Lipid signalling in Health and Disease
The Importance of Research in Lipid Signalling in Health and Disease
Lipids are crucial mediators of a host of molecular and cellular processes. Our research group investigates the contribution of bioactive lipids in a variety of physiological and pathophysiological settings. Endocannabinoids are small, ubiquitously expressed signalling lipids, and we have made significant contributions to the understanding of their function and metabolism, including their quantification in biological samples by liquid chromatography mass spectrometry.
Our Research Interests in Lipid Signalling in Health and Disease
Our research encompasses a broad spectrum of activities, from classical receptor pharmacology through to the control of gene expression by direct interactions with transcription factors. The functional effects of bioactive lipids, such as the endocannabinoid anandamide, on neuronal activity are investigated with calcium imaging and electrophysiological approaches. Our research has relevance to a wide range of diseases including pain, Alzheimer’s, cancer, diabetes, liver disease and cardiovascular disease.
For more information, please email Professor Victoria Chapman
See research degree opportunities related to this group .
Arthritis Research UK Pain Centre
The work of the Arthritis Research UK Pain Centre has been spotlighted in a report recently published by Universities UK and Research Councils UK called Big Ideas for the Future.
Group Publications
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- J Neurochem; Sarmad, S., Alexander, S.P., Barrett, D.A., Marsden, C.A., and Kendall, D.A.
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- Pain; Lichtman, A.H. and Chapman, V.