Research

The Centre for Genetics and Genomics (formally known as the Institute of Genetics) includes the former Department of Genetics (est. 1971) and other members from the School of Biology as its nucleus. In addition, many other members are included from other Schools within the Faculty of Medicine and Health Sciences.

To find individuals working in specific areas, type in a keyword below and the table will automatically filter.

Group Head
Lab Research Summary
Keywords
Aboobaker, Aziz
We are interested in the role of micro RNAs during the evolution of developmental processes and studies stem cells, regeneration and the absence of ageing in immortal flatworms.
Developmental
Biology, Evolution,
Bioinformatics,
Genomics
Alberio, Ramiro
We investigate early developmental decisions in vertebrate embryos, with particular interest in understanding the mechanisms by which cells in early embryos acquire and maintain the undifferentiated state.
Developmental
Biology, Cellular Reprogramming, Stem cells
Allegrucci, Cinzia
We study the epigenetic mechanisms regulating stem cell function in development and cancer.
Developmental Biology, Stem cells, Epigenetics, Genetics
Allers, Thorsten
We are seeking to understand the genetics of DNA repair and recombination in archaea, which
thrive under extreme conditions that threaten genomic integrity.
Microbiology, DNA
Repair, Genomics
Archer, David
We study the molecular events that determine stress responses during polarised growth, protein folding and secretion in yeasts and filamentous fungi.
Fungal Biology
Armour, John
We study the processes and patterns of human genetic diversity, with a particular focus on variation in gene number, to explore human evolution and the contribution of copy number variation to human disease.
Human Genetics,
Evolution, Disease,
Genomics
Avery, Simon
We study the molecular and cellular effects of stress on yeast cells, with a focus on oxidants such as toxic metals and on individual-cell responses.
Fungal Biology, stress responses, toxicology, yeast
Bolt, Ed
We investigate how cells counteract genome instability.
Microbiology, DNA
Repair
Brook, David
We work on the molecular genetics of inherited human disorders, in particular, conditions affecting the neuromuscular system and the development of the heart.
Human Genetics
Brookfield, John
We are interested in how the genome evolves, focusing on the evolution of DNA sequences that control development, particularly in Drosophila and on the evolution of mobile repetitive DNA sequences.
Evolution
Brown, William
We have developed new techniques for chromosome engineering and aims to resolve the paradox posed by centromeric DNA, whose function is conserved amongst eukaryotes, but whose sequence is amongst the most rapidly evolving.
Genome Dynamics
Chalmers, Ronald
We are working on the molecular mechanism of DNA transposons and their impact on the dynamics and control of prokaryotic and eukaryotic genomes.
Genome Dynamics
Chambers, Alistair
We study telomeres and the functions of telomere proteins in fission yeast (S. pombe).
Genome Dynamics
Clarke, Bryan
We have studied how natural selection acts to maintain genetic diversity within populations. This interest has involved studying genetic polymorphism at the ecological, phenotypic and molecular levels and the genetic changes that take place during the origin of a new species.
Evolution
Coyle, Beth
We are investigating normal apoptosis during cerebellum development and how this has been subverted in tumours.
Human Genetics
Crittenden, Peter
We are interested in the biology of lichens and the ecology of ecosystems in which lichens are major components.
Fungal Biology
Davison, Angus
We research population genetics, evolution and adaptation. Work in the lab is split between two main themes, the evolution and maintenance of colour polymorphisms, and, the evolution and development of left-right asymmetry in snails.
Evolution, Population Genetics, Developmental Biology
De-Pomerai, David
We are exploring stress-response networks in the nematode Caenorhabditis elegans using inducible stress-reporter strains.
Developmental Biology
Denning, Chris
We are using gene targeting and RNAi to precisely manipulate the genome of human embryonic stem cells and differentiated lineages to generate in vitro models of disease, including cardiomyocytes that exhibit Duchenne muscular dystrophy.
Developmental Biology, Disease
Dyer, Paul
We investigate the genetic and physiological mechanisms that control sex in fungi, with the aim of devising new fungal-disease control methods and promoting sex in beneficial species.
Fungal Biology
Gering, Martin
We study blood and endothelial development in vertebrate embryos using the Zebrafish as a model system.
Developmental Biology
Gonzalez-Estevez, Cristina
We are investigating autophagy functions during tissue homeostasis and regeneration.
Developmental Biology, Regeneration, Stem Cell, Planarian
Goodacre, Sara
We work on the evolutionary, population and conservation genetics of spiders.
Evolution, Population Genetics
Hanotte, Olivier
The research group is focusing on the unravelling and the understanding of the genetic polymorphisms controlling gene expression in eukaryotes. We use livestock species as a model to study both Mendelian and quantitative traits loci under natural and/or human selection.
Evolution, Population Genetics and Genomics, Conservation Genetics
Hewitt, Jane
We study the molecular mechanisms underlying inherited muscle disease, focusing on muscular dystrophies.
Human Genetics, Disease
Johnson, Andrew
We study the development and evolution of pluripotent stem cells using a combination of amphibian and mammalian systems, aiming to reprogram somatic cells to a pluripotent condition.
Developmental Biology, Evolution, Stem Cells
Kalsheker, Noor
We study humoral control of genes of the serine proteinase inhibitor family which regulate key biological pathways and contribute to complex diseases such as Alzheimer's disease and chronic lung disease.
Human Genetics
Lloyd, Robert
We investigate homologous recombination and its interplay with DNA replication, transcription and repair.
DNA Repair
Loose, Matthew
We study genetic regulatory networks in development and seek to understand how cell fate is controlled by the interplay of transcription factors and signals. We also aim to understand how GRNs vary between species.
Developmental Biology, Bioinformatics, Evolution
Louis, Ed
We are interested in telomere structure, function and dynamics in yeast and parasites as well as genome evolution.
Genome Dynamics, Evolution, Yeast, Telomere, Population genomics, Subtelomere
Morgan, Garry
We are using the giant nuclei of amphibian oocytes to examine the relationship between nuclear structure and function.
Developmental Biology
Morgan, Kevin
We aim to identify genetic factors that influence susceptibility to Alzheimer's or lung disease.
Human Genetics
Morgan, Linda
We are investigating the genetic basis of two related disorders of pregnancy - pre-eclampsia and fetal growth restriction.
Human Genetics
Nieduszynski, Conrad
We are using genetic, genomic and computational methods to understand how chromosome replication is regulated to ensure genome stability in order to help our understanding of diseases such as cancer and congenital disorders.
Genome Dynamics, Disease, Bioinformatics
O'Shea, Paul
We have interests in the behaviour and properties of cellular systems with particular emphasis on the many interactions of macromolecules within cells and their membranes.
Biophysics
Sablitzky, Fred
We study molecular mechanisms determining cell fate during vertebrate development using zebrafish and mice as model systems.
Developmental Biology
Scotting, Paul
We are interested in nervous system development in vertebrates, including the molecular mechanisms that specify neural cells from multipotent stem cells and the molecular and cellular biology of paediatric brain tumours.
Developmental Biology, Disease
Sockett, Elizabeth
We study the bactericidal mechanisms of the predatory bacterium Bdellovibrio bacteriovorus.
Microbiology
Sottile, Virginie
We focus on the biology of adult stem cells, isolated from the bone marrow and from the brain, and investigates the mechanisms regulating their differentiation potential in vitro and in vivo.
Developmental Biology, Stem Cells
Tewari, Rita
We are interested in Malaria development.
Parasitology,
Disease
Tufarelli, Cristina
We are interested in the epigenetic regulatory mechanisms in differentiating embryonic stem cells and disease
Developmental
Biology
Wade, Chris
We use DNA and protein sequences to determine evolutionary relationships among species, to examine genetic variation within populations and as molecular barcodes for the identification of species. Research in the lab is focussed in three main areas, the gastropod molluscs (snails and slugs), the Foraminifera (marine protists used as indicators of past climate) and parasitic nematodes (with emphasis on human and veterinary parasites of the genus Angiostrongylus).
Evolution, Population Genetics, Parasitology
Young, Lorraine
We are investigating the the epigenetic changes that occur in sperm and oocytes to reprogramme gametes into a functional embryonic nucleus.
Stem Cells, Disease

Centre for Genetics and Genomics

The University of Nottingham
Queen's Medical Centre
Nottingham, NG7 2UH

Tel: +44 (0) 115 823 0354
Fax: +44 (0) 115 823 0338
Email: genetics@nottingham.ac.uk

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