Institute of Genetics

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Prof Jan Bradley

Overview Research Publications Opportunities

All Publications

  • D'ELIA, RICCARDO, BEHNKE, JERZY M, BRADLEY, JANETTE E and ELSE, KATHRYN J, 2009. Regulatory T cells: a role in the control of helminth-driven intestinal pathology and worm survival. Journal of immunology (Baltimore, Md. : 1950), 182(4), 2340-8.
  • JACKSON, JOSEPH A, FRIBERG, IDA M, LITTLE, SUSAN and BRADLEY, JANETTE E, 2009. Review series on helminths, immune modulation and the hygiene hypothesis: immunity against helminths and immunological phenomena in modern human populations: coevolutionary legacies?. Immunology, 126(1), 18-27.
  • JACKSON, JOSEPH A, FRIBERG, IDA M, BOLCH, LUKE, LOWE, ANN, RALLI, CATRIONA, HARRIS, PHILIP D, BEHNKE, JERZY M and BRADLEY, JANETTE E, 2009. Immunomodulatory parasites and toll-like receptor-mediated tumour necrosis factor alpha responsiveness in wild mammals. BMC Biology, 7, 16.
  • AL-RIYAMI, L, EGAN, C A, BRADLEY, J E, LUSTIGMAN, S and HARNETT, W, 2008. Failure of ES-62 to inhibit T-helper type 1 responses to other filarial nematode antigens. Parasite immunology, 30(5), 304-8.
  • ANDREWS, J A, BLIGH, W J, CHIODINI, P L, BRADLEY, J E, NDE, P N and LUCIUS, R, 2008. The role of a recombinant hybrid protein based ELISA for the serodiagnosis of Onchocerca volvulus. Journal of clinical pathology, 61(3), 347-51.
  • BRADLEY, and JACKSON,, 2008. Measuring immune system variation to help understand host-pathogen community dynamics. Parasitology, 1-17.
  • TURNER, JOSEPH D, JACKSON, JOSEPH A, FAULKNER, HELEN, BEHNKE, JERZY, ELSE, KATHRYN J, KAMGNO, JOSEPH, BOUSSINESQ, MICHEL and BRADLEY, JANETTE E, 2008. Intensity of intestinal infection with multiple worm species is related to regulatory cytokine output and immune hyporesponsiveness. Journal of Infectious Diseases, 197(8), 1204-12.
  • HEDELER, C., PATON, N. W., BEHNKE, J. M., BRADLEY, J. E., HAMSHERE, M. G. and ELSE, K. J., 2006. A classification of tasks for the systematic study of immune response using functional genomics data. Parasitology (Cambridge), 132(2), 157-168.
  • JACKSON, J.A., PLEASS, R.J., CABLE, J., BRADLEY, J.E. and TINSLEY, R.C., 2006. Heterogenous interspecific interactions in a host-parasite system. International Journal for Parasitology, 36(13), 1341-1349.
  • JACKSON, J.A., TURNER, J.D., KAMAL, M., WRIGHT, V., BICKLE, Q., ELSE, K.J., RAMSAN, M. and BRADLEY, J.E., 2006. Gastrointestinal nematode infection is associated with variation in innate immune responsiveness. Microbes and Infection, 8(2), 487-492.
  • KARADAG, B., EGE, M., BRADLEY, J. E., BRAUN-FAHRLANDER, C., RIEDLER, J., NOWAK, D. and VON MUTIUS, E., 2006. The role of parasitic infections in atopic diseases in rural schoolchildren. Allergy, 61(8), 996-1001.
  • FAULKNER, H., TURNER, J., BEHNKE, J., KAMGNO, J., ROWLINSON, M. C., BRADLEY, J. E. and BOUSSINESQ, M., 2005. Associations between filarial and gastrointestinal nematodes. Royal Society of Tropical Medicine and Hygiene. Transactions, 99(4), 301-312.
  • JOHNSTON, C. E., BRADLEY, J. E., BEHNKE, J. M., MATTHEWS, K. R. and ELSE, K. J., 2005. Isolates of Trichuris muris elicit different adaptive immune responses in their murine host. Parasite Immunology, 27(3), 69-78.
  • TURNER, J.D., FAULKNER, H., KAMGNO, J., KENNEDY, M.W., BEHNKE, J., BOUSSINESQ, M. and BRADLEY, J.E., 2005. Allergen-specific IgE and IgG4 are markers of resistance and susceptibility in a human intestinal nematode infection. Microbes and Infection, 7(7-8), 990-996.
  • ACHUKWI, M. D., HARNETT, W., BRADLEY, J. and RENZ, A., 2004. Onchocerca ochengi acquisition in zebu Gudali cattle exposed to natural transmission: parasite population dynamics and IgG antibody subclass responses to Ov10/Ov11 recombinant antigens. Veterinary Parasitology, 122(1), 35-49.
  • BRADLEY, J. E. and JACKSON, J. A., 2004. Immunity, immunoregulation and the ecology of trichuriasis and ascariasis. Parasite Immunology, 26(11-12), 429-441.
  • JACKSON, J.A., TURNER, J.D., RENTOUL, L., FAULKNER, H., BEHNKE, J.M., HOYLE, M., GRENCIS, R.K., ELSE, K.J., KAMGNO, J., BRADLEY, J.E. and BOUSSINESQ, M., 2004. Cytokine response profiles predict species-specific infection patterns in human GI nematodes. International Journal for Parasitology, 34(11), 1237-1244.
  • JACKSON, J.A., TURNER, J.D., RENTOUL, L., FAULKNER, H., BEHNKE, J.M., HOYLE, M., GRENCIS, R.K., ELSE, K.J., KAMGNO, J., BOUSSINESQ, M and BRADLEY, J.E., 2004. T helper cell type 2 responsiveness predicts future susceptibility to gastrointestinal nematodes in humans. Journal of Infectious Diseases, 190(10), 1804-1811.
  • GAROFALO, A., KENNEDY, M. W. and BRADLEY, J. E., 2003. The FAR proteins of parasitic nematodes: their possible involvement in the pathogenesis of infection and the use of Caenorhabditis elegans as a model system to evaluate their function. Medical Microbiology and Immunology, 192(1), 47-52.
  • GAROFALO, A., ROWLINSON, M.-C., AMAMBUA, N.A., HUGHES, J.M., KELLY, S.M., PRICE, N.C., COOPER, A., WATSON, D.G., KENNEDY, M.W. and BRADLEY, J.E., 2003. The FAR protein family of the nematode Caenorhabditis elegans: differential lipid binding properties, structural characteristics, and developmental regulation. Journal of Biological Chemistry, 278(10), 8065-8074.
  • RODRí­GUEZ-PéREZ, M.A., DOMíNGUEZ-VáZQUEZ, A., MéNDEZ-GALVáN, J., SIFUENTES-RINCóN, A.M., LARRALDE-CORONA, P., BARRERA-SALDAñA, H.A. and BRADLEY, J.E., 2003. Antibody detection tests for Onchocerca volvulus: comparison of the sensitivity of a cocktail of recombinant antigens used in the indirect enzyme-linked immunosorbent assay with a rapid-format antibody card test. Transactions of the Royal Society of Tropical Medicine and Hygiene, 97(5), 539-41.
  • SOLOVYOVA, A. S., MEENAN, N., MCDERMOTT, L., GAROFALO, A., BRADLEY, J. E., KENNEDY, M. W. and BYRON, O., 2003. The polyprotein and FAR lipid binding proteins of nematodes: shape and monomer/dimer states in ligand-free and bound forms. European Biophysics Journal, 32(5), 465-476.
  • TURNER, J.D., FAULKNER, H., KAMGNO, J., CORMONT, F., VAN SNICK, J., ELSE, K.J., GRENCIS, R.K., BEHNKE, J.M., BOUSSINESQ, M. and BRADLEY, J.E., 2003. Th2 cytokines are associated with reduced worm burdens in a human intestinal helminth infection. Journal of Infectious Diseases, 188(11), 1768-1775.
  • FAULKNER, H., TURNER, J., KAMGNO, J., PION, S.D., BOUSSINESQ, M. and BRADLEY, J.E., 2002. Age- and infection intensity-dependent cytokine and antibody production in human trichuriasis: The importance of IgE. Journal of Infectious Diseases, 185(5), 665-672.
  • FAULKNER,H. and BRADLEY,J.E., 2002. Immune responses in humans - Trichuris trichiura. In: HOLLAND,C.V., KENNEDY,M.W., eds. The geohelminths: Ascaris, Trichuris and hookworm. Boston, Mass: Kluwer Academic, pp. 125-142
  • GAROFALO, A., KLAGER, S. L., ROWLINSON, M. C., NIRMALAN, N., KLION, A., ALLEN, J. E., KENNEDY, M. W. and BRADLEY, J. E., 2002. The FAR proteins of filarial nematodes: secretion, glycosylation and lipid binding characteristics. Molecular and Biochemical Parasitology, 122(2), 161 - 170.
  • MCDERMOTT, L., KENNEDY, M. W., MCMANUS, D. P., BRADLEY, J. E., COOPER, A. and STORCH, J., 2002. How Helminth Lipid-Binding Proteins Offload Their Ligands to Membranes: Differential Mechanisms of Fatty Acid Transfer by the ABA-1 Polyprotein Allergen and Ov-FAR-1 Proteins of Nematodes and Sj-FABPc of Schistosomes. Biochemistry, 41(21), 6706-6713.
  • NDE, P. N., POGONKA, T., BRADLEY, J. E., TITANJI, V. P. K. and LUCIUS, R., 2002. Sensitive and specific serodiagnosis of onchocerciasis with recombinant hybrid proteins. American Journal of Tropical Medicine and Hygiene, 66(5), 566-571.
  • TURNER, J., FAULKNER, H., KAMGNO, J., ELSE, K., BOUSSINESQ, M. and BRADLEY, J. E., 2002. A comparison of cellular and humoral immune responses to trichuroid derived antigens in human trichuriasis. Parasite Immunology, 24(2), 83-94.
  • WAKELIN, D., FARIAS, S. E. and BRADLEY, J. E., 2002. Variation and immunity to intestinal worms. Parasitology (Cambridge), 125(SUPP), S39-S50.
  • WAKELIN,D. and BRADLEY,J.E., 2002. Parasite strain diversity and host immune responses. In: HOLLAND,C.V., KENNEDY,M.W., eds. The geohelminths: Ascaris, Trichuris and hookworm. Boston, Mass.: Kluwer Academic, pp. 199-218
  • BRADLEY, J. E., NIRMALAN, N., KLAGER, S. L., FAULKNER, H. and KENNEDY, M. W., 2001. River blindness: a role for parasite retinoid-binding proteins in the generation of pathology?. Trends in Parasitology, 17(10), 471-475.
  • FAULKNER, H., GARDON, J., KAMGNO, J., ENYONG, P., BOUSSINESQ, M. and BRADLEY, J. E., 2001. Antibody responses in onchocerciasis as a function of age and infection intensity. Parasite Immunology, 23(9), 509-516.
  • SCHöNEMEYER, A., LUCIUS, R., SONNENBURG, B., BRATTIG, N., SABAT, R., SCHILLING, K., BRADLEY, J. and HARTMANN, S., 2001. Modulation of human T cell responses and macrophage functions by onchocystatin, a secreted protein of the filarial nematode Onchocerca volvulus. The Journal of Immunology, 167(6), 3207-3215.
  • KLäGER,S.L., HAGEN,H-.E. and BRADLEY,J.E., 1999. Effects of an Onchocerca-derived cysteine protease inhibitor on microfilariae in their simuliide vector. Parasitology (Cambridge), 118(3), 305-310.
  • NIRMALAN, N., CORDEIRO, N. J. V., KLAEGER, S. L., BRADLEY, J. E. and ALLEN, J. E., 1999. Comparative Analysis of Glycosylated and Nonglycosylated Filarial Homologues of the 20-Kilodalton Retinol Binding Protein from Onchocerca volvulus (Ov20). Infection and Immunity, 67(12), 6329-6334.
  • GARRAUD, O., PERLER, F. B., BRADLEY, J. E. and NUTMAN, T. B., 1997. Induction of Parasite Antigen-Specific Antibody Responses in Unsensitized Human B Cells Is Dependent on the Presence of Cytokines After T Cell Priming. The Journal of Immunology, 159(10), 4793-4798.
  • KENNEDY, M. W., GARSIDE, L. H., GOODRICK, L. E., MCDERMOTT, L., BRASS, A., PRICE, N. C., KELLY, S. M., COOPER, A. and BRADLEY, J. E., 1997. The Ov20 Protein of the Parasitic Nematode Onchocerca volvulus: A Structurally Novel Class of Small Helix-rich Retinol-binding Proteins. Journal of Biological Chemistry, 272(47), 29442-29448.