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NYIRENDA, MUKANTHU H, SANVITO, LARA, DARLINGTON, PETER J, O'BRIEN, KATE, ZHANG, GUANG-XIAN, CONSTANTINESCU, CRIS S, BAR-OR, AMIT and GRAN, BRUNO, 2011. TLR2 Stimulation Drives Human Naive and Effector Regulatory T Cells into a Th17-Like Phenotype with Reduced Suppressive Function. Journal of Immunology. PMID: 21775683 JAGESSAR SA, GRAN B, HEIJMANS N, BAUER J, LAMAN JD, 'T HART BA and CONSTANTINESCU CS, 2011. Discrepant Effects Of Human Interferon-Gamma On Clinical And Immunological Disease Parameters In A Novel Marmoset Model For Multiple Sclerosis. Journal Of Neuroimmune Pharmacology : The Official Journal Of The Society On Neuroimmune Pharmacology. 7, 253-65 T TOUIL, N CHU, U BOHLMANN, P BARGSTEN, Y LI, D FITZGERALD, GX ZHANG, B BECHER, AM ROSTAMI, B GRAN, 2010. A paradoxical effect of systemic IL-23 in EAE – Limitation of autoimmune inflammatory demyelination. The Open Autoimmunity Journal. 2, 141-150.
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CONSTANTINESCU, CRIS S and GRAN, BRUNO, 2010. Multiple sclerosis: Autoimmune associations in multiple sclerosis. Nature Reviews Neurology. 6(11), 591-2 O'BRIEN, K., FITZGERALD, D., ROSTAMI, A. and GRAN, B., 2010. The TLR7 agonist, imiquimod, increases IFN-beta production and reduces the severity of experimental autoimmune encephalomyelitis Journal of Neuroimmunology. VOL 221(NUMBER 1-2), 107-111 O'BRIEN, KATE, GRAN, BRUNO and ROSTAMI, ABDOLMOHAMAD, 2010. T-cell based immunotherapy in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunotherapy. 2(1), 99-115
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JEAN-GILLES, LUCIE, GRAN, BRUNO and CONSTANTINESCU, CRIS S, 2010. Interaction between cytokines, cannabinoids and the nervous system. Immunobiology. 215(8), 606-10 YAN, YAPING, ZHANG, GUANG-XIAN, GRAN, BRUNO, FALLARINO, FRANCESCA, YU, SHUO, LI, HONGMEI, CULLIMORE, MELISSA L, ROSTAMI, ABDOLMOHAMAD and XU, HUI, 2010. IDO Upregulates Regulatory T Cells via Tryptophan Catabolite and Suppresses Encephalitogenic T Cell Responses in Experimental Autoimmune Encephalomyelitis. Journal of Immunology. 185(10), 5953-61 LIU, HONGQI, FITZGERALD, DENISE, GRAN, BRUNO, LEONG, JOHN M and ALUGUPALLI, KISHORE R, 2010. Induction of Distinct Neurologic Disease Manifestations during Relapsing Fever Requires T Lymphocytes. Journal of Immunology. 184(10), 5859-64
TALLANTYRE, EMMA C, PAINE, SIMON M L, SHARP, COLIN P, LOWE, JAMES S and GRAN, BRUNO, 2009. Atypical progressive multifocal leukoencephalopathy associated with an unusual JC polyomavirus mutation. Archives of Neurology. 66(8), 1021-4
BRAITCH M, KAWABE K, NYIRENDA M, JEAN-GILLES L, ROBINS A, GRAN B, MURPHY S, SHOWE L and CONSTANTINESCU CS, 2009. Expression of Activity-Dependent Neuroprotective Protein in the Immune System: Possible Functions and Relevance to Multiple Sclerosis. Neuroimmunomodulation. 17(2), 120-125
NYIRENDA, MUKANTHU H, O'BRIEN, KATE, SANVITO, LARA, CONSTANTINESCU, CRIS S and GRAN, BRUNO, 2009. Modulation of regulatory T cells in health and disease: role of toll-like receptors. Inflammation & Allergy Drug Targets. 8(2), 124-9
O'BRIEN, KATE, FITZGERALD, DENISE C, NAIKEN, KARMESWAREE, ALUGUPALLI, KISHORE R, ROSTAMI, A M and GRAN, BRUNO, 2008. Role of the innate immune system in autoimmune inflammatory demyelination. Current Medicinal Chemistry. 15(11), 1105-15 TOUIL, TARIK, CIRIC, BOGOLJUB, VENTURA, ELVIRA, SHINDLER, KENNETH S, GRAN, BRUNO and ROSTAMI, ABDOLMOHAMAD, 2008. Bowman-Birk inhibitor suppresses autoimmune inflammation and neuronal loss in a mouse model of multiple sclerosis. Journal of the Neurological Sciences. 271(1-2), 191-202 LI, YONGHAI, CHU, NIANSHENG, HU, AIHUA, GRAN, BRUNO, ROSTAMI, ABDOLMOHAMAD and ZHANG, GUANG-XIAN, 2007. Increased IL-23p19 expression in multiple sclerosis lesions and its induction in microglia. Brain. 130(Pt 2), 490-501 LI Y, CHU N, HU A, GRAN B, ROSTAMI A and ZHANG GX, 2007. Inducible IL-23p19 expression in human microglia via p38 MAPK and NF-kappaB signal pathways. Experimental and Molecular Pathology. 84(1), 1-8 FITZGERALD, DC, CIRIC, B, TOUIL, T, HARLE, H, GRAMMATIKOPOLOU, J, DAS SARMA, J, GRAN, B, ZHANG, GX and ROSTAMI, A, 2007. Suppressive Effect of IL-27 on Encephalitogenic Th17 Cells and the Effector Phase of Experimental Autoimmune Encephalomyelitis. The Journal of Immunology. 179(5), 3268-75
FITZGERALD, DENISE C, ZHANG, GUANG-XIAN, EL-BEHI, MOHAMED, FONSECA-KELLY, ZOË, LI, HONGMEI, YU, SHUO, SARIS, CHRISTIAAN J, GRAN, BRUNO, CIRIC, BOGOLJUB and ROSTAMI, ABDOLMOHAMAD, 2007. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nature Immunology. 8(12), 1372-9 CHENG X, ZHAO Z, VENTURA ES, GRAN B, SHINDLER, KS, ROSTAMI, AM, 2007. The PD-1/PD-L pathway is up-regulated during IL-12-induced suppression of EAE mediated by IFN-gamma. Journal of Neuroimmunology. 185(1-2), 75-86 ZHANG, G.X., YU, S., CALIDA, D., ZHAO, Z., GRAN, B., KAMOUN, M. and ROSTAMI, A.M., 2006. Loss of the surface antigen 3G11 characterizes a distinct population of anergic/regulatory T cells in experimental autoimmune encephalomyelitis The Journal of Immunology. 176(6), 3366-3373 TOUIL, T., FITZGERALD, D., ZHANG, G-X., ROSTAMI, A. and GRAN, B., 2006. Cutting edge : TLR3 stimulation suppresses experimental autoimmune encephalomyelitis by inducing endogenous IFN-β Journal of Immunology. 177(11), 7505-7509 GRAN, B., TABIBZADEH, N., MARTIN, A., VENTURA, E.S., WARE, J.H., ZHANG, G.-X., PARR, J.L., KENNEDY, A.R. and ROSTAMI, A.M., 2006. The protease inhibitor, Bowman-Birk Inhibitor, suppresses experimental autoimmune encephalomyelitis:a potential oral therapy for multiple sclerosis Multiple Sclerosis. 12(6), 688-697 TOUIL, TARIK, FITZGERALD, DENISE, ZHANG, GUANG-XIAN, ROSTAMI, A M and GRAN, BRUNO, 2006. Pathophysiology of interleukin-23 in experimental autoimmune encephalomyelitis. Drug News and Perspectives. 19(2), 77-83
GRAN, B, TABIBZADEH, N, MARTIN, A, VENTURA, E S, WARE, J H, ZHANG, G X, PARR, J L, KENNEDY, A R and ROSTAMI, A M, 2006. The protease inhibitor, Bowman-Birk Inhibitor, suppresses experimental autoimmune encephalomyelitis: a potential oral therapy for multiple sclerosis. Multiple Sclerosis. 12(6), 688-97 TOUIL, TARIK, FITZGERALD, DENISE, ZHANG, GUANG-XIAN, ROSTAMI, ABDOLMOHAMAD and GRAN, BRUNO, 2006. Cutting Edge: TLR3 stimulation suppresses experimental autoimmune encephalomyelitis by inducing endogenous IFN-beta. The Journal of Immunology. 177(11), 7505-9
TOUIL,T., FITZGERALD,D., ZHANG,G., ROSTAMI,A. and GRAN,B., 2006. Pathophysiology of interleukin-23 in experimental autoimmune encephalomyelitis Drug News & Perspectives. 19(2), 77-83 ZHANG, G.-X., YU, S., GRAN, B. and ROSTAMI, A., 2005. Glucosamine Abrogates the Acute Phase of Experimental Autoimmune Encephalomyelitis by Induction of Th2 Response The Journal of Immunology. VOL 175(NUMB 11), 7202-7208
ZHANG, GUANG-XIAN, YU, SHUO, LI, YONGHAI, VENTURA, ELVIRA S, GRAN, BRUNO and ROSTAMI, ABDOLMOHAMAD, 2005. A paradoxical role of APCs in the induction of intravenous tolerance in experimental autoimmune encephalomyelitis. Journal of Neuroimmunology. 161(1-2), 101-12
ZHANG, G. X., YU, S., LI, Y., VENTURA, E. S., GRAN, B. and ROSTAMI, A., 2005. A paradoxical role of APCs in the induction of intravenous tolerance in experimental autoimmune encephalomyelitis Journal of Neuroimmunology. VOL 161(NUMBER 1-2), 101-112 ZHANG, GUANG-XIAN, YU, SHUO, GRAN, BRUNO and ROSTAMI, ABDOLMOHAMAD, 2005. Glucosamine abrogates the acute phase of experimental autoimmune encephalomyelitis by induction of Th2 response. The Journal of Immunology. 175(11), 7202-8
LI, JIFEN, GRAN, BRUNO, ZHANG, GUANG-XIAN, ROSTAMI, ABDOLMOHAMAD and KAMOUN, MALEK, 2005. IL-27 subunits and its receptor (WSX-1) mRNAs are markedly up-regulated in inflammatory cells in the CNS during experimental autoimmune encephalomyelitis. Journal of the Neurological Sciences. 232(1-2), 3-9
GRAN, B., CHU, N., ZHANG, G. X., YU, S., LI, Y., CHEN, X. H., KAMOUN, M. and ROSTAMI, A., 2004. Early administration of IL-12 suppresses EAE through induction of interferon-gamma. Journal of Neuroimmunology. 156(1-2), 123-131 ZHANG, GUANG-XIAN, YU, SHUO, GRAN, BRUNO, LI, JIFEN, CALIDA, DIVINA, VENTURA, ELVIRA, CHEN, XIAOHAN and ROSTAMI, ABDOLMOHAMAD, 2004. T cell and antibody responses in remitting-relapsing experimental autoimmune encephalomyelitis in (C57BL/6 x SJL) F1 mice. Journal of Neuroimmunology. 148(1-2), 1-10 GRAN, BRUNO, ZHANG, GUANG-XIAN and ROSTAMI, ABDOLMOHAMAD, 2004. Role of the IL-12/IL-23 system in the regulation of T-cell responses in central nervous system inflammatory demyelination. Critical Reviews in Immunology. 24(2), 111-28
GRAN, BRUNO, CHU, NIANSHENG, ZHANG, GUANG-XIAN, YU, SHUO, LI, YONGHAI, CHEN, XIAO-HAN, KAMOUN, MALEK and ROSTAMI, ABDOLMOHAMAD, 2004. Early administration of IL-12 suppresses EAE through induction of interferon-gamma. Journal of Neuroimmunology. 156(1-2), 123-31
ZHANG, G.-X., GRAN, B., YU, S., LI, J., SIGLIENTI, I., CHEN, X., KAMOUN, M. and ROSTAMI, A., 2003. Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-β2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system The Journal of Immunology. 170(4), 2153-2160 ZHANG, GUANG-XIAN, YU, SHUO, GRAN, BRUNO, LI, JIFEN, SIGLIENTI, INES, CHEN, XIAOHAN, CALIDA, DIVINA, VENTURA, ELVIRA, KAMOUN, MALEK and ROSTAMI, ABDOLMOHAMAD, 2003. Role of IL-12 receptor beta 1 in regulation of T cell response by APC in experimental autoimmune encephalomyelitis. The Journal of Immunology. 171(9), 4485-92
MURARO, P. A., WANDINGER, K.-P., BIELEKOVA, B., GRAN, B., MARQUES, A., UTZ, U., MCFARLAND, H. F., JACOBSON, S. and MARTIN, R., 2003. Molecular tracking of antigen-specific T cell clones in neurological immune-mediated disorders Brain. VOL 126(PART 1), 20-31 ZHANG, G.-X., YU, S., GRAN, B., LI, J., SIGLIENTI, I., CHEN, X., CALIDA, D., VENTURA, E., KAMOUN, M. and ROSTAMI, A., 2003. Role of IL-12 Receptor beta1 in Regulation of T Cell Response by APC in Experimental Autoimmune Encephalomyelitis The Journal of Immunology. VOL 171(PART 9), 4485-4492
LI, J., GRAN, B., ZHANG, G. X., VENTURA, E. S., SIGLIENTI, I., ROSTAMI, A. and KAMOUN, M., 2003. Differential expression and regulation of IL-23 and IL-12 subunits and receptors in adult mouse microglia Journal of the Neurological Sciences. VOL 215(NUMBER 1-2), 95-103 GRAN, B., ZHANG, G.-X., YU, S., LI, J., CHEN, X.-H., VENTURA, E. S., KAMOUN, M. and ROSTAMI, A., 2002. IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination The Journal of Immunology. 169(12), 7104-7110 ZHAO, Y., GRAN, B., PINILLA, C., MARKOVIC-PLESE, S., HEMMER, B., TZOU, A., WHITNEY, L.W., BIDDISON, W.E., MARTIN, R. and SIMON, R., 2001. Combinatorial peptide libraries and biometric score matrices permit the quantitative analysis of specific and degenerate interactions between clonotypic TCR and MHC peptide ligands The Journal of Immunology. 167(4), 2130-2141 GRAN, B and ROSTAMI, A, 2001. T cells, cytokines, and autoantigens in multiple sclerosis. Current Neurology and Neuroscience Reports. 1(3), 263-70
MARTIN, R, GRAN, B, ZHAO, Y, MARKOVIC-PLESE, S, BIELEKOVA, B, MARQUES, A, SUNG, M H, HEMMER, B, SIMON, R, MCFARLAND, H F and PINILLA, C, 2001. Molecular mimicry and antigen-specific T cell responses in multiple sclerosis and chronic CNS Lyme disease. Journal of Autoimmunity. 16(3), 187-92 CHEN, M., GRAN, B., COSTELLO, K., JOHNSON, K., MARTIN, R. and DHIB-JALBUT, S., 2001. Glatiramer acetate induces a Th2-biased response and crossreactivity with myelin basic protein in patients with MS Multiple Sclerosis. VOL 7(PART 4), 209-220 BALLERINI, C, CAMPANI, D, ROMBOLÀ, G, GRAN, B, NACMIAS, B, AMATO, M P, SIRACUSA, G, BARTOLOZZI, L, SORBI, S and MASSACESI, L, 2000. Association of apolipoprotein E polymorphism to clinical heterogeneity of multiple sclerosis. Neuroscience letters. 296(2-3), 174-6 HEMMER, B, KONDO, T, GRAN, B, PINILLA, C, CORTESE, I, PASCAL, J, TZOU, A, MCFARLAND, H F, HOUGHTEN, R and MARTIN, R, 2000. Minimal peptide length requirements for CD4(+) T cell clones--implications for molecular mimicry and T cell survival. International Immunology. 12(3), 375-83 HEMMER, B, PINILLA, C, GRAN, B, VERGELLI, M, LING, N, CONLON, P, MCFARLAND, H F, HOUGHTEN, R and MARTIN, R, 2000. Contribution of individual amino acids within MHC molecule or antigenic peptide to TCR ligand potency. Journal of Immunology. 164(2), 861-71
BIELEKOVA, B, GOODWIN, B, RICHERT, N, CORTESE, I, KONDO, T, AFSHAR, G, GRAN, B, EATON, J, ANTEL, J, FRANK, J A, MCFARLAND, H F and MARTIN, R, 2000. Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand. Nature Medicine. 6(10), 1167-75 MARTIN, R, BIELEKOVA, B, GRAN, B and MCFARLAND, H F, 2000. Lessons from studies of antigen-specific T cell responses in Multiple Sclerosis. Journal of neural transmission. Supplementum. 361-73
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REINHOLD, D, HEMMER, B, GRAN, B, BORN, I, FAUST, J, NEUBERT, K, MCFARLAND, H F, MARTIN, R and ANSORGE, S, 1998. Inhibitors of dipeptidyl peptidase IV/CD26 suppress activation of human MBP-specific CD4+ T cell clones. Journal of Neuroimmunology. 87(1-2), 203-9 GRAN, B, GESTRI, D, SOTTINI, A, QUIRÒS ROLDÀN, E, BETTINARDI, A, SIGNORINI, S, PRIMI, D, BALLERINI, C, TAIUTI, R, AMADUCCI, L and MASSACESI, L, 1998. Detection of skewed T-cell receptor V-beta gene usage in the peripheral blood of patients with multiple sclerosis. Journal of Neuroimmunology. 85(1), 22-32 VERGELLI, M, OLIVOTTO, J, CASTIGLI, E, GRAN, B, RAIMONDI, L, PIRISINO, R, AMADUCCI, L and MASSACESI, L, 1997. Immunosuppressive activity of 13-cis-retinoic acid in rats: aspects of pharmacokinetics and pharmacodynamics. Immunopharmacology. 37(2-3), 191-7 VERGELLI, M, MAZZANTI, B, BALLERINI, C, GRAN, B, AMADUCCI, L and MASSACESI, L, 1995. Transforming growth factor-beta 1 inhibits the proliferation of rat astrocytes induced by serum and growth factors. Journal of Neuroscience Research. 40(1), 127-33