Biotechnology and Biological Sciences Doctoral Training Programme
   
   
  

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Please note that the list of projects available will be increased over the next few weeks so please check frequently. Project details may also be subject to change before September 2018.

 

 

 

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Development and evaluation of apoferritin/organo and organometallic catalyst based 'Trojan Horse' drug delivery nanocapsules

Description
The overall project aim is to use oxidation catalysts incorporated into the hollow core of apoferritin, and to apply these to sulfoxidations and alcohol oxidations in the presence of biological material, such as whole cells or enzymes.

French Partnership: Engineering Clostridium for chemicals and fuel production from waste glycerol using a System Biology approach

Description
The goal of this proposal is to assemble a combined enzymatic system that will allow two sequential reactions to take place in flow. This system will generate amines from alcohols via a carbonyl intermediate. Amines are key functional groups of numerous intermediates for pharma and agrochemical applications, and enzymatic synthesis will offer a 'green' alternative to traditional methodologies. To overcome the limitations of mesophilic enzymes such as low stability in organic solvents, a novel system will be based on two halophilic biocatalysts that offer remarkable stability and excellent substrate scope. Both enzymes (HvADH2 and HvAAT1) are from the halophilic archaeon Haloferax volcanii. HvADH2 is exceptionally tolerant to organic solvents, has an unusually broad substrate scope, and shows enhanced stability upon covalent immobilization.

French Partnership: Cellolytic Clostridium acetobutylicum by repairing Cel48A

Description
The goal of this proposal is to assemble a combined enzymatic system that will allow two sequential reactions to take place in flow. This system will generate amines from alcohols via a carbonyl intermediate. Amines are key functional groups of numerous intermediates for pharma and agrochemical applications, and enzymatic synthesis will offer a 'green' alternative to traditional methodologies. To overcome the limitations of mesophilic enzymes such as low stability in organic solvents, a novel system will be based on two halophilic biocatalysts that offer remarkable stability and excellent substrate scope. Both enzymes (HvADH2 and HvAAT1) are from the halophilic archaeon Haloferax volcanii. HvADH2 is exceptionally tolerant to organic solvents, has an unusually broad substrate scope, and shows enhanced stability upon covalent immobilization.

Understanding DNA repair in adult tissues: Precision cut lung slices (PCLS) as a model for repair mechanisms and testing of gene editing strategies

Description
Triangle project:Developing precision cut lung slices as an ex vivo model to test novel gene therapies delivered by aerosol or dry powder inhaler

Investigating the differential regulation of cell surface GAG in breast cancer: Using NGPD to isolate cancer cell specific peptides

Description
In this project, we propose to identify cell-type specific variants in breast cancer patient samples in a high-throughput manner using phage display-libraries (1010 phage) of GET peptides and next-generation sequencing (NGS) in a process called next generation phage display (NGPD).

Molecular and in-silico interrogation of novel modes of binding at G protein-coupled receptors (GPCRs)

Description
We have recently identified, through advanced molecular modelling methods, a possible novel mode of binding of experimental subtype-selective ligands to beta adrenoceptors.The aim of this multidisciplinary project will be to design, synthesise and pharmacologically characterise a library of ligands to test this hypothesis more rigorously.

MicroRNA regulation on the inflammatory response

Description
This project aims to understand miRNA regulation in the context of the inflammatory response, in which cells rapidly switch on the production of many mRNAs that encode inflammatory proteins.

Molecular approaches to understanding allosteric modulation at the M1 Muscarinic Acetylcholine Receptor (mAChR)

Description
This chemical biology-focused project will span the disciplines of synthetic chemistry and pharmacology to increase our understanding of the M1 mAChR. With increasing numbers of allosteric ligands being discovered for the wider G protein-coupled receptor family, the results will be of direct relevance to many other important receptors.

A ligand-guided strategy for fluorescent labelling of native cellular receptors

Description
We have an internationally recognized track record in the design, synthesis and application of fluorescently conjugated G-Protein Coupled Receptor (GPCR) ligands. The hypothesis behind this project takes this concept and extends it to the design of molecules capable of covalently transferring a fluorescent cargo to a region of a GPCR distal to the ligand-binding site.

Structure and function of molecular machines involved in eukaryotic RNA degradation and microRNA-mediated repression

Description
The training includes an opportunity to work at world-class facilities at the Research Complex at Harwell. The student will benefit from transferable skills associated with protein expression and purification, enzymology, as well as the characterisation of biochemical samples using biophysical techniques
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Biotechnology and Biological Sciences Doctoral Training Programme

The University of Nottingham
University Park
Nottingham, NG7 2RD

Tel: +44 (0) 115 8466946
Email: bbdtp@nottingham.ac.uk