Biotechnology and Biological Sciences Doctoral Training Programme
   
   
  

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Please note the list of projects available will be updated with additional projects, so please check frequently. Project details may also be subject to change before September 2018.

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Exploring the Function of Gene Regulators by CRISPR CAS9 Genome Editing

Description
This project will utilise these cell lines in 'rescue' experiments by re-expression of wild type or mutant KAT6A to determine function. We will generate mutations in different functional domains in KAT6A to assess their requirement for regulation of a panel target genes by qPCR.

PIP5K1A – integrating lipid signalling with nuclear function

Description
The project will integrate with structure function studies ongoing with groups in Sweden and Nottingham. For example our collaborators in Sweden have generated a small molecule inhibitor of PIP5K1A (Semenas 2014 PNAS; (Sarwar et al Oncotarget 2016; Karlsson et al.,submitted) which prevents the growth of metastatic prostate tumours in animal models. We hope to determine the structure of PIP5K1A in complex with its inhibitor with our collaborators in structural biology
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Biotechnology and Biological Sciences Doctoral Training Programme

The University of Nottingham
University Park
Nottingham, NG7 2RD

Tel: +44 (0) 115 8466946
Email: bbdtp@nottingham.ac.uk