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Simon Langley-Evans

Head of School of Biosciences & Professor of Human Nutrition, Faculty of Science

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Biography

Professor Simon Langley-Evans graduated from the University of London in 1986 with a first class honours degree in Biochemistry with Microbiology. He studied for his PhD in the Department of Human Nutrition at the University of Southampton, under the supervision of Dr David York. He graduated in 1990 and after a period of postdoctoral work at both Southampton and the United Medical and Dentist School in London he obtained a Wellcome Trust Career Development Fellowship. He has subsequently held lectureship positions at the University of Southampton, University College Northampton and University of Nottingham.

Professor Langley-Evans was awarded a personal Chair in Human Nutrition in 2005. His research expertise lies in the area of the Developmental Origins of Adult Disease, where he has conducted pioneering work in the development of experimental models of nutritional programming. He is the author of over 140 peer reviewed papers and in 2009 published an undergraduate textbook entitled, "Nutrition: A Lifespan Approach." The second edition, "Nutrition, Health and Disease" was published in 2015. In 2005 he was awarded the Nutrition Society Silver Medal and in 2012 received his DSc from the University of Nottingham. Professor Langley-Evans is the Editor of the Journal of Human Nutrition and Dietetics.

Teaching Summary

Professor Langley-Evans has over 20 years experience of undergraduate teaching experience. He is not teaching during his tenure as Head of School of Biosciences. He is an assessor for the Nutrition… read more

Research Summary

Professor Langley-Evans' research focuses on the early life origins of adult disease. A wide range of epidemiological evidence suggests that there is a strong and significant relationship between… read more

Selected Publications

Professor Langley-Evans is currently the Head of the School of Biosciences.

His external roles include:

Editor-in-Chief of the Journal of Human Nutrition and Dietetics

BBSRC Pool of Experts

Member of Registration Committee for the Association for Nutrition

In the last few years Professor Langley-Evans has been a member of the Nutrition Society Council and the Medical Research Council College of Experts. He was a member of the RERAD Mid Programme Review Panel for the Scottish Government, 2008-2009.

Professor Langley-Evans has over 20 years experience of undergraduate teaching experience. He is not teaching during his tenure as Head of School of Biosciences. He is an assessor for the Nutrition Society's course accreditation scheme and has been an external examiner for undergraduate and PGT courses at the University of Sheffield, Robert Gordon University and the University of Plymouth.

Current Research

Professor Langley-Evans' research focuses on the early life origins of adult disease. A wide range of epidemiological evidence suggests that there is a strong and significant relationship between impairment of fetal growth and risk of coronary heart disease, hypertension and non-insulin-dependent diabetes in later life. The work in the Langley-Evans laboratory focuses on the contribution of maternal nutritional status to this programming of adult disease risk. Manipulation of the protein content, amino acid composition or fatty acid balance within the diets of pregnant rats has been demonstrated to induce lifelong hypertension in their offspring and to establish a wide range of physiological and metabolic abnormalities. Professor Langley-Evans current work in this area focuses on the elucidation of molecular and physiological mechanisms that underpin the association between maternal nutrition and altered functions in the adult offspring.

Use of RNA sequencing and proteomics techniques will enable a systematic approach to the search for candidate mechanisms. These studies are considering the impact of diet upon the developing hypothalamic-pituitary axis, renin-angiotensin system and the structure and function of the kidney. The expression of transcription factors, including the sterol response element binding proteins and peroxisome proliferator activated receptors, is disturbed by prenatal undernutrition. Langley-Evans work is considering how such changes, and how the additional challenge of ageing impact upon metabolic functions. The balance of oxidative and antioxidant processes in key tissues may also be subject to the programming effects of maternal diet in pregnancy. This could impact upon the ageing process, resulting in accelerated degeneration of key physiological functions and reduced lifespan.

Orcid ID: orcid.org/0000-0002-1969-8416 Broad research areas

Early life origins of disease Pregnancy nutrition Animal models of healthy ageing Infant feeding Obesity and the metabolic syndrome Specific Projects Finding biomarkers that predict heart disease at birth Fetal programming of the cell cycle Fetal programming and the insulin signalling pathway Intergenerational programming of reno-vascular function Maternal trans-fats and cardiovascular disease Fetal programming of kidney disease: the effect of sex Magnesium and vascular endothelial cell function Programming of behaviour Bumps and Beyond: an antenatal weight management intervention Nutrition policy in Uganda The Botswana Infant Nutrition Project Managing Weight in Pregnancy (MAGIC)

School of Biosciences

University of Nottingham
Sutton Bonington Campus
Nr Loughborough
LE12 5RD, UK

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