Biotechnology and Biological Sciences Doctoral Training Programme
   
   
  

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Please note the list of projects available will be updated with additional projects, so please check frequently. Project details may also be subject to change before September 2018.

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Investigating the differential regulation of cell surface GAG in breast cancer: Using NGPD to isolate cancer cell specific peptides

Description
In this project, we propose to identify cell-type specific variants in breast cancer patient samples in a high-throughput manner using phage display-libraries (1010 phage) of GET peptides and next-generation sequencing (NGS) in a process called next generation phage display (NGPD).

Molecular approaches to understanding allosteric modulation at the M1 Muscarinic Acetylcholine Receptor (mAChR)

Description
This chemical biology-focused project will span the disciplines of synthetic chemistry and pharmacology to increase our understanding of the M1 mAChR. With increasing numbers of allosteric ligands being discovered for the wider G protein-coupled receptor family, the results will be of direct relevance to many other important receptors.

A ligand-guided strategy for fluorescent labelling of native cellular receptors

Description
We have an internationally recognized track record in the design, synthesis and application of fluorescently conjugated G-Protein Coupled Receptor (GPCR) ligands. The hypothesis behind this project takes this concept and extends it to the design of molecules capable of covalently transferring a fluorescent cargo to a region of a GPCR distal to the ligand-binding site.

Structure and function of molecular machines involved in eukaryotic RNA degradation and microRNA-mediated repression

Description
The training includes an opportunity to work at world-class facilities at the Research Complex at Harwell. The student will benefit from transferable skills associated with protein expression and purification, enzymology, as well as the characterisation of biochemical samples using biophysical techniques
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Biotechnology and Biological Sciences Doctoral Training Programme

The University of Nottingham
University Park
Nottingham, NG7 2RD

Tel: +44 (0) 115 8466946
Email: bbdtp@nottingham.ac.uk