Biotechnology and Biological Sciences Doctoral Training Programme
   
   
  

Industrial Biotechnology and the Bioeconomy projects

 

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Please note that the list of projects available will be increased over the next few weeks so please check frequently. Project details may also be subject to change before September 2017.

 

BBSRC Doctoral Training Partnerships

 

 

 

View all Industrial Biotechnology and the Bioeconomy projects

Development and evaluation of apoferritin/organo and organometallic catalyst based 'Trojan Horse' drug delivery nanocapsules

Description
The overall project aim is to use oxidation catalysts incorporated into the hollow core of apoferritin, and to apply these to sulfoxidations and alcohol oxidations in the presence of biological material, such as whole cells or enzymes.

Rational design of sequence determinants of therapeutic mRNA stability

Description
The project will provide new information about the regulation of mRNA stability that is relevant for the design of mRNA therapeutics. Training includes protein expression and purification, in vitro transcription, mammalian cell culture, RNA transfection and reporter assays

French Partnership: Engineering Clostridium for chemicals and fuel production from waste glycerol using a System Biology approach

Description
The goal of this proposal is to assemble a combined enzymatic system that will allow two sequential reactions to take place in flow. This system will generate amines from alcohols via a carbonyl intermediate. Amines are key functional groups of numerous intermediates for pharma and agrochemical applications, and enzymatic synthesis will offer a 'green' alternative to traditional methodologies. To overcome the limitations of mesophilic enzymes such as low stability in organic solvents, a novel system will be based on two halophilic biocatalysts that offer remarkable stability and excellent substrate scope. Both enzymes (HvADH2 and HvAAT1) are from the halophilic archaeon Haloferax volcanii. HvADH2 is exceptionally tolerant to organic solvents, has an unusually broad substrate scope, and shows enhanced stability upon covalent immobilization.

French Partnership: Cellolytic Clostridium acetobutylicum by repairing Cel48A

Description
The goal of this proposal is to assemble a combined enzymatic system that will allow two sequential reactions to take place in flow. This system will generate amines from alcohols via a carbonyl intermediate. Amines are key functional groups of numerous intermediates for pharma and agrochemical applications, and enzymatic synthesis will offer a 'green' alternative to traditional methodologies. To overcome the limitations of mesophilic enzymes such as low stability in organic solvents, a novel system will be based on two halophilic biocatalysts that offer remarkable stability and excellent substrate scope. Both enzymes (HvADH2 and HvAAT1) are from the halophilic archaeon Haloferax volcanii. HvADH2 is exceptionally tolerant to organic solvents, has an unusually broad substrate scope, and shows enhanced stability upon covalent immobilization.

Optimisation and quality control of the production of anti-inflammatory compounds by Cordyceps militaris

Description
In this project you will profile the gene expression of cell lines treated with different batches of fungal extract and correlate these profiles with metabolomics profiles of the extracts. You will use bioinformatics and mathematical modelling to determine which metabolic "finger prints" correlate with apparent therapeutic and adverse effects on cells.

One ring to rule them all: circular RNAs to make spider silk

Description
The PhD project will focus initially on using circular RNAs to develop a new type of flexible and adaptable expression system. Building on previous work in the lab, and also on their own work during the rotation project, students will combine standard molecular biology tools with cutting edge RNA biology applications to engineer plasmid constructs for bacterial and eukaryotic expression of proteins.

Structure-guided enzyme engineering to enhance the biocatalysis toolbox

Description
The aim of this project is to gain a detailed molecular understanding of selected biocatalysts of the transaminase and amine oxidase family in order to optimize them by protein engineering for selective chemical transformations.

Characterisation and engineering of a key regulator in butanol-producing clostridia

Description
Characterisation and engineering of a key regulator in butanol-producing clostridia
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Biotechnology and Biological Sciences Doctoral Training Programme

The University of Nottingham
University Park
Nottingham, NG7 2RD

Tel: +44 (0) 115 8466946
Email: bbdtp@nottingham.ac.uk