Susan Chan

Contact

• workRoom E34C The University of Nottingham Medical School
• work0115 82 30150
• fax0115 82 30081
• sue.chan@nottingham.ac.uk

Expertise Summary

Nutrient homeostasis in the body involves the complex interplay of a number of hormones, neurotransmitters and several target tissues. Insulin is the most important hormonal regulator of these metabolic processes, which include promotion of nutrient storage and synthetic processes, and regulation of energy supply to tissues. Insufficient insulin results in a condition of diabetes mellitus, in which nutrient homeostasis becomes deranged and excess glucose accumulates in the body (hyperglycaemia).

My main research interest lies in understanding how nutrients regulate insulin secretion.

Stimulus-secretion coupling in the islet B-cell is well-researched but our knowledge remains limited in many areas with this very complex system, in which metabolism is closely tied into insulin biosynthesis and exocytosis. The research aim of the group is to generate information to provide for a richer understanding of the control of insulin secretion and thus, ultimately, for the development of new and strategically-targetted therapeutic agents to regulate the release of insulin.

Research Techniques/Expertise

• Isolation and manipulation of isolated islets of Langerhans
• In vitro insulin secretion studies
• Ligand binding
• Protein analysis and purification
• Monoclonal and polyclonal antibody production

Research Interests

• Diabetes
• Stimulus-secretion coupling and insulin secretion
• Imidazoline receptors and endogenous ligands
• ATP-sensitive potassium channels
• Adrenoceptors

Research Summary

Diabetes Stimulus-secretion coupling and insulin secretion Imidazoline receptors and endogenous ligands ATP-sensitive potassium channels Adrenoceptors

Recent Publications

• TAYLOR, J.P., JACKSON, D.A., MORGAN, N.G. and CHAN, S.L. F, 2006. Rhes expression in pancreatic beta-cells is regulated by efaroxan in a calcium-dependent process. Biochemical and Biophysical Research Communications. 349(2), 809-815
• PRELL, G. D., MARTINELLI, G. P., HOLSTEIN, G. R., MATULIC-ADAMIC, J., WATANABE, K. A., CHAN, S. L. F., MORGAN, N. G., HAXHIU, M. A. and ERNSBERGER, P., 2004. Imidazoleacetic acid-ribotide: An endogenous ligand that stimulates imidazol(in)e receptors Proceedings of the National Academy of Sciences of the United States of America. 101(37), 13677-13682
• BLAND, ROSEMARY, MARKOVIC, DANIJELA, HILLS, CLAIRE E, HUGHES, SUSAN V, CHAN, SUSAN L F, SQUIRES, PAUL E and HEWISON, MARTIN, 2004. Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in pancreatic islets. Journal of Steroid Biochemistry and Molecular Biology. 89-90(1-5), 121-5
• WANG, M., DUNN, W.R., CHAN, S.L., GARFIELD, B. and WILSON, V.G, 2003. Evidence for nonadrenoceptor responses to imidazoline derivatives in the porcine isolated rectal artery. Annals of the New York Academy of Sciences. 1009, 386-91

• View all publications

• TAYLOR, J.P., JACKSON, D.A., MORGAN, N.G. and CHAN, S.L. F, 2006. Rhes expression in pancreatic beta-cells is regulated by efaroxan in a calcium-dependent process. Biochemical and Biophysical Research Communications. 349(2), 809-815
• PRELL, G. D., MARTINELLI, G. P., HOLSTEIN, G. R., MATULIC-ADAMIC, J., WATANABE, K. A., CHAN, S. L. F., MORGAN, N. G., HAXHIU, M. A. and ERNSBERGER, P., 2004. Imidazoleacetic acid-ribotide: An endogenous ligand that stimulates imidazol(in)e receptors Proceedings of the National Academy of Sciences of the United States of America. 101(37), 13677-13682
• BLAND, ROSEMARY, MARKOVIC, DANIJELA, HILLS, CLAIRE E, HUGHES, SUSAN V, CHAN, SUSAN L F, SQUIRES, PAUL E and HEWISON, MARTIN, 2004. Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in pancreatic islets. Journal of Steroid Biochemistry and Molecular Biology. 89-90(1-5), 121-5
• WANG, M., DUNN, W.R., CHAN, S.L., GARFIELD, B. and WILSON, V.G, 2003. Evidence for nonadrenoceptor responses to imidazoline derivatives in the porcine isolated rectal artery. Annals of the New York Academy of Sciences. 1009, 386-91
• CHAN, S.L.F., MONKS, L.K., GAO, H., DEAVILLE, P. and MORGAN, N.G, 2002. Identification of the monomeric G-protein, Rhes, as an efaroxan-regulated protein in the pancreatic beta-cell. British Journal of Pharmacology. 136(1), 31-36
• MINYAN, W, . DUNN, W. R., BLAYLOCK, N. A., CHAN, S. L.F. and WILSON, V.G, 2001. Evidence for a non-adrenoceptor, imidazoline-mediated contractile response to oxymetazoline in the porcine isolated rectal artery. British Journal of Pharmacology. 132(7), 1359-1363
• CHAN, S.L.F., MOURTADA, M. and MORGAN, N.G, 2001. Characterization of a KATP channel-independent pathway involved in potentiation of insulin secretion by efaroxan. Diabetes. 50(2), 340-7
• MORGAN, N. G. and CHAN, S. L. F., 2001. Imidazoline Binding Sites in the Endocrine Pancreas: Can They Fulfil Their Potential as Targets for the Development of New Insulin Secretagogues? Current Pharmaceutical Design. VOL 7(PART 14), 1413-1432
• HøY, M, CHAN, S L, WENG, X G and GROMADA, J, 2001. Clonidine-displacing substance reduces glucagon secretion from mouse pancreatic alpha-cells by K(ATP)-channel-independent inhibition of exocytosis. Biochemical and Biophysical Research Communications. 288(2), 309-12