Rita Tewari

Lecturer, Faculty of Medicine & Health Sciences

Personal Details
Research
Publications

Contact

work Room C20b Medical School
Queen's Medical Centre
Nottingham
NG7 2UH
UK
work 0115 823 0362
fax 0115 823 0338
rita.tewari@nottingham.ac.uk

Biography

PhD, University of Delhi, India, 1989; Postdoctoral Fellow, INRA, France1990-1992; Senior Research Associate 1993-1994, University of Cambridge and NIMR, UK; Senior Research Associate 1994-1997, Erasmus University, Rotterdam, The Netherlands; Senior Scientist 1997-1999, Sars International Center for Marine Molecular Biology, Bergen, Norway; Research Lecturer 1999-2007, Imperial College London, UK; Lecturer, University of Nottingham Jan. 2008 -

Research Summary

Functional analysis of signalling pathways modulating malaria parasite development and parasite-host interactions: Research in my group aims to analyse parasite proteins, in particular kinases,… read more

Selected Publications

GUTTERY DS, FERGUSON DJP, POULIN B, XU Z, STRASCHIL U, KLOP O, SOLYAKOV L, SANDRINI SM, BRADY D, NIEDUSZYNSKI CA, JANSE CJ, HOLDER AA, TOBIN AB and TEWARI R, 2012. (External) A Putative Homologue Of Cdc20/Cdh1 In The Malaria Parasite Is Essential For Male Gamete Development. Plos Pathogens. 8(2), e1002554
GUTTERY DS, HOLDER AA and TEWARI R, 2012. (External) Sexual Development In Plasmodium: Lessons From Functional Analyses. Plos Pathogens. 8(1), e1002404
COPPI, ALIDA, NATARAJAN, RAMYA, PRADEL, GABRIELE, BENNETT, BRANDY L, JAMES, ERIC R, ROGGERO, MARIO A, CORRADIN, GIAMPIETRO, PERSSON, CATHRINE, TEWARI, RITA and SINNIS, PHOTINI, 2011. (External) The malaria circumsporozoite protein has two functional domains, each with distinct roles as sporozoites journey from mosquito to mammalian host. The Journal of Experimental Medicine. 1-16
TEWARI, RITA, STRASCHIL, URSULA, BATEMAN, ALEX, BÖHME, ULRIKE, CHEREVACH, INNA, GONG, PENG, PAIN, ARNAB and BILLKER, OLIVER, 2010. (External) The systematic functional analysis of Plasmodium protein kinases identifies essential regulators of mosquito transmission. Cell Host & Microbe. 8(4), 377-87

View all publications

Current Research

Functional analysis of signalling pathways modulating malaria parasite development and parasite-host interactions : Research in my group aims to analyse parasite proteins, in particular kinases, phosphatases and other novel proteins involved in parasite signalling pathways, development and invasion of host cells. Work in my group involves gene tranfection of rodent malaria models, with the overall aim being to identify novel drug and vaccine targets.

GUTTERY DS, HOLDER AA and TEWARI R, 2012. (External) Sexual Development In Plasmodium: Lessons From Functional Analyses. Plos Pathogens. 8(1), e1002404
GUTTERY DS, FERGUSON DJP, POULIN B, XU Z, STRASCHIL U, KLOP O, SOLYAKOV L, SANDRINI SM, BRADY D, NIEDUSZYNSKI CA, JANSE CJ, HOLDER AA, TOBIN AB and TEWARI R, 2012. (External) A Putative Homologue Of Cdc20/Cdh1 In The Malaria Parasite Is Essential For Male Gamete Development. Plos Pathogens. 8(2), e1002554
SLAVIC, KSENIJA, DELVES, MICHAEL J, PRUDÊNCIO, MIGUEL, TALMAN, ARTHUR M, STRASCHIL, URSULA, DERBYSHIRE, ELVIRA T, XU, ZHENGYAO, SINDEN, ROBERT E, MOTA, MARIA M, MORIN, CHRISTOPHE, TEWARI, RITA and K, 2011. (External) Use of a selective inhibitor to define the chemotherapeutic potential of the plasmodial hexose transporter in different stages of the parasite's life cycle. Antimicrobial agents and chemotherapy.
COPPI, ALIDA, NATARAJAN, RAMYA, PRADEL, GABRIELE, BENNETT, BRANDY L, JAMES, ERIC R, ROGGERO, MARIO A, CORRADIN, GIAMPIETRO, PERSSON, CATHRINE, TEWARI, RITA and SINNIS, PHOTINI, 2011. (External) The malaria circumsporozoite protein has two functional domains, each with distinct roles as sporozoites journey from mosquito to mammalian host. The Journal of Experimental Medicine. 1-16
OGUN, SOLABOMI A, TEWARI, RITA, OTTO, THOMAS D, HOWELL, STEVEN A, KNUEPFER, ELLEN, CUNNINGHAM, DEIRDRE A, XU, ZHENGYAO, PAIN, ARNAB and HOLDER, ANTHONY A, 2011. (External) Targeted Disruption of py235ebp-1: Invasion of Erythrocytes by Plasmodium yoelii Using an Alternative Py235 Erythrocyte Binding Protein. PLoS pathogens. 7(2), e1001288
GÓMEZ, NOÉ D, SAFEUKUI, INNOCENT, ADELANI, AANUOLUWA A, TEWARI, RITA, REDDY, JANARDAN K, RAO, SAM, HOLDER, ANTHONY, BUFFET, PIERRE, MOHANDAS, NARLA and HALDAR, KASTURI, 2011. (External) Deletion of a malaria invasion gene reduces death and anemia, in model hosts. PloS one. 6(9), e25477
TEWARI, R, BAILES, E and BUNTING, K.A. AND COATES, J.C, 2010. (External) Armadillo-repeat protein functions: questions for little creatures Trends in Cell Biology. 20(8), 470-481
STRASCHIL, U, TALMAN, A. M, FERGUSON, D. J. P, BUNTING, K. A, XU, Z, BAILES, E, SINDEN, R. E, HOLDER, A. A, SMITH, E. F and COATES, J.C. , TEWARI, R., 2010. (External) The Armadillo Repeat Protein PF16 Is Essential for Flagellar Structure and Function in Plasmodium Male Gametes PLoS One. 5(9),
TEWARI, RITA, STRASCHIL, URSULA, BATEMAN, ALEX, BÖHME, ULRIKE, CHEREVACH, INNA, GONG, PENG, PAIN, ARNAB and BILLKER, OLIVER, 2010. (External) The systematic functional analysis of Plasmodium protein kinases identifies essential regulators of mosquito transmission. Cell Host & Microbe. 8(4), 377-87
SLAVIC, KSENIJA, STRASCHIL, URSULA, REININGER, LUC, DOERIG, CHRISTIAN, MORIN, CHRISTOPHE, TEWARI, RITA* and KRISHNA, SANJEEV*, 2010. (External) Life cycle studies of the hexose transporter of Plasmodium species and genetic validation of their essentiality. Molecular Microbiology. Feb1(Feb1),
MAUDUIT, MARJORIE, TEWARI, RITA, DEPINAY, NADYA, KAYIBANDA, MICHÈLE, LALLEMAND, ELIETTE, CHAVATTE, JEAN-MARC, SNOUNOU, GEORGES, RÉNIA, LAURENT and GRÜNER, ANNE CHARLOTTE, 2010. A minimal role for the circumsporozoite protein in the induction of sterile immunity by vaccination with live rodent malaria sporozoites. Infection and immunity.
MAUDUIT, MARJORIE, GRÜNER, ANNE CHARLOTTE, TEWARI, RITA, DEPINAY, NADYA, KAYIBANDA, MICHÈLE, CHAVATTE, JEAN-MARC, FRANETICH, JEAN-FRANÇOIS, CRISANTI, ANDREA, MAZIER, DOMINIQUE and SNOUNOU,, 2009. (External) A Role for Immune Responses against Non-CS Components in the Cross-Species Protection Induced by Immunization with Irradiated Malaria Sporozoites. PloS one. 4(11), e7717
REININGER L,*, TEWARI R*, FENNELL C,, HOLLAND,, GOLDRING,, RANFORD-CARTWRIGHT,, BILLKER, and DOERIG,, 2009. (External) An Essential Role for the Plasmodium Nek-2 Nima-Related Protein Kinase in the Sexual Development of Malaria Parasites. Journal of Biological Chemistry. 284((31):), 20858-68
ECKER A , BUSHELL E, TEWARI R, SINDEN RE., 2008. Reverse genetics screen identifies six proteins important for malaria development in the mosquito. Molecular Microbiology. 70((1)), 209-20
LIU, YANJIE*, TEWARI, RITA*, NING, JUE, BLAGBOROUGH, ANDREW M, GARBOM, SARA, PEI, JIMIN, GRISHIN, NICK V, STEELE, ROBERT E, SINDEN, ROBERT E, SNELL, WILLIAM J and BILLKER, OLIVER, 2008. (External) The conserved plant sterility gene HAP2 functions after attachment of fusogenic membranes in Chlamydomonas and Plasmodium gametes. Genes and Development. 22(8), 1051-68
GRÜNER, ANNE CHARLOTTE, MAUDUIT, MARJORIE, TEWARI, RITA, ROMERO, JACKELINE F, DEPINAY, NADYA, KAYIBANDA, MICHÈLE, LALLEMAND, ELIETTE, CHAVATTE, JEAN-MARC, CRISANTI, ANDREA, SINNIS, PHOTINI and , 2007. (External) Sterile protection against malaria is independent of immune responses to the circumsporozoite protein. PLoS ONE. 2(12), e1371
COPPI, ALIDA, TEWARI, RITA, BISHOP, JOSEPH R, BENNETT, BRANDY L, LAWRENCE, ROGER, ESKO, JEFFREY D, BILLKER, OLIVER and SINNIS, PHOTINI, 2007. Heparan sulfate proteoglycans provide a signal to Plasmodium sporozoites to stop migrating and productively invade host cells. Cell Host & Microbe. 2(5), 316-27
ESCARON, CLAIRE J, LEES, DELPHINE M, TEWARI, RITA, SMITH, DEBORAH F and CARON, EMMANUELLE, 2007. (External) A simple, robust and versatile method to characterise intracellular parasitism. Molecular and Biochemical Parasitology. 153(1), 72-6
RAINE, J DALE, ECKER, ANDREA, MENDOZA, JACQUI, TEWARI, RITA, STANWAY, REBECCA R and SINDEN, ROBERT E, 2007. Female inheritance of malarial lap genes is essential for mosquito transmission. PLoS Pathogens. 3(3), e30
TEWARI, RITA*, DORIN, DOMINIQUE*, MOON, ROBERT, DOERIG, CHRISTIAN and BILLKER, OLIVER, 2005. An atypical mitogen-activated protein kinase controls cytokinesis and flagellar motility during male gamete formation in a malaria parasite. Molecular Microbiology. 58(5), 1253-63
TEWARI, RITA, OGUN, SOLABOMI A, GUNARATNE, RUWANI S, CRISANTI, ANDREA and HOLDER, ANTHONY A, 2005. Disruption of Plasmodium berghei merozoite surface protein 7 gene modulates parasite growth in vivo. Blood. 105(1), 394-6
TEWARI, RITA, RATHORE, DHARMENDAR and CRISANTI, ANDREA, 2005. Motility and infectivity of Plasmodium berghei sporozoites expressing avian Plasmodium gallinaceum circumsporozoite protein. Cellular Microbiology. 7(5), 699-707
REININGER, LUC*, BILLKER, OLIVER*, TEWARI, RITA, MUKHOPADHYAY, ARUNIMA, FENNELL, CLARE, DORIN-SEMBLAT, DOMINIQUE, DOERIG, CAROLINE, GOLDRING, DEAN, HARMSE, LEONIE, RANFORD-CARTWRIGHT, LISA and PACKER, JERE, 2005. A NIMA-related protein kinase is essential for completion of the sexual cycle of malaria parasites. Journal of Biological Chemistry. 280(36), 31957-64
EDVARDSEN, ROLF B, LERAT, EMMANUELLE, MAELAND, ANNE DORTHEA, FLÅT, METTE, TEWARI, RITA, JENSEN, MARIT F, LEHRACH, HANS, REINHARDT, RICHARD, SEO, HEE-CHAN and CHOURROUT, DANIEL, 2004. Hypervariable and highly divergent intron-exon organizations in the chordate Oikopleura dioica. Journal of molecular evolution. 59(4), 448-57
BILLKER, OLIVER, DECHAMPS, SANDRINE, TEWARI, RITA, WENIG, GERALD, FRANKE-FAYARD, BLANDINE and BRINKMANN, VOLKER, 2004. Calcium and a calcium-dependent protein kinase regulate gamete formation and mosquito transmission in a malaria parasite. Cell. 117(4), 503-14
GILLEMANS, NYNKE, MCMORROW, TARA, TEWARI, RITA, WAI, ALBERT W K, BURGTORF, CAROLA, DRABEK, DUBRAVKA, VENTRESS, NICKI, LANGEVELD, AN, HIGGS, DOUGLAS, TAN-UN, KIAN, GROSVELD, FRANK and PHILIPSEN, SJAAK, 2003. Functional and comparative analysis of globin loci in pufferfish and humans. Blood. 101(7), 2842-9
KROPF, PASCALE, HERATH, SHANTI, TEWARI, RITA, SYED, NELOFER, KLEMENZ, ROMAN and MÜLLER, INGRID, 2002. Identification of two distinct subpopulations of Leishmania major-specific T helper 2 cells. Infection and Immunity. 70(10), 5512-20
TEWARI, RITA, SPACCAPELO, ROBERTA, BISTONI, FRANCESCO, HOLDER, ANTHONY A and CRISANTI, ANDREA, 2002. Function of region I and II adhesive motifs of Plasmodium falciparum circumsporozoite protein in sporozoite motility and infectivity. Journal of Biological Chemistry. 277(49), 47613-8
GILLEMANS, N, TEWARI, R, LINDEBOOM, F, ROTTIER, R, DE WIT, T, WIJGERDE, M, GROSVELD, F and PHILIPSEN, S, 1998. (External) Altered DNA-binding specificity mutants of EKLF and Sp1 show that EKLF is an activator of the beta-globin locus control region in vivo. Genes and Development. 12(18), 2863-73
TEWARI, R, GILLEMANS, N, WIJGERDE, M, NUEZ, B, VON LINDERN, M, GROSVELD, F and PHILIPSEN, S, 1998. (External) Erythroid Krüppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the beta-globin locus control region. EMBO Journal. 17(8), 2334-41
TEWARI, R, GILLEMANS, N, HARPER, A, WIJGERDE, M, ZAFARANA, G, DRABEK, D, GROSVELD, F and PHILIPSEN, S, 1996. The human beta-globin locus control region confers an early embryonic erythroid-specific expression pattern to a basic promoter driving the bacterial lacZ gene. Development (Cambridge). 122(12), 3991-9
NAKAYAMA, I, FORESTI, F, TEWARI, R, SCHARTL, M and CHOURROUT, D, 1994. (External) Sex chromosome polymorphism and heterogametic males revealed by two cloned DNA probes in the ZW/ZZ fish Leporinus elongatus. Chromosoma. 103(1), 31-9
RITA TEWARI1, CHRISTINE MICHARD-VANHEE1, ELIZABETH PERROT1 AND DANIEL CHOURROUT1, 1992. Mendelian transmission, structure and expression of transgenes following their injection into the cytoplasm of trout eggs Transgenic Research. 1(6), 250-260
TEWARI, R and RAO, S R, 1991. Replication status of the fragile X chromosome and its implications for reproductive performance in the Indian mole rat (Nesokia indica). Journal of reproduction and fertility. 91(1), 203-6
THELMA, B K, TEWARI, R, JUYAL, R C and RAO, S R, 1991. (External) Random/nonrandom X-chromosome inactivation in Nesokia indica: possible influence of heterochromatin. Cytogenetics and Cell Genetics. 56(2), 87-90
THELMA, B K, JUYAL, R C, TEWARI, R and RAO, S R, 1988. (External) Does heterochromatin variation potentiate speciation? A study in Nesokia. Cytogenetics and Cell Genetics. 47(4), 204-8
TEWARI, R, JUYAL, R C, THELMA, B K, DAS, B C and RAO, S R, 1987. (External) Folate-sensitive fragile sites on the X-chromosome heterochromatin of the Indian mole rat, Nesokia indica. Cytogenetics and Cell Genetics. 44(1), 11-7
SIMON, M M, ALI, S, TEWARI, R, SIMON, H G, MÜLLER-HERMELINK, H K and EPPLEN, J T, 1986. (External) Leukemic cells arise from cloned cytotoxic lymphocytes during cell culture. European journal of immunology. 16(10), 1269-76

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