Biotechnology and Biological Sciences Doctoral Training Programme
   
   
  

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Please note the list of projects available will be updated with additional projects, so please check frequently. Project details may also be subject to change before September 2018.

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Rational design of sequence determinants of therapeutic mRNA stability

Description
The project will provide new information about the regulation of mRNA stability that is relevant for the design of mRNA therapeutics. Training includes protein expression and purification, in vitro transcription, mammalian cell culture, RNA transfection and reporter assays

Understanding the role of small molecules in the infection of insects by fungi

Description
In this project, you will study the production of nucleosides and other small molecules by fungi of the order Hypocreales using metabolomics methods (samples obtained from Warwick). Then you will test the molecular effects of these nucleosides on the immune responses of a Drosophila immune cell line.

Optimisation and quality control of the production of anti-inflammatory compounds by Cordyceps militaris

Description
In this project you will profile the gene expression of cell lines treated with different batches of fungal extract and correlate these profiles with metabolomics profiles of the extracts. You will use bioinformatics and mathematical modelling to determine which metabolic "finger prints" correlate with apparent therapeutic and adverse effects on cells.

Here today, corn tomorrow: developing African crop bio-protectants for the future.

Description
This project will be of particular interest to researchers wanting to address immediate welfare and economic issues in developing countries, but will also generate important data and methodologies for further research into plant biology and diverse applications of compounds derived from natural sources (e.g. anti-microbials, therapeutics, insect repellents, detergents).

EGFR under stress – understanding gene expression in health and disease.

Description
The project will use a combination of standard molecular biology tools (e.g. PCR, western analysis, microscopy, cloning, cell culture, RNA/DNA manipulations, gene expression analysis) alongside more technically adventurous techniques such as polysome profiling and bioinformatic analysis.

One ring to rule them all: circular RNAs to make spider silk

Description
The PhD project will focus initially on using circular RNAs to develop a new type of flexible and adaptable expression system. Building on previous work in the lab, and also on their own work during the rotation project, students will combine standard molecular biology tools with cutting edge RNA biology applications to engineer plasmid constructs for bacterial and eukaryotic expression of proteins.

Structure-guided enzyme engineering to enhance the biocatalysis toolbox

Description
The aim of this project is to gain a detailed molecular understanding of selected biocatalysts of the transaminase and amine oxidase family in order to optimize them by protein engineering for selective chemical transformations.

Characterisation and engineering of a key regulator in butanol-producing clostridia

Description
Characterisation and engineering of a key regulator in butanol-producing clostridia
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Biotechnology and Biological Sciences Doctoral Training Programme

The University of Nottingham
University Park
Nottingham, NG7 2RD

Tel: +44 (0) 115 8466946
Email: bbdtp@nottingham.ac.uk