Biotechnology and Biological Sciences Doctoral Training Programme
   
   
  

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Please note that the list of projects available will be increased over the next few weeks so please check frequently. Project details may also be subject to change before September 2018.

 

 

 

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Transformation of South American waste glycerin into biofuel

Description
The mini project will serve as an introduction to the available gene tools to be deployed in Clostridium pasteurianum. The student will:- (i) receive a safety induction to cover safe laboratory practice within the confines of SBRC laboratories and equipment within the Centre; (ii) be trained in the use of anaerobic cabinets and the cultivation of Clostridium pasteurianum; (iii) undertake CRISPR/Cas9-mediated and ClosTron-based gene knock-out(www.clostron.com); (iv) become trained in the application of ACE technology, by integrative correction of a mutant pyrE allele in the chromosome.

Genome engineering for medicine and synthetic biology

Description
For the mini project we will design a 'bite-sized' program addressing a simple question that can be addressed in the limited time available. The laboratory continually generates candidate recombinases with improved activities. Several of these will be made available to the student to investigate. Various approaches may be taken, ranging from biochemical analysis of the purified proteins, to testing their gene delivery and recombinational potential in cultured human cells. Ideally, biochemical analysis, using our established assays, would be correlated with the efficiency of transgenesis in cultured mammalian cells. This would provide the student with a broad-based training in the routine techniques of molecular and cell biology, as well as an exposure to advanced recombineering techniques.

Metabolic heterogeneity in isogenic microbial populations and its impact on bioproduction

Description
The mini project will focus on designing and developing genetically encoded biosensors relevant to synthetic metabolic pathways for production of added value chemicals. It will serve as an introduction to the available gene tools and analytic techniques to be deployed in PhD project.

Engineering pathways and biosensor systems for production and detection of chemical compounds in bacteria

Description
The use of biotechnology for the sustainable production of chemicals and materials, the synthesis of which has traditionally depended heavily on the fossil fuel-based chemical industry, is becoming increasingly important.
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Biotechnology and Biological Sciences Doctoral Training Programme

The University of Nottingham
University Park
Nottingham, NG7 2RD

Tel: +44 (0) 115 8466946
Email: bbdtp@nottingham.ac.uk