Sarah Rayment

Contact

• workRoom W/E/1331 E Floor, West Block, QMC
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 82 31142
• fax0115 82 31160
• sarah.rayment@nottingham.ac.uk

Research Summary

Faecal incontinence is a common condition that is particularly prevalent in the elderly population. Our research currently focuses on understanding the underlying mechanisms involved in continence as… read more

Recent Publications

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Current Research

Faecal incontinence is a common condition that is particularly prevalent in the elderly population. Our research currently focuses on understanding the underlying mechanisms involved in continence as well as identifying and developing novel pharmacological treatments for the condition. We also aim to develop more relevant physiological models for our in vitro studies.

Techniques include isometric tension recording, immunohistochemistry, western blotting, radio-ligand binding and autoradiography.

• RAYMENT SJ, EAMES T, SIMPSON JA, DASHWOOD MR, HENRY Y, GRUSS H, ACHESON AG, SCHOLEFIELD JH, WILSON VG, 2010. Investigation of the distribution and function of alpha adrenoceptors in the sheep isolated internal anal sphincter British Journal of Pharmacology. 160(7), 1727-40
• SURI S, LIU XH, RAYMENT S, HUGHES DA, KROON PA, NEEDS PW, TAYLOR MA, TRIBOLO S and WILSON VG, 2010. Quercetin And Its Major Metabolites Selectively Modulate Cyclic Gmp-Dependent Relaxations And Associated Tolerance In Pig Isolated Coronary Artery. British Journal Of Pharmacology. 159(3), 566-75
• ACHESON A, RAYMENT S, EAMES T, MUNDEY M, NISAR P, SCHOLEFIELD J and WILSON VG, 2009. Investigation of the role of adrenergic and non-nitrergic, non-adrenergic neurotransmission in the sheep isolated internal anal sphincter. Neurogastroenterology and Motility. 21(3), 335-345
• RAYMENT, S.J., RALEVIC, V., BARRETT, D.A., CORDELL, R. and ALEXANDER, S.P.H, 2007. A novel mechanism of vasoregulation: ADP-induced relaxation of the porcine isolated coronary artery is mediated via adenosine release. The FASEB Journal. 21(2), 577-85
• RAYMENT, S.J., LATIF, M.L., RALEVIC, V. and ALEXANDER, S.P.H, 2007. Evidence for the expression of multiple uracil nucleotide-stimulated P2 receptors coupled to smooth muscle contraction in porcine isolated arteries. British Journal of Pharmacology. 150(5), 604-612
• WOOLLARD KJ, RAYMENT SJ, BEVAN R, SHAW JA, LUNEC J and GRIFFITHS HR, 2006. Alpha-Tocopherol Supplementation Does Not Affect Monocyte Endothelial Adhesion Or C-Reactive Protein Levels But Reduces Soluble Vascular Adhesion Molecule-1 In The Plasma Of Healthy Subjects. Redox Report : Communications In Free Radical Research. 11(5), 214-22
• RAYMENT SJ, SHAW J, WOOLLARD KJ, LUNEC J and GRIFFITHS HR, 2003. Vitamin C Supplementation In Normal Subjects Reduces Constitutive Icam-1 Expression. Biochemical And Biophysical Research Communications. 308(2), 339-45
• RAYMENT SJ, LEE BJ, HAMPSON DJ and LIVESLEY MA, 1998. Identification Of A Gene Sequence Encoding A Putative Pyruvate Oxidoreductase In Serpulina Pilosicoli. Fems Microbiology Letters. 166(1), 121-6
• RAYMENT SJ, BARRETT SP and LIVESLEY MA, 1997. Sub-Specific Differentiation Of Intestinal Spirochaete Isolates By Macrorestriction Fragment Profiling. Microbiology (Reading, England). 143 ( Pt 9), 2923-9