Vincent Wilson

Contact

• workRoom E34b The University of Nottingham Medical School
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 82 30189
• fax0115 82 30142
• vince.wilson@nottingham.ac.uk

Research Summary

Interests

• The effect of dietary flavonoids and manipulation cellular cholesterol on vascular function
• Autonomic neurotransmission in vascular and gastrointestinal muscle.
• Bacterial products and the interaction between immune systems and the vasculature

Techniques

• Isometric tension recording of large and small blood vessels (wire myography).
• Radioligand binding and cyclic nucleotide measurements in smooth muscle.
• Flow cytometry.

Projects

• The effect of statins and manipulation of cellular cholesterol on smooth muscle, endothelial and nervous functionPharmacological strategies for treating faecal incontinence and haemorrhoids (Norgine and Pfizer, UK)
• An integrated assessment of the ability of dietary flavonoids to improve vascular function (BBSRC)
• Steroids and sepsis: Development of an in vitro human model to evaluate the effects of glucocorticoids on vascular reactivity (European Anaesthetic Society).

Centre Collaborators

• Dr. William Dunn
• Dr. Ravi Mahajan
• Dr. Moira Taylor

UK Collaborators

• Professor John Scholefield (Department of Surgery University of Nottingham).
• Professor D, Pritchard (School of Pharmaceutical Sciences, University of Nottingham).
• Dr David Hughes (BBSRC Insitute of Food Research, Colney Lane Norwich)

International Collaborators

• Dr James Brock (Prince of Wales Medical Research Institute, Sydney, Austraila).

Recent Publications

• AL-SHALMANI S, SURI S, HUGHES DA, KROON PA, NEEDS PW, TAYLOR MA, TRIBOLO S and WILSON VG, 2011. Quercetin and its principal metabolites, but not myricetin, oppose lipopolysaccharide-induced hyporesponsiveness of the porcine isolated coronary artery. British Journal of Pharmacology. 162(7), 1485-1497
• LOHSIRIWAT V, SCHOLEFIELD J, DASHWOOD MR and WILSON VG, 2011. Pharmacological characteristics of endothelin receptors on sheep rectal blood vessels. Pharmacological Research. 63(6), 490-495
• SURI S, LIU XH, RAYMENT S, HUGHES DA, KROON PA, NEEDS PW, TAYLOR MA, TRIBOLO S and WILSON VG, 2010. Quercetin and its major metabolites selectively modulate cyclic GMP-dependent relaxations and associated tolerance in pig isolated coronary artery. British Journal of Pharmacology. 159(3), 566-575
• RAYMENT SJ, EAMES T, SIMPSON JA, DASHWOOD MR, HENRY Y, GRUSS H, ACHESON A, SCHOLEFIELD J and WILSON VG, 2010. Investigation of the distribution and function of alpha-adrenoceptors in the sheep isolated internal anal sphincter. British Journal of Pharmacology. 160(7), 1727-1740

• View all publications

Future Research

I have a long-standing interest in the pharmacological properties of isolated blood vessels, with particular interest in the factors that influence the functional expression of the receptors negatively-coupled to adenylyl cyclase and the activity of compounds of microbial origin.

• AL-SHALMANI S, SURI S, HUGHES DA, KROON PA, NEEDS PW, TAYLOR MA, TRIBOLO S and WILSON VG, 2011. Quercetin and its principal metabolites, but not myricetin, oppose lipopolysaccharide-induced hyporesponsiveness of the porcine isolated coronary artery. British Journal of Pharmacology. 162(7), 1485-1497
• LOHSIRIWAT V, SCHOLEFIELD J, DASHWOOD MR and WILSON VG, 2011. Pharmacological characteristics of endothelin receptors on sheep rectal blood vessels. Pharmacological Research. 63(6), 490-495
• SURI S, LIU XH, RAYMENT S, HUGHES DA, KROON PA, NEEDS PW, TAYLOR MA, TRIBOLO S and WILSON VG, 2010. Quercetin and its major metabolites selectively modulate cyclic GMP-dependent relaxations and associated tolerance in pig isolated coronary artery. British Journal of Pharmacology. 159(3), 566-575
• RAYMENT SJ, EAMES T, SIMPSON JA, DASHWOOD MR, HENRY Y, GRUSS H, ACHESON A, SCHOLEFIELD J and WILSON VG, 2010. Investigation of the distribution and function of alpha-adrenoceptors in the sheep isolated internal anal sphincter. British Journal of Pharmacology. 160(7), 1727-1740
• ACHESON A, RAYMENT S, EAMES T, MUNDEY M, NISAR P, SCHOLEFIELD J and WILSON VG, 2009. Investigation of the role of adrenergic and non-nitrergic, non-adrenergic neurotransmission in the sheep isolated internal anal sphincter. Neurogastroenterology and Motility. 21(3), 335-345
• TRIBOLO S, LODI F, CONNOR C, SURI S, WILSON VG, TAYLOR MA, NEEDS PW, KROON PA and HUGHES DA, 2008. Comparative effects of quercetin and its predominant human metabolites on adhesion molecule expression in activated human vascular endothelial cells Atherosclerosis.. 197(1), 50-56
• SURI S, TAYLOR MA, VERITY A, TRIBOLO S, NEEDS PW, KROON PA, HUGHES DA and WILSON VG, 2008. A comparative study of the effects of quercetin and its glucuronide and sulfate metabolites on human neutrophil function in vitro. Biochemical Pharmacology. 76(5), 645-653
• QI, W, WEI, J X, DORAIRAJ, I, MAHAJAN, R P and WILSON, V G, 2007. Evidence that a prostanoid produced by cyclo-oxygenase-2 enhances contractile responses of the porcine isolated coronary artery following exposure to lipopolysaccharide. British Journal of Anaesthesia. 98(3), 323-30
• JONAS-OBICHERE, M., SCHOLEFIELD, J.H., ACHESON, A., MUNDEY, M., TYLER, H. and WILSON, V.G., 2005. Comparison of the effects of nitric oxide donors and calcium channel blockers on the intrinsic myogenic tone of sheep isolated internal anal sphincter British Journal of Surgery. 92(10), 1263-1269
• ACHESON, A. G., GRIFFIN, N., SCHOLEFIELD, J. H. and WILSON, V. G., 2003. l-Arginine-induced relaxation of the internal anal sphincter is not mediated by nitric oxide British Journal of Surgery. 90(9), 1155-1162
• MINYAN, W, . DUNN, W. R., BLAYLOCK, N. A., CHAN, S. L.F. and WILSON, V.G, 2001. Evidence for a non-adrenoceptor, imidazoline-mediated contractile response to oxymetazoline in the porcine isolated rectal artery. British Journal of Pharmacology. 132(7), 1359-1363
• MUNDEY, M K, JONAS, M, WORTHLEY, T, SCHOLEFIELD, J H and WILSON, V G, 2000. Pharmacological characterization of neurogenic responses of the sheep isolated internal anal sphincter. British Journal of Pharmacology. 130(3), 489-94
• TING, N, THAMBYRAJA, A, SUGDEN, D, SCALBERT, E, DELAGRANGE, P and WILSON, V G, 2000. Pharmacological studies on the inhibitory action of melatonin and putative melatonin analogues on porcine vascular smooth muscle. Naunyn-Schmiedeberg's Archives of Pharmacology. 361(3), 327-33
• LAWRENCE, R. N., DUNN, W. R., BYCROFT, B., CAMARA, M., CHHABRA, S. R., WILLIAMS, P. and WILSON, V. G., 1999. The Pseudomonas aeruginosa quorum-sensing signal molecule, N-(3-oxododecanoyl)-L-homoserine lactone, inhibits porcine arterial smooth muscle contraction British Journal of Pharmacology. VOL 128(NUMBER 4), 845-848
• LAWRENCE, R N, CLELLAND, C, BEGGS, D, SALAMA, F D, DUNN, W R and WILSON, V G, 1998. Differential role of vasoactive prostanoids in porcine and human isolated pulmonary arteries in response to endothelium-dependent relaxants. British Journal of Pharmacology. 125(6), 1128-37
• LAWRENCE, R N, DUNN, W R and WILSON, V G, 1998. Endothelium-dependent relaxation in response to ethanol in the porcine isolated pulmonary artery. Journal of Pharmacy and Pharmacology. 50(8), 885-90
• ALI, A, CHENG, H Y, TING, K N and WILSON, V G, 1998. Rilmenidine reveals differences in the pharmacological characteristics of prejunctional alpha2-adrenoceptors in the guinea-pig, rat and pig. British Journal of Pharmacology. 125(1), 127-35
• LAWRENCE, R. N., DUNN, W. R. and WILSON, V. G., 1997. Evidence for different mechanisms of relaxation by ethanol in isolated pulmonary and coronary arteries from the pig British Journal of Pharmacology. VOL 122(SUPP 1), 140P
• WILSON, V.G., LAWRENCE, R.N. and DUNN, W.R., 1997. Endothelium-dependent responses to acetylcholine in the porcine isolated pulmonary artery Journal of Vascular Research. 34(Supplement 1), 26
• TING, K N, DUNN, W R, DAVIES, D J, SUGDEN, D, DELAGRANGE, P, GUARDIOLA-LEMAîTRE, B, SCALBERT, E and WILSON, V G, 1997. Studies on the vasoconstrictor action of melatonin and putative melatonin receptor ligands in the tail artery of juvenile Wistar rats. British Journal of Pharmacology. 122(7), 1299-306
• TING, K. N., DAVIS, D. J., SCALBERT, E., DELAGRANGE, P., SUGDEN, D. and WILSON, V. G., 1997. Constant lighting does not affect the functional response of ML~1-like receptor in the tail artery of juvenile Wistar rats British Journal of Pharmacology. VOL 120(NUMBER 6//SUP), 45P
• TOMLINSON, A.E. and WILSON, V.G., 1997. Differential effects of isoprenaline and forskolin on cyclic AMP production in the porcine coronary artery Journal of Vascular Research. 34(Supplement 1), 40
• TAMBYRAJA, A., WILSON, V.G. and LOT, T.Y., 1997. A role for endothelin and a prostanoid in ODQ-induced contractions of the porcine isolated splenic artery Journal of Vascular Research. 34(Supplement 1), 44
• RANDALL, V A, MACLENNAN, S J, MARTIN, G R and WILSON, V G, 1996. The effect of forskolin on 5-HT1-like and angiotensin II-induced vasoconstriction and cyclic AMP content of the rabbit isolated femoral artery. British Journal of Pharmacology. 118(3), 627-34