Jonathan Fray
GSK Teaching Fellow in medicinal and organic chemistry, Faculty of Science
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Biography
Dr. Fray graduated from Oxford University in 1981 and stayed on for a D.Phil. in natural products total synthesis with Dr. (now Prof.) E.J. Thomas. He then spent two years (1984-5) with Prof. Barry Trost at the University of Wisconsin, Madison (SERC/NATO fellowship), working on the total synthesis of taxol. In 1986, Dr. Fray joined Pfizer Global Research and Development in Sandwich, Kent as a medicinal chemist and worked on a variety of drug discovery projects. In 2003, he joined and subsequently led the Synthesis Support Group at Pfizer which contributed to early-stage scale-up activities and preparation of isotopically labelled compounds. After leaving Pfizer last year, Dr. Fray joined the staff at Nottingham as the GlaxoSmithKline Teaching Fellow in Organic and Medicinal Chemistry.
Expertise Summary
Organic synthesis, particularly as applied to pharmaceuticals; process chemistry; synthesis of fluorinated compounds; palladium catalysed cross coupling reactions; synthesis of isotopically labelled compounds especially deuterium and tritium.
Medicinal chemistry; previous experience with Pfizer comprised SNRIs, MMP-3 inhibitors, uPA inhibitors, NMDA (glycine site) receptor antagonists, PAF antagonists.
Teaching Summary
Medicinal, Organic and Process Chemistry.
Past Research
Selected Recent Publications Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reducing ion channel activity. M. Jonathan Fray, Paul V. Fish,* Gillian A. Allan, Gerwyn Bish, Nick Clarke, Anthony C. Harrison, Jean-Loic Le Net, Rachel McCoy, Stephen C. Phillips, Nicola Regan, Alan Stobie, Florian Wakenhut, Dominique Westbrook, Simon L. Westbrook, Gavin A. Whitlock, Bioorg. Med. Chem. Lett., 2010, 20, 3788. [3 + 2] Dipolar cycloadditions of an unstabilised azomethine ylide under continuous flow conditions. Mark Grafton, Andrew C. Mansfield and M. Jonathan Fray*, Tetrahedron Lett. 2010, 51, 1026. Optimisation of Permanganate Oxidation and Suzuki-Miyaura Coupling Steps in the Synthesis of a NaV1.8 Sodium Channel Modulator M. Jonathan Fray,* Adam T. Gillmore, Melanie S. Glossop, David Mcmanus, Ian B. Moses, Céline F.B. Praquin, Keith A. Reeves, Lisa R. Thompson, Org. Proc. Res. Dev., 2010, 14, 263. Unusual Base-Catalysed Exchange in the Synthesis of Deuterated PF-2413873. Stuart J. Rozze and M. Jonathan Fray,*J. Lab. Compd. Radiopharm., 2009, 52, 435.