Ian Mellor

Research Lecturer, Faculty of Medicine & Health Sciences

Personal Details
Research
Publications

Contact

work Room A70 Biology
University Park
Nottingham
NG7 2RD
UK
work 0115 9513257
ian.mellor@nottingham.ac.uk

Biography

BSc (Hons) Medicinal and Pharmaceutical Chemistry, Loughborough University of Technology, 1986. PhD The Biophysics of Peptide Ion Channels, University of Nottingham, 1993.

Teaching Summary

Molecular and Cellular Neuroscience (convenor)

Human Physiology and Pharmacology

Research Projects

Investigating and writing about biology

Research Summary

Selected Publications

ANDERSEN, T.F., TIKHONOV, D.B., BØLCHO, U., BOLSHAKOV, K., NELSON, J.K., PLUTEANU, F., MELLOR, I.R., EGEBJERG, J. and STRØMGAARD, K., 2006. (External) Uncompetitive antagonism of AMPA receptors: Mechanistic insights from studies of polyamine toxin derivatives Journal of Medicinal Chemistry. 49(18), 5414-5423
CLARKSON, C., MELLOR, I.R., LAMBERT, M. and JAROSZEWSKI, J.W., 2006. (External) 5alpha-Cardenolides from Kanahia laniflora Inhibit Ionotropic Acetylcholine Receptors. Planta Medica. 72, 1418-1420
OLSEN, C. A., MELLOR, I. R., WELLENDORPH, P., USHERWOOD, P. N. R., WITT, M., FRANZYK, H. and JAROSZEWSKI, J. W., 2006. (External) Tuning Wasp Toxin Structure for Nicotinic Receptor Antagonism: Cyclohexylalanine-Containing Analogues as Potent and Voltage-Dependent Blockers ChemMedChem. VOL 1(NUMB 3), 303-305
BOLSHAKOV, K.V., KIM, K.H., POTAPJEVA, N.N., GMIRO, V.E., TIKHONOV, D.B., USHERWOOD, P.N.R., MELLOR, I.R. and MAGAZANIK, L.G., 2005. (External) Design of antagonists for NMDA and AMPA receptors Neuropharmacology. 49(2), 144-155

View all publications

Current Research

My research interests have been focused mainly on polyamine-containing compounds from natural and synthetic sources and their effects on several important ionotropic receptors including nicotinic acetylcholine receptors (nAChR), ionotropic glutamate receptors (IGR) and vanilloid receptors (TRPV1). Examples of such compounds include the philanthotoxins, originally discovered in the venom of a solitary wasp, Philanthus triangulum , and polymethylene tetraamines of synthetic origin.

The research is carried out using electrophysiological techniques including patch-clamp of neuronal cultures and cell lines, and voltage-clamp of Xenopus oocytes expressing the receptors. Structure-activity studies have enabled the identification of potent and selective antagonists and potentiators of these receptors and their mechanisms of action have been determined. The purpose of this research is to employ these compounds as tools to study receptor structure and to identify potentially useful therapeutic agents and pesticides. Other research interests include the study of toxins from animal and plant sources with respect to their effects on ionotropic receptors and ion channels using the methods described above. This research is predominantly a bioprospecting exercise to discover novel compounds that may be leads for the pharmaceutical and pesticide industries.

MATSA, ELENA, RAJAMOHAN, DIVYA, DICK, EMILY, YOUNG, LORRAINE, MELLOR, IAN, STANIFORTH, ANDREW and DENNING, CHRIS, 2011. (External) Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation. Eur Heart J. 32(8), 952-62
BURTON, MARK J, MELLOR, IAN R, DUCE, IAN R, DAVIES, T G EMYR, FIELD, LINDA M and WILLIAMSON, MARTIN S, 2011. (External) Differential resistance of insect sodium channels with kdr mutations to deltamethrin, permethrin and DDT. Insect biochemistry and molecular biology. 41(9), 723-32
MELLOR, I.R., 2010. (External) The AMPA receptor as a therapeutic target: current perspectives and emerging possibilities. Future Medicinal Chemistry. 2(5), 877-891
PENG, FANG, MELLOR, IAN R, WILLIAMSON, MARTIN S, DAVIES, T G EMYR, FIELD, LINDA M and USHERWOOD, PETER N R, 2009. Single channel study of deltamethrin interactions with wild-type and mutated rat Na(V)1.2 sodium channels expressed in Xenopus oocytes. Neurotoxicology. 30(3), 358-67
ROSINI, MICHELA, SIMONI, ELENA, BARTOLINI, MANUELA, CAVALLI, ANDREA, CECCARINI, LUISA, PASCU, NICOLETA, MCCLYMONT, DAVID W, TAROZZI, ANDREA, BOLOGNESI, MARIA L, MINARINI, ANNA, TUMIATTI, VINCENZO, ANDRISANO, VINCENZA, MELLOR, IAN R AND MELCHIORRE, CARLO, 2008. Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush. Journal of Medicinal Chemistry. 51(15), 4381-4
ANDERSON, D., SELF, T., MELLOR, I.R., GOH, G., HILL, S.J. and DENNING, C., 2007. (External) Transgenic enrichment of cardiomyocytes from human embryonic stem cells. Molecular Therapy. 15(11), 2027-2036
USHERWOOD, P N R, DAVIES, T G E, MELLOR, I R, O'REILLY, A O, PENG, F, VAIS, H, KHAMBAY, B P S, FIELD, L M and WILLIAMSON, M S, 2007. (External) Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding domains for pyrethroids and DDT. FEBS Letters. 581(28), 5485-92
ANDERSEN, T.F., TIKHONOV, D.B., BØLCHO, U., BOLSHAKOV, K., NELSON, J.K., PLUTEANU, F., MELLOR, I.R., EGEBJERG, J. and STRØMGAARD, K., 2006. (External) Uncompetitive antagonism of AMPA receptors: Mechanistic insights from studies of polyamine toxin derivatives Journal of Medicinal Chemistry. 49(18), 5414-5423
OLSEN, C. A., MELLOR, I. R., WELLENDORPH, P., USHERWOOD, P. N. R., WITT, M., FRANZYK, H. and JAROSZEWSKI, J. W., 2006. (External) Tuning Wasp Toxin Structure for Nicotinic Receptor Antagonism: Cyclohexylalanine-Containing Analogues as Potent and Voltage-Dependent Blockers ChemMedChem. VOL 1(NUMB 3), 303-305
CLARKSON, C., MELLOR, I.R., LAMBERT, M. and JAROSZEWSKI, J.W., 2006. (External) 5alpha-Cardenolides from Kanahia laniflora Inhibit Ionotropic Acetylcholine Receptors. Planta Medica. 72, 1418-1420
JØRGENSEN, M.R., OLSEN, C.A., MELLOR, I.R., USHERWOOD, P.N.R., WITT, M., FRANZYK, H. and JAROSZEWSKI, J.W., 2005. (External) The effects of conformational constraints and steric bulk in the amino acid moiety of philanthotoxins on AMPAR antagonism Journal of Medicinal Chemistry. 48(1), 56-70
BOLSHAKOV, K.V., KIM, K.H., POTAPJEVA, N.N., GMIRO, V.E., TIKHONOV, D.B., USHERWOOD, P.N.R., MELLOR, I.R. and MAGAZANIK, L.G., 2005. (External) Design of antagonists for NMDA and AMPA receptors Neuropharmacology. 49(2), 144-155
ZALAT, S., ELBANA, S., RIZZOLI, S., SCHMIDT, J. O. and MELLOR, I. R., 2005. (External) Modulation of nicotinic acetylcholine and N-methyl-d-aspartate receptors by some Hymenopteran venoms Toxicon. VOL 46(NUMBER 3), 282-290
MOORE, PAULINE, OGILVIE, JANE, HORRIDGE, ELISABETH, MELLOR, IAN R and CLOTHIER, RICHARD H, 2005. (External) The development of an innervated epithelial barrier model using a human corneal cell line and ND7/23 sensory neurons. European Journal of Cell Biology. 84(5), 581-92
STRØMGAARD, K. and MELLOR, I., 2004. (External) AMPA receptor ligands: synthetic and pharmacological studies of polyamines and polyamine toxins Medicinal Research Reviews. 24(5), 589-620
TIKHONOV, D.B., MELLOR, I.R. and USHERWOOD, P.N.R., 2004. (External) Modeling noncompetitive antagonism of a nicotinic acetylcholine receptor Biophysical Journal. 87(1), 159-170
MELLOR, I.R. and USHERWOOD, P.N.R., 2004. (External) Targeting ionotropic receptors with polyamine-containing toxins Toxicon. 43(5), 493-508
MELLOR, I.R, OGILVIE, J., PLUTEANU, F., CLOTHIER, R.H., PARKER, T.L., ROSINI, M., MINARINI, A., TUMIATTI, V. and MELCHIORRE, C., 2004. (External) Methoctramine analogues inhibit responses to capsaicin and protons in rat dorsal root ganglion neurons. European Journal of Pharmacology. 505(1-3), 37-50
BRIER, T.J., MELLOR, I.R., TIKHONOV, D.B., NEAGOE, I., SHAO, Z., BRIERLEY, M.J., STRØMGAARD, K., JAROSZEWSKI, J.W., KROGSGAARD-LARSEN, P. and USHERWOOD, P.N.R., 2003. (External) Contrasting actions of philanthotoxin-343 and philanthotoxin-(12) on human muscle nicotinic acetylcholine receptors Molecular Pharmacology. 64(4), 954-964
MELLOR, I.R., BRIER, T.J., PLUTEANU, F., STRØMGAARD, K., SAGHYAN, A., ELDURSI, N., BRIERLEY, M.J., ANDERSEN, K., JAROSZEWSKI, J.W., KROGSGAARD-LARSEN, P. and USHERWOOD, P.N.R., 2003. (External) Modification of the philanthotoxin-343 polyamine moiety results in different structure-activity profiles at muscle nicotinic ACh, NMDA and AMPA receptors Neuropharmacology. 44(1), 70-80
OLSEN, C.A., JORGENSEN, M.R., WITT, M., MELLOR, I.R., USHERWOOD, P.N.R., JAROSZEWSKI, J.W. and FRANZYK, H., 2003. (External) The choice of phosphane reagent in Fukuyama - Mitsunobu alkylation: intramolecular selectivity between primary and secondary alcohols in the preparation of asymmetric tetraamine building blocks for synthesis of philanthotoxins European Journal of Organic Chemistry. 17, 3288-3299
TIKHONOV, D.B., MELLOR, J.R., USHERWOOD, P.N.R. and MAGAZANIK, L.G., 2002. (External) Modeling of the pore domain of the GLUR1 channel: homology with K<sup>+</sup> channel and binding of channel blockers Biophysical Journal. 82(4), 1884-1893
BRIER,T.J., MELLOR,I.R. and USHERWOOD,P.N.R., 2002. Allosteric and steric interactions of polyamines and polyamine-containing toxins with nicotinic acetylcholine receptors. In: MENEZ,A., ed., Perspectives in Molecular Toxinology John Wiley & Sons, Chichester, UK. 281-297
STROMGAARD, K., MELLOR, I. R., ANDERSEN, K., NEAGOE, I., PLUTEANU, F., USHERWOOD, P. N., KROGSGAARD-LARSEN, P. and JAROSZEWSKI, J. W., 2002. (External) Solid-Phase synthesis and pharmacological evaluation of analogues of PhTX-12-A potent and selective nicotinic acetylcholine receptor antagonist Bioorganic and Medicinal Chemistry Letters. VOL 12(NUMBER 8), 1159-1162
BIXEL, M.G., WEISE, C., BOLOGNESI, M.L., ROSINI, M., BRIERLY, M.J., MELLOR, I.R., USHERWOOD, P.N.R., MELCHIORRE, C. and HUCHO, F., 2001. (External) Location of the polyamine binding site in the vestibule of the nicotinic acetylcholine receptor ion channel Journal of Biological Chemistry. 276(9), 6151-6160
ZHELIASKOVA, A., NAIDENOVA, S., MARINOV, Y., MELLOR, I. R., USHERWOOD, P. N. R. and PETROV, A. G., 2001. Detection of Heavy Metal Ions (Cd^2^+ and Hg^2^+) by Their Influence on Flexoelectricity of Patch Clamped Lipid Membranes COMPTES RENDUS- ACADEMIE BULGARE DES SCIENCES. VOL 54(PART 12), 53-56
STROMGAARD, K., BJORNSDOTTIR, I., ANDERSEN, K., BRIERLEY, M., RIZOLI, S., ELDURSI, N., MELLOR, I. R., USHERWOOD, P. N., HANSEN, S. H. and KROGSGAARD-LARSEN, P., 2000. (External) Solid Phase Synthesis and Biological Evaluation of Enantiomerically Pure Wasp Toxin Analogues PhTX-343 and PhTX-12 Chirality. VOL 12(PART 2), 93-102
BIXEL, M.G., KRAUSS, M., LIU, Y., BOLOGNESI, M.L., ROSINI, M., MELLOR, I.S., USHERWOOD, P.N.R., MELCHIORRE, C., NAKANISHI, K. and HUCHO, F., 2000. (External) Stucture-activity relationship and site of binding of polyamine derivatives at the nicotinic acetylcholine receptor European Journal of Biochemistry. 267(1), 110-120
TIKHONOV, D. B., MAGAZANIK, L. G., MELLOR, I. R. and USHERWOOD, P. N. R., 2000. POSSIBLE INFLUENCE OF INTRAMOLECULAR HYDROGEN BONDS ON THE THREE-DIMENSIONAL STRUCTURE OF POLYAMINE AMIDES AND THEIR INTERACTION WITH IONOTROPIC GLUTAMATE RECEPTORS Receptors and Channels. VOL 7(PART 3), 227-236
STROMGAARD, K., BRIER, T. J., ANDERSEN, K., MELLOR, I. R., SAGHYAN, A., TIKHONOV, D., USHERWOOD, P. N. R., KROGSGAARD-LARSEN, P. and JAROSZEWSKI, J. W., 2000. (External) Solid-Phase Synthesis and Biological Evaluation of a Combinatorial Library of Philanthotoxin Analogues Journal of Medicinal Chemistry. VOL 43(PART 23), 4526-4533
MELLOR, I. R., MILLER, B. A., PETROV, A. G., TABAREAN, I. and USHERWOOD, P. N. R., 1999. (External) Mechanosensitive potassium channels in locust muscle membrane European Biophysics Journal. VOL 28(NUMBER 4), 346-350
GRZYWNA, Z. J., SIWY, Z., FULINSKI, A., MELLOR, I. and USHERWOOD, P. N. R., 1999. Chaos in the Potassium Current Through Channels of Locust Muscle Membrane Cellular and Molecular Biology Letters. VOL 4(NUMBER 1), 37-54
STROMGAARD, K., BRIERLEY, M. J., ANDERSEN, K., SLOK, F. A., MELLOR, I. R., USHERWOOD, P. N., KROGSGAARD-LARSEN, P. and JAROSZEWSKI, J. W., 1999. (External) Analogues of Neuroactive Polyamine Wasp Toxins That Lack Inner Basic Sites Exhibit Enhanced Antagonism Toward a Muscle-Type Mammalian Nicotinic Acetylcholine Receptor Journal of Medicinal Chemistry. VOL 42(PART 25), 5224-5234
ROSINI, M., BUDRIESI, R., BIXEL, M. G., BOLOGNESI, M. L., CHIARINI, A., HUCHO, F., KROGSGAARD-LARSEN, P., MELLOR, I. R., MINARINI, A. and TUMIATTI, V., 1999. (External) Design, Synthesis, and Biological Evaluation of Symmetrically Unsymmetrically Substituted Methoctramine-Related Polyamines as Muscular Nicotinic Receptor Noncompetitive Antagonists Journal of Medicinal Chemistry. VOL 42(PART 25), 5212-5223

School of Biology

University of Nottingham
University Park
Nottingham, NG7 2RD

telephone: +44 (0)115 9513300 (Undergraduate Enquiries)
+44 (0)115 8230311 (Postgraduate Enquiries)
fax: +44 (0)115 8230338
email: biology@nottingham.ac.uk

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