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The Gene Regulation Group investigates the molecular mechanisms controlling gene expression in mammalian cells. Our current focus is on two families of transcription factors, the Nuclear Receptors (NRs) and the Interferon Regulated Factors (IRFs), as well as mechanisms of post-transcriptional gene regulation by the Ccr4-Not deadenylase complex. We are investigating the structure and function of NRs and IRFs, their interactions with coactivator and corepressor complexes, and the effects of these complexes on chromatin modification, post-transcriptional gene regulation and the cell cycle. We also have interests in how these functions are disrupted in human disease such as cancer, and thus have a number of projects investigating aberrant gene regulation in leukaemias, B-cell lymphoma and breast cancer.
The Gene Regulation Group is located in the Centre for Biomolecular Sciences . We employ a wide range of techniques including biochemistry, cell biology, confocal microscopy, flow cytometry, fluorescence-activated cell-sorting, real time PCR, microarray expression profiling, and ChIP-on-chip promoter arrays. We also specialise in protein-protein interactions using techniques such as yeast two-hybrid, co-immunoprecipitations and FRET.
Funding for our research programs has been secured through grants, fellowships and studentships awarded by the AICR, BBSRC, Cancer Research UK, MRC, Leukaemia Research, RPSGB and the Wellcome Trust.
Professor David M Heery - Professor in Gene Regulation Dr Nicole Clarke - Lecturer in Gene Regulation Dr G Sebastiaan Winkler - Lecturer in Gene Regulation
Dr Hilary M Collins - Experimental Officer Dr Ishwinder Kaur - Postdoctoral Research Assistant Rachel Doidge - Postgraduate Student Joel Fulton - Postgraduate Student Andrew Lewis - Postgraduate Student Maryati Maryati - Postgraduate Student Barbara Rampersad - Technician Loretta Waddon - Secretary
Dr Alessandro Rettino - Postdoctoral Research Assistant Dr Baigong Yue - Postdoctoral Research Assistant Dr Frances Wadelin - Clinical Research Training Fellow Dr Marie Messmer - Postdoctoral Research Assistant Dr Akhmed Aslam - Postdoctoral Research Assistant Dr Saloni Mittal - Postdoctoral Research Assistant Dr Karin B Kindle - Postdoctoral Research Assistant Dr Jerome Xicluna - Postdoctoral Research Assistant Chun Ming Chan - Postgraduate Student Sian Deeves - Postgraduate Student Alex Garvin - Postgraduate Student Blessing Oveh - Postgraduate Student (MRes) Nijjareeya Sirisriro - Postgraduate Student Magdy Korashy - Postgraduate Student Cecilie Bay-Richter - Postgraduate Student Debbie Evens - Technician
University of Nottingham University Park Nottingham, NG7 2RD
telephone: +44 (0) 115 951 5100 fax: +44 (0) 115 951 5102 email: pharmacy-enquiries@nottingham.ac.uk
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