Krish Ragunath

Contact

• workQMC
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 924 9924
• fax0115 942 2232
• k.ragunath@nottingham.ac.uk

Research Summary

Interests

• Mucosal Imaging; Optical Techniques; EUS; GI Cancers; Endoscopic mucosal resection
• Barrett's oesophagus
• Endoscpy Training and Teaching
• Mucosal and submucosal imaging of the gut using zoom endoscopy, EUS and other novel optical techniques to detect early GI cancer and endoscopic therapy for early GI cancer including endoscopic mucosal resection, laser, photodynamic therapy and radiofrequency ablation.

Techniques

• Chromoendoscopy, zoom endoscopy, Autofluorescence Imaging, Narrow Band Imaging.
• Mucosal ablation using Argon Plasma Coagulation,PDT, Radiofrequency ablation.
• Endoscopic mucosal resection
• EUS

Current Research Projects

• Narrow Band Imaging (NBI) and Autofluoresence Imaging (AFI) endoscopy
• Radiofrequency ablation in Barretts
• Endo thearpy for Barretts early neoplasia

Selected Publications

• ANAGNOSTOPOULOS, G.K., YAO, K., KAYE, P., HAWKEY, C.J. and RAGUNATH, K, 2007. Novel endoscopic observation in Barrett's oesophagus using high resolution magnification endoscopy and narrow band imaging. Alimentary Pharmacology and Therapeutics. 26(3), 501-507
• ANAGNOSTOPOULOS, G.K., YAO, K., KAYE, P., FOGDEN, E., FORTUN, P., SHONDE, A., FOLEY, S., SUNIL, S., ATHERTON, J.J., HAWKEY, C. and RAGUNATH, K., 2007. High-resolution magnification endoscopy can reliably identify normal gastric mucosa, <i>Helicobacter pylori</i>-associated gastritis, and gastric atrophy Endoscopy. 39(3), 202-207
• FORTUN, P.J., ANAGNOSTOPOULOS, G.K., KAYE, P., JAMES, M., FOLEY, S., SHONDE, S.A., BADRELDIN, R., CAMPBELL, E., HAWKEY, C.J. and RAGUNATH, K., 2006. Acetic acid-enhanced magnification endoscopy in the diagnosis of specialized intestinal metaplasia, dysplasia and early cancer in Barrett's oesophagus Alimentary Pharmacology and Therapeutics. 23(6), 735-742
• RAGUNATH, K., KRASNER, N., RAMAN, V.S., HAQQANI, M.T, PHILLIPS, C.J. and CHEUNG, I., 2005. Endoscopic ablation of dysplastic Barrett's oesophagus comparing argon plasma coagulation and photodynamic therapy: a randomized prospective trial assessing efficacy and cost-effectiveness. Scandinavian Journal of Gastroenterology. 40(7), 750-758

• View all publications

• SUBRAMANIAN V, MANNATH J, TELAKIS E, RAGUNATH K and HAWKEY CJ, 2012. Efficacy Of New Playback Functions At Reducing Small-Bowel Wireless Capsule Endoscopy Reading Times. Digestive Diseases And Sciences. (In Press.)
• SUBRAMANIAN V, MANNATH J, RAGUNATH K and HAWKEY CJ, 2011. Meta-analysis: The diagnostic yield of chromoendoscopy for detecting dysplasia in patients with colonic inflammatory bowel disease Aliment Pharmacol & Ther. 33(3), 304-312
• SUBRAMANIAN V, MANNATH J, HAWKEY CJ and RAGUNATH K, 2011. High definition colonoscopy vs standard video endoscopy for the detection of colonic polyps: a meta-analysis Endoscopy. 43(6), 499-505
• GREEN S, BHANDARI P, DECAESTECKER J, BARR H, RAGUNATH K, JANKOWSKI J, SINGH R, LONGCROFT-WHEATON G and BENNETT C, 2011. Endoscopic Therapies For The Prevention And Treatment Of Early Esophageal Neoplasia. Expert Review Of Gastroenterology & Hepatology. 5(6), 731-43
• MANNATH J and RAGUNATH K, 2011. Endoscopy: High-Definition Imaging And Nbi-Improving Colonic Imaging? Nature Reviews. Gastroenterology & Hepatology. 8(11), 604-5
• MANNATH J and RAGUNATH K, 2011. Endoscopic Mucosal Resection: Who And How? Therapeutic Advances In Gastroenterology. 4(5), 275-82
• THOMAS T, ABRAMS KR, SUBRAMANIAN V, MANNATH J and RAGUNATH K, 2011. Esophageal Stents For Benign Refractory Strictures: A Meta-Analysis. Endoscopy. 43(5), 386-93
• MANNATH J, SUBRAMANIAN V, SINGH R, TELAKIS E and RAGUNATH K, 2011. Polyp Recurrence After Endoscopic Mucosal Resection Of Sessile And Flat Colonic Adenomas. Digestive Diseases And Sciences. 56(8), 2389-95
• IGNJATOVIC A, EAST JE, GUENTHER T, HOARE J, MORRIS J, RAGUNATH K, SHONDE A, SIMMONS J, SUZUKI N, THOMAS-GIBSON S and SAUNDERS BP, 2011. What Is The Most Reliable Imaging Modality For Small Colonic Polyp Characterization? Study Of White-Light, Autofluorescence, And Narrow-Band Imaging. Endoscopy. 43(2), 94-9
• KAYE PV, HAIDER SA, JAMES PD, SOOMRO I, CATTON J, PARSONS SL, RAGUNATH K and ILYAS M, 2010. Novel Staining Pattern Of P53 In Barrett's Dysplasia--The Absent Pattern. Histopathology. 57(6), 933-5
• THOMAS T, GILBERT D, KAYE PV, PENMAN I, AITHAL GP and RAGUNATH K, 2010. High-Resolution Endoscopy And Endoscopic Ultrasound For Evaluation Of Early Neoplasia In Barrett's Esophagus. Surgical Endoscopy. 24(5), 1110-6
• MANNATH J and RAGUNATH K, 2010. Reflux And Barrett's Disease. Endoscopy. 42(1), 34-7
• MANNATH J, SUBRAMANIAN V, KAYE PV and RAGUNATH K, 2010. Life-Threatening Bleeding Following Barrett's Surveillance Biopsies. Endoscopy. 42 Suppl 2, E211-2
• MANNATH J and RAGUNATH K, 2010. Era Of Barrett's Surveillance: Does Equipment Matter? World Journal Of Gastroenterology : Wjg. 16(37), 4640-5
• CURVERS WL, HERRERO LA, WALLACE MB, WONG KEE SONG L, RAGUNATH K, WOLFSEN HC, PRASAD GA, WANG KK, SUBRAMANIAN V, WEUSTEN BLAM, TEN KATE FJ and BERGMAN JJGHM, 2010. Endoscopic Tri-Modal Imaging Is More Effective Than Standard Endoscopy In Identifying Early-Stage Neoplasia In Barrett's Esophagus. Gastroenterology. 139(4), 1106-14
• FITZGERALD RC, HARDWICK R, HUNTSMAN D, CARNEIRO F, GUILFORD P, BLAIR V, CHUNG DC, NORTON J, RAGUNATH K, VAN KRIEKEN JH, DWERRYHOUSE S, CALDAS C and INTERNATIONAL GASTRIC CANCER LINKAGE CONSORTIUM, 2010. Hereditary Diffuse Gastric Cancer: Updated Consensus Guidelines For Clinical Management And Directions For Future Research. Journal Of Medical Genetics. 47(7), 436-44
• BENNETT C, GREEN S, BARR H, BHANDARI P, DECAESTECKER J, RAGUNATH K, SINGH R, TAWIL A and JANKOWSKI J, 2010. Surgery Versus Radical Endotherapies For Early Cancer And High Grade Dysplasia In Barrett's Oesophagus. Cochrane Database Of Systematic Reviews (Online). CD007334
• THOMAS T, BEBB J, MANNATH J, RAGUNATH K, KAYE PV and AITHAL GP, 2010. Eus-Guided Pancreatic Cyst Brushing: A Comparative Study In A Tertiary Referral Centre. Jop : Journal Of The Pancreas. 11(2), 163-9
• MANNATH J, SUBRAMANIAN V, HAWKEY CJ and RAGUNATH K, 2010. Narrow Band Imaging For Characterization Of High Grade Dysplasia And Specialized Intestinal Metaplasia In Barrett's Esophagus: A Meta-Analysis. Endoscopy. 42(5), 351-9
• MANNATH J and RAGUNATH K, 2010. Narrow Band Imaging And High Resolution Endoscopy With Magnification Could Be Useful In Identifying Gastric Atrophy. Digestive Diseases And Sciences. 55(6), 1799-800
• KAYE PV, HAIDER SA, ILYAS M, JAMES PD, SOOMRO I, FAISAL W, CATTON J, PARSONS SL and RAGUNATH K, 2009. Barrett's Dysplasia And The Vienna Classification: Reproducibility, Prediction Of Progression And Impact Of Consensus Reporting And P53 Immunohistochemistry. Histopathology. 54(6), 699-712
• SINGH R, KARAGEORGIOU H, OWEN V, GARSED K, FORTUN P, FOGDEN E, SUBRAMANIAN V, SHONDE A, KAYE PV, HAWKEY CJ and RAGUNATH K, 2009. Comparison of high-resolution magnification narrow-band imaging and white-light endoscopy in the prediction of histology in Barrett's oesophagus. Scandinavian J Gastroenterol. 44(1), 85-92
• SUBRAMANIAN V and RAGUNATH K, 2009. Gastrointestinal Bleeding: Trends In Gastrointestinal Bleeding: Top Down And Bottom Up! Nature Reviews. Gastroenterology & Hepatology. 6(11), 632-3
• SINGH R, OWEN V, SHONDE A, KAYE P, HAWKEY C and RAGUNATH K, 2009. White Light Endoscopy, Narrow Band Imaging And Chromoendoscopy With Magnification In Diagnosing Colorectal Neoplasia. World Journal Of Gastrointestinal Endoscopy. 1(1), 45-50
• YAO K, ANAGNOSTOPOULOS GK and RAGUNATH K, 2009. Magnifying Endoscopy For Diagnosing And Delineating Early Gastric Cancer. Endoscopy. 41(5), 462-7
• CURVERS WL, SINGH R, WALLACE MB, SONG LWK, RAGUNATH K, WOLFSEN HC, TEN KATE FJ, FOCKENS P and BERGMAN JJGHM, 2009. Identification Of Predictive Factors For Early Neoplasia In Barrett's Esophagus After Autofluorescence Imaging: A Stepwise Multicenter Structured Assessment. Gastrointestinal Endoscopy. 70(1), 9-17
• GREEN S, TAWIL A, BARR H, BENNETT C, BHANDARI P, DECAESTECKER J, RAGUNATH K, SINGH R and JANKOWSKI J, 2009. Surgery Versus Radical Endotherapies For Early Cancer And High Grade Dysplasia In Barrett's Oesophagus. Cochrane Database Of Systematic Reviews (Online). CD007334
• THOMAS T, KAYE PV, RAGUNATH K and AITHAL GP, 2009. Endoscopic-Ultrasound-Guided Mural Trucut Biopsy In The Investigation Of Unexplained Thickening Of Esophagogastric Wall. Endoscopy. 41(4), 335-9
• THOMAS T, SINGH R and RAGUNATH K, 2009. Trimodal Imaging-Assisted Endoscopic Mucosal Resection Of Early Barrett's Neoplasia. Surgical Endoscopy. 23(7), 1609-13
• THOMAS T, KAYE PV, RAGUNATH K and AITHAL G, 2009. Efficacy, Safety, And Predictive Factors For A Positive Yield Of Eus-Guided Trucut Biopsy: A Large Tertiary Referral Center Experience. The American Journal Of Gastroenterology. 104(3), 584-91
• MANNATH J and RAGUNATH K, 2009. Management Of Barrett's Oesophagus. F1000 Medicine Reports. 1,
• KAYE, P.V., GARSED, K., RAGUNATH, K., JAWHARI, A., PICK, B. and ATHERTON, J.C., 2008. The Clinical Utility and Diagnostic Yield of Routine Gastric Biopsies in the Investigation of Iron Deficiency Anemia: A Case-Control Study American Journal of Gastroenterology. 103(11), 2883-2889
• KAYE, P., ABDULLA, K., WOOD, J., JAMES, P., FOLEY, S., RAGUNATH, K. and ATHERTON, J., 2008. Iron-induced mucosal pathology of the upper gastrointestinal tract: a common finding in patients on oral iron therapy Histopathology. 53(3), 311-317
• SINGH R, ANAGNOSTOPOULOS GK, YAO K, KARAGEORGIOU H, FORTUN P, SHONDE A, GARSED K, KAYE PV, HAWKEY CJ and RAGUNATH K, 2008. Narrow-band imaging with magnification in Barrett's esophagus: validation of a simplified grading system of mucosal morphology patterns against histology Endoscopy. 40(6), 457-63
• CURVERS W, BAAK L, KIESSLICH R, VAN OIJEN A, RABENSTEIN T, RAGUNATH K, REY J, SCHOLTEN P, SEITZ U, TEN KATE F, FOCKENS P and BERGMAN J, 2008. Chromoendoscopy And Narrow-Band Imaging Compared With High-Resolution Magnification Endoscopy In Barrett's Esophagus. Gastroenterology. 134(3), 670-9
• CURVERS WL, SINGH R, SONG LW, WOLFSEN HC, RAGUNATH K, WANG K, WALLACE MB, FOCKENS P and BERGMAN JJGHM, 2008. Endoscopic Tri-Modal Imaging For Detection Of Early Neoplasia In Barrett's Oesophagus: A Multi-Centre Feasibility Study Using High-Resolution Endoscopy, Autofluorescence Imaging And Narrow Band Imaging Incorporated In One Endoscopy System. Gut. 57(2), 167-72
• SINGH R, KAYE PV and RAGUNATH K, 2008. Distinction Between Neoplastic And Non-Neoplastic Colorectal Polyps Utilizing Narrow Band Imaging With Magnification: A Novel Technique To Increase The Efficacy Of Colorectal Cancer Screening? Scandinavian Journal Of Gastroenterology. 43(3), 380-1
• SINGH R, YAO K, ANAGNOSTOPOULOS G, KAYE P and RAGUNATH K, 2008. Microcarcinoid Tumor Diagnosed With High-Resolution Magnification Endoscopy And Narrow Band Imaging. Endoscopy. 40 Suppl 2, E12
• YAO K, ANAGNOSTOPOULOS GK, JAWHARI AU, KAYE PV, HAWKEY CJ and RAGUNATH K, 2008. Optical Microangiography: High-Definition Magnification Colonoscopy With Narrow Band Imaging (Nbi) For Visualizing Mucosal Capillaries And Red Blood Cells In The Large Intestine. Gut And Liver. 2(1), 14-8
• YAO K, TAKAKI Y, MATSUI T, IWASHITA A, ANAGNOSTOPOULOS GK, KAYE P and RAGUNATH K, 2008. Clinical Application Of Magnification Endoscopy And Narrow-Band Imaging In The Upper Gastrointestinal Tract: New Imaging Techniques For Detecting And Characterizing Gastrointestinal Neoplasia. Gastrointestinal Endoscopy Clinics Of North America. 18(3), 415-33, vii-viii
• RAGUNATH K, 2008. Refractory Benign Esophageal Strictures: Extending The Role Of Expandable Stents. The American Journal Of Gastroenterology. 103(12), 2995-6
• CURVERS WL, BOHMER CJ, MALLANT-HENT RC, NABER AH, PONSIOEN CI, RAGUNATH K, SINGH R, WALLACE MB, WOLFSEN HC, SONG LWK, LINDEBOOM R, FOCKENS P and BERGMAN JJ, 2008. Mucosal Morphology In Barrett's Esophagus: Interobserver Agreement And Role Of Narrow Band Imaging. Endoscopy. 40(10), 799-805
• ANAGNOSTOPOULOS, G.K., YAO, K., KAYE, P., HAWKEY, C.J. and RAGUNATH, K, 2007. Novel endoscopic observation in Barrett's oesophagus using high resolution magnification endoscopy and narrow band imaging. Alimentary Pharmacology and Therapeutics. 26(3), 501-507
• ANAGNOSTOPOULOS, G.K., YAO, K., KAYE, P., FOGDEN, E., FORTUN, P., SHONDE, A., FOLEY, S., SUNIL, S., ATHERTON, J.J., HAWKEY, C. and RAGUNATH, K., 2007. High-resolution magnification endoscopy can reliably identify normal gastric mucosa, <i>Helicobacter pylori</i>-associated gastritis, and gastric atrophy Endoscopy. 39(3), 202-207
• AITHAL, G P, ANAGNOSTOPOULOS, G K, TAM, W, DEAN, J, ZAITOUN, A, KOCJAN, G, RAGUNATH, K and PEREIRA, S P, 2007. EUS-guided tissue sampling: comparison of "dual sampling" (Trucut biopsy plus FNA) with "sequential sampling" (Trucut biopsy and then FNA as required). Endoscopy. 39(8), 725-30
• KAYE, P V, MAJUMDAR, D, RAGUNATH, K and AITHAL, G, 2007. Lesson of the month. Beware the eosinophils. Histopathology. 50(7), 936-8
• FORTUN, P.J., ANAGNOSTOPOULOS, G.K., KAYE, P., JAMES, M., FOLEY, S., SHONDE, S.A., BADRELDIN, R., CAMPBELL, E., HAWKEY, C.J. and RAGUNATH, K., 2006. Acetic acid-enhanced magnification endoscopy in the diagnosis of specialized intestinal metaplasia, dysplasia and early cancer in Barrett's oesophagus Alimentary Pharmacology and Therapeutics. 23(6), 735-742
• ANAGNOSTOPOULOS, G.-K., RAGUNATH, K., SHONDE, A., HAWKEY, C.J. and YAO, K., 2006. Diagnosis of autoimmune gastritis by high resolution magnification endoscopy World journal of gastroenterology : WJG. 12(28), 4586-7
• ANAGNOSTOPOULOS, G.K., PICK, B., CUNLIFFE, R., FORTUN, P., KAYE, P. and RAGUNATH, K., 2006. Barrett's esophagus specialist clinic: what difference can it make? Diseases of the Esophagus. 19(2), 84-87
• RAGUNATH, K, ANAGNOSTOPOULOS, G K and DUNN, K, 2006. Education and imaging. Hepatobiliary and pancreatic: Choledochopancreatic fistula complicating acute pancreatitis. Journal of Gastroenterology and Hepatology. 21(11), 1753
• ANAGNOSTOPOULOS, GEORGE K, AITHAL, GURUPRASAD P, RAGUNATH, KRISH, KAYE, PHILIP and ROWLANDS, BRIAN J, 2006. Squamous cell carcinoma of the pancreas: report of a case and review of the literature. JOP [electronic resource] : Journal of the pancreas.. 7(1), 47-50
• YAO, KENSHI, TAKAKI, YASUHIRO, OHARA, JIRO, KIKUCHI, YOSUKE, MATSUI, TOSHIYUKI, YAO, TSUNEYOSHI, IWASHITA, AKINORI and RAGUNATH, KRISH, 2006. Magnification endoscopy outlines the microvascular architecture and extent of Barrett's intramucosal carcinoma prior to endoscopic resection. Gastrointestinal endoscopy. 63(7), 1064-5; discussion 1065
• ANAGNOSTOPOULOS, G K, SHONDE, T, KAYE, P and RAGUNATH, K, 2006. A case of a "fragile" oesophagus. Gut. 55(10), 1495
• RAGUNATH, K. and ANAGNOSTOPOULOS, G., 2006. Taking a Closer Look at Gastritis. Endoscopy. 38, 200-200
• ANAGNOSTOPOULOS, G.K., FORTUN, P., RAGUNATH, K. and HAWKEY, C.J., 2005. Images of interest: gastrointestinal: early endoscopic findings in watermelon stomach identified by the magnifying endoscopy-adaptive IHb color enhancement technique Journal of Gastroenterology and Hepatology. 20(7), 1122
• RAGUNATH, K., KRASNER, N., RAMAN, V.S., HAQQANI, M.T, PHILLIPS, C.J. and CHEUNG, I., 2005. Endoscopic ablation of dysplastic Barrett's oesophagus comparing argon plasma coagulation and photodynamic therapy: a randomized prospective trial assessing efficacy and cost-effectiveness. Scandinavian Journal of Gastroenterology. 40(7), 750-758
• ANAGNOSTOPOULOS, G. K., RAGUNATH, K., FORTUN, P. J. and YAO, K., 2005. Identifying Helicobacter pylori-associated gastritis, gastric atrophy and intestinal metaplasia with magnification endoscopy and adaptive index of haemoglobin enhancement technique Digestive and Liver Disease. VOL 37(NUMBER 12), 980-981
• ANAGNOSTOPOULOS, GEORGE, FOLEY, STEVE and RAGUNATH, KRIS, 2005. Dieulafoy lesion in the duodenum. The New Zealand medical journal.. 118(1225), U1730
• RAGUNATH, K., KRASNER, N., RAMAN, V.S., HAQQANI, M.T. and CHEUNG, W.Y., 2003. A randomized, prospective cross-over trial comparing methylene blue-directed biopsy and conventional random biopsy for detecting intestinal metaplasia and dysplasia in Barrett's esophagus Endoscopy. 35(12), 998-1003
• WILLIAMS, G. L., RAGUNATH, K., DAVIES, M., HARVEY, J. S. and THOMAS, G. A. O., 2003. Distal Migration of a Self-Expandable Metal Oesophageal Stent, Presenting As Constipation Endoscopy. VOL 35(PART 10), 884
• RAGUNATH, K, THOMAS, L A, CHEUNG, W Y, DUANE, P D and RICHARDS, D G, 2003. Objective evaluation of ERCP procedures: a simple grading scale for evaluating technical difficulty. Postgraduate Medical Journal. 79(934), 467-70
• RAGUNATH, K. and WILLIAMS, J. G., 2002. A review of oesophageal manometry testing in a district general hospital Postgraduate Medical Journal. VOL 78(JAN), 34-36
• RAGUNATH, K. and KRASNER, N., 2001. Methylene blue staining in Barrett's esophagus Gastrointestinal Endoscopy. VOL 54(PART 5), 673-674
• RAGUNATH, K and WILLIAMS, J G, 2001. Review article: balsalazide therapy in ulcerative colitis. Alimentary Pharmacology and Therapeutics. 15(10), 1549-54
• GREEN, J T, RHODES, J, RAGUNATH, K, THOMAS, G A, WILLIAMS, G T, MANI, V, FEYERABEND, C and RUSSELL, M A, 1998. Clinical status of ulcerative colitis in patients who smoke. American Journal of Gastroenterology. 93(9), 1463-7
• THOMAS, G. A. O., RHODES, J., RAGUNATH, K., MANI, V., WILLIAMS, G. T., NEWCOMBE, R. G., RUSSELL, M. A. H. and FEYERABEND, C., 1996. Transdermal nicotine compared with oral prednisolone therapy for active ulcerative colitis European Journal of Gastroenterology and Hepatology. VOL 8(NUMBER 8), 769-776
• RAGUNATH, KRISH, ROBERTS, ASHLEY, SENAPATI, SIBA and CLARK, GEOFF, Retrograde jejunoduodenal intussusception caused by a migrated percutaneous endoscopic gastrostomy tube. Digestive diseases and sciences. 49(11-12), 1815-7