Jane May

Contact

• workRoom S/D2101 Cardiovascular Medicine, D Floor South Block, Queen's Medical Centre, Nottingham, NG7 2UH
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 823 1012
• fax0115 823 1017
• jane.may@nottingham.ac.uk

Expertise Summary

I am the Head Technician in the Thrombosis and Haemostasis Research Group at the University of Nottingham and provide the technical expertise for much of the research that is performed. I have developed a particular expertise in studies of platelet function and also in setting up and contributing to the technical aspects of clinical trials, for example those in which the effects of antiplatelet agents or dietary manipulations have an effect on platelet function.

I am the designated safety officer in the Division of Cardiovascular Medicine, of which the Thrombosis and Haemostasis Research Group forms a part.

Research Summary

I was a co-applicant (with Stan Heptinstall and Sue Fox) of a successful bid for a DPFS grant from the MRC to engage in development of a simple-to-use technology to assess platelet function.… read more

Recent Publications

• FOX, S C, MAY, J A, SHAH, A, NEUBERT, U and HEPTINSTALL, S, 2009. Measurement of platelet P-selectin for remote testing of platelet function during treatment with clopidogrel and/or aspirin. Platelets. 20(4), 250-9
• HEPTINSTALL, STAN, ESPINOSA, DAVID IYU, MANOLOPOULOS, PANAGIOTIS, GLENN, JACKIE R, WHITE, ANN E, JOHNSON, ANDREW, DOVLATOVA, NATALIA, FOX, SUE C, MAY, JANE A, HERMANN, DAVID, MAGNUSSON, OLAFUR and STEFAN, 2008. DG-041 inhibits the EP3 prostanoid receptor--a new target for inhibition of platelet function in atherothrombotic disease. Platelets. 19(8), 605-13
• MAY, JANE A, FOX, SUE, GLENN, JACKIE, CRAXFORD, SIMON and HEPTINSTALL, STAN, 2008. Platelet function reduces significantly during the morning. Platelets. 19(7), 556-8
• WHITE, A., GLENN, J., FOX, S., JOHNSON, A., MYERS, B. and AND HEPTINSTALL, S., 2007. Reduced platelet aggregation to ADP and ATP in patients with leucocytosis is due to enhanced rates of adenine nucleotide metabolism mediated by the NTPDase CD39 Platelets. 18(1), 100

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Current Research

I was a co-applicant (with Stan Heptinstall and Sue Fox) of a successful bid for a DPFS grant from the MRC to engage in development of a simple-to-use technology to assess platelet function. Development of kits to enable this now takes up a considerable amount of my time. The other collaborative projects to which I contribute include a study of platelet function in patients with cancer, and a study of platelet function in patients with inflammatory bowel disease. I also contribute to assessment of new antiplatelet drugs, most recently the EP3 receptor antagonist DG-041.

• FOX, S C, MAY, J A, SHAH, A, NEUBERT, U and HEPTINSTALL, S, 2009. Measurement of platelet P-selectin for remote testing of platelet function during treatment with clopidogrel and/or aspirin. Platelets. 20(4), 250-9
• HEPTINSTALL, STAN, ESPINOSA, DAVID IYU, MANOLOPOULOS, PANAGIOTIS, GLENN, JACKIE R, WHITE, ANN E, JOHNSON, ANDREW, DOVLATOVA, NATALIA, FOX, SUE C, MAY, JANE A, HERMANN, DAVID, MAGNUSSON, OLAFUR and STEFAN, 2008. DG-041 inhibits the EP3 prostanoid receptor--a new target for inhibition of platelet function in atherothrombotic disease. Platelets. 19(8), 605-13
• MAY, JANE A, FOX, SUE, GLENN, JACKIE, CRAXFORD, SIMON and HEPTINSTALL, STAN, 2008. Platelet function reduces significantly during the morning. Platelets. 19(7), 556-8
• WHITE, A., GLENN, J., FOX, S., JOHNSON, A., MYERS, B. and AND HEPTINSTALL, S., 2007. Reduced platelet aggregation to ADP and ATP in patients with leucocytosis is due to enhanced rates of adenine nucleotide metabolism mediated by the NTPDase CD39 Platelets. 18(1), 100
• FOX, S.C, MAY, J.A and AND HEPTINSTALL, S., 2007. Measurement of endothelial microparticles in blood is impaired if chylomicrons are present after a fatty meal. Journal of Thrombosis and Haemostasis: JTH. 5(Supplement 2), P-S-526
• MAY, J.A, FOX, S.C, HEPTINSTALL, S and AND KWIK-URIBE, C., 2007. Effects of a flavanol-rich cocoa beverage on platelet and leucocyte function in man. Journal of Thrombosis and Haemostasis: JTH. 5(Supplement 2), P-T-685
• WIRE, R, MAY, J.A, HEPTINSTALL, S, CHEN, D, LU,Y and AND ZHAO, L., 2007. Heteroclitin D, A component of plants of the Kadsura species inhibits paf-induced platelet aggregation, P-selectin expression and platelet-leucocyte conjugate formation. Journal of Thrombosis and Haemostasis: JTH. 5(Supplement 2), P-S-344
• FOX, S., MAY, J. and AND HEPTINSTALL, S., 2007. Quantitation of endothelial microparticles in plasma samples is impaired by chylomicrons following ingestion of a fatty meal Platelets. 18(1), 85-86
• HEPTINSTALL, STAN, MAY, JANE, FOX, SUE, KWIK-URIBE, CATHERINE and ZHAO, LIAN, 2006. Cocoa flavanols and platelet and leukocyte function: recent in vitro and ex vivo studies in healthy adults. Journal of cardiovascular pharmacology. 47 Suppl 2, S197-205; discussion S206-9
• HEPTINSTALL, S., MANOLOPOULOS, M., GLENN, J.R., FOX, S.C., MAY, J.A., DOVLATOVA, N., TANG, S-W., BAUER, N., HESSE, M., THOMAS, N.R. and RALEVIC, V., 2006. Acyl derivatives of coenzyme A inhibit ADP-induced platelet function via antagonism at P2Y1 and P2Y12 receptors. Purinergic Signalling. 2, 92-93
• HEPTINSTALL,S., TANG,S., MANOLOPOULOS,P., FOX,S., MAY,J., GLENN,J. and RALEVIC,V., 2005. Derivatives of coenzymes A inhibit platelet aggregation via efects at P2Y1 and P2Y12 receptors. In: 20th Congress of the International Society on Thrombosis & Haemostasis. OR334
• MAY, J., ZHAO, L. and HEPTINSTALL, S., 2005. Dietary flavanols - Effects on platelets and leukocytes. In: International Society of Thrombosis & Haemostasis. PO953
• FOX, S.C., MANOLOPOULOS, P., MAY, J.A. and HEPTINSTALL, S., 2005. Platelet aggregation, microparticle formation and platelet-leukocyte conjugate formation induced by combinations of 5-HT and epinephrine are inhibited by Sarpogrelate and BP-984 In: International Society Thrombosis & Haemostasis, Sydney, Australia. PO2149
• STOREY, R. F., MAY, J. A. and HEPTINSTALL, S., 2005. Potentiation of platelet aggregation by heparin in human whole blood is attenuated by P2Y12 and P2Y1 antagonists but not aspirin Thrombosis Research. VOL 115(NUMBER 4), 301-307
• MAY, J.A. and HEPTINSTALL, S., 2004. Effects of anticoagulants used during blood collection on human platelet function.. In: Platelets and Megakaryocytes Vol 1: Functional Assays