TATLER AL, JOHN AE, JOLLY L, HABGOOD A, PORTE J, BRIGHTLING C, KNOX AJ, PANG L, SHEPPARD D, HUANG X and JENKINS G, 2011. Integrin Αvβ5-Mediated Tgf-Β Activation By Airway Smooth Muscle Cells In Asthma. Journal Of Immunology (Baltimore, Md. : 1950). 187(11), 6094-107 CLIFFORD RL, COWARD WR, KNOX AJ and JOHN AE, 2011. Transcriptional Regulation Of Inflammatory Genes Associated With Severe Asthma. Current Pharmaceutical Design. 17(7), 653-66
BÅGE T, KATS A, LOPEZ BS, MORGAN G, NILSSON G, BURT I, KOROTKOVA M, CORBETT L, KNOX AJ, PINO L, JAKOBSSON P, MODÉER T and YUCEL-LINDBERG T, 2011. Expression Of Prostaglandin E Synthases In Periodontitis Immunolocalization And Cellular Regulation. The American Journal Of Pathology. 178(4), 1676-88 SMYTH, ALAN R, CIFELLI, PARAMITA M, ORTORI, CATHARINE A, RIGHETTI, KARIMA, LEWIS, SARAH, ERSKINE, PENNY, HOLLAND, ELAINE D, GIVSKOV, MICHAEL, WILLIAMS, PAUL, CÁMARA, MIGUEL, BARRETT, DAVID A and KNO, 2010. Garlic as an inhibitor of Pseudomonas aeruginosa quorum sensing in cystic fibrosis--a pilot randomized controlled trial. Pediatric Pulmonology. 45(4), 356-62 FORRESTER, D L and KNOX, A J, 2009. Airway smooth muscle: telling the eosinophil how to behave. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 39(7), 938-9
CERESA, CLAUDIA C, KNOX, ALAN J and JOHNSON, SIMON R, 2009. Use of a three-dimensional cell culture model to study airway smooth muscle-mast cell interactions in airway remodeling. American Journal of Physiology: Lung Cellular and Molecular Physiology. 296(6), L1059-66 CLIFFORD, RACHEL L and KNOX, ALAN J, 2009. Vitamin D - a new treatment for airway remodelling in asthma? British journal of pharmacology. 158(6), 1426-8 JOHN, ALISON E, ZHU, YONG M, BRIGHTLING, CHRISTOPHER E, PANG, LINHUA and KNOX, ALAN J, 2009. Human airway smooth muscle cells from asthmatic individuals have CXCL8 hypersecretion due to increased NF-kappa B p65, C/EBP beta, and RNA polymerase II binding to the CXCL8 promoter. Journal of immunology (Baltimore, Md. : 1950). 183(7), 4682-92
COWARD,, WATTS,, FEGHALI-BOSTWICK,, KNOX, and PANG,, 2009. Defective Histone Acetylation Is Responsible for the Diminished Expression of Cyclooxygenase-2 in Idiopathic Pulmonary Fibrosis. Molecular and cellular biology.
XU, MING YAN, PORTE, JOANNE, KNOX, ALAN J, WEINREB, PAUL H, MAHER, TOBY M, VIOLETTE, SHELIA M, MCANULTY, ROBIN J, SHEPPARD, DEAN and JENKINS, GISLI, 2009. Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q). The American journal of pathology. 174(4), 1264-79
SUTCLIFFE, AMY M, CLARKE, DEBORAH L, BRADBURY, DAWN A, CORBETT, LISA M, PATEL, JAMIE A and KNOX, ALAN J, 2009. Transcriptional regulation of monocyte chemotactic protein-1 release by endothelin-1 in human airway smooth muscle cells involves NF-kappaB and AP-1. British journal of pharmacology. 157(3), 436-50
CLARKE, DEBORAH L, SUTCLIFFE, AMY, DEACON, KARL, BRADBURY, DAWN, CORBETT, LISA and KNOX, ALAN J, 2008. PKCbetaII augments NF-kappaB-dependent transcription at the CCL11 promoter via p300/CBP-associated factor recruitment and histone H4 acetylation. Journal of immunology (Baltimore, Md. : 1950). 181(5), 3503-14
CLAYTON, ANDREW A, FORRESTER, DOUGLAS L and KNOX, ALAN J, 2008. Aspirin and asthma: barking up the right tree? Thorax. 63(6), 485-6
MULLAN, CHARLOTTE S, RILEY, MICHAEL, CLARKE, DEBORAH, TATLER, AMANDA, SUTCLIFFE, AMY, KNOX, ALAN J and PANG, LINHUA, 2008. Beta-tryptase regulates IL-8 expression in airway smooth muscle cells by a PAR-2-independent mechanism. American journal of respiratory cell and molecular biology. 38(5), 600-8
EL-HAROUN, H, CLARKE, D L, DEACON, K, BRADBURY, D, CLAYTON, A, SUTCLIFFE, A and KNOX, ALAN J, 2008. IL-1beta, BK, and TGF-beta1 attenuate PGI2-mediated cAMP formation in human pulmonary artery smooth muscle cells by multiple mechanisms involving p38 MAP kinase and PKA. American Journal of Physiology: Lung Cellular and Molecular Physiology. 294(3), L553-62 MASTERTON, R G, GALLOWAY, A, FRENCH, G, STREET, M, ARMSTRONG, J, BROWN, E, CLEVERLEY, J, DILWORTH, P, FRY, C, GASCOIGNE, A D, KNOX, ALAN, NATHWANI, DILIP, SPENCER, ROBERT and WILCOX, MARK, 2008. Guidelines for the management of hospital-acquired pneumonia in the UK: report of the working party on hospital-acquired pneumonia of the British Society for Antimicrobial Chemotherapy. The Journal of antimicrobial chemotherapy. 62(1), 5-34
TATLER, AMANDA L, PORTE, JOANNE, KNOX, ALAN, JENKINS, GISLI and PANG, LINHUA, 2008. Tryptase activates TGFbeta in human airway smooth muscle cells via direct proteolysis. Biochemical and biophysical research communications. 370(2), 239-42
HENDERSON, N., MARKWICK, L.J., ELSHAW, S.R., FREYER, A.M., KNOX, A.J. and JOHNSON, S.R., 2007. Collagen I and thrombin activate MMP-2 by MMP-14 dependent and -independent pathways: implications for airway smooth muscle migration. American Journal of Physiology: Lung Cellular and Molecular Physiology. 292(4), L1030-L1038 TOUW,DJ,KNOX,AJ,SMYTH,A, 2007. Population pharmacokinetics of tobramycin administered thrice daily and once daily in children and adults with cystic fibrosis Journal of Cystic Fibrosis. 6(1), (In Press.)
HENDERSON, NEIL, MARKWICK, LEE J, ELSHAW, SHONA R, FREYER, ANETTE M, KNOX, ALAN J and JOHNSON, SIMON RICHARD, 2007. Collagen I and thrombin activate MMP-2 by MMP-14-dependent and -independent pathways: implications for airway smooth muscle migration. American Journal of Physiology: Lung Cellular and Molecular Physiology. 292(4), L1030-8 PANG, L., NIE, M., CORBETT, L., SUTCLIFFE, A. and KNOX, A.J., 2006. Mast cell β-tryptase selectively cleaves eotaxin and RANTES and abrogates their eosinophil chemotactic activities The Journal of Immunology. 176(6), 3788-3795 MULHERAN, M., HYMAN-TAYLOR, P.S., TAN, K.H.V., LEWIS, S., STABLEFORTH, D., KNOX, A. and SMYTH, A., 2006. Absence of cochleotoxicity measured by standard and high-frequency pure tone audiometry in a trial of once- versus three-times daily tobramycin in cystic fibrosis patients Antimicrobial Agents and Chemotherapy. 50(7), 2293-2299 SUTCLIFFE, AMY M and KNOX, ALAN J, 2006. Key developments in respiratory medicine. The Practitioner. 250(1681), 185-6, 189-92
MULHERAN, MICHAEL, HYMAN-TAYLOR, PAULINE, TAN, KELVIN H-V, LEWIS, SARAH, STABLEFORTH, DAVID, KNOX, ALAN and SMYTH, ALAN, 2006. Absence of cochleotoxicity measured by standard and high-frequency pure tone audiometry in a trial of once- versus three-times-daily tobramycin in cystic fibrosis patients. Antimicrobial Agents and Chemotherapy. 50(7), 2293-9
SMYTH, A., TAN, K.H., HYMAN-TAYLOR, P., MULHERAN, M., LEWIS, S., STABLEFORTH, D. and KNOX, A., 2005. Once versus three-times daily regimens of tobramycin treatment for pulmonary exacerbations of cystic fibrosis - the TOPIC study : a randomised controlled trial Lancet. 365(9459), 573-578 CLAYTON, A., HOLLAND, E., PANG, L. and KNOX, A., 2005. Interleukin-1β differentially regulates β<sub>2</sub> adrenoreceptor and prostaglandin E<sub>2</sub>-mediated cAMP accumulation and chloride efflux from Calu-3 bronchial epithelial cells: Role of receptor changes, adenylyl cyclase, cyclo-oxygenase 2, and protein kinase A Journal of Biological Chemistry. 280(25), 23451-23463 BRADBURY, D., CLARKE, D., SEEDHOUSE, C., CORBETT, L., STOCKS, J. and KNOX, A., 2005. Vascular endothelial growth factor induction by prostaglandin E<sub>2</sub> in human airway smooth muscle cells is mediated by E prostanoid EP<sub>2</sub>/EP<sub>4</sub> receptors and SP-1 transcription factor binding sites Journal of Biological Chemistry. 280(34), 29993-30000 STOCKS, JOANNE, BRADBURY, DAWN, CORBETT, LISA, PANG, LINHUA and KNOX, ALAN J, 2005. Cytokines upregulate vascular endothelial growth factor secretion by human airway smooth muscle cells: Role of endogenous prostanoids. FEBS Letters. 579(12), 2551-6 SUTCLIFFE, A. M. and KNOX, A. J., 2005. Muscling into cystic fibrosis airways Thorax. VOL 60(NUMB 3), 181-182 KNOX, A. J., STOCKS, J. and SUTCLIFFE, A., 2005. Angiogenesis and vascular endothelial growth factor in COPD Thorax. VOL 60(NUMB 2), 88-89 ELSHAW, SHONA R, HENDERSON, NEIL, KNOX, ALAN J, WATSON, SUSAN A, BUTTLE, DAVID J and JOHNSON, SIMON R, 2004. Matrix metalloproteinase expression and activity in human airway smooth muscle cells. British Journal of Pharmacology. 142(8), 1318-24 HAMAD, AHMED M, SUTCLIFFE, AMY M and KNOX, ALAN J, 2004. Aspirin-induced asthma: clinical aspects, pathogenesis and management. Drugs. 64(21), 2417-32
PETKOVA, D K, CLELLAND, C, RONAN, J, PANG, L, COULSON, J M, LEWIS, S and KNOX, A J, 2004. Overexpression of cyclooxygenase-2 in non-small cell lung cancer. Respiratory Medicine. 98(2), 164-72 HOWARTH, PETER H, KNOX, ALAN J, AMRANI, YASSINE, TLIBA, OMAR, PANETTIERI, REYNOLD A and JOHNSON, MALCOLM, 2004. Synthetic responses in airway smooth muscle. Journal of Allergy and Clinical Immunology. 114(2 Suppl), S32-50 NIE, M., PANG, L., INOUE, H. and KNOX, A.J., 2003. Transcriptional regulation of cyclooxygenase 2 by bradykinin and interleukin-1β in human airway smooth muscle cells: involvement of different promoter elements, transcription factors, and histone H4 acetylation Molecular and Cellular Biology. 23(24), 9233-9244 BRADBURY, D.A., NEWTON, R., ZHU, Y.M., EL-HAROUN, H., CORBETT, L. and KNOX, A.J., 2003. Cyclooxygenase-2 induction by bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic AMP response element through a novel autocrine loop involving endogenous prostaglandin E<sub>2</sub>, E-prostanoid 2 (EP2), and EP4 Receptors Journal of Biological Chemistry. 278(50), 49954-49964 PANG, LINHUA, NIE, MEI, CORBETT, LISA and KNOX, ALAN J, 2003. Cyclooxygenase-2 expression by nonsteroidal anti-inflammatory drugs in human airway smooth muscle cells: role of peroxisome proliferator-activated receptors. The Journal of Immunology. 170(2), 1043-51
TAN, KELVIN H-V, MULHERAN, MICHAEL, KNOX, ALAN J and SMYTH, ALAN R, 2003. Aminoglycoside prescribing and surveillance in cystic fibrosis. American Journal of Respiratory and Critical Care Medicine. 167(6), 819-23 HAMAD, AHMED M, CLAYTON, ANDREW, ISLAM, BAHARUL and KNOX, ALAN J, 2003. Guanylyl cyclases, nitric oxide, natriuretic peptides, and airway smooth muscle function. American Journal of Physiology: Lung Cellular and Molecular Physiology. 285(5), L973-83
SáNCHEZ-ALCáZAR, J A, BRADBURY, D A, BREA-CALVO, G, NAVAS, P and KNOX, A J, 2003. Camptothecin-induced apoptosis in non-small cell lung cancer is independent of cyclooxygenase expression. Apoptosis. 8(6), 639-47 PETKOVA, D K, CLELLAND, C A, RONAN, J E, LEWIS, S and KNOX, A J, 2003. Reduced expression of cyclooxygenase (COX) in idiopathic pulmonary fibrosis and sarcoidosis. Histopathology. 43(4), 381-6 TATTERSFIELD, A.E., KNOX, A.J., BRITTON, J.R. and HALL, I.P., 2002. Asthma Lancet. 360(9342), 1313-1322 MIDDLETON, B., RODGERS, H.C., CAMARA, M., KNOX, A.J., WILLIAMS, P. and HARDMAN, A., 2002. Direct detection of N-acylhomoserine lactones in cystic fibrosis sputum FEMS Microbiology Letters. 207(1), 1-7 PANG, L., NIE, M., CORBETT, L., DONNELLY, R., GRAY, S. and KNOX, A.J., 2002. Protein kinase C-ε mediates bradykinin-induced cyclooxygenase-2 expression in human airway smooth muscle cells FASEB Journal. 16(11), 1435-1437 JOHNSON, S R, CLELLAND, C A, RONAN, J, TATTERSFIELD, A E and KNOX, A J, 2002. The TSC-2 product tuberin is expressed in lymphangioleiomyomatosis and angiomyolipoma. Histopathology. 40(5), 458-63 BRADBURY, D A, NEWTON, R, ZHU, Y-M, STOCKS, J, CORBETT, L, HOLLAND, E D, PANG, L H and KNOX, A J, 2002. Effect of bradykinin, TGF-beta1, IL-1beta, and hypoxia on COX-2 expression in pulmonary artery smooth muscle cells. American Journal of Physiology: Lung Cellular and Molecular Physiology. 283(4), L717-25 RODGERS, HELEN C, PANG, LINHUA, HOLLAND, ELAINE, CORBETT, LISA, RANGE, SIMON and KNOX, ALAN J, 2002. Bradykinin increases IL-8 generation in airway epithelial cells via COX-2-derived prostanoids. American Journal of Physiology: Lung Cellular and Molecular Physiology. 283(3), L612-8
SMYTH,A, HYMAN-TAYLOR,P., LEWIS,S., KNOX,A.J. and STEPHENSON,T, 2002. Recruitment of women into trials. Lancet. 359(9301), 165-166 TAN,K.H., HYMAN-TAYLOR,P., MULHERAN,M., KNOX,A.J. and SMYTH,A, 2002. Lack of concordance in the use and monitoring of intravenous aminoglycosides in UK cystic fibrosis centres. Pediatric Pulmonology. 33(2), 165 TAN, KELVIN H-V, HYMAN-TAYLOR, PAULINE, MULHERAN, MIKE, KNOX, ALAN and SMYTH, ALAN, 2002. Once-daily tobramycin monotherapy in cystic fibrosis. Pediatric Pulmonology. 33(5), 406; author reply 407
CHUNG, F, BARNES, N, ALLEN, M, ANGUS, R, CORRIS, P, KNOX, A, MILES, J, MORICE, A, O'REILLY, J and RICHARDSON, M, 2002. Assessing the burden of respiratory disease in the UK. Respiratory Medicine. 96(12), 963-75 KNOX, A. J., 2002. How prevalent is aspirin induced asthma? Thorax. VOL 57(PART 7), 565 SANCHEZ-ALCAZAR, J.A., SCHNEIDER, E., HERNANDEZ-MUNOZZ, I., RUIZ-CABELLO, J., SILES-RIVAS, E., BORSTEIN, B., BREA, G., ARENAS, J., GARESSE, R., SOLIS-HERRUZO, J.A., KNOX, A. and NAVAS, P., 2002. Reactive oxygen species mediate the down-regulation of mitochondrial transcipts and proteins by Tumor Necrosis Factor-alpha in L929 cells Biochemical Journal. PMID: 12470298,
LEWIS, S.A., PAVORD, I.D., STRINGER, J.R., KNOX, A.J., WEISS, S.T. and BRITTON, J.R., 2001. The relation between peripheral blood leukocyte counts and respiratory symptoms, atopy, lung function, and airway responsiveness in adults Chest. 119(1), 105-114 BRITTON, J, and KNOX, A., 2001. Nottingham University and British American Tobacco Thorax. 56(4), 249 KNOX, A.J., CORBETT, L., STOCKS, J., HOLLAND, E., ZHU, Y.M. and PANG, L., 2001. Human airway smooth muscle cells secrete vascular endothelial growth factor: up-regulation by bradykinin via a protein kinase C and prostanoid-dependent mechanism The FASEB Journal: official publication of the Federation of American Societies for Experimental Biology. 15(13), 2480-2488 KNOX, A.J., PANG, L.H. and ZHU, Y.M., 2001. Targetting remodelling in respiratory inflammation Current Opinion in Investigational Drugs. 1, 428-434
PANG, L and KNOX, A J, 2000. Synergistic inhibition by beta(2)-agonists and corticosteroids on tumor necrosis factor-alpha-induced interleukin-8 release from cultured human airway smooth-muscle cells. American Journal of Respiratory Cell and Molecular Biology. 23(1), 79-85
HAMAD, A. M., JOHNSON, S. R. and KNOX, A. J., 1999. Antiproliferative effects of NO and ANP in cultured human airway smooth muscle American Journal of Physiology. VOL 277(ISSUE 5), L910-L918
JOHNSON, S and KNOX, A, 1999. Autocrine production of matrix metalloproteinase-2 is required for human airway smooth muscle proliferation. American Journal of Physiology. 277(6 Pt 1), L1109-17
HAMAD, A M, RANGE, S P, HOLLAND, E and KNOX, A J, 1999. Desensitization of guanylyl cyclases in cultured human airway smooth-muscle cells. American Journal of Respiratory Cell and Molecular Biology. 20(5), 1087-95
PANG, L and KNOX, A J, 1998. Bradykinin stimulates IL-8 production in cultured human airway smooth muscle cells: role of cyclooxygenase products. The Journal of Immunology. 161(5), 2509-15
JOHNSON, S R and KNOX, A J, 1997. Synthetic functions of airway smooth muscle in asthma. Trends in Pharmacological Sciences. 18(8), 288-92 RANGE, S P, HOLLAND, E D, BASTEN, G P and KNOX, A J, 1997. Regulation of guanosine 3':5'-cyclic monophosphate in ovine tracheal epithelial cells. British Journal of Pharmacology. 120(7), 1249-54 HAMAD, A M, RANGE, S, HOLLAND, E and KNOX, A J, 1997. Regulation of cGMP by soluble and particulate guanylyl cyclases in cultured human airway smooth muscle. American Journal of Physiology. 273(4 Pt 1), L807-13
PITT, A. and KNOX, A.J., 1996. Molecular characterisation of the human airway smooth muscle Na+/Ca2+ exchanger American Journal of Respiratory Cell and Molecular Biology. 15, 726-730