Biotechnology and Biological Sciences Doctoral Training Programme
   
   
  

Molecules, Cells and Organisms projects

 

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Please note that the list of projects available will be increased over the next few weeks so please check frequently. Project details may also be subject to change before September 2017.

 

BBSRC Doctoral Training Partnerships

 

 

 

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Exploring the Function of Gene Regulators by CRISPR CAS9 Genome Editing

Description
This project will utilise these cell lines in 'rescue' experiments by re-expression of wild type or mutant KAT6A to determine function. We will generate mutations in different functional domains in KAT6A to assess their requirement for regulation of a panel target genes by qPCR.

Transcription factor regulation by ubiquitination – molecular basis of how to activate or deactivate

Description
We will use structural biology tools to investigate the effect of mono-ubiquitination on the structure and interactions using biochemical and biophysical methods. In a second line of investigation we will characterise the interaction with the deubiquitinating enzyme USP17

Generation and characterisation of different human macrophage subsets using magnetic cell sorting, fluorescent microscopy and ELSIA

Description
Generation and characterisation of different human macrophage subsets using magnetic cell sorting, fluorescent microscopy and ELSIA
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Biotechnology and Biological Sciences Doctoral Training Programme

The University of Nottingham
University Park
Nottingham, NG7 2RD

Tel: +44 (0) 115 8466946
Email: bbdtp@nottingham.ac.uk