Searle obtained his B.A. and M.A. in Chemistry from the University of Oxford in 1983 and 1985 respectively. His Ph.D. from the MRC, National Institute for Medical Research, Mill Hill, London followed in 1986. Three years as an Australian Research Council (ARC) Research Fellow preceded his return to the UK as a SERC/GLAXO Research Fellow in Cambridge from 1990 until 1995. In 1995, Dr. Searle was appointed as a Lecturer in Organic Chemistry at the University of Nottingham and promoted through the ranks to full Professor of Biological Chemistry in 2003, serving as Head of School of Chemistry from 2005 to 2013.He is based within the Nottingham Centre for Biomolecular Sciences on the University Park Campus.
Professor Searle's research is in the application of biophysics and NMR structural biology to studies of biomolecular interactions in cell signaling, RNA translation, ligand transport and uptake and in drug discovery. High-field NMR provides insights into molecular structure and dynamics at high resolution. Complementary techniques such as crystallography, ITC, CD and molecular simulations are used in parallel to solution NMR studies in collaborative projects across Biomedical Sciences, Pharmacy, Biosciences and with Chemistry at Nottingham
Searle has an extensive track record in biophysics and structural biology, having published >150 peer reviewed papers (h-index 36; March 2014). His research interests span fundamental studies of… read more
GOODE A, BUTLER K, LONG J, CAVEY J, SCOTT D, SHAW B, SOLLENBERGER J, GELL C, JOHANSEN T, OLDHAM NJ, SEARLE MS and LAYFIELD R, 2016. Defective recognition of LC3B by mutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism in ALS-FTLD. Autophagy. 12(7), 1094-104 CINI, MELCHIOR, WILLIAMS, HUW, FAY, MIKE W., SEARLE, MARK S., WOODWARD, SIMON and BRADSHAW, TRACEY D., 2016. Enantiopure titanocene complexes - direct evidence for paraptosis in cancer cells METALLOMICS. 8(3), 286-297
SCOTT, DANIEL, OLDHAM, NEIL J., STRACHAN, JO, SEARLE, MARK S. and LAYFIELD, ROBERT, 2015. Ubiquitin-binding domains: Mechanisms of ubiquitin recognition and use as tools to investigate ubiquitin-modified proteomes PROTEOMICS. 15(5-6), 844-861
Searle has an extensive track record in biophysics and structural biology, having published >150 peer reviewed papers (h-index 36; March 2014). His research interests span fundamental studies of protein-ligand interactions, protein-protein recognition in ubiquitin-mediated signal transduction, autophagy and bone disease, quadruplex nucleic acid structure and recognition, regulation of RNA translation, and protein-protein interactions linked to cell adhesion, contact activation and inflammatory response.
Projects have been supported continuously by BBSRC since 1996 and through EU Marie Curie Fellowships, the Leverhulme Trust, AICR, Arthritis Research UK, Motor Neurone Disease Association, Royal Society, through CASE collaborations with GSK, Roche UK and AstraZeneca, and through collaborations with a number of industry/SME partners. His research expertise combines a range of biophysical approaches, in particular NMR methods, for studying biomolecular structure and interactions to model structure and dynamics in ligand complexes.
The Biophysics and Structural Biology Group (MSS) is located in state of the art facilities within the Nottingham Centre for Biomolecular Sciences (opened in 2007) and is well-equipped with Chirascan-Plus CD, an AP SMX fluorescence stopped-flow system, and MicroCal isothermal titration (ITC) and differential scanning calorimetry (DSC) for studies of protein stability and biomolecular interactions (SRIF2 funded), and NMR facilities (800 MHz cryoprobe instrument) for structural biology. The NMR facility provides a hub for collaboration in solid-state and biomolecular NMR across the University.