Biotechnology and Biological Sciences Doctoral Training Programme
   
   
  

Molecules, Cells and Organisms projects

 

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Please note that the list of projects available will be increased over the next few weeks so please check frequently. Project details may also be subject to change before September 2017.

 

BBSRC Doctoral Training Partnerships

 

 

 

View all Molecules, Cells and Organisms projects

Investigating pharmacological properties of novel molecules isolated from Malaysian rainforest flora

Description
In this rotation, the student will begin to examine this hypothesis testing activity of a novel Malaysian rainforest-derived natural product. The student will subcultivate human-derived carcinoma cell lines and examine by MTT and clonogenic assays the effect of a novel compound on cell proliferation and viability.

Realtime measurement of staphylococcal quorum sensing signal biosynthesis

Description
The student will learn a range of fundamental molecular biology and genetic engineering in both E. coli and S. aureus. This will then be followed by training to perform microbiological-based assays that measure reconstituted Nanoluciferase bioluminescence (Promega Nanobit Technology) in response to the secretion of an established modified staphylococci agrD peptide, which is a precursor of the staphylococcal autoinducing peptide (AIP).

Unravelling the mechanism of pseudomonal resistance to the peptide antibiotic argyrin

Description
The student will be trained to perform standard antimicrobial biassay, including quantitative analysis using the professional software Prism. The assay will be performed using argyrin analogues, and against a number of standard test organisms.

The role of polyadenylation in growth factor signalling.

Description
In this project, you will investigate if these mRNAs are indeed regulated by polyadenylation during growth factor stimulation and which RNA binding proteins mediate the poly(A) tail changes. Using bioinformatic analysis, you will identify RNA binding proteins likely to be involved in this regulation.

Discovery of GET peptides that specifically target drug therapies to children's brain tumours.

Description
This training project will be to isolate cancer-specific peptides using the phage system. The aim/hypothesis is that this approach will enable isolation of GET-versions that in the future can be used as drug delivery vectors.
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Biotechnology and Biological Sciences Doctoral Training Programme

The University of Nottingham
University Park
Nottingham, NG7 2RD

Tel: +44 (0) 115 8466946
Email: bbdtp@nottingham.ac.uk