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Eunice Ngai

Assistant Professor, Faculty of Science

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Teaching Summary

I am primarily involved in the teaching in the following modules:

1. Biotechnology in Animal Physiology (D235Z1)

2. Introduction to Animal Physiology (D212Z5)

3. Applied Bioethics: Sustainable Food Production, Biotechnology and the Environment (D236Z6)

Research Summary

Targeting epigenetics for cancer therapy in invasive lobular carcinoma of the breast.

Selected Publications

Past Research

DNA methylation and histone deacetylation as the silencing factors of tumor suppressor gene in human breast adenocarcinoma cell line.

5-azacytidine and Trichostatin A enhance the expression of E-cadherin (CDH1) tumor suppressor gene in human breast adenocarcinoma cell lines.

Transgene silencing following lentiviral gene delivery into hematopoietic stem cells.

Purification and reaction of a recombinant lipase from Bacilus sp. Strain 42.

  • SHAIMAA AHMED SALEEM AL ODEH, WEI YANG KONG, SONIA HOW MING WONG and SIEW CHING NGAI, 2017. Effects of epigenetic drugs Zebularine and Trichostatin A on human breast adenocarcinoma cells. In: 28th Intervarsity Biochemistry Seminar, UCSI University, Kuala Lumpur.
  • SONIA HOW MING WONG, CHEE MUN FANG, SANDY HWEI SAN LOH and SIEW CHING NGAI, 2017. The potential of epigenetic drugs, Trichostatin A and Zebularine, in sensitizing the triple negative breast cancer cell line, MDA-MB-231, towards TRAIL apoptosis-inducing effect. In: 2nd Global Insight Conference on Breast Cancer, Rome, Italy.
  • YUAN SENG WU, SIEW CHING NGAI, BEY-HING GOH, KOK-GAN CHAN, LEARN-HAN LEE and LAY-HONG CHUAH, 2017. Anti-cancer activity of surfactin and potential application of nanotechnology assisted surfactin delivery Frontiers in Pharmacology. 8, 761
  • SONIA HOW MING WONG, CHEE MUN FANG, LAY-HONG CHUAH, CHEE ONN LEONG and SIEW CHING NGAI, 2017. E-cadherin: Its dysregulation in carcinogenesis and clinical implications. Critical Reviews in Oncology/Hematology. (In Press.)
  • SONIA WONG, CM FANG, HS LOH and SC NGAI, 2016. TRAIL, an anti-cancer agent which does not kill the healthy cells. In: UNMC Research Showcase 2016.
  • SIEW CHING NGAI, 2016. Breaking the wall of breast cancer. In: Falling Walls Lab Malaysia 2016. AIMST University, Malaysia.
  • JUN YEN NG, RHUN YIAN KOH, PREMDASS RAMDAS and SIEW CHING NGAI, 2016. Re-expression of CDH1 tumour suppressor gene by 5-azacytidine and Trichostatin A reduces metastatic breast cancer cell proliferation and migration rates. In: 2nd Annual Epigenetics Discovery Congress, London, United Kingdom.
  • SONIA HOW MING WONG, CHEE MUN FANG, SANDY HWEI SAN LOH and SIEW CHING NGAI, 2016. The epigenetic drugs Zebularine and Trichostatin A treatment followed by Tumour Necrosis Factor-related Apoptosis Inducing Ligand (TRAIL) potentially induce apoptosis in drug resistant breast adenocarcinoma cells. In: Monash Science Symposium, Monash University, Malaysia.
  • WEI YANG KONG, AMELIA FARAHANI BINTI ZULKIFLI, THIEN TON NU QUY, SOPHIA SOK PING MEOW, SONIA HOW MING WONG and SIEW CHING NGAI, 2016. The Effects of epigenetic drugs Zebularine and Scriptaid on breast cancer cells. In: Monash Science Symposium, Monash University, Malaysia.
  • SULEIMAN Y. ALHAJI, OMAR HABIB, SHARIZA NORDIN, LAI M. I, NGAI S. CHING and SYAHRIL ABDULLAH, 2016. Stable lentiviral gene expression driven by constitutive promoters in mouse pluripotent stem cells. In: 6th Malaysian Tissue Engineering and Regenerative Medicine Scientific Meeting (6th MTERMS) 2016 and 2nd Malaysian Stem Cell Meeting, Seberang Jaya, Penang.
  • SIEW CHING NGAI, ROZITA ROSLI, AKRAM AL ABBAR and SYAHRIL ABDULLAH, 2015. DNA methylation and histone modifications are the molecular lock in lentivirally-transduce hematopoietic progenitor cells. Biomed Research International. 2015, 346134
  • POH TEE LOW, MEI AI LAI, SIEW CHING NGAI and SYAHRIL ABDULLAH, 2014. Transgene expression from CpG-reduced lentiviral gene delivery vectors in vitro. Gene. 533, 451-455
  • SIEW CHING NGAI, ROZITA ROSLI, RAJESH RAMASAMY and SYAHRIL ABDULLAH, 2014. Decline in gene expression of the genetically modified hematopoietic stem cells following transplantation. Regenerative Medicine. 3(2), 124-126
  • SIEW CHING NGAI, ROZITA ROSLI, RAJESH RAMASAMY and SYAHRIL ABDULLAH, 2013. Comparison of efficiency and persistency of transgene expression delivered via viral and non-viral methods. In: International Congress on Chemical Biological and Environmental Sciences, Bali, Indonesia..
  • SIEW CHING NGAI, RAJESH RAMASAMY and SYAHRIL ABDULLAH, 2012. Production of lentivirus carrying green fluorescent protein with different promoters for in vitro gene transfer. Pertanika Journal of Science and Technology. 20(2), 269-281
  • SIEW CHING NGAI, 2012. Epigenetics interplay between DNA methylation and histone modifications in breast cancer. Advances in Genetic Engineering and Biotechnology. 1(1),
  • SIEW CHING NGAI, RAJESH RAMASAMY, ROZITA ROSLI and SYAHRIL ABDULLAH, 2012. Gene expression profile of hematopoietic stem cells transduced by lentiviral vector. In: 4th Malaysian Tissue Engineering and Regenerative Medicine Scientific Meeting, Langkawi, Malaysia.
  • SIEW CHING NGAI, RAJESH RAMASAMY, ROZITA ROSLI and SYAHRIL ABDULLAH, 2010. Comparison of transgene expression and gene transfer efficiency driven by UbC and CMV promoter in non-viral and viral gene delivery context in vitro. In: 19th Scientific Conference of Electron Microscopy Society of Malaysia. Langkawi, Malaysia.
  • SIEW CHING NGAI, RAJESH RAMASAMY, ROZITA ROSLI and SYAHRIL ABDULLAH, 2010. DNA methylation and histone deacetylation are factors of transgene silencing in hematopoietic stem cells transduced with lentiviral vector. In: XVIIIth Annual Congress of the European Society of Gene and Cell Therapy. Milano, Italy.
  • SIEW CHING NGAI, RAJESH RAMASAMY, ROZITA ROSLI and SYAHRIL ABDULLAH, 2009. Transgene silencing in hematopoietic stem cells is associated with DNA methylation and histone deacetylation. In: 7th Asean Microscopy Conference. Bali, Indonesia.
  • SIEW CHING NGAI, RAJESH RAMASAMY, ROZITA ROSLI and SYAHRIL ABDULLAH, 2009. Lentiviral with CMV promoter mediates longer duration of transgene expression in vitro than lentiviral with UbC promoter. In: 8th Malaysia Genetics Congress. Awana Genting, Pahang, Malaysia.
  • SIEW CHING NGAI, RAJESH RAMASAMY, ROZITA ROSLI and SYAHRIL ABDULLAH, 2009. Optimization of the production of third-generation self-inactivating lentivirus carrying green fluorescent protein for in vitro gene transfer. In: 3rd Regional Conference on Molecular Medicine. Kota Bharu, Kelantan, Malaysia.
  • SIEW CHING NGAI, RAJESH RAMASAMY, ROZITA ROSLI and SYAHRIL ABDULLAH, 2008. Optimization of lentiviral production carrying green fluorescent protein with different promoters for in vitro cell transfection. In: 17th Electron Microscopy Society of Malaysia (EMSM) Scientific Conference. Shah Alam, Malaysia.

School of Biosciences

University of Nottingham
Sutton Bonington Campus
Nr Loughborough
LE12 5RD, UK

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