KAWABE K, LINDSAY D, BRAITCH M, FAHEY AJ, SHOWE L and CONSTANTINESCU CS, 2012. Il-12 Inhibits Glucocorticoid-Induced T Cell Apoptosis By Inducing Gmeb1 And Activating Pi3k/Akt Pathway. Immunobiology. 217(1), 118-23 CONSTANTINESCU, CRIS S, FAROOQI, NASR, O'BRIEN, KATE and GRAN, BRUNO, 2011. Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS). British Journal of Pharmacology. PMID 21371012 SANVITO, LARA, CONSTANTINESCU, CRIS S and GRAN, BRUNO, 2011. Novel Therapeutic Approaches to Autoimmune Demyelinating Disorders. Current pharmaceutical design. in press, PMID 21864270 NYIRENDA, MUKANTHU H, SANVITO, LARA, DARLINGTON, PETER J, O'BRIEN, KATE, ZHANG, GUANG-XIAN, CONSTANTINESCU, CRIS S, BAR-OR, AMIT and GRAN, BRUNO, 2011. TLR2 Stimulation Drives Human Naive and Effector Regulatory T Cells into a Th17-Like Phenotype with Reduced Suppressive Function. Journal of Immunology. PMID: 21775683 JAGESSAR SA, GRAN B, HEIJMANS N, BAUER J, LAMAN JD, 'T HART BA and CONSTANTINESCU CS, 2011. Discrepant Effects Of Human Interferon-Gamma On Clinical And Immunological Disease Parameters In A Novel Marmoset Model For Multiple Sclerosis. Journal Of Neuroimmune Pharmacology : The Official Journal Of The Society On Neuroimmune Pharmacology. 7, 253-65 LINCOLN NB, YUILL F, HOLMES J, DRUMMOND AER, CONSTANTINESCU CS, ARMSTRONG S and PHILLIPS C, 2011. Evaluation Of An Adjustment Group For People With Multiple Sclerosis And Low Mood: A Randomized Controlled Trial. Multiple Sclerosis (Houndmills, Basingstoke, England). 17(10), 1250-7 CONSTANTINESCU CS, NIEPEL G, PATTERSON M, JUDD A, BRAITCH M, FAHEY AJ, HARIKRISHNAN S, EDWARDS LJ, TENCH CR, BENNETT GW and GHATEI M, 2011. Orexin A (Hypocretin-1) Levels Are Not Reduced While Cocaine/Amphetamine Regulated Transcript Levels Are Increased In The Cerebrospinal Fluid Of Patients With Multiple Sclerosis: No Correlation With Fatigue And Sleepiness. Journal Of The Neurological Sciences. 307(1-2), 127-31 EDWARDS LJ, SHARRACK B, ISMAIL A, TUMANI H and CONSTANTINESCU CS, 2011. Central Inflammation Versus Peripheral Regulation In Multiple Sclerosis. Journal Of Neurology. 258(8), 1518-27 EDWARDS, L J, ROBINS, R A and CONSTANTINESCU, C S, 2010. Th17/Th1 phenotype in demyelinating disease. Cytokine. 50(1), 19-23
PETZOLD, AXEL, ALTINTAS, AYSE, ANDREONI, LAURA, BARTOS, ALES, BERTHELE, ACHIM, BLANKENSTEIN, MARINUS A, BUEE, LUC, CASTELLAZZI, MASSIMILIANO, CEPOK, SABINE, COMABELLA, MANUEL, CONSTANTINESCU, CRIS S and , 2010. Neurofilament ELISA validation. Journal of immunological methods. 352(1-2), 23-31
CONSTANTINESCU, CRIS S and GRAN, BRUNO, 2010. Multiple sclerosis: Autoimmune associations in multiple sclerosis. Nature Reviews Neurology. 6(11), 591-2 JEAN-GILLES, LUCIE, GRAN, BRUNO and CONSTANTINESCU, CRIS S, 2010. Interaction between cytokines, cannabinoids and the nervous system. Immunobiology. 215(8), 606-10 BRAITCH M and CONSTANTINESCU CS, 2010. The Role Of Osteopontin In Experimental Autoimmune Encephalomyelitis (Eae) And Multiple Sclerosis (Ms). Inflammation & Allergy Drug Targets. 9(4), 249-56
KAVIA RBC, DE RIDDER D, CONSTANTINESCU CS, STOTT CG and FOWLER CJ, 2010. Randomized Controlled Trial Of Sativex To Treat Detrusor Overactivity In Multiple Sclerosis. Multiple Sclerosis (Houndmills, Basingstoke, England). 16(11), 1349-59 RAVNBORG M, SØRENSEN PS, ANDERSSON M, CELIUS EG, JONGEN PJ, ELOVAARA I, BARTHOLOMÉ E, CONSTANTINESCU CS, BEER K, GARDE E and SPERLING B, 2010. Methylprednisolone In Combination With Interferon Beta-1A For Relapsing-Remitting Multiple Sclerosis (Mecombin Study): A Multicentre, Double-Blind, Randomised, Placebo-Controlled, Parallel-Group Trial. Lancet Neurology. 9(7), 672-80 LIM SY and CONSTANTINESCU CS, 2010. Current And Future Disease-Modifying Therapies In Multiple Sclerosis. International Journal Of Clinical Practice. 64(5), 637-50 TANASESCU R and CONSTANTINESCU CS, 2010. Cannabinoids And The Immune System: An Overview. Immunobiology. 215(8), 588-97 ROLLS AES, GIOVANNONI G, CONSTANTINESCU CS, BONIFACE D and HAWKES CH, 2010. Multiple Sclerosis, Lymphoma And Nasopharyngeal Carcinoma: The Central Role Of Epstein-Barr Virus? European Neurology. 63(1), 29-35 FRANCIS, SUSAN, LIN, XIA, ABOUSHOUSHAH, SAMIA, WHITE, THOMAS P, PHILLIPS, MARGARET, BOWTELL, RICHARD and CONSTANTINESCU, CRIS S, 2009. fMRI analysis of active, passive and electrically stimulated ankle dorsiflexion. NeuroImage. 44(2), 469-79
JEAN-GILLES L, FENG S, TENCH CR, CHAPMAN, V, KENDALL, DA, BARRETT, DA and CONSTANTINESCU, CS., 2009. Plasma endocannabinoid levels in multiple sclerosis. Journal of the Neurological Sciences. NYIRENDA, MUKANTHU H, O'BRIEN, KATE, SANVITO, LARA, CONSTANTINESCU, CRIS S and GRAN, BRUNO, 2009. Modulation of regulatory T cells in health and disease: role of toll-like receptors. Inflammation & Allergy Drug Targets. 8(2), 124-9
KUBAJEWSKA, ILONA and CONSTANTINESCU, CRIS S, 2009. Cannabinoids and experimental models of multiple sclerosis. Immunobiology.
SOTIROPOULOS, STAMATIOS N, BAI, LI, MORGAN, PAUL S, CONSTANTINESCU, CRIS S and TENCH, CHRISTOPHER R, 2009. Brain tractography using Q-ball imaging and graph theory: Improved connectivities through fibre crossings via a model-based approach. NeuroImage.
EDWARDS, LAURA J and CONSTANTINESCU, CRIS S, 2009. Platelet activating factor/platelet activating factor receptor pathway as a potential therapeutic target in autoimmune diseases. Inflammation & allergy drug targets. 8(3), 182-90
EDWARDS LJ and CONSTANTINESCU CS, 2009. Parasite Immunomodulation In Autoimmune Disease: Focus On Multiple Sclerosis. Expert Review Of Clinical Immunology. 5(5), 487-9 ZELLINI F, NIEPEL G, TENCH CR and CONSTANTINESCU CS, 2009. Hypothalamic Involvement Assessed By T1 Relaxation Time In Patients With Relapsing-Remitting Multiple Sclerosis. Multiple Sclerosis (Houndmills, Basingstoke, England). 15(12), 1442-9 BRAITCH, MANJIT, NUNAN, ROBERT, NIEPEL, GRAHAM, EDWARDS, LAURA J and CONSTANTINESCU, CRIS S, 2008. Increased osteopontin levels in the cerebrospinal fluid of patients with multiple sclerosis. Archives of neurology. 65(5), 633-5
SEGAL BM, CONSTANTINESCU CS, RAYCHAUDHURI A, KIM L, FIDELUS-GORT R, KASPER LH and USTEKINUMAB MS INVESTIGATORS, 2008. Repeated Subcutaneous Injections Of Il12/23 P40 Neutralising Antibody, Ustekinumab, In Patients With Relapsing-Remitting Multiple Sclerosis: A Phase Ii, Double-Blind, Placebo-Controlled, Randomised, Dose-Ranging Study. Lancet Neurology. 7(9), 796-804 FAHEY, A.J, ROBINS, R.A. and CONSTANTINESCU, C.S., 2007. Curcumin modulation of IFN-beta and IL-12 signalling and cytokine induction in human T cell Journal of Cellular and Molecular Medicine. 11(5), 1129-1137 FAHEY, A.J., ROBINS, R.A. and CONSTANTINESCU, C.S., 2007. Reciprocal effects of IFN-β and IL-12 on STAT4 activation and cytokine induction in T cells. Journal of Leukocyte Biology. 81(6), 1562-1567 PHILLIPS,, BHOPALE,, CONSTANTINESCU,, CIRIC,, HILLIARD,, VENTURA,, LAVI, and ROSTAMI,, 2007. Effect of DAB(389)IL-2 immunotoxin on the course of experimental autoimmune encephalomyelitis in Lewis rats. Journal of the Neurological Sciences. RAMAN,, LIN,, SURI,, HEWITT,, CONSTANTINESCU, and PHILLIPS,, 2007. A presenilin 1 mutation (Arg278Ser) associated with early onset Alzheimer's disease and spastic paraparesis. Journal of the Neurological Sciences. 260(1-2), 78-82 FAHEY, A.J., ROBINS, R.A., KINDLE, K.B., HEERY, D.M. and CONSTANTINESCU, C.S., 2006. Effects of glucocorticoids on STAT4 activation in human T cells are stimulus-dependent Journal of Leukocyte Biology. 80(1), 133-144 NIEPEL, G, TENCH,CR, MORGAN, PS, EVANGELOU, N, AUER, D and CONSTANTINESCU, CS, 2006. Deep gray matter and fatigue in MS : A T1 relaxation time study. Journal of Neurology. 253(7), 896-902 CONSTANTINESCU, C.S., TANI, M., RANSOHOFF, R.M., WYSOCKA, M., HILLIARD, B., FUJIOKA, T., MURPHY, S., TIGHE, P.J., SARMA, J.D., TRINCHIERI, G. and ROSTAMI, A., 2005. Astrocytes as antigen-presenting cells: expression of IL-12/IL-23 Journal of Neurochemistry. 95(2), 331-340 LIN, X., TENCH, C. R., MORGAN, P. S., NIEPEL, G. and CONSTANTINESCU, C. S., 2005. Importance sampling in MS Use of diffusion tensor tractography to quantify pathology related to specific impairment Journal of the Neurological Sciences. 237(1-2), 13-19 TENCH, C. R., MORGAN, P. S. and CONSTANTINESCU, C. S., 2005. Measurement of Cervical Spinal Cord Cross-Sectional Area by MRI Using Edge Detection and Partial Volume Correction Journal of Magnetic Resonance Imaging. 21(3), 197-203 TENCH, C. R., MORGAN, P. S., JASPAN, T., AUER, D. P. and CONSTANTINESCU, C. S., 2005. Spinal Cord Imaging in Multiple Sclerosis Journal of Neuroimaging. VOL 15(NUMB 4), 94S-102S LIN, X, TENCH, C R, TURNER, B, BLUMHARDT, L D and CONSTANTINESCU, C S, 2003. Spinal cord atrophy and disability in multiple sclerosis over four years: application of a reproducible automated technique in monitoring disease progression in a cohort of the interferon beta-1a (Rebif) treatment trial. Journal of Neurology, Neurosurgery and Psychiatry. 74(8), 1090-4 TENCH, C. R., MORGAN, P. S., BLUMHARDT, L. D. and CONSTANTINESCU, C., 2002. Improved White Matter Fiber Tracking Using Stochastic Labeling Magnetic Resonance in Medicine. VOL 48(PART 4), 677-683 CALIDA, D.M., CONSTANTINESCU, C., PUREV, E., ZHANG, G.X., VENTURA, E.S., LAVI, E. and ROSTAMI, A., 2001. Cutting edge: C3, a key component of complement activation, is not required for the development of myelin oligodendrocyte glycoprotein peptide-induced experimental autoimmune encephalomyelitis in mice The Journal of Immunology. 166(2), 723-726 CONSTANTINESCU, C. S., HONDOWICZ, B. D., ELLOSO, M. M., WYSOCKA, M., TRINCHIERI, G. and SCOTT, P., 1998. The role of IL-12 in the maintenance of an established Th1 immune response in experimental leishmaniasis European Journal of Immunology. VOL 28(NUMBER 7), 2227-2233 CONSTANTINESCU, C S, WYSOCKA, M, HILLIARD, B, VENTURA, E S, LAVI, E, TRINCHIERI, G and ROSTAMI, A, 1998. Antibodies against IL-12 prevent superantigen-induced and spontaneous relapses of experimental autoimmune encephalomyelitis. The Journal of Immunology. 161(9), 5097-104
CONSTANTINESCU, C S, GOODMAN, D B, GROSSMAN, R I, MANNON, L J and COHEN, J A, 1997. Serum angiotensin-converting enzyme in multiple sclerosis. Archives of Neurology. 54(8), 1012-5
FREI, K, EUGSTER, H P, BOPST, M, CONSTANTINESCU, C S, LAVI, E and FONTANA, A, 1997. Tumor necrosis factor alpha and lymphotoxin alpha are not required for induction of acute experimental autoimmune encephalomyelitis. Journal of Experimental Medicine. 185(12), 2177-82