Institute of Genetics

Print this Page
Email this Page

Text Only Version
High Contrast Version

Email Enquiry

  Staff & Students

Prof Ed Louis FSB

Overview Research Publications Yeast Genomic Resources Opportunities
id photo

Prof of Genome Dynamics, Dir.Inst of Genetics,Royal Soc.Wolfson Research Merit award 08-2013, FSB (Institute Member)

Room: D115 (Medical School)

Address: Institute of Genetics, The University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK

Tel: +44 (0)115 823 0375 (int 30375)
Fax: 0115 823 0338
Email: ed.louis@nottingham.ac.uk

PA: Heather Barnett, Tel:  +44 (0)115 823 0354 (int 30354), Fax:  +44 (0)115 823 0338, Email:  heather.barnett@nottingham.ac.uk

Date for your diaries: 15-20 October 2011 EMBO conference on Comparative Genomics of Eukaryotic Microorganisms to be held in San Feliu de Guixols, Spain (watch this space).

Research Overview: Telomeres, genome dynamics and evolution 

Telomeres and telomere associated sequences (subtelomeres) are dynamic and highly polymorphic in virtually all linear chromosomes. They are associated with genome stability over all as well as in ageing, cancer, pathogenicity and evolution. We study the structure, function and dynamics of these sequences in the yeast S. cerevisiae at several levels. In addition we study genome evolution and speciation in yeasts and telomeres in parasites.

Education, appointments and honours

BSc in Biology and Mathematics, Clarkson University 1981; PhD in Genetics, University of California at Berkeley 1986 (National Science Foundation Scholarship; American Cancer Society Postdoctoral Research Fellow, Brandeis University 1986-1991; Wellcome Trust Senior Research Fellow, Institute of Molecular Medicine, Oxford 1991-1998; Lecturer and Tutorial Fellow, Dept. of Biochemistry and Corpus Christi College, Oxford 1998-2000; Professor of Genetics, University of Leicester 2000-2005; Professor of Genome Dynamics, University of Nottingham 2005- current. Fellow of the Society of Biology 2009.

Selected Publications

  • GIANNI LITI, DAVID M. CARTER, ALAN M. MOSES, JONAS WARRINGER, LEOPOLD PARTS, STEPHEN A. JAMES, ROBERT P. DAVEY, IAN N. ROBERTS, AUSTIN BURT, VASSILIKI KOUFOPANOU, ISHENG J. TSAI, CASEY M. BERGMAN, DOUDA BENSASSON, MICHAEL J. T. O’KELLY, ALEXANDER VAN OUDENAARDEN, DAVID B. H. BARTON, ELIZABETH BAILES, MATTHEW JONES, MICHAEL A. QUAIL, IAN GOODHEAD, SARAH SIMS, FRANCES SMITH, ANDERS BLOMBERG, RICHARD DURBIN & EDWARD J. LOUIS, 2009. Population genomics of domestic and wild yeasts. Nature, 458, 337-341.
  • LOUIS, EDWARD J, 2009. Evolutionary genetics: Origins of reproductive isolation. Nature, 457(7229), 549-50.
  • LOUIS, EDWARD J, 2007. Evolutionary genetics: making the most of redundancy. Nature, 449(7163), 673-4.
  • STRAATMAN, and LOUIS,, 2007. Localization of telomeres and telomere-associated proteins in telomerase-negative Saccharomyces cerevisiae. Chromosome Research, 15, 1033-1050.
  • CODD, VERYAN, DOLEZEL, DAVID, STEHLIK, JAN, PICCIN, ALBERTO, GARNER, KAREN J, RACEY, SETH N, STRAATMAN, KORNELIS R, LOUIS, EDWARD J, COSTA, RODOLFO, SAUMAN, IVO, KYRIACOU, CHARALAMBOS P and ROSATO, EZIO, 2007. Circadian Rhythm Gene Regulation in the Housefly Musca domestica. Genetics, 177(3), 1539-51.
  • LITI, G., BARTON, D.B.H. and LOUIS, E.J., 2006. Sequence diversity, reproductive isolation and species concepts in Saccharomyces. Genetics, 174(2), 839-850.
  • POPE, G.A., D.A. MACKENZIE, M. DEFERNEZ, M.A. AROSO, L.J. FULLER, F.A. MELLON, W.B. DUNN, M. BROWN, R. GOODACRE, D.B. KELL, M.E. MARVIN, E.J. LOUIS, AND I.N. ROBERTS, 2007. Metabolic footprinting as a tool for discriminating between brewing yeasts. Yeast, 24, 667-669.
  • INGLIS, P. W., RIGDEN, D. J., MELLO, L. V., LOUIS, E. J. and VALADARES-INGLIS, M. C., 2005. Monomorphic subtelomeric DNA in the filamentous fungus, Metarhizium anisopliae,contains a RecQ helicase-like gene. Molecular Genetics and Genomics, 274(1), 79-90.
  • LITI, G. and LOUIS, E.J., 2005. Yeast evolution and comparative genomics. Annual Review of Microbiology, 59, 135-154.
  • LITI, G., PERUFFO, A., JAMES, S. A., ROBERTS, I. N. and LOUIS, E. J., 2005. Inferences of evolutionary relationships from a population survey of LTR-retrotransposons and telomeric-associated sequences in the Saccharomyces sensu stricto complex. Yeast, 22(3), 177-192.
  • VASA-NICOTERA, M., BROUILETTE, S., MANGINO, M., THOMPSON, J.R., BRAUND, P., CLEMITSON, J.-R., MASON, A., BODYCOTE, C.L., RALEIGH, S.M., LOUIS, E. and SAMANI, N.J., 2005. Mapping of a major locus that determines telomere length in humans. American Journal of Human Genetics, 76(1), 147-151.
  • LOUIS, E.J. and VERSHININ, A.V., 2005. Chromosome ends: different sequences may provide conserved functions. BioEssays, 27(7), 685-697.
  • MOORE, S. P., LITI, G., STEFANISKO, K. M., NYSWANER, K. M., CHANG, C., LOUIS, E. J. and GARFINKEL, D. J., 2004. Analysis of a Ty1-less variant of Saccharomyces paradoxus: the gain and loss of Ty1 elements. Yeast, 21(8), 649-660.
  • BECKER, M., AITCHESON, N., BYLES, E., WICKSTEAD, B., LOUIS, E. and RUDENKO, G., 2004. Isolation of the repertoire of VSG expression site containing telomeres of Trypanosoma brucei 427 using transformation-associated recombination in yeast. Genome Research, 14(11), 2319-2329.

Group Members

Felix Dafhnis Research Fellow +44 (0)115 823 0379 /77
internal (QMC) 30379 / 30377		 D119
Jenny McLaughlan Research Fellow +44 (0)115 823 0379/30377
internal (QMC) 30379/30377		 D119
Dr Marion Becker Research Fellow +44 (0)115 823 0377/30379
internal (QMC) 30377/30379		 D114
Dr Gianni Liti Research Fellow +44 (0)115 823 0377/30379
internal (QMC) 30379/30377		 D119
Dr Marcus Marvin Research Fellow +44 (0)115 823 0379/30377
internal (QMC) 30379/30377		 D119
Dr Sarah Sharp Research Associate +44 (0)115 82 30377/30379
internal (QMC) 30377/30379		 D119
Mr Alex Mott Technician +44(0)115 823 0379
internal (UP) 30379		 D119
Dr Shun Adachi Research Visitor +44(0)115 823 0374
internal (UP) 30377		 D119
Mohammad Al-Otaibi Postgraduate Student +44 (0)115 823 0374
internal (QMC) 30377 		D119
Francisco Cubillos Postgraduate Student +44 (0)115 823 0374
internal (QMC) 30377 		D119
Li Li Postgraduate Student +44 (0)115 823 0374
internal (QMC) 30377 		D119
Thomas Tan Postgraduate Student +44 (0)115 823 0379
internal (QMC) 30377 		D113
Philippa Muston Postgraduate Student +44 (0)115 823 0374
internal (QMC) 30377 		D119
Kanika Jain MRes Student +44 (0)115 823 0374
internal (QMC) 30377 		D119
Shailendra Sharma MRes Student +44(0)115 823 0377
internal (QMC) 30377 		D119