Biotechnology and Biological Sciences Doctoral Training Programme
   
   
  

Molecules, Cells and Organisms projects

 

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Please note that the list of projects available will be increased over the next few weeks so please check frequently. Project details may also be subject to change before September 2017.

 

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View all Molecules, Cells and Organisms projects

Dark chocolate is best: Neural substrates of stimulus selection

Description
Selection of some incoming stimuli for further processing (while ignoring other stimuli) is essential for efficient cognitive processing and many everyday behaviours are triggered by environmental cues. Associative learning procedures test our ability to link a cue (conditioned stimulus, CS, e.g. food taste) with an outcome (unconditioned stimulus, US, e.g. illness). These procedures are readily adapted to measure cue competition with different stimuli and the salience of available cues is an important determinant of learning. The inherent features of the CS are one important determinant of salience, e.g. relative intensity or other facets which in effect determine how obvious the CS is relative to other available cues (intrinsic salience). Salience can also be based on past experience with a cue (acquired salience).

Using eye-tracking to investigate recognition memory

Description
Normal visual recognition memory requires communication between brain regions (especially the perirhinal cortex) and involve known, specific neurotransmitters. These uncontroversial conclusions have been drawn from the findings of experiments that use imaging, lesion and inactivation techniques with humans, primates and rodents.

Understanding DNA repair in adult tissues: Precision cut lung slices (PCLS) as a model for repair mechanisms and testing of gene editing strategies

Description
Triangle project:Developing precision cut lung slices as an ex vivo model to test novel gene therapies delivered by aerosol or dry powder inhaler

Investigating the differential regulation of cell surface GAG in breast cancer: Using NGPD to isolate cancer cell specific peptides

Description
In this project, we propose to identify cell-type specific variants in breast cancer patient samples in a high-throughput manner using phage display-libraries (1010 phage) of GET peptides and next-generation sequencing (NGS) in a process called next generation phage display (NGPD).

Molecular and in-silico interrogation of novel modes of binding at G protein-coupled receptors (GPCRs)

Description
We have recently identified, through advanced molecular modelling methods, a possible novel mode of binding of experimental subtype-selective ligands to beta adrenoceptors.The aim of this multidisciplinary project will be to design, synthesise and pharmacologically characterise a library of ligands to test this hypothesis more rigorously.

MicroRNA regulation on the inflammatory response

Description
This project aims to understand miRNA regulation in the context of the inflammatory response, in which cells rapidly switch on the production of many mRNAs that encode inflammatory proteins.

Molecular approaches to understanding allosteric modulation at the M1 Muscarinic Acetylcholine Receptor (mAChR)

Description
This chemical biology-focused project will span the disciplines of synthetic chemistry and pharmacology to increase our understanding of the M1 mAChR. With increasing numbers of allosteric ligands being discovered for the wider G protein-coupled receptor family, the results will be of direct relevance to many other important receptors.
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Biotechnology and Biological Sciences Doctoral Training Programme

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Email: bbdtp@nottingham.ac.uk