Cardiovascular research
The Importance of Cardiovascular Research
Our group is concerned with how smooth muscle in blood vessels, the gastrointestinal and respiratory systems and the bladder is controlled and affected by drugs. While we are mainly a cardiovascular group, interest and expertise is now applied to other systems to examine the role of smooth muscle.
Our Cardiovascular Research Interests
We are interested in the control of smooth muscle by autonomic nerves (including co-transmission and purines), the endothelium (both as a semi-permeable barrier and through the release of mediators such as nitric oxide and the endothelium-derived hyperpolarizing factor, EDHF), the role of gap junctions and novel mediators such as endocannabinoids and hydrogen sulphide. Our interests are in the control of function and the underlying mechanisms, involving cell signalling (eg Rho kinase activity, peroxisome proliferator-activated receptors, tyrosine phosphorylation) and ion channel function in normal physiology and in diseases such as hypertension, diabetes and pre-eclampsia.
For more information, please email Dr Michael Randall .
See research degree opportunities related to this group .
Group Publications
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- Purinergic Signal; Alexander, S.P.H. and Ralevic, V.
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- Microcirculation; Leach, L. and Mann, G.E.
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- Microcirculation; Leach, L.