Biotechnology and Biological Sciences Doctoral Training Programme
   
   
  

Molecules, Cells and Organisms projects

 

Please note that the list of projects available will be increased over the next few weeks so please check frequently. Project details may also be subject to change before September 2018.

 

BBSRC Doctoral Training Partnerships

 

 

 

View all Molecules, Cells and Organisms projects

MicroRNA regulation on the inflammatory response

Description
This project aims to understand miRNA regulation in the context of the inflammatory response, in which cells rapidly switch on the production of many mRNAs that encode inflammatory proteins.

Molecular and in-silico interrogation of novel modes of binding at G protein-coupled receptors (GPCRs)

Description
We have recently identified, through advanced molecular modelling methods, a possible novel mode of binding of experimental subtype-selective ligands to beta adrenoceptors.The aim of this multidisciplinary project will be to design, synthesise and pharmacologically characterise a library of ligands to test this hypothesis more rigorously.

Understanding DNA repair in adult tissues: Precision cut lung slices (PCLS) as a model for repair mechanisms and testing of gene editing strategies

Description
This PhD project will assess DNA repair and gene editing in native human lung tissue with the same tissue architecture and biological activity as that found in the body. The project will use patient-derived precision cut lung slices (PCLS) in vitro a model, and explore the DNA repair activity in the different stem cells, and post-mitotic cells.

Molecular approaches to understanding allosteric modulation at the M1 Muscarinic Acetylcholine Receptor (mAChR)

Description
This chemical biology-focused project will span the disciplines of synthetic chemistry and pharmacology to increase our understanding of the M1 mAChR. With increasing numbers of allosteric ligands being discovered for the wider G protein-coupled receptor family, the results will be of direct relevance to many other important receptors.

A ligand-guided strategy for fluorescent labelling of native cellular receptors

Description
We have an internationally recognized track record in the design, synthesis and application of fluorescently conjugated G-Protein Coupled Receptor (GPCR) ligands. The hypothesis behind this project takes this concept and extends it to the design of molecules capable of covalently transferring a fluorescent cargo to a region of a GPCR distal to the ligand-binding site.
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Biotechnology and Biological Sciences Doctoral Training Programme

The University of Nottingham
University Park
Nottingham, NG7 2RD

Tel: +44 (0) 115 8466946
Email: bbdtp@nottingham.ac.uk