable bowel syndrome: J Gastroenterol 42 Suppl 17, 41-7
SPILLER, R. C., 2007. Irritable bowel syndrome: bacteria and inflammation--clinical relevance now: Curr Treat Options Gastroenterol 10(4), 312-21
SPILLER, R. C., 2007. Is IBS caused by infectious diarrhea?: Nat Clin Pract Gastroenterol Hepatol 4(12), 642-3
SPILLER, R. and BENNETT, A., 2007. Searching for the answer to irritable bowel syndrome in the colonic mucosa: SERTainty and unSERTainty: Gastroenterology 132(1), 437-41
SPILLER, R., AZIZ, Q., CREED, F., EMMANUEL, A., HOUGHTON, L., HUNGIN, P., JONES, R., KUMAR, D., RUBIN, G., TRUDGILL, N. and WHORWELL, P., 2007. Guidelines on the irritable bowel syndrome: mechanisms and practical management: Gut 56(12), 1770-98
SPILLER, R., 2007. Clinical update: irritable bowel syndrome: Lancet 369(9573), 1586-8
COLEMAN, N. S., FOLEY, S., DUNLOP, S. P., WHEATCROFT, J., BLACKSHAW, E., PERKINS, A. C., SINGH, G., MARSDEN, C. A., HOLMES, G. K. and SPILLER, R. C., 2006. Abnormalities of serotonin metabolism and their relation to symptoms in untreated celiac disease: Clin Gastroenterol Hepatol 4(7), 874-81
DUNLOP, S. P., HEBDEN, J., CAMPBELL, E., NAESDAL, J., OLBE, L., PERKINS, A. C. and SPILLER, R. C., 2006. Abnormal intestinal permeability in subgroups of diarrhea-predominant irritable bowel syndromes: Am J Gastroenterol 101(6), 1288-94
LONGSTRETH, G. F., THOMPSON, W. G., CHEY, W. D., HOUGHTON, L. A., MEARIN, F. and SPILLER, R. C., 2006. Functional bowel disorders: Gastroenterology 130(5), 1480-91
MARCIANI, L., PFEIFFER, J. C., HORT, J., HEAD, K., BUSH, D., TAYLOR, A. J., SPILLER, R. C., FRANCIS, S. and GOWLAND, P. A., 2006. Improved methods for fMRI studies of combined taste and aroma stimuli: J Neurosci Methods 158(2), 186-94
MARCIANI, L., WICKHAM, M. S., BUSH, D., FAULKS, R., WRIGHT, J., FILLERY-TRAVIS, A. J., SPILLER, R. C. and GOWLAND, P. A., 2006. Magnetic resonance imaging of the behaviour of oil-in-water emulsions in the gastric lumen of man: Br J Nutr 95(2), 331-9
PERKINS, A. C., FRIER, M., BLACKSHAW, P. E., SPILLER, R. C., FAIRBAIRN, K. J., DANSEREAU, R. J., KINGHORN, T., SAN, P. and HOSKING, D., 2006. Esophageal transit of the weekly film-coated risedronate (Actonel) placebo tablet in subjects with Kyphosis: Int J Pharm 311(1-2), 20-5
SPILLER, R., 2006. Role of motility in chronic diarrhoea: Neurogastroenterol Motil 18(12), 1045-55
SPILLER, R., 2006. How inflammation changes neuromuscular function and its relevance to symptoms in diverticular disease: J Clin Gastroenterol 40 Suppl 3, S117-20
SPILLER, R., HARTLEB, M., NOWAK, A., BLASZCZYNSKA, M., LAMPE, P. and KAJOR, M., 2006. Hypervascular pancreatic mass: Gut 55(1), 122, 140
SPILLER, R. and CAMPBELL, E., 2006. Post-infectious irritable bowel syndrome: Curr Opin Gastroenterol 22(1), 13-7
DUNLOP, S. P., COLEMAN, N. S., BLACKSHAW, E., PERKINS, A. C., SINGH, G., MARSDEN, C. A. and SPILLER, R. C., 2005. Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome: Clin Gastroenterol Hepatol 3(4), 349-57
MARCIANI, L., BUSH, D., WRIGHT, P., WICKHAM, M., PICK, B., WRIGHT, J., FAULKS, R., FILLERY-TRAVIS, A., SPILLER, R. C. and GOWLAND, P. A., 2005. Monitoring of gallbladder and gastric coordination by EPI: J Magn Reson Imaging 21(1), 82-5
MARCIANI, L., COLEMAN, N. S., DUNLOP, S. P., SINGH, G., MARSDEN, C. A., HOLMES, G. K., SPILLER, R. C. and GOWLAND, P. A., 2005. Gallbladder contraction, gastric emptying and antral motility: single visit assessment of upper GI function in untreated celiac disease using echo-planar MRI: J Magn Reson Imaging 22(5), 634-8
MODLIN, I. M., ADLER, G., ALEXANDER, K., ARNOLD, R., BRENNER, D. A., CORAZZIARI, E., FLOCH, M. H., LAPORTE, R. E., PETERSON, W. L., QUIGLEY, E. M., SHAPIRO, M. D., SPECHLER, S. J., SPILLER, R. C., TYTGAT, G. N. and WIEGERS, W., 2005. Information assimilation and distribution challenges and goals for real and virtual journals: J Clin Gastroenterol 39(3), 181-8
SIMPSON, J. and SPILLER, R., 2005. Colonic diverticular disease: Clin Evid 543-50
SPILLER, R., 2005. How Gut handles your manuscript: Gut 54(12), 1667
SPILLER, R., 2005. Probiotics: an ideal anti-inflammatory treatment for IBS?: Gastroenterology 128(3), 783-5
WICKS, D., WRIGHT, J., RAYMENT, P. and SPILLER, R., 2005. Impact of bitter taste on gastric motility: Eur J Gastroenterol Hepatol 17(9), 961-5
WHEATCROFT, J., WAKELIN, D., SMITH, A., MAHONEY, C. R., MAWE, G. and SPILLER, R., 2005. Enterochromaffin cell hyperplasia and decreased serotonin transporter in a mouse model of postinfectious bowel dysfunction: Neurogastroenterol Motil 17(6), 863-70
SPILLER, R. C., 2005. Potential future therapies for irritable bowel syndrome: will disease modifying therapy as opposed to symptomatic control become a reality?: Gastroenterol Clin North Am 34(2), 337-54
CONSEDINE, N. S., MAGAI, C., SPILLER, R., NEUGUT, A. I. and CONWAY, F., 2004. Breast cancer knowledge and beliefs in subpopulations of African American and Caribbean women: Am J Health Behav 28(3), 260-71
DUNLOP, S. P., JENKINS, D. and SPILLER, R. C., 2004. Age-related decline in rectal mucosal lymphocytes and mast cells: Eur J Gastroenterol Hepatol 16(10), 1011-5
HOAD, C. L., RAYMENT, P., SPILLER, R. C., MARCIANI, L., ALONSO BDE, C., TRAYNOR, C., MELA, D. J., PETERS, H. P. and GOWLAND, P. A., 2004. In vivo imaging of intragastric gelation and its effect on satiety in humans: J Nutr 134(9), 2293-300
PELLEGRINI, M., URSO, R., GIORGI, G., CERRETANI, D., SPILLER, R. C. and SHERWOOD, P., 2004. Influence of antisecretory drugs on Helicobacter pylori eradication rates: Gut 53(11), 1720; author reply 1720
SIMPSON, J. and SPILLER, R., 2004. Colonic diverticular disease: Clin Evid 599-609
SPILLER, R., 2004. Can paroxetine improve well-being in patients with irritable bowel syndrome who do not respond to a high-fiber diet?: Nat Clin Pract Gastroenterol Hepatol 1(1), 14-5
SPILLER, R. C., 2004. Progress report: Gut 53(3), 317
SPILLER, R. C., 2004. Infection, immune function, and functional gut disorders: Clin Gastroenterol Hepatol 2(6), 445-55
SPILLER, R. C., 2004. Inflammation as a basis for functional GI disorders: Best Pract Res Clin Gastroenterol 18(4), 641-61
SPILLER, R. C., 2004. Irritable bowel syndrome: Br Med Bull 72, 15-29
COLEMAN, N. S., MARCIANI, L., BLACKSHAW, E., WRIGHT, J., PARKER, M., YANO, T., YAMAZAKI, S., CHAN, P. Q., WILDE, K., GOWLAND, P. A., PERKINS, A. C. and SPILLER, R. C., 2003. Effect of a novel 5-HT3 receptor agonist MKC-733 on upper gastrointestinal motility in humans: Aliment Pharmacol Ther 18(10), 1039-48
CORAZZIARI, E., BYTZER, P., DELVAUX, M., HOLTMANN, G., MALAGELADA, J. R., MORRIS, J., MULLER-LISSNER, S., SPILLER, R. C., TACK, J. and WHORWELL, P. J., 2003. Clinical trial guidelines for pharmacological treatment of irritable bowel syndrome: Aliment Pharmacol Ther 18(6), 569-80
DUNLOP, S. P., JENKINS, D., NEAL, K. R., NAESDAL, J., BORGAONKER, M., COLLINS, S. M. and SPILLER, R. C., 2003. Randomized, double-blind, placebo-controlled trial of prednisolone in post-infectious irritable bowel syndrome: Aliment Pharmacol Ther 18(1), 77-84
DUNLOP, S. P., JENKINS, D., NEAL, K. R. and SPILLER, R. C., 2003. Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS: Gastroenterology 125(6), 1651-9
DUNLOP, S. P., JENKINS, D. and SPILLER, R. C., 2003. Distinctive clinical, psychological, and histological features of postinfective irritable bowel syndrome: Am J Gastroenterol 98(7), 1578-83
NAKAMURA, M., SPILLER, R. C., BARRETT, D. A., WIBAWA, J. I., KUMAGAI, N., TSUCHIMOTO, K. and TANAKA, T., 2003. Gastric juice, gastric tissue and blood antibiotic concentrations following omeprazole, amoxicillin and clarithromycin triple therapy: Helicobacter 8(4), 294-9
SIMPSON, J., NEAL, K. R., SCHOLEFIELD, J. H. and SPILLER, R. C., 2003. Patterns of pain in diverticular disease and the influence of acute diverticulitis: Eur J Gastroenterol Hepatol 15(9), 1005-10
SIMPSON, J., LOBO, D. N., SPILLER, R. C. and SCHOLEFIELD, J. H., 2003. Diverticular abscess of the appendix: report of a case and review of the literature: Dis Colon Rectum 46(6), 832-4
SIMPSON, J., SCHOLEFIELD, J. H. and SPILLER, R. C., 2003. Origin of symptoms in diverticular disease: Br J Surg 90(8), 899-908
SIMPSON, J. and SPILLER, R., 2003. Colonic diverticular disease: Clin Evid 478-87
SPILLER, R., 2003. A change at the tiller: Gut 52(7), 917
SPILLER, R. C., 2003. Estimating the importance of infection in IBS: Am J Gastroenterol 98(2), 238-41
SPILLER, R. C., 2003. Postinfectious irritable bowel syndrome: Gastroenterology 124(6), 1662-71
SPILLER, R. C., 2003. Infection as a cause of irritable bowel syndrome: Hosp Med 64(5), 270-4
SPILLER, R. C., 2003. Treatment of Irritable Bowel Syndrome: Curr Treat Options Gastroenterol 6(4), 329-337
SPILLER, R. C., 2003. Mechanisms of postoperative intestinal motor dysfunction: Curr Opin Gastroenterol 19(2), 103-5
COLEMAN, N. and SPILLER, R., 2002. No cause for alarm in IBS: Practitioner 246(1638), 557
HEBDEN, J. M., BLACKSHAW, E., D'AMATO, M., PERKINS, A. C. and SPILLER, R. C., 2002. Abnormalities of GI transit in bloated irritable bowel syndrome: effect of bran on transit and symptoms: Am J Gastroenterol 97(9), 2315-20
MARCIANI, L., LITTLE, S. L., SNEE, J., COLEMAN, N. S., TYLER, D. J., SYKES, J., JOLLIFFE, I. G., DETTMAR, P. W., SPILLER, R. C. and GOWLAND, P. A., 2002. Echo-planar magnetic resonance imaging of Gaviscon alginate rafts in-vivo: J Pharm Pharmacol 54(10), 1351-6
NEAL, K. R., BARKER, L. and SPILLER, R. C., 2002. Prognosis in post-infective irritable bowel syndrome: a six year follow up study: Gut 51(3), 410-3
SHERWOOD, P. V., WIBAWA, J. I., ATHERTON, J. C., JORDAN, N., JENKINS, D., BARRETT, D. A., SHAW, P. N. and SPILLER, R. C., 2002. Impact of acid secretion, gastritis, and mucus thickness on gastric transfer of antibiotics in rats: Gut 51(4), 490-5
SIMPSON, J., SCHOLEFIELD, J. H. and SPILLER, R. C., 2002. Pathogenesis of colonic diverticula: Br J Surg 89(5), 546-54
SIMPSON, J. and SPILLER, R., 2002. Colonic diverticular disease: Clin Evid 436-44
SPILLER, R., 2002. Serotonergic modulating drugs for functional gastrointestinal diseases: Br J Clin Pharmacol 54(1), 11-20
SPILLER, R., 2002. Pharmacotherapy: non-serotonergic mechanisms: Gut 51 Suppl 1, i87-90
TALLEY, N. J. and SPILLER, R., 2002. Irritable bowel syndrome: a little understood organic bowel disease?: Lancet 360(9332), 555-64
SPILLER, R. C., 2002. Role of nerves in enteric infection: Gut 51(6), 759-62
SPILLER, R. C., 2002. Neuropathology of IBS?: Gastroenterology 123(6), 2144-7
AUSTIN, A. S. and SPILLER, R. C., 2001. Inflammatory bowel disease, azathioprine and skin cancer: case report and literature review: Eur J Gastroenterol Hepatol 13(2), 193-4
DUNLOP, S. P. and SPILLER, R. C., 2001. Nutritional issues in irritable bowel syndrome: Curr Opin Clin Nutr Metab Care 4(6), 537-40
MARCIANI, L., GOWLAND, P. A., FILLERY-TRAVIS, A., MANOJ, P., WRIGHT, J., SMITH, A., YOUNG, P., MOORE, R. and SPILLER, R. C., 2001. Assessment of antral grinding of a model solid meal with echo-planar imaging: Am J Physiol Gastrointest Liver Physiol 280(5), G844-9
MARCIANI, L., GOWLAND, P. A., SPILLER, R. C., MANOJ, P., MOORE, R. J., YOUNG, P. and FILLERY-TRAVIS, A. J., 2001. Effect of meal viscosity and nutrients on satiety, intragastric dilution, and emptying assessed by MRI: Am J Physiol Gastrointest Liver Physiol 280(6), G1227-33
MARCIANI, L., RAMANATHAN, C., TYLER, D. J., YOUNG, P., MANOJ, P., WICKHAM, M., FILLERY-TRAVIS, A., SPILLER, R. C. and GOWLAND, P. A., 2001. Fat emulsification measured using NMR transverse relaxation: J Magn Reson 153(1), 1-6
MARCIANI, L., YOUNG, P., WRIGHT, J., MOORE, R., COLEMAN, N., GOWLAND, P. A. and SPILLER, R. C., 2001. Antral motility measurements by magnetic resonance imaging: Neurogastroenterol Motil 13(5), 511-8
PERKINS, A. C., WILSON, C. G., FRIER, M., BLACKSHAW, P. E., DANSEREAU, R. J., VINCENT, R. M., WENDEROTH, D., HATHAWAY, S., LI, Z. and SPILLER, R. C., 2001. The use of scintigraphy to demonstrate the rapid esophageal transit of the oval film-coated placebo risedronate tablet compared to a round uncoated placebo tablet when administered with minimal volumes of water: Int J Pharm 222(2), 295-303
PERKINS, A. C., WILSON, C. G., FRIER, M., BLACKSHAW, P. E., JUAN, D., DANSEREAU, R. J., HATHAWAY, S., LI, Z., LONG, P. and SPILLER, R. C., 2001. Oesophageal transit, disintegration and gastric emptying of a film-coated risedronate placebo tablet in gastro-oesophageal reflux disease and normal control subjects: Aliment Pharmacol Ther 15(1), 115-21
THORNLEY, J. P., JENKINS, D., NEAL, K., WRIGHT, T., BROUGH, J. and SPILLER, R. C., 2001. Relationship of Campylobacter toxigenicity in vitro to the development of postinfectious irritable bowel syndrome: J Infect Dis 184(5), 606-9
SPILLER, R. C., 2001. Effects of serotonin on intestinal secretion and motility: Curr Opin Gastroenterol 17(2), 99-103
SPILLER, R. C., 2001. ABC of the upper gastrointestinal tract: Anorexia, nausea, vomiting, and pain: BMJ 323(7325), 1354-7
HEBDEN, J. M., BLACKSHAW, P. E., PERKINS, A. C., WILSON, C. G. and SPILLER, R. C., 2000. Limited exposure of the healthy distal colon to orally-dosed formulation is further exaggerated in active left-sided ulcerative colitis: Aliment Pharmacol Ther 14(2), 155-61
JONES, J., BOORMAN, J., CANN, P., FORBES, A., GOMBORONE, J., HEATON, K., HUNGIN, P., KUMAR, D., LIBBY, G., SPILLER, R., READ, N., SILK, D. and WHORWELL, P., 2000. British Society of Gastroenterology guidelines for the management of the irritable bowel syndrome: Gut 47 Suppl 2, ii1-19
MARCIANI, L., GOWLAND, P. A., SPILLER, R. C., MANOJ, P., MOORE, R. J., YOUNG, P., AL-SAHAB, S., BUSH, D., WRIGHT, J. and FILLERY-TRAVIS, A. J., 2000. Gastric response to increased meal viscosity assessed by echo-planar magnetic resonance imaging in humans: J Nutr 130(1), 122-7
MARCIANI, L., YOUNG, P., WRIGHT, J., MOORE, R. J., EVANS, D. F., SPILLER, R. C. and GOWLAND, P. A., 2000. Echoplanar imaging in GI clinical practice: assessment of gastric emptying and antral motility in four patients: J Magn Reson Imaging 12(2), 343-6
SHERWOOD, P. and SPILLER, R., 2000. Could the duration of anti-Helicobacter pylori treatment be shorter?: Dig Liver Dis 32(4), 281-4
SPILLER, R. C., JENKINS, D., THORNLEY, J. P., HEBDEN, J. M., WRIGHT, T., SKINNER, M. and NEAL, K. R., 2000. Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome: Gut 47(6), 804-11
SPILLER, R. C., 2000. Haute cuisine and the colon: Gut 46(2), 150-1
BAYERDORFFER, E., LIND, T., DITE, P., BARDHAN, K. D., O'MORAIN, C., DELCHIER, J. C., SPILLER, R., VELDHUYZEN VAN ZANTEN, S., SIPPONEN, P., MEGRAUD, F. and ZEIJLON, L., 1999. Omeprazole, amoxycillin and metronidazole for the cure of Helicobacter pylori infection: Eur J Gastroenterol Hepatol 11 Suppl 2, S19-22; discussion S23-4
BOULBY, P., MOORE, R., GOWLAND, P. and SPILLER, R. C., 1999. Fat delays emptying but increases forward and backward antral flow as assessed by flow-sensitive magnetic resonance imaging: Neurogastroenterol Motil 11(1), 27-36
GODDARD, A. F., LOGAN, R. P., LAWES, S. and SPILLER, R. C., 1999. Randomized controlled comparison of nitroimidazoles for the eradication of Helicobacter pylori and relief of ulcer-associated and non-ulcer dyspepsia: Aliment Pharmacol Ther 13(5), 637-42
HEBDEN, J. M., GILCHRIST, P. J., BLACKSHAW, E., FRIER, M. E., PERKINS, A. C., WILSON, C. G. and SPILLER, R. C., 1999. Night-time quiescence and morning activation in the human colon: effect on transit of dispersed and large single unit formulations: Eur J Gastroenterol Hepatol 11(12), 1379-85
HEBDEN, J. M., GILCHRIST, P. J., PERKINS, A. C., WILSON, C. G. and SPILLER, R. C., 1999. Stool water content and colonic drug absorption: contrasting effects of lactulose and codeine: Pharm Res 16(8), 1254-9
HEBDEN, J. M., WILSON, C. G., SPILLER, R. C., GILCHRIST, P. J., BLACKSHAW, E., FRIER, M. E. and PERKINS, A. C., 1999. Regional differences in quinine absorption from the undisturbed human colon assessed using a timed release delivery system: Pharm Res 16(7), 1087-92
LIND, T., MEGRAUD, F., UNGE, P., BAYERDORFFER, E., O'MORAIN, C., SPILLER, R., VELDHUYZEN VAN ZANTEN, S., BARDHAN, K. D., HELLBLOM, M., WRANGSTADH, M., ZEIJLON, L. and CEDERBERG, C., 1999. The MACH2 study: role of omeprazole in eradication of Helicobacter pylori with 1-week triple therapies: Gastroenterology 116(2), 248-53
MALFERTHEINER, P., BAYERDORFFER, E., DIETE, U., GIL, J., LIND, T., MISIUNA, P., O'MORAIN, C., SIPPONEN, P., SPILLER, R. C., STASIEWICZ, J., TREICHEL, H., UJSZASZY, L., UNGE, P., ZANTEN, S. J. and ZEIJLON, L., 1999. The GU-MACH study: the effect of 1-week omeprazole triple therapy on Helicobacter pylori infection in patients with gastric ulcer: Aliment Pharmacol Ther 13(6), 703-12
MEGRAUD, F., LEHN, N., LIND, T., BAYERDORFFER, E., O'MORAIN, C., SPILLER, R., UNGE, P., VAN ZANTEN, S. V., WRANGSTADH, M. and BURMAN, C. F., 1999. Antimicrobial susceptibility testing of Helicobacter pylori in a large multicenter trial: the MACH 2 study: Antimicrob Agents Chemother 43(11), 2747-52
PERKINS, A. C., WILSON, C. G., FRIER, M., VINCENT, R. M., BLACKSHAW, P. E., DANSEREAU, R. J., JUHLIN, K. D., BEKKER, P. J. and SPILLER, R. C., 1999. Esophageal transit of risedronate cellulose-coated tablet and gelatin capsule formulations: Int J Pharm 186(2), 169-75
ZANTEN, S. J., BRADETTE, M., FARLEY, A., LEDDIN, D., LIND, T., UNGE, P., BAYERDORFFER, E., SPILLER, R. C., O'MORAIN, C., SIPPONEN, P., WRANGSTADH, M., ZEIJLON, L. and SINCLAIR, P., 1999. The DU-MACH study: eradication of Helicobacter pylori and ulcer healing in patients with acute duodenal ulcer using omeprazole based triple therapy: Aliment Pharmacol Ther 13(3), 289-95
SPILLER, R. C., 1999. Upper gut dysmotility in slow-transit constipation: is it evidence for a pan-enteric neurological deficit in severe slow transit constipation?: Eur J Gastroenterol Hepatol 11(7), 693-6
SPILLER, R. C., 1999. Is there any difference in Helicobacter pylori eradication rates in patients with active peptic ulcer, inactive peptic ulcer and functional dyspepsia?: Eur J Gastroenterol Hepatol 11 Suppl 2, S25-8; discussion S43-5
SPILLER, R. C., 1999. Disturbances in large bowel motility: Baillieres Best Pract Res Clin Gastroenterol 13(3), 397-413
SPILLER, R. C., 1999. Problems and challenges in the design of irritable bowel syndrome clinical trials: experience from published trials: Am J Med 107(5A), 91S-97S
SPILLER, R. C., 1999. Impact of dietary fiber on absorption from the small intestine: Curr Opin Gastroenterol 15(2), 100-2
GODDARD, A. F., ERAH, P. O., BARRETT, D. A., SHAW, P. N. and SPILLER, R. C., 1998. The effect of protein binding and lipophilicity of penicillins on their in-vitro flux across gastric mucosa: J Antimicrob Chemother 41(2), 231-6
HEBDEN, J. M., BLACKSHAW, P. E., PERKINS, A. C., D'AMATO, M. and SPILLER, R. C., 1998. Small bowel transit of a bran meal residue in humans: sieving of solids from liquids and response to feeding: Gut 42(5), 685-9
MARCIANI, L., MANOJ, P., HILLS, B. P., MOORE, R. J., YOUNG, P., FILLERY-TRAVIS, A., SPILLER, R. C. and GOWLAND, P. A., 1998. Echo-planar imaging relaxometry to measure the viscosity of a model meal: J Magn Reson 135(1), 82-6
MCINTYRE, A. S., AYRES, R., ATHERTON, J., SPILLER, R. C. and COCKEL, R., 1998. Dissecting intramural haematoma of the oesophagus: QJM 91(10), 701-5
WASHINGTON, N., RIDLEY, P., THOMAS, C., SPILLER, R. C., WATTS, P. J. and WILSON, C. G., 1998. Mebeverine decreases mass movements and stool frequency in lactulose-induced diarrhoea: Aliment Pharmacol Ther 12(6), 583-8
WASHINGTON, N., HARRIS, M., MUSSELLWHITE, A. and SPILLER, R. C., 1998. Moderation of lactulose-induced diarrhea by psyllium: effects on motility and fermentation: Am J Clin Nutr 67(2), 317-21
SPILLER, R. C., 1998. How can we improve on the efficacy of Helicobacter pylori treatment?: Ital J Gastroenterol Hepatol 30(4), 351-4
BOULBY, P., GOWLAND, P., ADAMS, V. and SPILLER, R. C., 1997. Use of echo planar imaging to demonstrate the effect of posture on the intragastric distribution and emptying of an oil/water meal: Neurogastroenterol Motil 9(1), 41-7
DUGGAN, A. E., ATHERTON, J. C., COCKAYNE, A., BALSITIS, M., EVISON, S., HALE, T., HAWKEY, C. J. and SPILLER, R. C., 1997. Clarification of the link between polyunsaturated fatty acids and Helicobacter pylori-associated duodenal ulcer disease: a dietary intervention study: Br J Nutr 78(4), 515-22
ERAH, P. O., GODDARD, A. F., BARRETT, D. A., SHAW, P. N. and SPILLER, R. C., 1997. The stability of amoxycillin, clarithromycin and metronidazole in gastric juice: relevance to the treatment of Helicobacter pylori infection: J Antimicrob Chemother 39(1), 5-12
GODDARD, A. F., LOGAN, R. P., ATHERTON, J. C., JENKINS, D. and SPILLER, R. C., 1997. Healing of duodenal ulcer after eradication of Helicobacter heilmannii: Lancet 349(9068), 1815-6
GODDARD, A. F. and SPILLER, R. C., 1997. In vitro assessment of gastric mucosal transfer of anti-Helicobacter therapeutic agents: Antimicrob Agents Chemother 41(6), 1246-9
JESSA, M. J., GODDARD, A. F., BARRETT, D. A., SHAW, P. N. and SPILLER, R. C., 1997. The effect of omeprazole on the pharmacokinetics of metronidazole and hydroxymetronidazole in human plasma, saliva and gastric juice: Br J Clin Pharmacol 44(3), 245-53
MCINTYRE, A., VINCENT, R. M., PERKINS, A. C. and SPILLER, R. C., 1997. Effect of bran, ispaghula, and inert plastic particles on gastric emptying and small bowel transit in humans: the role of physical factors: Gut 40(2), 223-7
NEAL, K. R., HEBDEN, J. and SPILLER, R., 1997. Prevalence of gastrointestinal symptoms six months after bacterial gastroenteritis and risk factors for development of the irritable bowel syndrome: postal survey of patients: BMJ 314(7083), 779-82
SPILLER, R., 1997. Investigation and management of gastrointestinal motility disease: J R Coll Physicians Lond 31(6), 607-13
ATHERTON, J. C., CULLEN, D. J., KIRK, G. E., HAWKEY, C. J. and SPILLER, R. C., 1996. Enhanced eradication of Helicobacter pylori by pre- versus post-prandial amoxycillin suspension with omeprazole: implications for antibiotic delivery: Aliment Pharmacol Ther 10(4), 631-5
GARDNER, N., HARESIGN, W., SPILLER, R., FARRAJ, N., WISEMAN, J., NORBURY, H. and ILLUM, L., 1996. Development and validation of a pig model for colon-specific drug delivery: J Pharm Pharmacol 48(7), 689-93
GODDARD, A. F., JESSA, M. J., BARRETT, D. A., SHAW, P. N., IDSTROM, J. P., CEDERBERG, C. and SPILLER, R. C., 1996. Effect of omeprazole on the distribution of metronidazole, amoxicillin, and clarithromycin in human gastric juice: Gastroenterology 111(2), 358-67
GODDARD, A. F. and SPILLER, R. C., 1996. Helicobacter pylori eradication in clinical practice: one-week low-dose triple therapy is preferable to classical bismuth based triple therapy: Aliment Pharmacol Ther 10(6), 1009-13
GODDARD, A. F. and SPILLER, R. C., 1996. The effect of omeprazole on gastric juice viscosity, pH and bacterial counts: Aliment Pharmacol Ther 10(1), 105-9
JESSA, M. J., BARRETT, D. A., SHAW, P. N. and SPILLER, R. C., 1996. Rapid and selective high-performance liquid chromatographic method for the determination of metronidazole and its active metabolite in human plasma, saliva and gastric juice: J Chromatogr B Biomed Appl 677(2), 374-9
LIND, T., VELDHUYZEN VAN ZANTEN, S., UNGE, P., SPILLER, R., BAYERDORFFER, E., O'MORAIN, C., BARDHAN, K. D., BRADETTE, M., CHIBA, N., WRANGSTADH, M., CEDERBERG, C. and IDSTROM, J. P., 1996. Eradication of Helicobacter pylori using one-week triple therapies combining omeprazole with two antimicrobials: the MACH I Study: Helicobacter 1(3), 138-44
SPILLER, R. C., 1996. Cholesterol, fibre, and bile acids: Lancet 347(8999), 415-6
ADKIN, D. A., GOWLAND, P., SPILLER, R. C., FREEMAN, A., HYKIN, J., ISSA, B., HUCKLE, P. D. and WILDING, I. R., 1995. Echo-planar magnetic resonance imaging to assess water volume in the distal small bowel: Pharm Res 12(8), 1134-9
ATHERTON, J. C., COCKAYNE, A., BALSITIS, M., KIRK, G. E., HAWKEY, C. J. and SPILLER, R. C., 1995. Detection of the intragastric sites at which Helicobacter pylori evades treatment with amoxycillin and cimetidine: Gut 36(5), 670-4
ATHERTON, J. C., WASHINGTON, N., BLACKSHAW, P. E., GREAVES, J. L., PERKINS, A. C., HAWKEY, C. J. and SPILLER, R. C., 1995. Effect of a test meal on the intragastric distribution of urea in the 13C-urea breath test for Helicobacter pylori: Gut 36(3), 337-40
CHARNLEY, R. M., BANERJEE, A. K., WHITAKER, S. C., SPILLER, R. C. and DORAN, J., 1995. Peritoneal seeding of pancreatic cancer following transperitoneal biliary procedures: Br J Surg 82(3), 393
DE FRANCO, D. J., SPILLER, R. E., JR. and VON FRAUNHOFER, J. A., 1995. Frictional resistances using Teflon-coated ligatures with various bracket-archwire combinations: Angle Orthod 65(1), 63-72; discussion 73-4
VINCENT, R., ROBERTS, A., FRIER, M., PERKINS, A. C., MACDONALD, I. A. and SPILLER, R. C., 1995. Effect of bran particle size on gastric emptying and small bowel transit in humans: a scintigraphic study: Gut 37(2), 216-9
VAUTIER, G. and SPILLER, R. C., 1995. Safety of complementary medicines should be monitored: BMJ 311(7005), 633
THOMPSON, L. and SPILLER, R. C., 1995. Impact of polyunsaturated fatty acids on human colonic bacterial metabolism: an in vitro and in vivo study: Br J Nutr 74(5), 733-41
ATHERTON, J. C., HUDSON, N., KIRK, G. E., HAWKEY, C. K. and SPILLER, R. C., 1994. Amoxycillin capsules with omeprazole for the eradication of Helicobacter pylori. Assessment of the importance of antibiotic dose timing in relation to meals: Aliment Pharmacol Ther 8(5), 495-8
ATHERTON, J. C. and SPILLER, R. C., 1994. The urea breath test for Helicobacter pylori: Gut 35(6), 723-5
ATHERTON, J. C., WASHINGTON, N., BRACEWELL, M. A., SUTTON, L. J., GREAVES, J. L., PERKINS, A. C., HAWKEY, C. J. and SPILLER, R. C., 1994. Scintigraphic assessment of the intragastric distribution and gastric emptying of an encapsulated drug: the effect of feeding and of a proton pump inhibitor: Aliment Pharmacol Ther 8(5), 489-94
CANN, P. A., ROVATI, L. C., SMART, H. L., SPILLER, R. C. and WHORWELL, P. J., 1994. Loxiglumide, a CCK-A antagonist, in irritable bowel syndrome. A pilot multicenter clinical study: Ann N Y Acad Sci 713, 449-50
CHARNLEY, R. M., SPILLER, R. C. and DORAN, J., 1994. Surgery for pancreatic cancer: BMJ 308(6945), 1715
PERKINS, A. C., WILSON, C. G., BLACKSHAW, P. E., VINCENT, R. M., DANSEREAU, R. J., JUHLIN, K. D., BEKKER, P. J. and SPILLER, R. C., 1994. Impaired oesophageal transit of capsule versus tablet formulations in the elderly: Gut 35(10), 1363-7
THOMPSON, L., COCKAYNE, A. and SPILLER, R. C., 1994. Inhibitory effect of polyunsaturated fatty acids on the growth of Helicobacter pylori: a possible explanation of the effect of diet on peptic ulceration: Gut 35(11), 1557-61
SPILLER, R. E., JR., 1994. Dispenser tube for stainless steel ligatures: J Clin Orthod 28(3), 142
SPILLER, R. C., 1994. Pharmacology of dietary fibre: Pharmacol Ther 62(3), 407-27
SPILLER, R. C., 1994. Intestinal absorptive function: Gut 35(1 Suppl), S5-9
SPILLER, R. C., 1994. Irritable bowel or irritable mind? Medical treatment works for those with clear diagnosis: BMJ 309(6969), 1646-7
BARROW, L., STEED, K. P., SPILLER, R. C., MASKELL, N. A., BROWN, J. K., WATTS, P. J., MELIA, C. D., DAVIES, M. C. and WILSON, C. G., 1993. Quantitative, noninvasive assessment of antidiarrheal actions of codeine using an experimental model of diarrhea in man: Dig Dis Sci 38(6), 996-1003
STEED, K. P., BOHEMEN, E. K., LAMONT, G. M., EVANS, D. F., WILSON, C. G. and SPILLER, R. C., 1993. Proximal colonic response and gastrointestinal transit after high and low fat meals: Dig Dis Sci 38(10), 1793-800
BARROW, L., STEED, K. P., SPILLER, R. C., WATTS, P. J., MELIA, C. D., DAVIES, M. C. and WILSON, C. G., 1992. Scintigraphic demonstration of lactulose-induced accelerated proximal colon transit: Gastroenterology 103(4), 1167-73
MANSELL, P. I., TATTERSALL, R. B., BALSITIS, M., LOWE, J. and SPILLER, R. C., 1991. Megaduodenum due to hollow visceral myopathy successfully managed by duodenoplasty and feeding jejunostomy: Gut 32(3), 334-7
PROBERT, C. S., SPILLER, R., ATKINSON, M. and MAYBERRY, J. F., 1991. Achalasia and diet: assessment of the effect of achalasia on the diet of patients and their spouses: Dysphagia 6(3), 145-6
PAYNE-JAMES, J. J., SPILLER, R. C., MISIEWICZ, J. J. and SILK, D. B., 1990. Use of ethanol-induced tumor necrosis to palliate dysphagia in patients with esophagogastric cancer: Gastrointest Endosc 36(1), 43-6
SPILLER, R., 1990. Management of constipation. 2. When fibre fails: BMJ 300(6731), 1064-5; discussion 1063
SPILLER, R. E., JR., HELLSTEIN, J. W. and BASQUILL, P. J., 1990. Radiographic support in highly mobile operations: Mil Med 155(10), 486-9
SPILLER, R. C., 1990. Feedforward and feedback control mechanisms in the gut. With special emphasis on inhibitory feedback by nutrients in the distal small bowel and colon: Dig Dis 8(4), 189-205
GARDNER-MEDWIN, J., SAYER, J., MAHIDA, Y. R. and SPILLER, R. C., 1989. Spontaneous rupture of spleen following streptokinase therapy: Lancet 2(8676), 1398
PENAGINI, R., SPILLER, R. C., MISIEWICZ, J. J. and FROST, P. G., 1989. Effect of ileal infusion of glycochenodeoxycholic acid on segmental transit, motility, and flow in the human jejunum and ileum: Gut 30(5), 609-17
PENAGINI, R., SPILLER, R. C., MISIEWICZ, J. J., FROST, P. G. and SILK, D. B., 1988. Effect of cholecystectomy on mouth-to-cecum transit of a liquid meal: Dig Dis Sci 33(1), 19-22
SPILLER, R. C., TROTMAN, I. F., ADRIAN, T. E., BLOOM, S. R., MISIEWICZ, J. J. and SILK, D. B., 1988. Further characterisation of the 'ileal brake' reflex in man--effect of ileal infusion of partial digests of fat, protein, and starch on jejunal motility and release of neurotensin, enteroglucagon, and peptide YY: Gut 29(8), 1042-51
SPILLER, R. C., LOVELL, D. and SILK, D. B., 1988. Adult acquired cytomegalovirus infection with gastric and duodenal ulceration: Gut 29(8), 1109-11
SPILLER, R. C. and MISIEWICZ, J. J., 1987. Ethanol-induced tumour necrosis for palliation of malignant dysphagia: Lancet 2(8562), 792
SPILLER, R. C., LEE, Y. C., EDGE, C., RALPHS, D. N., STEWART, J. S., BLOOM, S. R. and SILK, D. B., 1987. Delayed mouth-caecum transit of a lactulose labelled liquid test meal in patients with steatorrhoea caused by partially treated coeliac disease: Gut 28(10), 1275-82
SPILLER, R. C., JONES, B. J. and SILK, D. B., 1987. Jejunal water and electrolyte absorption from two proprietary enteral feeds in man: importance of sodium content: Gut 28(6), 681-7
SPILLER, R. C., FROST, P. F., STEWART, J. S., BLOOM, S. R. and SILK, D. B., 1987. Delayed postprandial plasma bile acid response in coeliac patients with slow mouth-caecum transit: Clin Sci (Lond) 72(2), 217-23
SPILLER, R. C., BROWN, M. L. and PHILLIPS, S. F., 1987. Emptying of the terminal ileum in intact humans. Influence of meal residue and ileal motility: Gastroenterology 92(3), 724-9
SPILLER, R. C., BROWN, M. L., PHILLIPS, S. F. and AZPIROZ, F., 1986. Scintigraphic measurements of canine ileocolonic transit. Direct and indirect effects of eating: Gastroenterology 91(5), 1213-20
SPILLER, R. C., BROWN, M. L. and PHILLIPS, S. F., 1986. Decreased fluid tolerance, accelerated transit, and abnormal motility of the human colon induced by oleic acid: Gastroenterology 91(1), 100-7
SPILLER, R. C., 1986. Where do all the tablets go in 1986?: Gut 27(8), 879-85
KEOHANE, P. P., GRIMBLE, G. K., BROWN, B., SPILLER, R. C. and SILK, D. B., 1985. Influence of protein composition and hydrolysis method on intestinal absorption of protein in man: Gut 26(9), 907-13
SPILLER, W. F. and SPILLER, R. F., 1985. Cryoanesthesia and electrosurgical treatment of benign skin tumors: Cutis 35(6), 551-2
SPILLER, W. F. and SPILLER, R. F., 1984. Treatment of basal cell epithelioma by curettage and electrodesiccation: J Am Acad Dermatol 11(5 Pt 1), 808-14
SPILLER, R. C., TROTMAN, I. F., HIGGINS, B. E., GHATEI, M. A., GRIMBLE, G. K., LEE, Y. C., BLOOM, S. R., MISIEWICZ, J. J. and SILK, D. B., 1984. The ileal brake--inhibition of jejunal motility after ileal fat perfusion in man: Gut 25(4), 365-74
SPILLER, R. C., HIGGINS, B. E., FROST, P. G. and SILK, D. B., 1984. Inhibition of jejunal water and electrolyte absorption by therapeutic doses of clindamycin in man: Clin Sci (Lond) 67(1), 117-20
KEOHANE, P. P., ATTRILL, H., GRIMBLE, G., SPILLER, R., FROST, P. and SILK, D. B., 1983. Enteral nutrition in malnourished patients with hepatic cirrhosis and acute encephalopathy: JPEN J Parenter Enteral Nutr 7(4), 346-50
KRAWCZYNSKI, M., SPILLER, R. and BORSKI, K., 1983. [Klippel-Feil syndrome associated with renal agenesia and heart defect in an 11-year-old girl]: Wiad Lek 36(18), 1527-31
SHOUSHA, S., SPILLER, R. C. and PARKINS, R. A., 1983. The endoscopically abnormal duodenum in patients with dyspepsia: biopsy findings in 60 cases: Histopathology 7(1), 23-34
SPILLER, W. F. and SPILLER, R. F., 1983. Giemsa stain for Tzanck smear: J Am Acad Dermatol 9(3), 464
SPILLER, R. C. and PARKINS, R. A., 1983. Recurrent gastrointestinal bleeding of obscure origin: report of 17 cases and a guide to logical management: Br J Surg 70(8), 489-93
SPILLER, R. C., SHOUSHA, S. and BARRISON, I. G., 1982. Heterotopic gastric tissue in the duodenum: a report of eight cases: Dig Dis Sci 27(10), 880-3
SPILLER, R. C., CATTO, J. V. and KANE, S. P., 1981. Spontaneous dissecting intramural haematoma of the oesophagus: a rare cause of haematemesis and dysphagia: Endoscopy 13(3), 128-30

Nottingham Digestive Diseases Centre

University of Nottingham
E Floor, West Block/Medical School QMC
Queen's Medical Centre
Nottingham, NG7 2UH

telephone: +44 (0)115 82 31090
fax: +44 (0)115 82 31409
email: nddcbru@nottingham.ac.uk