Jeff Fry

Contact

• workRoom E81 University of Nottingham Medical School
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 82 30160
• fax0115 82 30142
• jeff.fry@nottingham.ac.uk

Research Summary

My research is focused on the areas of reactive metabolite generation and toxicity, and regulation of cytoprotection systems

Recent Publications

• ABU BAKAR, M. F, MOHAMAD, M, RAHMAT, A and AND FRY, J. R., 2011. Bambangan (Mangifera pajang) seed kernel: antioxidant properties and anti-cancer effects. In: PREEDY, V. R, WATSON, R. R and PATEL, V. B., eds., Nuts and Seeds in Health and Disease Prevention Elsevier Inc.. 183-187
• ABU BAKAR, M. F, MOHAMAD, M, RAHMAT, A and BURR, S. A. AND FRY, J. R., 2010. Cytotoxicity and polyphenol diversity in selected parts of Mangifera pajang and Artocarpus odoratissimus fruits Nutrition & Food Science. 40, 29-38
• ABU BAKAR M. F. MOHAMAD M. RAHMAT A. BURR S. A and AND FRY J. R., 2010. Cytotoxicity, cell cycle arrest, and apoptosis in breast cancer cell lines exposed to an extract of the seed kernel of Mangifera pajang (bambangan) Food and Chemical Toxicology. 48, 1688-1697
• FAN, MING QI, BELL, ALEX R, BELL, DAVID R, CLODE, SALLY, FERNANDES, ALWYN, FOSTER, PAUL M D, FRY, JEFFREY R, JIANG, TAO, LOIZOU, GEORGE, MACNICOLL, ALAN, MILLER, BRIAN G, ROSE, MARTIN and SHAIKH-OMAR, OS, 2009. Recombinant expression of aryl hydrocarbon receptor for quantitative ligand-binding analysis. Analytical biochemistry. 384(2), 279-87

• View all publications

• ABU BAKAR, M. F, MOHAMAD, M, RAHMAT, A and AND FRY, J. R., 2011. Bambangan (Mangifera pajang) seed kernel: antioxidant properties and anti-cancer effects. In: PREEDY, V. R, WATSON, R. R and PATEL, V. B., eds., Nuts and Seeds in Health and Disease Prevention Elsevier Inc.. 183-187
• ABU BAKAR, M. F, MOHAMAD, M, RAHMAT, A and BURR, S. A. AND FRY, J. R., 2010. Cytotoxicity and polyphenol diversity in selected parts of Mangifera pajang and Artocarpus odoratissimus fruits Nutrition & Food Science. 40, 29-38
• ABU BAKAR M. F. MOHAMAD M. RAHMAT A. BURR S. A and AND FRY J. R., 2010. Cytotoxicity, cell cycle arrest, and apoptosis in breast cancer cell lines exposed to an extract of the seed kernel of Mangifera pajang (bambangan) Food and Chemical Toxicology. 48, 1688-1697
• FAN, MING QI, BELL, ALEX R, BELL, DAVID R, CLODE, SALLY, FERNANDES, ALWYN, FOSTER, PAUL M D, FRY, JEFFREY R, JIANG, TAO, LOIZOU, GEORGE, MACNICOLL, ALAN, MILLER, BRIAN G, ROSE, MARTIN and SHAIKH-OMAR, OS, 2009. Recombinant expression of aryl hydrocarbon receptor for quantitative ligand-binding analysis. Analytical biochemistry. 384(2), 279-87
• ABU BAKAR, M. F, MOHAMMED, M and RAHMAT, A. AND FRY, J. R., 2009. Phytochemicals and antioxidant activity of different parts of bambangan (Mangifera pajang) and tarap (Artocarpus odoratissimus) Food Chemistry. 113, 479-483
• GOTTSCHALG, E., MOORE, N. E., RYAN, A. K., TRAVIS, L. C., WALLER, R. C., PRATT, S., ATMACA, M., KIND, C. N. and FRY, J. R., 2006. Phenotypic anchoring of arsenic and cadmium toxicity in three hepatic-related cell systems reveals compound- and cell-specific selective up-regulation of stress protein expression: Implications for fingerprint profiling of cytotoxicity Chemico-Biological Interactions. 161(3), 251-261
• RAY, D. E. and FRY, J. R., 2006. A reassessment of the neurotoxicity of pyrethroid insecticides Pharmacology and Therapeutics. VOL 111(NUMBER 1), 174-193
• FARZANEH, P., ALLAMEH, A., PRATT, S., MOORE, N., TRAVIS, L., GOTTSCHALG, E., KIND, C. and FRY, J, 2005. Increased heat shock protein 70 expression following toxicant-mediated cytotoxicity: a ubiquitous marker of toxicant exposure? Alternatives to Laboratory Animals: ATLA. 33(2), 105-110
• THOMAS, R. J., BHANDARI, R., BARRETT, D. A., BENNETT, A. J., FRY, J. R., POWE, D., THOMSON, B. J. and SHAKESHEFF, K. M., 2005. The Effect of Three-Dimensional Co-Culture of Hepatocytes and Hepatic Stellate Cells on Key Hepatocyte Functions in vitro CELLS TISSUES ORGANS. VOL 181(NUMBER 2), 67-79
• FRY, J. R., HAMMOND, A. H., JASSI, K. L., BASS, A. E., BRUCE, G., LAUGHTON, C., SHAW, P. N., BYLOV, I. E. and KOVALENKO, S. M., 2004. Selectivity of 7-alkoxycoumarins as probe substrates for rat hepatic cytochrome P450 forms is influenced by the substitution pattern on the coumarin nucleus Xenobiotica. 34(8), 707-722
• EASTON, N., FRY, J., O'SHEA, E., WATKINS, A., KINGSTON, S. and MARSDEN, C. A., 2003. Synthesis, in vitro formation, and behavioural effects of glutathione regioisomers of alpha-methyldopamine with relevance to MDA and MDMA (ecstasy) Brain Research. VOL 987(NUMBER 2), 144-154
• RICCALTON-BANKS, LISA, LIEW, CLAIRE, BHANDARI, RENA, FRY, JEFFREY and SHAKESHEFF, KEVIN, 2003. Long-term culture of functional liver tissue: three-dimensional coculture of primary hepatocytes and stellate cells. Tissue Engineering. 9(3), 401-10
• GARLE, M. J. and FRY, J. R., 2003. Sensory nerves, neurogenic inflammation and pain: missing components of alternative irritation strategies? A review and a potential strategy Alternatives to Laboratory Animals: ATLA. VOL 31(PART 3), 295-316
• RICCALTON-BANKS, L., BHANDARI, R., FRY, J. and SHAKESHEFF, K. M., 2003. A simple method for the simultaneous isolation of stellate cells and hepatocytes from rat liver tissue Molecular and Cellular Biochemistry. VOL 248(NUMBER 1/2), 97-102
• HAMMOND, A. H., GARLE, M. J., SOORIAKUMARAN, P. and FRY, J. R., 2002. Modulation of hepatocyte thiol content by medium composition: implications for toxicity studies Toxicology In Vitro. 16(3), 259-265
• O SHEA, E., EASTON, N., FRY, J. R., GREEN, A. R. and MARSDEN, C. A., 2002. Protection against 3,4-methylenedioxymethamphetamine-induced neurodegeneration produced by glutathione depletion in rats is mediated by attenuation of hyperthermia Journal of Neurochemistry. VOL 81(PART 4), 686-695
• FRY, J. and GEORGE, E., 2001. In vitro toxicology in the light of new technologies Alternatives to Laboratory Animals: ATLA. VOL 29(PART 6), 745-748
• BHANDARI, R N, RICCALTON, L A, LEWIS, A L, FRY, J R, HAMMOND, A H, TENDLER, S J and SHAKESHEFF, K M, 2001. Liver tissue engineering: a role for co-culture systems in modifying hepatocyte function and viability. Tissue Engineering. 7(3), 345-57