Georgina Jackson

Contact

• workA Floor, South Block
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 823 0416
• georgina.jackson@nottingham.ac.uk

Research Summary

My research interests concern selection and control of action, co-ordination of goal-directed action.

Human behaviour is highly flexible and in any given situation there may be a number of actions we might pursue. Selecting one action may often require that we suppress competing responses and this maybe particularly difficult when the alternative responses are habitual or strongly reflexive.

I am interested in understanding how behaviour is regulated, particularly the control mechanisms involved in goal directed behaviour, and understanding how these mechanisms are affected by neuropsychiatric disorders. I have explored this issue using behavioural, electrophysiologicaland functional brain imaging measures using a wide range of behaviouraltasks: from very cognitive tasks (e.g. shifting between evaluating whether a letter is a vowel/consonant or is written in upper or lower case script) to more motoric tasks (e.g. shifting between responding immediately or delaying a response.

Recently I have investigated mechanisms of behavioural regulation in Tourette syndrome: using this disorder as a model for understanding the development of cognitive control more generally. Over the course of adolescence most individuals with Tourette syndrome will show a reduction in their tics(unwanted movements), presumably as a consequence of learning to suppress their tics.

We have demonstrated that the brain networks activated during tic suppression are also implicated in the control of goal directed action. With colleagues in the IoN I have shown cognitive control is actually enhanced in children with Tourette syndrome relative to their age matched controls. We are currently investigating the neural basis of this finding and plan to examine the contribution of social context to the development of control mechanisms.

Selected Publications

• SWAINSON, R., JACKSON, S. and JACKSON, G.M., 2006. Using advance information in dynamic cognitive control: an ERP study of task-switching Brain Research. 1105(1), 61-72
• MUELLER, S.C., JACKSON, G., DHALLA, R., DATSOPOULOS, S. and HOLLIS, C.P., 2006. Enhanced cognitive control in young people with Tourettes Syndrome Current Biology. 166(6), 570-573
• ASTLE, D.E., JACKSON, G.M. and SWAINSON, R., 2006. Dissociating neural indices of dynamic cognitive control in advance task-set preparation: An ERP study of task switching Brain Research. 1125, 94-103
• ASTLE, D.E, JACKSON, G.M and SWAINSON, R., 2012. Two measures of task-specific inhibition Quarterly Journal of Experimental Psychology. 65(2), 233-251

• View all publications

• ASTLE, D.E, JACKSON, G.M and SWAINSON, R., 2012. Two measures of task-specific inhibition Quarterly Journal of Experimental Psychology. 65(2), 233-251
• JACKSON, SR, PARKINSON, A, JUNG, J, RYAN, SE, MORGAN, PS, HOLLIS, C and JACKSON, GM, 2011. Compensatory Neural Reorganization In Tourette Syndrome Current Biology. 21(7), 580-585
• ROESSNER V, PLESSEN KJ, ROTHENBERGER A, LUDOLPH AG, RIZZO R, SKOV L, STRAND G, STERN JS, TERMINE C, HOEKSTRA PJ and ESSTS GUIDELINES GROUP, 2011. European Clinical Guidelines For Tourette Syndrome And Other Tic Disorders. Part Ii: Pharmacological Treatment. European Child & Adolescent Psychiatry. 20(4), 173-96
• MÜLLER-VAHL KR, CATH DC, CAVANNA AE, DEHNING S, PORTA M, ROBERTSON MM, VISSER-VANDEWALLE V and ESSTS GUIDELINES GROUP, 2011. European Clinical Guidelines For Tourette Syndrome And Other Tic Disorders. Part Iv: Deep Brain Stimulation. European Child & Adolescent Psychiatry. 20(4), 209-17
• VERDELLEN C, VAN DE GRIENDT J, HARTMANN A, MURPHY T and ESSTS GUIDELINES GROUP, 2011. European Clinical Guidelines For Tourette Syndrome And Other Tic Disorders. Part Iii: Behavioural And Psychosocial Interventions. European Child & Adolescent Psychiatry. 20(4), 197-207
• KANTINI, E., CASSADAY, H.J., HOLLIS, C. and JACKSON, G.M., 2011. The Normal Inhibition of Associations is Impaired by Clonidine in Tourette Syndrome. J Can Acad Child Adolesc Psychiatry. 20(2), 96-106
• KANTINI. E., CASSADAY, H.J., BATTY, M.J., HOLLIS, C. and JACKSON, G.M., 2011. Associative learning in ADHD: improved expression under methylphenidate. Open Journal of Psychiatry.
• GROOM MJ, CAHILL JD, BATES AT, JACKSON GM, CALTON TG, LIDDLE PF and HOLLIS C, 2010. Electrophysiological Indices Of Abnormal Error-Processing In Adolescents With Attention Deficit Hyperactivity Disorder (Adhd). Journal Of Child Psychology And Psychiatry, And Allied Disciplines. 51(1), 66-76
• LIDDLE, E.B, JACKSON, G.M, RORDEN, C. and JACKSON, S.R., 2009. Lateralized temporal order judgement in dyslexia. Neuropsychologia. 47(14), 3244-54
• MULLER, S, SWAINSON, R. and JACKSON, G.M., 2009. ERP indices of persisting and current inhibitory control: a study of saccadic task switching Neuroimage. 45(1), 191-197
• GROOM, M.J., BATES, A.T., JACKSON, G.M., CALTON, T.G., LIDDLE, P.F. and HOLLIS, C.P., 2008. Event-related potentials in adolescents with schizophrenia and their siblings: a comparison with ADHD Biological Psychiatry. 63, 784-792
• ASTLE, D.E, JACKSON, G.M and SWAINSON, R., 2008. Fractionating the cognitive control required to bring about a change in task-set :A dense-sensor ERP study. Journal of Cognitive Neuroscience. 20(2), 255-267
• GROOM, M.J, JACKSON, G.M, CALTON, T.G, ANDREWS, H.K, BATES, A.T, LIDDLE, P.F. and HOLLIS, C., 2008. Cognitive deficits in early-onset schizophrenia spectrum patients and their non-psychotic siblings: a comparison with ADHD. Schizophrenia Research. 99(1), 85-95
• ASTLE, D.E, JACKSON, G.M. and SWAINSON, R., 2008. The role of spatial information in advance task-set control: an event-related potential study. European Journal of Neuroscience. 28(7), 1404-18
• MUELLER, S. C and SWAINSON, R. JACKSON, G. M., 2007. Behavioural and neurophysiological correlates of bivalent and univalent responses during task switching. Brain Research. 1157, 56-65
• JACKSON, G. M, MUELLER, S. C and HAMBLETON, K, HOLLIS, C.P, 2007. Enhanced cognitive control in Tourette Syndrome during task uncertainty Experiment Brain Research. 182(3), 357-364
• MUELLER, S.C., JACKSON, G., DHALLA, R., DATSOPOULOS, S. and HOLLIS, C.P., 2006. Enhanced cognitive control in young people with Tourettes Syndrome Current Biology. 166(6), 570-573
• SWAINSON, R., JACKSON, S. and JACKSON, G.M., 2006. Using advance information in dynamic cognitive control: an ERP study of task-switching Brain Research. 1105(1), 61-72
• ASTLE, D.E., JACKSON, G.M. and SWAINSON, R., 2006. Dissociating neural indices of dynamic cognitive control in advance task-set preparation: An ERP study of task switching Brain Research. 1125, 94-103
• JACKSON, G.M., SHEPHERD, T., MUELLER, S.C., HUSAIN, M. and JACKSON, S.R., 2006. Dorsal simultanagnosia: an impairment of visual processing or visual awareness? Cortex: a journal devoted to the study of the nervous system and behavior. 42(5), 740-749
• JACKSON, G. M., 2006. Tourettes Syndrome Current Biology. VOL 16(NUMBER 12), R443-R444
• JACKSON, S., NEWPORT, R., MORT, D., HUSAIN, M., JACKSON, G., SWAINSON, R., PEARS, S. and WILSON, B., 2005. Action binding and the parietal lobes: some new perspectives on optic ataxia. In: HUMPHREYS, G.W. and RIDDOCH, M.J., eds., Attention in action: advances from cognitive neuroscience Hove: Psychology Press.
• LIDDLE, E., JACKSON, G. and JACKSON, S., 2005. An evaluation of a visual biofeedback intervention in dyslexic adults Dyslexia: the journal of the British Dyslexia Association. 11(1), 61-77
• CORNISH, KIM, SWAINSON, RACHEL, CUNNINGTON, ROSS, WILDING, JOHN, MORRIS, PETER and JACKSON, GEORGINA, 2004. Do women with fragile X syndrome have problems in switching attention: preliminary findings from ERP and fMRI. Brain and Cognition. 54(3), 235-9
• JACKSON, G.M., SWAINSON, R., MULLIN, A., CUNNINGTON, R. and JACKSON, S.R., 2004. ERP correlates of a receptive language-switching task Quarterly Journal of Experimental Psychology. Section A: Human Experimental Psychology. 57(2), 223-240
• JACKSON, G.M., SWAINSON, R., MORT, D., HUSAIN, M. and JACKSON, S., 2004. Implicit processing of global information in Balint's syndrome Cortex: a journal devoted to the study of the nervous system and behavior. 40(1), 179-180
• SWAINSON, R., JACKSON, S. and JACKSON, G., 2004. Electrophysiology of cognitive control: predictability and precueing of task-switches. International Journal of Psychophysiology. 54(1-2), 14
• SWAINSON, R., CUNNINGTON, R., JACKSON, G.M., RORDEN, C., PETERS, A.M., MORRIS, P.G. and JACKSON, S.R., 2003. Cognitive control mechanisms revealed by ERP and fMRI: evidence from repeated task-switching Journal of Cognitive Neuroscience. 15(6), 785-799
• PLODOWSKI, A., SWAINSON, R., JACKSON, G.M., RORDEN, C. and JACKSON, S.R., 2003. Mental representation of number in different numerical forms Current Biology. 13(23), 2045-2050
• JACKSON, G.M., JACKSON, S.R., NEWPORT, R. and HARVEY, M., 2002. Co-ordination of bimanual movements in a centrally deafferented patient executing open loop reach-to-grasp movements Acta Psychologica. 110(2-3), 231-246
• JACKSON, G. M., GERMAN, K. and PEACOCK, K., 2002. Functional coupling between the limbs during bimanual reach-to-grasp movements Human Movement Science. 21(3), 317-333
• JACKSON, G., SWAINSON, R., CUNNINGTON, R. and JACKSON, S., 2001. ERP correlates of executive control in language-switching. Neuroimage. 13(6), S322
• JACKSON, G.M., SWAINSON, R., CUNNINGTON, R. and JACKSON, S., 2001. ERP correlates of executive control during repeated language-switching. Bilingualism: Language and Cognition. 4(2), 169-178
• HUSAIN, M., JACKSON, S.R., JACKSON, G.M., HARVEY, M., KRAMER, T. and DOW, L, 2000. The coordination of bimanual prehension movements in a centrally deafferented patient Brain: a journal of neurology. 123(2), 380-393
• JACKSON, G M, JACKSON, S R and HINDLE, J V, 2000. The control of bimanual reach-to-grasp movements in hemiparkinsonian patients. Experimental Brain Research. 132(3), 390-8
• JACKSON, S.R., JACKSON, G.M. and ROBERTS, M., 1999. The selection and suppression of action: ERP correlates of executive control in humans NeuroReport. 10(4), 861-865
• JACKSON, G.M., JACKSON, S.R. and KRITIKOS, A., 1999. Attention for action: co-ordinating bimanual reach-to-grasp movements British Journal of Psychology. 90(2), 247-270
• KRITIKOS, A., JACKSON, G.M. and JACKSON, S.R., 1998. The influence of initial hand posture on the expression of prehension parameters Experimental Brain Research. 119(1), 9-16
• JACKSON, G.M., 1998. Cognitive and motoric contributions to sequence learning European Journal of Neuroscience. 10(10), 401
• JACKSON, G M, JACKSON, S R, HARRISON, J, HENDERSON, L and KENNARD, C, 1995. Serial reaction time learning and Parkinson's disease: evidence for a procedural learning deficit. Neuropsychologia. 33(5), 577-93
• JACKSON, G.M. and JACKSON, S.R., 1995. Do measures of explicit learning actually measure what is being learnt in the SRT task?: A critique of current methods Psyche: An International Journal of Research on Consciousness. 2(1),
• JACKSON, S.R. and JACKSON, G.M., The internal control of action and Parkinson's disease: A kinematic analysis of visually-guided and memory-guided prehension movements. Experimental Brain Research. 105(1), 147-162
• HOLLIS, C, GROOM, M.J, DAS, D, CALTON, T, BATES, A.T, ANDREWS, H.K, JACKSON, G.M. and LIDDLE, P.F., Different psychological effects of cannabis use in adolescents at genetic high risk for schizophrenia and with attention deficit/hyperactivity disorder (ADHD) Schizophrenia Research. (In Press.)
• JACKSON, G.M, SWAINSON, R, MORT, D, HUSAIN, M. and JACKSON, S.R., Attention, competition, and the parietal lobes: Insights from Balint's syndrome Psychological Research. (In Press.)
• JACKSON, S.R, JACKSON, G.M. and ROSICKY, J., Are non-relevant objects represented in working memory?: The effect of non-target objects on reaching and grasping kinematics. Experimental Brain Research. 102(3), 519-530