Siobhan Loughna

Contact

• workRoom E170 The University of Nottingham Medical School
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 82 30178
• fax0115 82 30142
• siobhan.loughna@nottingham.ac.uk

Research Summary

This laboratory is broadly interested in the formation of the heart and vascular systems. Specifically, I aim to provide further insights into the role of genes in normal and abnormal cardiovascular… read more

Recent Publications

• RUTLAND, CS, POLO-PARADA, L, EHLER, E, ALIBHAI, A, THORPE, A, SUREN, S, EMES, RD, PATEL, B and LOUGHNA, S, 2011. Knockdown Of Embryonic Myosin Heavy Chain Reveals An Essential Role In The Morphology And Function Of The Developing Heart Development. 138(18), 3955-3966
• WALSH, R, RUTLAND, C, THOMAS, R and LOUGHNA, S, 2010. Cardiomyopathy: A Systematic Review Of Disease-Causing Mutations In Myosin Heavy Chain 7 And Their Phenotypic Manifestations Cardiology. 115(1), 49-60
• RUTLAND, C, WARNER, L, THORPE, A, ALIBHAI, A, ROBINSON, T, SHAW, B, LAYFIELD, R, BROOK, JD and LOUGHNA, S, 2009. Knockdown Of Alpha Myosin Heavy Chain Disrupts The Cytoskeleton And Leads To Multiple Defects During Chick Cardiogenesis Journal Of Anatomy. 214(6), 905-915
• CHING, Y.-H., GHOSH, T.K., CROSS, S.J., PACKHAM, E.A., HONEYMAN, L., LOUGHNA, S., ROBINSON, T.E., DEARLOVE, A.M., RIBAS, G., BONSER, A.J., THOMAS, N.R., SCOTTER, A.J., CAVES, L.S.D., TYRRELL, G.P., NEWBURY-ECOB, R.A., MUNNICH, A., BONNET, D. and BROOK, J.D., 2005. Mutation in myosin heavy chain 6 causes atrial septal defect Nature Genetics. 37(4), 423-428

• View all publications

Current Research

This laboratory is broadly interested in the formation of the heart and vascular systems. Specifically, I aim to provide further insights into the role of genes in normal and abnormal cardiovascular development. Currently, our main focus is structural proteins. We are investigating a number of different structual proteins to determine their role in development.

Past Research

I have worked on early stages of vascular kidney development, and the roles of the Angiopoietin/Tie signalling system in cardiovascular development.

Future Research

I am interested in any transcription factor or structural protein which is important in early stages of cardiovascular development.

• RUTLAND, CS, POLO-PARADA, L, EHLER, E, ALIBHAI, A, THORPE, A, SUREN, S, EMES, RD, PATEL, B and LOUGHNA, S, 2011. Knockdown Of Embryonic Myosin Heavy Chain Reveals An Essential Role In The Morphology And Function Of The Developing Heart Development. 138(18), 3955-3966
• WALSH, R, RUTLAND, C, THOMAS, R and LOUGHNA, S, 2010. Cardiomyopathy: A Systematic Review Of Disease-Causing Mutations In Myosin Heavy Chain 7 And Their Phenotypic Manifestations Cardiology. 115(1), 49-60
• RUTLAND, C, WARNER, L, THORPE, A, ALIBHAI, A, ROBINSON, T, SHAW, B, LAYFIELD, R, BROOK, JD and LOUGHNA, S, 2009. Knockdown Of Alpha Myosin Heavy Chain Disrupts The Cytoskeleton And Leads To Multiple Defects During Chick Cardiogenesis Journal Of Anatomy. 214(6), 905-915
• CHING, Y.-H., GHOSH, T.K., CROSS, S.J., PACKHAM, E.A., HONEYMAN, L., LOUGHNA, S., ROBINSON, T.E., DEARLOVE, A.M., RIBAS, G., BONSER, A.J., THOMAS, N.R., SCOTTER, A.J., CAVES, L.S.D., TYRRELL, G.P., NEWBURY-ECOB, R.A., MUNNICH, A., BONNET, D. and BROOK, J.D., 2005. Mutation in myosin heavy chain 6 causes atrial septal defect Nature Genetics. 37(4), 423-428
• SATO, T N, LOUGHNA, S, DAVIS, E C, VISCONTI, R P and RICHARDSON, C D, 2002. Selective functions of angiopoietins and vascular endothelial growth factor on blood vessels: the concept of "vascular domain". Cold Spring Harbor Symposia on Quantitative Biology. 67, 171-80
• LOUGHNA,S., 2002. Vascular development. In: Mouse development: patterning, morphogenesis and organogenesis. Academic Press, Incorporated, Orlando, Florida, USA.
• LOUGHNA, S. and SATO, T. N., 2001. A combinatorial role of angiopoietin-1 and orphan receptor TIE1 pathways in establishing vascular polarity during angiogenesis Molecular Cell. 7(1), 233-239
• LOUGHNA, S. and SATO, T. N., 2001. Angiopoietin and Tie signaling pathways in vascular development Matrix Biology. 20(5-6), 319-325
• MOTOIKE, T, LOUGHNA, S, PERENS, E, ROMAN, B L, LIAO, W, CHAU, T C, RICHARDSON, C D, KAWATE, T, KUNO, J, WEINSTEIN, B M, STAINIER, D Y and SATO, T N, 2000. Universal GFP reporter for the study of vascular development. Genesis. 28(2), 75-81
• LOUGHNA, S, YUAN, H T and WOOLF, A S, 1998. Effects of oxygen on vascular patterning in Tie1/LacZ metanephric kidneys in vitro. Biochemical and Biophysical Research Communications. 247(2), 361-6
• WOOLF, A S and LOUGHNA, S, 1998. Origin of glomerular capillaries: is the verdict in? Experimental nephrology.. 6(1), 17-21
• LOUGHNA, S, HARDMAN, P, LANDELS, E, JUSSILA, L, ALITALO, K and WOOLF, A S, 1997. A molecular and genetic analysis of renalglomerular capillary development. Angiogenesis. 1(1), 84-101
• LOUGHNA, S, LANDELS, E and WOOLF, A S, 1996. Growth factor control of developing kidney endothelial cells. Experimental nephrology.. 4(2), 112-8
• LOUGHNA, S, BENNETT, P and MOORE, G, 1995. Molecular analysis of the expression of transthyretin in intestine and liver from trisomy 18 fetuses. Human Genetics. 95(1), 89-95
• HENDERSON, D J, SHERMAN, L S, LOUGHNA, S C, BENNETT, P R and MOORE, G E, 1994. Early embryonic failure associated with uniparental disomy for human chromosome 21. Human Molecular Genetics. 3(8), 1373-6
• NEWTON, R, STANIER, P, LOUGHNA, S, HENDERSON, D J, FORBES, S A, FARRALL, M, JENSSON, O and MOORE, G E, 1994. Linkage analysis of 62 X-chromosomal loci excludes the X chromosome in an Icelandic family showing apparent X-linked recessive inheritance of neural tube defects. Clinical genetics.. 45(5), 241-9
• LOUGHNA, S, BENNETT, P, GAU, G, NICOLAIDES, K, BLUNT, S and MOORE, G, 1993. Overexpression of esterase D in kidney from trisomy 13 fetuses. American Journal of Human Genetics. 53(4), 810-6
• BENNETT, P, VAUGHAN, J, HENDERSON, D, LOUGHNA, S and MOORE, G, 1992. Association between confined placental trisomy, fetal uniparental disomy, and early intrauterine growth retardation. Lancet. 340(8830), 1284-5