Peter Jones

Contact

• workRoom D75 University of Nottingham Medical School
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 82 30123
• fax0115 82 30142
• peter.jones@nottingham.ac.uk

Research Summary

The research interest of the lab is directed in exploring how cell adhesion to the extracellular matrix regulates cell migration and cell fate through regulating the activity of signalling pathways… read more

Recent Publications

• GOUDEVENOU, K, MARTIN, P, YEH, YJ, JONES, P and SABLITZKY, F, 2011. Def6 Is Required For Convergent Extension Movements During Zebrafish Gastrulation Downstream Of Wnt5b Signaling Plos One. 6(10), -
• MEIJER, H.A., BUSHELL, M., HILL, K., GANT, T.W., WILLIS, A.E., JONES, P. and DE MOOR, C.H., 2007. A novel method for poly(A) fractionation reveals a large population of mRNAs with a short poly(A) tail in mammalian cells.<b>Nucleic Acids Research</b> Oxford University Press. Available at: <http://dx.doi.org/10.1093/nar/gkm830>
• WOODRUFF,M, JONES,P, FARRAR,D, GRANT,DM and SCOTCHFORD,CA, 2007. Human osteoblast cell spreading and vinculin expression upon biomaterial surfaces. Journal of molecular histology. 38(5), 491-9
• MAVRAKIS, K.J., MCKINLAY, K.J., JONES, P. and SABLITZKY, F., 2004. DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA Experimental Cell Research. 294(2), 335-344

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Current Research

The research interest of the lab is directed in exploring how cell adhesion to the extracellular matrix regulates cell migration and cell fate through regulating the activity of signalling pathways and gene expression. This involves looking at the reciprocal relationship between the ability of cells to modify their immediate surroundings through the synthesis of extracellular proteins and extracellular proteases and how the composition of the extracellular matrix, in turn, influences changes in gene expression through the coordinated activity or numerous signal transduction pathways. Ongoing projects include (1)investingation of the signalling crosstalk that takes place between collagen binding integrins and vascular endothelial growth factor receptor 2; (2) exploring the role of Def 6, a small GEF in organisation of cell contacts between cells of the immune sytem and (3) determining the consequences of tyrosine phosphorylation of the actin-binding protein cofilin and its potential roles in regulating gene expression and apoptosis.

• GOUDEVENOU, K, MARTIN, P, YEH, YJ, JONES, P and SABLITZKY, F, 2011. Def6 Is Required For Convergent Extension Movements During Zebrafish Gastrulation Downstream Of Wnt5b Signaling Plos One. 6(10), -
• MEIJER, H.A., BUSHELL, M., HILL, K., GANT, T.W., WILLIS, A.E., JONES, P. and DE MOOR, C.H., 2007. A novel method for poly(A) fractionation reveals a large population of mRNAs with a short poly(A) tail in mammalian cells.<b>Nucleic Acids Research</b> Oxford University Press. Available at: <http://dx.doi.org/10.1093/nar/gkm830>
• WOODRUFF,M, JONES,P, FARRAR,D, GRANT,DM and SCOTCHFORD,CA, 2007. Human osteoblast cell spreading and vinculin expression upon biomaterial surfaces. Journal of molecular histology. 38(5), 491-9
• MAVRAKIS, K.J., MCKINLAY, K.J., JONES, P. and SABLITZKY, F., 2004. DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA Experimental Cell Research. 294(2), 335-344
• FORD, J. L., JONES, P. and DOWNES, S., 2002. Cellularity of human annulus tissue: an investigation into the cellularity of tissue of different pathologies Histopathology. 41(6), 531-537
• WRIGHT, T.J., LEACH, L., SHAW, P.E. and JONES, P, 2002. Dynamics of vascular endothelial-cadherin and beta-catenin localization by vascular endothelial growth factor-induced angiogenesis in human umbilical vein cells. Experimental Cell Research. 280(2), 159-168
• OKAN, E., DREWETT, V., SHAW, P. E. and JONES, P., 2001. The small-GTPase RalA activates transcription of the urokinase plasminogen activator receptor (uPAR) gene via an AP1-dependent mechanism Oncogene. 20(15), 1816-1824
• MULLER, S. M., OKAN, E. and JONES, P., 2000. Regulation of Urokinase Receptor Transcription by Ras- and Rho-Family GTPases Biochemical and Biophysical Research Communications. VOL 270(PART 3), 892-898
• TRIGWELL, S, WOOD, L and JONES, P, 2000. Soluble urokinase receptor promotes cell adhesion and requires tyrosine-92 for activation of p56/59(hck). Biochemical and Biophysical Research Communications. 278(2), 440-6