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Research Fellow investigating the role of integrins and TGFbeta activation in asthma and IPF, Faculty of Medicine & Health Sciences
Investigating the mechanisms of TGF-beta activation in asthmatic airway remodelling and idiopathic pulmonary fibrosis, with a particular interest in integrin-mediated TGF-beta activation. Recently, I… read more
Investigating the mechanisms of TGF-beta activation in asthmatic airway remodelling and idiopathic pulmonary fibrosis, with a particular interest in integrin-mediated TGF-beta activation. Recently, I have described a mechanism by which airway smooth muscel cells may contribute to airway remodelling in asthma by activating TGF-beta via the alphaVbeta5 integrin in response to cellular contraction. This work was published inthe Journal of Immunology and featured in a JI editorial in December 2011. Future work aims to investigate this further.
Currently, I am investigating the transcriptional regulation of the TGF-beta activating integrin beta6 subunit in idiopathic pulmonary fibrosis using state of the art techniques including chromatin immunoprecipitation and other molecular biology techniques. I am experienced in several in vivo models of lung disease including the bleomycin model of pulmonary fibrosis and models of allergic asthma and airway remdoelling.
D Floor, East BlockQueen's Medical Centre Nottingham, NG7 2UH
telephone: +44 (0) 115 823 0695 fax: +44 (0) 115 823 0704 email: scs-enquiries@nottingham.ac.uk