Karl Klisch

Contact

• workRoom A54 School of Veterinary Medicine and Science
  Sutton Bonington Campus
  Sutton Bonington
  Leicestershire
  LE12 5RD
  UK
• work0115 951 6247
• karl.klisch@nottingham.ac.uk

Biography

Dr Klisch graduated from the University of Veterinary Medicine Hannover, Germany in 1994. After a few month in general veterinary practice he started in 1995 postgraduate studies for a doctoral thesis at the Institute of Veterinary Anatomy, Justus-Liebig University Giessen, Germany. The doctorate (Dr. med. vet,) was granted in 1998 with the highest possible grade (summa cum laude).

From 1999 until 2007 Dr. Klisch worked as a postdoc at the the Centre of Anatomy, Hannover Medical School, Germany. His research was centered at the glycosylation of pregnancy associated glycoproteins (PAGs) of the ruminant placenta. His teaching was primarily in histology and cell biology, but also included all aspects of human gross anatomy.

In 2007 Dr. Klisch joined the School of Veterinary Medicine and Science, University of Nottingham as a Lecturer of Clinical Veterinary Anatomy. His research is on aspects of glycosylation in reproductive organs. His teaching is mainly gross anatomy of domestic mammals in lectures and dissection practicals, but also includes some aspects of histology..

Research Summary

My research interest is the impact of proteinglycosylation in reproduction. I use carbohydrate specific antibodies and lectins to identify and characterise a subpopulation of spermatogonia in testes… read more

Selected Publications

• KLISCH, KARL, JEANROND, EVELYNE, PANG, POH-CHOO, PICH, ANDREAS, SCHULER, GERHARD, DANTZER, VIBEKE, KOWALEWSKI, MARIUSZ P and DELL, ANNE, 2008. A tetraantennary glycan with bisecting N-acetylglucosamine and the Sd(a) antigen is the predominant N-glycan on bovine pregnancy-associated glycoproteins. Glycobiology. 18(1), 42-52
• WOODING, F B P, DANTZER, V B, KLISCH, K, JONES, C J and FORHEAD, A J, 2007. Glucose transporter 1 localisation throughout pregnancy in the carnivore placenta: light and electron microscope studies. Placenta. 28(5-6), 453-64
• KLISCH, K and MESS, A, 2007. Evolutionary differentiation of Cetartiodactyl placentae in the light of the viviparity-driven conflict hypothesis. Placenta. 28(4), 353-60
• SCHULER, G, TEICHMANN, U, KOWALEWSKI, M P, HOFFMANN, B, MADORE, E, FORTIER, M A and KLISCH, K, 2007. Expression of cyclooxygenase-II (COX-II) and 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD)/prostaglandin F-synthase (PGFS) in bovine placentomes: implications for the initiation of parturition in cattle. Placenta. 27(9-10), 1022-9

• View all publications

Current Research

My research interest is the impact of proteinglycosylation in reproduction. I use carbohydrate specific antibodies and lectins to identify and characterise a subpopulation of spermatogonia in testes of animals and humans . One aim of this research is to identify adult stem cells in the testis and isolate such cells. A second aim is to develop new non-invasive diagnostic tools for the detection of a precursor of testicular cancer (testicular carcinoma in situ) in humans.

Past Research

-In my thesis I studied the polyploidisation of ruminant trophoblast cells. These studies were extendet to trophoblast cells of camelids.

-Later I focussed on the glycosylation of ruminant placental proteins.

• KLISCH K, CONTRERAS, DA, SUN, X, BREHM, R, BERGMANN, M and AND ALBERIO R., 2011. The Sda/GM2-glycan is a carbohydrate marker of porcine primordial germ cells and of a subpopulation of spermatogonia in cattle, pigs, horses and llama. Reproduction (Cambridge, England).
• KLISCH, K, WOODING, FBP and JONES, CJP, 2010. The Glycosylation Pattern Of Secretory Granules In Binucleate Trophoblast Cells Is Highly Conserved In Ruminants
• MAJEWSKA, MARTA, PANASIEWICZ, GRZEGORZ, KLISCH, KARL, OLIVERA, LOUIS V M, MAMANI, JAVIER M, ABD-ELNAEIM, MAHMOUD M and SZAFRANSKA, BOZENA, 2009. Pregnancy-associated glycoprotein (PAG) family: transcripts and gene amplicons in camelids. Reproductive biology. 9(2), 127-50
• KLISCH, KARL, JEANROND, EVELYNE, PANG, POH-CHOO, PICH, ANDREAS, SCHULER, GERHARD, DANTZER, VIBEKE, KOWALEWSKI, MARIUSZ P and DELL, ANNE, 2008. A tetraantennary glycan with bisecting N-acetylglucosamine and the Sd(a) antigen is the predominant N-glycan on bovine pregnancy-associated glycoproteins. Glycobiology. 18(1), 42-52
• BARBATO,, SOUSA,, KLISCH,, CLERGET,, DEBENEDETTI,, BARILE,, MALFATTI, and BECKERS,, 2008. Isolation of new pregnancy-associated glycoproteins from water buffalo (Bubalus bubalis) placenta by Vicia villosa affinity chromatography. Research in Veterinary Science.
• WOODING, F B P, DANTZER, V B, KLISCH, K, JONES, C J and FORHEAD, A J, 2007. Glucose transporter 1 localisation throughout pregnancy in the carnivore placenta: light and electron microscope studies. Placenta. 28(5-6), 453-64
• BRIDGER, P S, HAUPT, S, KLISCH, K, LEISER, R, TINNEBERG, H-R and PFARRER, C, 2007. Validation of primary epitheloid cell cultures isolated from bovine placental caruncles and cotyledons. Theriogenology. 68(4), 592-603
• SCHULER, G, TEICHMANN, U, KOWALEWSKI, M P, HOFFMANN, B, MADORE, E, FORTIER, M A and KLISCH, K, 2007. Expression of cyclooxygenase-II (COX-II) and 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD)/prostaglandin F-synthase (PGFS) in bovine placentomes: implications for the initiation of parturition in cattle. Placenta. 27(9-10), 1022-9
• KLISCH, K and MESS, A, 2007. Evolutionary differentiation of Cetartiodactyl placentae in the light of the viviparity-driven conflict hypothesis. Placenta. 28(4), 353-60
• FINK, C, TATAR, M, FAILING, K, HOSPES, R, KRESSIN, M and KLISCH, K, 2006. Serotonin-containing cells in the gastrointestinal tract of newborn foals and adult horses. Anatomia Histologia Embryologia - Journal of Veterinary Medicine Series C. 35(1), 23-7
• KLISCH, K, BOOS, A, FRIEDRICH, M, HERZOG, K, FELDMANN, M, SOUSA, NM, BECKERS, JF, LEISER, R and SCHULER, G, 2006. The glycosylation of pregnancy-associated glycoproteins and prolactin-related protein-I in bovine binucleate trophoblast giant cells changes before parturition. Reproduction. 132(5), 791-8
• CARVALHO, A F, KLISCH, K, MIGLINO, M A, PEREIRA, F T V and BEVILACQUA, E, 2006. Binucleate trophoblast giant cells in the water buffalo (Bubalus bubalis) placenta. Journal of morphology. 267(1), 50-6
• KLISCH, KARL, DE SOUSA, NOELITA MELO, BECKERS, JEAN-FRANÇOIS, LEISER, RUDOLF and PICH, ANDREAS, 2005. Pregnancy associated glycoprotein-1, -6, -7, and -17 are major products of bovine binucleate trophoblast giant cells at midpregnancy. Molecular Reproduction and Development. 71(4), 453-60
• KLISCH, K, BEVILACQUA, E and OLIVERA, L V M, 2005. Mitotic polyploidization in trophoblast giant cells of the alpaca. Cells, tissues, organs. 181(2), 103-8
• KLISCH, KARL, THOMSEN, PREBEN D, DANTZER, VIBEKE and LEISER, RUDOLF, 2004. Genome multiplication is a generalised phenomenon in placentomal and interplacentomal trophoblast giant cells in cattle. Reproduction, Fertility and Development. 16(3), 301-6
• ABD-ELNAEIM, M M M, SABER, A, HASSAN, A, ABOU-ELMAGD, A, KLISCH, K, JONES, C J P and LEISER, R, 2003. Development of the areola in the early placenta of the one-humped camel (Camelus dromedarius): a light, scanning and transmission electron microscopical study. Anatomia Histologia Embryologia - Journal of Veterinary Medicine Series C. 32(6), 326-34
• KLISCH, KARL and LEISER, RUDOLF, 2003. In bovine binucleate trophoblast giant cells, pregnancy-associated glycoproteins and placental prolactin-related protein-I are conjugated to asparagine-linked N-acetylgalactosaminyl glycans. Histochemistry and Cell Biology. 119(3), 211-7
• PFARRER, C, EBERT, B, MIGLINO, M A, KLISCH, K and LEISER, R, 2001. The three-dimensional feto-maternal vascular interrelationship during early bovine placental development: a scanning electron microscopical study. Journal of Anatomy. 198(Pt 5), 591-602
• SCHULER, G, WIRTH, C, KLISCH, K, PFARRER, C, LEISER, R and HOFFMANN, B, 1999. Immunolocalization of progesterone receptors in bovine placentomes throughout mid and late gestation and at parturition. Biology of Reproduction. 61(3), 797-801
• KLISCH, K, PFARRER, C, SCHULER, G, HOFFMANN, B and LEISER, R, 1999. Tripolar acytokinetic mitosis and formation of feto-maternal syncytia in the bovine placentome: different modes of the generation of multinuclear cells. Anatomy and Embryology. 200(2), 229-37
• KLISCH, K, HECHT, W, PFARRER, C, SCHULER, G, HOFFMANN, B and LEISER, R, 1999. DNA content and ploidy level of bovine placentomal trophoblast giant cells. Placenta. 20(5-6), 451-8
• LEISER, R, KREBS, C, KLISCH, K, EBERT, B, DANTZER, V, SCHULER, G and HOFFMANN, B, 1997. Fetal villosity and microvasculature of the bovine placentome in the second half of gestation. Journal of Anatomy. 191 ( Pt 4), 517-27
• TARLINTON RE, YON L, KLISCH K, TÖTEMEYER S and GOUGH KC, 1. Confidence As A Barrier To The Use Of Problem-Based Learning In Veterinary Undergraduate Students. Journal Of Veterinary Medical Education. 38(3), 305-10