Catrin Rutland

Contact

• workRoom A11a The School of Veterinary Medicine and Science
  Sutton Bonington Campus
  Sutton Bonington
  Leicestershire
  LE12 5RD
  UK
• work0115 951 6573
• catrin.rutland@nottingham.ac.uk

Teaching Summary

I am the module convenor for Cardiorespiratory 1 and I also teach anatomy in the gastrointestinal, neuroscience, and musculoskeletal modules.

Research Summary

My research areas are integrated into three of the School of Veterinary Medicine and Research themes; Comparative medicine, reproductive biology and educational research.

Within the comparative and reproductive biology themes my investigations are centred around cardiovascular system and includes researching cardiac disorders, angiogenesis and metabolism. One area of interest uses knock down models to discover possible disease causing genes and another area of interest concentrates on looking into companion animals that are suffering from cardiovascular disorders and trying to elucidate the genes that are affected/causative. My angiogenesis research focuses on the normal development of the fetus and placenta and also includes projects investigating the genetic, proteomic, anatomical and functional effects of a low protein diet during development. The angiogenesis work also includes blood vessel corrosion casting projects and research into ocular diseases, especially those presenting with abnormal vasculature. The laboratory is also very interested in ocular metabolism studies within both the normal eye and disease affected eyes. My research investigates both naturally-acquired and induced diseases in many species throughout development, into adulthood and in old age. The overall aim of the work is to elucidate the molecular mechanisms behind both normal and diseased states. The work will help us to better understand these disorders (including cardiomyopathies and blindness) and nutrition requirements so more effective diagnosis techniques, treatments and advice for patients can be developed. An integrated approach to disease and development is undertaken and therefore collaborators include both scientists and clinicians and a number of veterinary surgeries.

My veterinary educational research revolves around developing the veterinary museum to enable more effective learning and also includes developing teaching and museum materials, working on the international online anatomy museum grant and also Widening Participation grants. I am also researching the effects of educational background, gender and nationality upon the student experience and grade outcomes, using both qualitative and quantitative approaches.

Past and Present Laboratory Members: Aziza Alibhai - Senior research technician

Gar Wai Kerry Chung - Graduate Intern and research technician

Paul (Pablo) Barrett - Graduate Intern

Ammar Alibhai - BBSRC studentship

Claire Bordoli - Museum curator and research technician

Kirsty Hillier - Museum curator

Mark Plested, Sarah Geldart, Robin Cheung - Veterinary undergraduate research projects

Selected Publications

• WALSH, R, RUTLAND, C, THOMAS, R and LOUGHNA, S, 2010. Cardiomyopathy: a systematic review of disease-causing mutations in myosin heavy chain 7 and their phenotypic manifestations. Cardiology. 115(1), 49-60
• RUTLAND, CATRIN S, JIANG, KEYI, SOFF, GERALD A and MITCHELL, CHRISTOPHER A, 2009. Maternal administration of anti-angiogenic agents, TNP-470 and Angiostatin4.5, induces fetal microphthalmia. Molecular vision. 15, 1260-9
• RUTLAND, C, WARNER, L, THORPE, A, ALIBHAI, A, ROBINSON, T, SHAW, B, LAYFIELD, R, BROOK, JD, LOUGHNA, S, 2009. Knockdown of alpha myosin heavy chain disrupts the cytoskeleton and leads to multiple defects during chick cardiogenesis. Journal of Anatomy. 214(6), 905-15
• RUTLAND, CATRIN S, MITCHELL, CHRISTOPHER A, NASIR, MUNEEB, KONERDING, MORITZ A and DREXLER, HANNES C A, 2007. Microphthalmia, persistent hyperplastic hyaloid vasculature and lens anomalies following overexpression of VEGF-A188 from the alphaA-crystallin promoter. Molecular vision. 13, 47-56

• View all publications

Future Research

Dr Karl Klisch and I organised the 6th Meeting of the Young Generation of Veterinary Anatomists (YGVA)

The sixth YGVA meeting was held 6-9^th July 2011 in the School of Veterinary Medicine and Science, University of Nottingham with 46 participants representing 15 different countries.

Throughout the meeting, 39 poster and oral presentations were given, focussing on anatomy and histology research and advances in veterinary education and anatomical teaching. The relaxed and friendly atmosphere of the meeting led to very lively and constructive discussions after oral presentations and around the posters. We also had presentations and discussions regarding the 'European College' and 'Anatomical Education' which gave us the opportunity to share experiences, put ideas forward and to discuss possible future directions. We were delighted to see the progress that has been made with the European Masters of Comparative Morphology. In addition to the tour of the Vet School, there was also a 3 hour workshop about the use of technology in teaching veterinary anatomy. This included the 'hands on' exploration of teaching tools and innovations used in the lecture theatres, clinical skills, dissection and surgery laboratories. This gave us more opportunities to compare the different techniques used in Veterinary Schools across Europe (and beyond). Much of the discussion was around the use of technologies (including models, computer software development) and about the clinical importance and integration of anatomy into the modern curriculum. As always, this meeting was lively and sociable. We enjoyed a reception dinner at the Vet School, English afternoon strawberry tea during a poster session and a countryside walk to have dinner at a 'Traditional British Pub'. We also participated in an 'electrifying' cricket match, where despite the famous British rain, thunder and lightning, play continued until all of the Young Generation Anatomists retired for a barbeque party. We would like to thank the 'Anatomical Society' and 'James Cook University Australia' for their kind sponsorship. We would also like to thank Dr Pieter Cornillie (YGVA representative), Professor Salazar (European Association of Veterinary Anatomists' President) and everyone that helped us to organise, plan and carry out the meeting. Finally, we would like to thank all of the delegates who provided us with such an exciting and informative meeting.

• 2012. In: The Chicken 1st. Ivy Publishing. (In Press.)
• RUTLAND, CATRIN S, ATKINSON, SARAH D, MUKHOPADHYAY, MALLINATH, JIANG, KEYI, SOFF, GERALD A, MAYHEW, TERRENCE M and MITCHELL, CHRISTOPHER A, 2011. Thrombophilic-Type Placental Pathologies and Skeletal Growth Delay Following Maternal Administration of Angiostatin4.5 in Mice. Biology of reproduction.
• RUTLAND, CS, POLO-PARADA, L, EHLER, E, ALIBHAI, A, THORPE, A, SUREN, S, EMES, RD, PATEL, B and LOUGHNA, S, 2011. Knockdown Of Embryonic Myosin Heavy Chain Reveals An Essential Role In The Morphology And Function Of The Developing Heart Development. 138(18), 3955-3966
• WALSH, R, RUTLAND, C, THOMAS, R and LOUGHNA, S, 2010. Cardiomyopathy: a systematic review of disease-causing mutations in myosin heavy chain 7 and their phenotypic manifestations. Cardiology. 115(1), 49-60
• RUTLAND, C, WARNER, L, THORPE, A, ALIBHAI, A, ROBINSON, T, SHAW, B, LAYFIELD, R, BROOK, JD, LOUGHNA, S, 2009. Knockdown of alpha myosin heavy chain disrupts the cytoskeleton and leads to multiple defects during chick cardiogenesis. Journal of Anatomy. 214(6), 905-15
• RUTLAND, CATRIN S, JIANG, KEYI, SOFF, GERALD A and MITCHELL, CHRISTOPHER A, 2009. Maternal administration of anti-angiogenic agents, TNP-470 and Angiostatin4.5, induces fetal microphthalmia. Molecular vision. 15, 1260-9
• RUTLAND, C, THORPE, A, ALIBHAI, A, POLO-PARADA, L and LOUGHNA, S, 2009. Knockdown of embryonic myosin heavy chain leads to abnormal development and electrical activity of the heart In: 16th Annual Conference of the International-Society-of-Development-Biologists. S71-S71
• RUTLAND, CS, JIANG, KY, SOFF, GA and MITCHELL, CA, 2009. Maternal Administration Of Anti-Angiogenic Agents, Tnp-470 And Angiostatin(4.5), Induces Fetal Microphthalmia Molecular Vision. 15(134), 1260-1269
• RUTLAND,, 2008. Histological and Histochemical Methods 4th Edition. Journal of anatomy.
• RUTLAND, C.S., LATUNDE-DADA, A.O., THORPE, A., PLANT, R., LANGLEY-EVANS, S. and LEACH, L., 2007. Effect of gestational nutrition on vascular integrity in the murine placenta Placenta. 28(7), 734-742
• RUTLAND, CATRIN S, MITCHELL, CHRISTOPHER A, NASIR, MUNEEB, KONERDING, MORITZ A and DREXLER, HANNES C A, 2007. Microphthalmia, persistent hyperplastic hyaloid vasculature and lens anomalies following overexpression of VEGF-A188 from the alphaA-crystallin promoter. Molecular vision. 13, 47-56
• LOUGHNA, S AND RUTLAND, C, 2007. Cardiovascular genomics Human Genetics. 121(3-4), 523-524
• RUTLAND, CS, MITCHELL, CA, NASIR, M, KONERDING, MA and DREXLER, HCA, 2007. Microphthalmia, Persistent Hyperplastic Hyaloid Vasculature And Lens Anomalies Following Overexpression Of Vegf-A(188) From The Alpha A-Crystallin Promoter Molecular Vision. 13(6), 47-56
• MITCHELL, CHRISTOPHER A, RUTLAND, CATRIN S, WALKER, MICHAEL, NASIR, MUNEEB, FOSS, ALEXANDER J E, STEWART, CHRISTINE, GERHARDT, HOLGER, KONERDING, MORITZ A, RISAU, WERNER and DREXLER, HANNES C A, 2006. Unique vascular phenotypes following over-expression of individual VEGFA isoforms from the developing lens. Angiogenesis. 9(4), 209-24
• RUTLAND, C.S., MUKHOPADHYAY, M., UNDERWOOD, S., CLYDE, N., MAYHEW, T.M. and MITCHELL, C.A., 2005. Induction of intrauterine growth restriction by reducing placental vascular growth with the angioinhibin TNP-470. Biology of Reproduction. 73(6), 1164-1173
• RUTLAND,, COOPER, and MITCHELL,, 2002. Inhibition of murine placental and embryonic growth by the angiogenesis inhibitor TNP-470. 200(5), 530
• RUTLAND, C, HONEYMAN, L, THORPE, A, ALIBHAI, A, GHAFARI, F, BROOK, JD and LOUGHNA, S, Morpholino induced beta-myosin heavy chain knockdown leads to heart defects in the chick In: 767-767
• HONEYMAN, L, RUTLAND, C, THORPE, A, ROBINSON, T, BROOK, JD and LOUGHNA, S, Alpha myosin heavy chain knockdown leads to defects in atrial septal development In: 768-768
• RUTLAND, CS, LANGLEY-EVANS, S and LEACH, L, Effect of gestational protein restriction on growth and beta-catenin expression in the murine placenta In: 790-790
• RUTLAND, CS, LATUNDE-DADA, AO, THORPE, A, LANGLEY-EVANS, S and LEACH, L, Effects of gestational nutrition on vascular function in the murine placenta and embryo In: 565-565
• RUTLAND, CS, MAYHEW, TM, MUKHOPADHYAY, M, UNDERWOOD, S and MITCHELL, CA, Effects of the anti-angiogenic factor TNP-470 on growth of the mouse fetus and placenta. In: A12-A12