Global Resource of EczemA Trials (GREAT database)
Global Resource of EczemA Trials
(GREAT database)
2000 - 2011
www.greatdatabase.org.uk
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Treatment categories
TREATMENT CATEGORIES
Antihistamines and Mast Cell Stabilisers
treatments
AN0128
trials
Beutner-2007-A randomised, double-blind, vehicle-controlled, multi-center study to evaluate the safety and efficacy of topically applied AN0128 cream, 1% for the treatment of mild to moderate atopic dermatitis.
Antihistamines
trials
Rahman-2006-Effectiveness of montelukast in the treatment of atopic dermatitis
Cetirizine
trials
Capella-2001-A randomized trial of leukotriene receptor antagonist montelukast in moderate-to-severe atopic dermatitis of adults
Diepgen-2002-Long-term treatment with cetirizine of infants with atopic dermatitis: A multi-country, double-blind, randomized, placebo-controlled trial (the ETAC trial) over 18 months
Chlorpheniramine
trials
Munday-2002-Chlorpheniramine Is No More Effective than Placebo in Relieving the Symptoms of Childhood Atopic Dermatitis with a Nocturnal Itching and Scratching Component
Defensamide
trials
Kim-2010-Therapeutic efficacy of defensamide in atopic dermatitis
Fexofenadine
trials
Kawashima-2003-Addition of fexofenadine to a topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1-week randomized, multicentre, double-blind, placebo-controlled, parallel-group study
Nakagawa-2006-Efficacy and safety of fexofenadine hydrochloride in pediatric patients with atopic dermatitis in a phase III, randomized, double-blind, multi-center comparative study.
Ketotifen
trials
Nakagawa-2006-Efficacy and safety of fexofenadine hydrochloride in pediatric patients with atopic dermatitis in a phase III, randomized, double-blind, multi-center comparative study.
Loratadine
trials
Shi-2008-Clinical study in treatment of atopic dermatitis by intergrated traditional chinese and western medicine.
Miltefosine
trials
Dolle-2010-Long-term reduction in local inflammation by a lipid raft molecule in atopic dermatitis
Sodium cromoglycate
trials
Stainer-2005-Efficacy and acceptability of a new topical skin lotion of sodium cromoglicate (Altoderm) in atopic dermatitis in children aged 2-12 years: a double-blind, randomized, placebo-controlled trial
Topical doxepin
trials
Lee-2006-The antipruritic effect of topical doxepin cream in patients with atopic dermatitis
Antimicrobial and Antiseptic Agents
treatments
Ciclopiroxolamine
trials
Mayser-2006-Treatment of Head and Neck Dermatitis with Ciclopiroxolamine Cream - Results of a Double-Blind, Placebo-Controlled Study
Clarythromycin
trials
Capella-2001-A randomized trial of leukotriene receptor antagonist montelukast in moderate-to-severe atopic dermatitis of adults
Fusidic acid
trials
Hung-2007-Staphylococcus colonisation in atopic dermatitis treated with fluticasone or tacrolimus with or without antibiotics
Larsen-2007-An Efficient New Formulation of Fusidic Acid and Betamethasone 17-Valerate (Fucicort Lipid Cream) for Treatment of Clinically Infected Atopic Dermatitis
Ravenscroft-2003-Short-term effects of topical fusidic acid or mupirocin on the prevalence of fusidic acid resistant (FusR) Staphylococcus aureus in atopic eczema
Ketoconazole
trials
Back-2001-Systemic Ketoconazole for yeast allergic patients with atopic dermatitis
Lintu-2001-Systemic ketoconazole is an effective treatment of atopic dermatitis with IgE-mediated hypersensitivity to yeasts
Levocetirizine
trials
Kirkcik-2010-Management of pruritis with levocetirizine dihydrochloride in atopic dermatitis in a randomised, double blind, placebo controlled study - Interim analysis
Mupirocin
trials
Gong-2006-Skin colonisation by Staphylococcus aureus in patients with eczema and atopic dermatitis and relevant combined topical therapy: a double-blind multicentre randomized controlled trial
Ravenscroft-2003-Short-term effects of topical fusidic acid or mupirocin on the prevalence of fusidic acid resistant (FusR) Staphylococcus aureus in atopic eczema
Tetracycline
Triclosan
trials
Tan-2010-A randomised double-blind controlled trial to compare a triclosan containing emollient with vehicle for the treatment of atopic dermatitis
Complementary therapies
treatments
Aromatherapy
trials
Anderson-2000-Evaluation of Massage with Essential Oils on Childhood Atopic Eczema
Bystron-2005-Assessment of a double blind, placebo controlled study using the medication JOALIS (Joalis BAMBI CUTIS, Joalis BAMBI IMUN, Joalis BAMBI ANALERG a COLA de CABALLO) on patients suffering from atopic eczema
Chinese herbal medicine
trials
Henderson-2000-An open study comparing the efficacy of two different Chinese herbal therapy formulations in atopic eczema and their effects on circulating activated T-lymphocytes
Hon-2007-Efficacy and tolerability of a Chinese herbal medicine concoction for treatment of atopic dermatitis: a randomized, double-blind, placebo-controlled study
Klovekorn-2007-A randomized, double-blind, vehicle-controlled, half-side comparison with a herbal ointment containing Mahonia aquifolium, Viola tricolor and Centella asiatica for the treatment of mild-to-moderate atopic dermatitis
Kobayashi-2010-Efficacy and Safety of a traditional Herbal Medicine, Hochu-ekki-to in the Long Term Management of Kikyo (Delicate Constitution) Patients with Atopic Dermatitis: A 6-month, Multicentre, Double-blind, Randomised, Placebo-controlled Study
Shapira-2005-Treatment of atopic dermatitis with herbal combination of Eleuthercoccus, Achilla millefolium, and Lamium album had no advantage over placebo: A double blind, placebo-controlled, randomized trial
Shi-2008-Clinical study in treatment of atopic dermatitis by intergrated traditional chinese and western medicine.
Hypnotherapy/biofeedback
trials
Senser-2004-Hypnotherapy in atopic dermatitis
Massage therapy
trials
Anderson-2000-Evaluation of Massage with Essential Oils on Childhood Atopic Eczema
St John's Wort
trials
Schempp-2003-Topical treatment of atopic dermatitis with St. John's wort cream - a randomized, placebo controlled, double blind half-side comparison
Dietary interventions
treatments
Borage oil
trials
Takwale-2003-Efficacy and tolerability of borage oil in adults and children with atopic eczema: randomised, double blind, placebo controlled, parallel group trial
Gold compound
trials
Freeman-2006-A new treatment for atopic dermatitis: a randomized double-blind placebo-controlled study
Hemp seed oil
trials
Callaway-2005-Efficacy of dietary hempseed oil in patients with atopic dermatitis
Hydrolysed infant formula
trials
Brouwer-2006-No effects of probiotics on atopic dermatitis in infancy: a randomised placebo-controlled trial
Isolauri-2000-Probiotics in the management of atopic eczema
Leung-2004-A randomized, single-blind and crossover study of an amino acid-based milk formula in treating young children with atopic dermatitis
van der Aa-2010-Effect of a new symbiotic mixture on atopic dermatitis in infants: a randomised - controlled trial
Kiwi extract
trials
Mraz-2006-A multicenter, double-blind, placebo-controlled study of the effectiveness of kiwi fruit extract in adults with atopic dermatitis of moderate severity
Licorice extract
trials
Saeedi-2003-The treatment of atopic dermatitis with licorice gel
Olive oil
trials
Callaway-2005-Efficacy of dietary hempseed oil in patients with atopic dermatitis
Takwale-2003-Efficacy and tolerability of borage oil in adults and children with atopic eczema: randomised, double blind, placebo controlled, parallel group trial
Probiotics
trials
Brouwer-2006-No effects of probiotics on atopic dermatitis in infancy: a randomised placebo-controlled trial
Cukrowska-2008-The influence of probiotic Lactobacillus casei and paracasei strains on clinical status of atopic eczema in children with food allergy on cow's milk proteins.
Folster Holst-2006-Prospective, randomized controlled trial on Lactobacillus rhamnosus in infants with moderate to severe atopic dermatitis.
Gerasimov-2010-Probiotic Supplement Reduces Atopic Dermatitis in Preschool Children. A Randomised, Double-Blind, Placebo-Controlled, Clinical Trial
Gobel-2010-Probiotics to young children with atopic dermatitis: a randomised palcebo-controlled trial
Gruber-2007-Randomized, placebo-controlled trial of Lactobacillus rhamnosus GG as treatment of atopic dermatitis in infancy
Hattori-2003-Effects of administration of bifidobacteria on fecal microflora and clinical symptoms in infants with atopic dermatitis.
Isolauri-2000-Probiotics in the management of atopic eczema
Moroi-2010-Beneficial effect of a diet containing heat-killed Lactobacillus paracasei K71 on adult type atopic dermatitis
Murosaki-2006-Effects of intake of syrup supplemented with nigerooligosaccharides and heat-killed Lactobacillus plantarum L-137 on skin symptom and immune function in patients with atopic dermatitis
Rosenfeldt-2003-Effect of probiotic Lactobacillus strains in children with atopic dermatitis
Viljanen-2005-Probiotics in the treatment of atopic eczema/dermatitis syndrome in infants: a double-blind placebo-controlled trial
Woo-2010-Effect of Lactobacillus sakei supplementation on children with atopic eczema-dermatitis syndrome
Yoshida-2010-Clinical Effects of Probiotic Bifidobacterium breve Supplementation in Adult Patients with Atopic Dermatitis
Saccharides
trials
Murosaki-2006-Effects of intake of syrup supplemented with nigerooligosaccharides and heat-killed Lactobacillus plantarum L-137 on skin symptom and immune function in patients with atopic dermatitis
Palombo-2004-A special pill-mask to rehydrate the skin affected by atopic dermatitis
Shibata-2009-Clinical effects of kestose, a prebiotic oligosaccharide, on the treatment of atopic dermatitis in infants.
Synbiotics
trials
van der Aa-2010-Effect of a new symbiotic mixture on atopic dermatitis in infants: a randomised - controlled trial
Vitamin D
trials
Sidbury-2008-Randomised controlled trial of vitamin D supplementation for winter-related atopic dermatits in Boston: A pilot study
Non-pharmacological treatments
treatments
Camellia oil
trials
Hamanda-2008-The usefulness of camellia oil spray for treatment of atopic dermatitis
Camomile extract
trials
Patzelt-Wenczler-2000-Proof of Efficacy of Kamillosan Cream in Atopic Eczema
Dermatologist consulation
trials
Schuttelaar-2010-A randomised controlled trial in children with eczema: nurse practitioner vs. dermatologist
Dermatology nurse consultation
trials
Chinn-2002-Randomized controlled trial of a single dermatology nurse consultation in primary care on the quality of life of children with atopic eczema
Education
trials
Cooenraads-2001-Intensive patient education and treatment program for young adults with atopic eczema.
Grillo-2006-Pediatric Atopic Eczema: The Impact of an Educational Intervention
Shaw-2008-A Study of Targeted Enhanced Patient Care for Pediatric Atopic Dermatitis (STEP PAD)
Span-2001-Intensive daycare for young adults with atopic eczema
Staab-2006-Age related, structured educational programmes for the management of atopic dermatitis in children and adolescents: multicentre, randomised controlled trial
Staab-2002-Evaluation of a parental training program for the management of childhood atopic dermatitis
Excimer laser
trials
Brenninkmeijer-2010-Excimer laser vs. clobetisol propionate 0.05% ointment on prurigo form of atopic dermatitis: a randomised controlled trial, a pilot
House dust mite desensitisation
trials
Pajno-2007-Sublingual immunotherapy in mite-sensitized children with atopic dermatitis: A randomized, double-blind, placebo-controlled study
Nurse Practitioner consultation
trials
Schuttelaar-2010-A randomised controlled trial in children with eczema: nurse practitioner vs. dermatologist
Oral psoralen
trials
Tzaneva-2010-5-Methoxypsoralen plus ultraviolet (UV) A is superior to medium-dose UVA1 in the treatment of severe atopic dermatitis: a randomised crossover trial
Specialised clothing
trials
Guager-2005-Efficacy and functionality of silver-coated textiles in patients with atopic eczema.
Koller-2007-Action of a silk fabric treated with AEGIS in children with atopic dermatitis: A 3-month trial
Ozawa-2008-Effect of underwear made from MEDIELE on skin barrier function of atopic dermatitis patients in winter season.
Stinco-2008-A Randomized Double-Blind Study to Investigate the Clinical Efficacy of Adding a Non-Migrating Antimicrobial to a Special Silk Fabric in the Treatment of Atopic Dermatitis
Yokoyama-2009-Ethylene Vinyl Alcohol (EVOH) Fiber Compared to Cotton Underwear in the Treatment of Childhood Atopic Dermatitis: A Double-Blind Randomized Study
Staying in a different climate
trials
Byremo-2006-Effect of climatic change in children with atopic eczema
Support group
trials
Blessman Weber-2008-Improvement of pruritis and quality of life of children with atopic dermatitis and their families after joining support groups
Thermal spring water
trials
Licu-2002-Efficacy of thermal spring water in the treatment of mild atopic dermatitis.
Ultraviolet light
trials
Der Petrossian-2000-Half-side comparison study on the efficacy of 8-methoxypsoralen bath-PUVA versus narrow-band ultraviolet B phototherapy in patients with severe chronic atopic dermatitis.
Dittmar-2001-UVA1 Therapy Dose-Finding Study in Patients with Acute Exacerbated Atopic Dermatitis
Gambichler-2009-Medium-dose ultraviolet (UV) A1 vs. Narrowband UVB phototherapy in atopic eczema: a randomized crossover study
Granlund-2001-Comparison of Cyclosporin and UVAB Phtotherapy for Intermittent One-year Treatment of Atopic Dermatitis
Hoey-2006-Fixed low dose versus increasing dose of ultraviolet B-TLoâ‚ in the treatment of atopic eczema.
Majoie-2009-Narrowband ultraviolet B and medium-dose ultraviolet A1 are equally effective in the treatment of moderate to severe atopic dermatitis
Reynolds-2001-Narrow-band ultraviolet B and broad-band ultraviolet A phototherapy in adult atopic eczema: a randomised controlled trial
Selvaag-2005-Optimized UVB Treatment of Atopic Dermatitis Using Skin Reflectance Measurements. A Controlled, Left-Right Comparison Trial
Tzaneva-2010-5-Methoxypsoralen plus ultraviolet (UV) A is superior to medium-dose UVA1 in the treatment of severe atopic dermatitis: a randomised crossover trial
Tzung-2006-Pimecrolimus and Narrowband UVB as Monotherapy or Combination Therapy in Children and Adolescents with Atopic Dermatitis
Valkova-2004-UVA/UVB phototherapy for atopic dermatitis revisited
Vaccine
trials
Arkwright-2001-Intradermal administration of a killed Mycobacterium vaccae suspension (SRL 172) is associated with improvement in atopic dermatitis in children with moderate-to-severe disease.
Arkwright-2003-Effect of Mycobacterium vaccae on atopic dermatitis in children of different ages
Berth-Jones-2006-Killed Mycobacterium vaccae suspension in children with moderate-to-severe atopic dermatitis: a randomised, double-blind, placebo-controlled trial
Water softener
trials
Thomas-2011-A multicentre randomized controlled trial of ion-exchange water softeners for the treatment of eczema in children: protocol for the Softened Water Eczema Trial (SWET) (ISRCTN: 71423189)
Other comparators
treatments
Control
trials
Anderson-2000-Evaluation of Massage with Essential Oils on Childhood Atopic Eczema
Blessman Weber-2008-Improvement of pruritis and quality of life of children with atopic dermatitis and their families after joining support groups
Koller-2007-Action of a silk fabric treated with AEGIS in children with atopic dermatitis: A 3-month trial
Laumann-2006-The efficacy and safety of MimyX Cream in reducing the risk of relapse in atopic dermatitis
Licu-2002-Efficacy of thermal spring water in the treatment of mild atopic dermatitis.
Rahman-2008-Efficacy of topical tacrolimus in atopic dermatitis
Yokoyama-2009-Ethylene Vinyl Alcohol (EVOH) Fiber Compared to Cotton Underwear in the Treatment of Childhood Atopic Dermatitis: A Double-Blind Randomized Study
No treatment
trials
Byremo-2006-Effect of climatic change in children with atopic eczema
Chinn-2002-Randomized controlled trial of a single dermatology nurse consultation in primary care on the quality of life of children with atopic eczema
Cooenraads-2001-Intensive patient education and treatment program for young adults with atopic eczema.
Grimalt-2007-The steroid-sparing effect of an emollient therapy in infants with atopic dermatitis: A randomized controlled study
Kawana-2010-Efficacy of a 5-HT1a receptor agonist in atopic dermatitis
Paul-2002-A randomized controlled evaluator-blinded trial of intravenous immunoglobin in adults with severe atopic dermatitis
Ramon-2006-Evaluation of the corticosteroid-sparing effect of a new emollient in 162 atopic infants
Senser-2004-Hypnotherapy in atopic dermatitis
Staab-2006-Age related, structured educational programmes for the management of atopic dermatitis in children and adolescents: multicentre, randomised controlled trial
Staab-2002-Evaluation of a parental training program for the management of childhood atopic dermatitis
Yang-2010-The adjuvant treatment of atopic dermatitis with medical skin preparation containing extracts from Portulaca oleracea and avocado
Placebo
trials
Back-2001-Systemic Ketoconazole for yeast allergic patients with atopic dermatitis
Berth-Jones-2003-Twice weekly fluticasone propionate added to emollient maintenance treatment to reduce risk of relapse in atopic dermatitis: randomised, double blind, parallel group study
Berth-Jones-2002-Azothiaprine in severe atopic dermatitis: a double-blind, placebo-controlled, crossover trial
Berth-Jones-2006-Killed Mycobacterium vaccae suspension in children with moderate-to-severe atopic dermatitis: a randomised, double-blind, placebo-controlled trial
Biglardi-2007-Treatment of pruritus with topically applied opiate receptor antagonist
Craig-2002-The effects of montelukast on atopic dermatitis (AD): A placebo controlled, double-blind, parallel study
Diepgen-2002-Long-term treatment with cetirizine of infants with atopic dermatitis: A multi-country, double-blind, randomized, placebo-controlled trial (the ETAC trial) over 18 months
Eichenfield-2006-Two randomized , double-blind, placebo-controlled studies of fluticasone propionate lotion 0.05% for the treatment of atopic dermatitis in subjects from 3 months of age
Folster Holst-2006-Prospective, randomized controlled trial on Lactobacillus rhamnosus in infants with moderate to severe atopic dermatitis.
Friedmann-2007-A double-blind, placebo-controlled trial of montelukast in adult atopic eczema.
Ger Rikken-2010-SUN13834 in the Treatment of Subjects with Atopic Dermatitis
Gerasimov-2010-Probiotic Supplement Reduces Atopic Dermatitis in Preschool Children. A Randomised, Double-Blind, Placebo-Controlled, Clinical Trial
Gobel-2010-Probiotics to young children with atopic dermatitis: a randomised palcebo-controlled trial
Gruber-2007-Randomized, placebo-controlled trial of Lactobacillus rhamnosus GG as treatment of atopic dermatitis in infancy
Guager-2005-Efficacy and functionality of silver-coated textiles in patients with atopic eczema.
Hamanda-2008-The usefulness of camellia oil spray for treatment of atopic dermatitis
Heil-2010-Omalizumab therapy in atopic deratitis: depletion of IgE does not improve the clinical course - a randomised, placebo-controlled and double blind pilot study
Hon-2007-Efficacy and tolerability of a Chinese herbal medicine concoction for treatment of atopic dermatitis: a randomized, double-blind, placebo-controlled study
Jang-2000-Clinical improvement and immunohistochemical findings in severe atopic dermatitis treated with interferon gamma
Januchowski-2009-Evaluation of Topical Vitamin B12 for the Treatment of Childhood Eczema
Kawashima-2003-Addition of fexofenadine to a topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1-week randomized, multicentre, double-blind, placebo-controlled, parallel-group study
Kirkcik-2010-Management of pruritis with levocetirizine dihydrochloride in atopic dermatitis in a randomised, double blind, placebo controlled study - Interim analysis
Kobayashi-2010-Efficacy and Safety of a traditional Herbal Medicine, Hochu-ekki-to in the Long Term Management of Kikyo (Delicate Constitution) Patients with Atopic Dermatitis: A 6-month, Multicentre, Double-blind, Randomised, Placebo-controlled Study
Kuznecovs-2010-Atopvastatin and polyprenol effect on atopic dermatitis: pathogenesis links in adult patients
Lintu-2001-Systemic ketoconazole is an effective treatment of atopic dermatitis with IgE-mediated hypersensitivity to yeasts
Loden-2002-A Double-Blind Study Comparing the Effect of Glycerin and Urea on Dry, Eczematous Skin in Atopic Patients
Melamed-2010-The benefit of montelukast in atopic dermatitis induced by food allergies
Moroi-2010-Beneficial effect of a diet containing heat-killed Lactobacillus paracasei K71 on adult type atopic dermatitis
Mraz-2006-A multicenter, double-blind, placebo-controlled study of the effectiveness of kiwi fruit extract in adults with atopic dermatitis of moderate severity
Munday-2002-Chlorpheniramine Is No More Effective than Placebo in Relieving the Symptoms of Childhood Atopic Dermatitis with a Nocturnal Itching and Scratching Component
Oldhoff-2005-Anti-IL-5 recombinant humanized monoclonal antibody (Mepolizumab) for the treatment of atopic dermatitis
Pajno-2007-Sublingual immunotherapy in mite-sensitized children with atopic dermatitis: A randomized, double-blind, placebo-controlled study
Rosenfeldt-2003-Effect of probiotic Lactobacillus strains in children with atopic dermatitis
Shapira-2005-Treatment of atopic dermatitis with herbal combination of Eleuthercoccus, Achilla millefolium, and Lamium album had no advantage over placebo: A double blind, placebo-controlled, randomized trial
Sidbury-2008-Randomised controlled trial of vitamin D supplementation for winter-related atopic dermatits in Boston: A pilot study
Silny-2006-Specific immunotherapy in the treatment of patients with atopic dermatitis--results of double blind placebo controlled study
Svejgaard-2004-Treatment of head and neck dermatitis comparing itraconazole 200 mg and 400 mg daily for 1 week with placebo
Takwale-2003-Efficacy and tolerability of borage oil in adults and children with atopic eczema: randomised, double blind, placebo controlled, parallel group trial
Viljanen-2005-Probiotics in the treatment of atopic eczema/dermatitis syndrome in infants: a double-blind placebo-controlled trial
Woo-2010-Effect of Lactobacillus sakei supplementation on children with atopic eczema-dermatitis syndrome
Yang-2000-Effect of dietary supplementation with sea buckthorn (Hippophae rhamnoides) seed and pulp oils on the fatty acid composition of skin glycerophospholipids of patients with atopic dermatitis
Yoshida-2010-Clinical Effects of Probiotic Bifidobacterium breve Supplementation in Adult Patients with Atopic Dermatitis
Standard treatment
trials
Grillo-2006-Pediatric Atopic Eczema: The Impact of an Educational Intervention
Hindley-2006-A randomised study of "wet wraps" versus conventional treatment for atopic eczema.
Leung-2004-A randomized, single-blind and crossover study of an amino acid-based milk formula in treating young children with atopic dermatitis
Shaw-2008-A Study of Targeted Enhanced Patient Care for Pediatric Atopic Dermatitis (STEP PAD)
Span-2001-Intensive daycare for young adults with atopic eczema
Thomas-2011-A multicentre randomized controlled trial of ion-exchange water softeners for the treatment of eczema in children: protocol for the Softened Water Eczema Trial (SWET) (ISRCTN: 71423189)
Vehicle
trials
Abramovits-2010-Hydrocortisone Butyrate 0.1% Lipocream in Pediatric Patients with Atopic Dermatitis
Abramovits-2006-A multicenter, randomized, vehicle-controlled clinical study to examine the efficacy and safety of MAS063DP (Atopiclair) in the management of mild to moderate atopic dermatitis in adults
Arkwright-2003-Effect of Mycobacterium vaccae on atopic dermatitis in children of different ages
Arkwright-2001-Intradermal administration of a killed Mycobacterium vaccae suspension (SRL 172) is associated with improvement in atopic dermatitis in children with moderate-to-severe disease.
Barba-2003-Pimecrolimus cream 1% is effective, well tolerated and safe in infants/ children with atopic eczema of the face
Belloni-2005-A Randomised, double-blind, vehicle-controlled study to evaluate the efficacy and safety of MAS063D (Atopiclair®), in the treatment of mild to moderate atopic dermatitis
Beutner-2007-A randomised, double-blind, vehicle-controlled, multi-center study to evaluate the safety and efficacy of topically applied AN0128 cream, 1% for the treatment of mild to moderate atopic dermatitis.
Boguniewicz-2007-MAS063DP is effective monotherapy for mild to moderate atopic dermatitis in infants and children: A multicenter, randomized, vehicle-controlled study
Breneman-2008-Intermittent therapy for flare prevention and long-term disease control in stabilized atopic dermatitis: A randomized comparison of 3-times-weekly applications of tacrolimus ointment versus vehicle
Brouwer-2006-No effects of probiotics on atopic dermatitis in infancy: a randomised placebo-controlled trial
Cato-2001-Azone enhances clinical effectiveness of an optimized formulation of triamcinolone acetonide in atopic dermatitis.
Cukrowska-2008-The influence of probiotic Lactobacillus casei and paracasei strains on clinical status of atopic eczema in children with food allergy on cow's milk proteins.
del Rosso-2010-Daily application of fluocinonide 0.1% cream for the treatment of atopic dermatitis
Dou-2006-The impact of tacrolimus ointment on health-related quality of life of Chinese adult and pediatric patients with atopic dermatitis
Eichenfield-2002-Safety and efficacy of pimecrolimus (ASM 981) cream 1% in the treatment of mild and moderate atopic dermatitis in children and adolescents.
Eichenfield-2007-A randomized, double-blind, placebo-controlled, parallel group study of nanocrystalline silver (NPI 32101) cream in pediatric atopic dermatitis (AD)
Foelster Holst-2010-The novel protease inhibitor SRD441 ointment is not effective in the treatment of adult subjects with atopic dermatitis: results of a randomised, vehicle-controlled study
Fowler-2007-Improvement in pruritis in Children with atopic dermatitis using pimecrolimus cream 1%
Gong-2006-Skin colonisation by Staphylococcus aureus in patients with eczema and atopic dermatitis and relevant combined topical therapy: a double-blind multicentre randomized controlled trial
Griffiths-2002-Randomised comparison of the type 4 phosphodiesterase inhibitor cipamfylline cream, cream vehicle and hydrocortisone 17-butyrate cream for the treatment of atopic dermatitis.
Gueniche-2008-Effects of nonpathogenic gram-negative bacterium Vitreoscilla filiformis lysate on atopic dermatitis: a prospective, randomized, double-blind, placebo-controlled clinical study
Gueniche-2006-Improvement of atopic dermatitis skin symptoms by Vitreoscilla filiformis bacterial extract
Gupta-2006-Efficacy of fluocinonide 0.1% cream in the treatment of atopic dermatitis.
Hanifin-2002-Intermittent dosing of fluticasone propionate cream for reducing the risk of relapse in atopic dermatitis patients
Hanifin-2001-Tacrolimus ointment for the treatment of atopic dermatitis in adult patients: Part I, Efficacy
Hattori-2003-Effects of administration of bifidobacteria on fecal microflora and clinical symptoms in infants with atopic dermatitis.
Ho-2003-Safety and efficacy of nonsteroid pimecrolimus cream 1% in the treatment of atopic dermatitis in infants
Kaufmann-2006-Onset of pruritus relief with pimecrolimus cream 1% in adult patients with atopic dermatitis: a randomized trial
Kaufmann-2004-Pimecrolimus Cream 1% Provides Long-Term Disease Management in Children with Severe Atopic Dermatitis
Kim-2010-Therapeutic efficacy of defensamide in atopic dermatitis
Kimata-2006-Improvement of Atopic Dermatitis and Reduction of Skin Allergic Responses by Oral Intake of Kanjac Ceramide
Klovekorn-2007-A randomized, double-blind, vehicle-controlled, half-side comparison with a herbal ointment containing Mahonia aquifolium, Viola tricolor and Centella asiatica for the treatment of mild-to-moderate atopic dermatitis
Korting-2010-Efficacy and tolerability of pale sulphonated shale oil cream 4% in the treatment of mid to moderate atopic eczema in children: a multicentre, randomised vehicle-controlled trial
Larsen-2007-An Efficient New Formulation of Fusidic Acid and Betamethasone 17-Valerate (Fucicort Lipid Cream) for Treatment of Clinically Infected Atopic Dermatitis
Lee-2008-Effect of rosmarinic acid on atopic dermatitis
Lee-2006-The antipruritic effect of topical doxepin cream in patients with atopic dermatitis
Leo-2004-Effect of pimecrolimus cream 1% on skin condition and sleep disturbance in children with atopic dermtitis
Levy-2005-Tacrolimus cream 0.03% is safe and effective in the treatment of mild to moderate atopic dermatitis in adults
Loden-2001-Instrumental and dermatologist evaluation of the effect of glycerine and urea on dry skin in atopic dermatitis
Luger-2001-SDZ ASM 981: an emerging safe and effective treatment for atopic dermatitis
Masako-2005-A novel method to control the balance of skin microflora Part 2. A study to assess the effect of a cream containing faresol and xylitol on atopic dry skin
Mayser-2006-Treatment of Head and Neck Dermatitis with Ciclopiroxolamine Cream - Results of a Double-Blind, Placebo-Controlled Study
Murosaki-2006-Effects of intake of syrup supplemented with nigerooligosaccharides and heat-killed Lactobacillus plantarum L-137 on skin symptom and immune function in patients with atopic dermatitis
Palombo-2004-A special pill-mask to rehydrate the skin affected by atopic dermatitis
Patzelt-Wenczler-2000-Proof of Efficacy of Kamillosan Cream in Atopic Eczema
Saeedi-2003-The treatment of atopic dermatitis with licorice gel
Salavec-2004-First experiences with 1% Pimecrolimus cream therapy in prevention of atopic eczema flares in children
Schempp-2003-Topical treatment of atopic dermatitis with St. John's wort cream - a randomized, placebo controlled, double blind half-side comparison
Schnopp-2002-Topical Steroids under Wet-wrap Dressings in Atopic Dermatitis- A Vehicle-Controlled Trial
Shibagaki-2005-Clinical efficacy of bath additive containing a diamide derivative in patients with atopic dermatitis
Stainer-2005-Efficacy and acceptability of a new topical skin lotion of sodium cromoglicate (Altoderm) in atopic dermatitis in children aged 2-12 years: a double-blind, randomized, placebo-controlled trial
Stern-2002-Black seed oil ointment - A new approach for the treatment of atopic dermatitis?
Tan-2010-A randomised double-blind controlled trial to compare a triclosan containing emollient with vehicle for the treatment of atopic dermatitis
Thaci-2008-Proactive disease management with 0.03% tacrolimus ointment for children with atopic dermatitis: results of randomized multicentre comparative study
Thaci-2005-Treatment effects of 1% pimecrolimus ointment formulations in adult patients with atopic dermatitis
Wahn-2002-Efficacy and Safety of Pimecrolimus Cream in the Long Term Management of Atopic Dermatitis in Children
Wollenburg-2008-Proactive treatment of atopic dermatitis in adults with 0.1% tacrolimus ointment
Wollenburg-2008-Proactive treatment of atopic dermatitis in adults with 0.1% tacrolimus ointment
Zuberbier-2007-Steroid-Sparing Effect of Pimecrolimus Cream 1% in Children with Severe Atopic Dermatitis
Other interventions
treatments
Analogous blood therapy
trials
Kief-2007-A prospective, controlled study on the efficacy of the treatment with AHIT and treatment with Patient's blood in atopic dermatitis
Antioxidants
trials
Tripodi-2009-Lack of efficacy of topical furfuryl palmitate in pediatric atopic dermatitis: A randomized double-blind study.
Atorvastatin
trials
Kuznecovs-2010-Atopvastatin and polyprenol effect on atopic dermatitis: pathogenesis links in adult patients
Bacterial lysate
trials
Gueniche-2008-Effects of nonpathogenic gram-negative bacterium Vitreoscilla filiformis lysate on atopic dermatitis: a prospective, randomized, double-blind, placebo-controlled clinical study
Gueniche-2006-Improvement of atopic dermatitis skin symptoms by Vitreoscilla filiformis bacterial extract
Chymase Inhibitor
trials
Ger Rikken-2010-SUN13834 in the Treatment of Subjects with Atopic Dermatitis
Cipamfylline
trials
Griffiths-2002-Randomised comparison of the type 4 phosphodiesterase inhibitor cipamfylline cream, cream vehicle and hydrocortisone 17-butyrate cream for the treatment of atopic dermatitis.
Farnesol
trials
Masako-2005-A novel method to control the balance of skin microflora Part 2. A study to assess the effect of a cream containing faresol and xylitol on atopic dry skin
Heparin
trials
Arenberger-2010-Additive effect of Heparin and Levomenthol against Atopic Dermatitis
Konjac ceramide
trials
Kimata-2006-Improvement of Atopic Dermatitis and Reduction of Skin Allergic Responses by Oral Intake of Kanjac Ceramide
Levomenol
trials
Arenberger-2010-Additive effect of Heparin and Levomenthol against Atopic Dermatitis
Lipids
trials
Laumann-2006-The efficacy and safety of MimyX Cream in reducing the risk of relapse in atopic dermatitis
Polyprenol
trials
Kuznecovs-2010-Atopvastatin and polyprenol effect on atopic dermatitis: pathogenesis links in adult patients
Pramoxine
trials
Fleisher-2006-Comparative efficacy and patient preference of 1% pramoxine lotion and 1% hydrocortisone cream in reducing pruritus in mild atopic dermatitis
Protease inhibitor
trials
Foelster Holst-2010-The novel protease inhibitor SRD441 ointment is not effective in the treatment of adult subjects with atopic dermatitis: results of a randomised, vehicle-controlled study
Tandospirone citrate
trials
Kawana-2010-Efficacy of a 5-HT1a receptor agonist in atopic dermatitis
Wet wraps
trials
Foelster-Holst-2006-Efficacy of Crisis Intervention Treatment with Topical Corticosteroid Prednicarbat with and without Partial Wet-Wrap Dressing in Atopic Dermatitis
Hindley-2006-A randomised study of "wet wraps" versus conventional treatment for atopic eczema.
Schnopp-2002-Topical Steroids under Wet-wrap Dressings in Atopic Dermatitis- A Vehicle-Controlled Trial
Xylitol
trials
Masako-2005-A novel method to control the balance of skin microflora Part 2. A study to assess the effect of a cream containing faresol and xylitol on atopic dry skin
Other topical agents
treatments
Atopiclair
trials
Abramovits-2006-A multicenter, randomized, vehicle-controlled clinical study to examine the efficacy and safety of MAS063DP (Atopiclair) in the management of mild to moderate atopic dermatitis in adults
Belloni-2005-A Randomised, double-blind, vehicle-controlled study to evaluate the efficacy and safety of MAS063D (Atopiclair®), in the treatment of mild to moderate atopic dermatitis
Boguniewicz-2007-MAS063DP is effective monotherapy for mild to moderate atopic dermatitis in infants and children: A multicenter, randomized, vehicle-controlled study
Bath additives
trials
Shibagaki-2005-Clinical efficacy of bath additive containing a diamide derivative in patients with atopic dermatitis
Black seed oil
trials
Stern-2002-Black seed oil ointment - A new approach for the treatment of atopic dermatitis?
Emollients
trials
Berardesca-2001-Evaluation of efficacy of a skin lipid mixture in patients with irritant contact dermatitis, allergic contact dermatitis or atopic dermatitis: a multicenter study
Bissonette-2010-A double-blind study of tolerance and efficacy of a new urea-containing moisturiser in patients with atopic dermatitis
de Belilovsky-2010-Natural peroxisome proliferator activated-activated receptor-alpha agonist cream demonstrates similar therapeutic response to topical steroids in atopic dermatitis
Grimalt-2007-The steroid-sparing effect of an emollient therapy in infants with atopic dermatitis: A randomized controlled study
Loden-2001-Instrumental and dermatologist evaluation of the effect of glycerine and urea on dry skin in atopic dermatitis
Loden-2002-A Double-Blind Study Comparing the Effect of Glycerin and Urea on Dry, Eczematous Skin in Atopic Patients
Ramon-2006-Evaluation of the corticosteroid-sparing effect of a new emollient in 162 atopic infants
Tan-2010-A randomised double-blind controlled trial to compare a triclosan containing emollient with vehicle for the treatment of atopic dermatitis
Yang-2010-The adjuvant treatment of atopic dermatitis with medical skin preparation containing extracts from Portulaca oleracea and avocado
Naltrexone cream
trials
Biglardi-2007-Treatment of pruritus with topically applied opiate receptor antagonist
Nanocrystalline silver
trials
Eichenfield-2007-A randomized, double-blind, placebo-controlled, parallel group study of nanocrystalline silver (NPI 32101) cream in pediatric atopic dermatitis (AD)
Pale shale oil
trials
Korting-2010-Efficacy and tolerability of pale sulphonated shale oil cream 4% in the treatment of mid to moderate atopic eczema in children: a multicentre, randomised vehicle-controlled trial
Rosmarinic acid
trials
Lee-2008-Effect of rosmarinic acid on atopic dermatitis
Sea buckthorn cream
trials
Thumm-2000-Randomized trial to study efficacy of a 20% and 10% Hippophae rhamnoides containing creme used by patients with mild to intermediate atopic dermatitis
Yang-2000-Effect of dietary supplementation with sea buckthorn (Hippophae rhamnoides) seed and pulp oils on the fatty acid composition of skin glycerophospholipids of patients with atopic dermatitis
Topical corticosteroids
trials
Berardesca-2001-Evaluation of efficacy of a skin lipid mixture in patients with irritant contact dermatitis, allergic contact dermatitis or atopic dermatitis: a multicenter study
Topical vitamin B12
trials
Januchowski-2009-Evaluation of Topical Vitamin B12 for the Treatment of Childhood Eczema
Urea
trials
Bissonette-2010-A double-blind study of tolerance and efficacy of a new urea-containing moisturiser in patients with atopic dermatitis
Wash cloth
trials
Hosokawa-2008-Evaluation of a low-irritant washcloth for patients with atopic dermatitis
Systemic immunomodulatory agents
treatments
Azathioprine
trials
Berth-Jones-2002-Azothiaprine in severe atopic dermatitis: a double-blind, placebo-controlled, crossover trial
Cyclosporin
trials
Bemanian-2005-High Doses Intravenous Immunoglobulin versus Oral Cyclosporine in the Treatment of Severe Atopic Dermatitis
Czech-2000-A body-weight-independent dosing of regimen of cyclosporin microemulsion is effective in severe atopic dermatitis and improves the quality if life
Granlund-2001-Comparison of Cyclosporin and UVAB Phtotherapy for Intermittent One-year Treatment of Atopic Dermatitis
Schmitt-2010-Prednisolone vs. ciclosporin for severe adult. An investigator-initiated double-blind placebo-controlled multicentre trial
Immunoglobulin
trials
Bemanian-2005-High Doses Intravenous Immunoglobulin versus Oral Cyclosporine in the Treatment of Severe Atopic Dermatitis
Paul-2002-A randomized controlled evaluator-blinded trial of intravenous immunoglobin in adults with severe atopic dermatitis
Immunotherapy
trials
Silny-2006-Specific immunotherapy in the treatment of patients with atopic dermatitis--results of double blind placebo controlled study
Interferon gamma
trials
Jang-2000-Clinical improvement and immunohistochemical findings in severe atopic dermatitis treated with interferon gamma
Mepolizumab
trials
Oldhoff-2005-Anti-IL-5 recombinant humanized monoclonal antibody (Mepolizumab) for the treatment of atopic dermatitis
Montelukast
trials
Craig-2002-The effects of montelukast on atopic dermatitis (AD): A placebo controlled, double-blind, parallel study
Friedmann-2007-A double-blind, placebo-controlled trial of montelukast in adult atopic eczema.
Melamed-2010-The benefit of montelukast in atopic dermatitis induced by food allergies
Rahman-2006-Effectiveness of montelukast in the treatment of atopic dermatitis
Omalizumab
trials
Heil-2010-Omalizumab therapy in atopic deratitis: depletion of IgE does not improve the clinical course - a randomised, placebo-controlled and double blind pilot study
Prednisolone
trials
Schmitt-2010-Prednisolone vs. ciclosporin for severe adult. An investigator-initiated double-blind placebo-controlled multicentre trial
Topical corticosteroids
treatments
Betamethasone
trials
Larsen-2007-An Efficient New Formulation of Fusidic Acid and Betamethasone 17-Valerate (Fucicort Lipid Cream) for Treatment of Clinically Infected Atopic Dermatitis
Luger-2001-SDZ ASM 981: an emerging safe and effective treatment for atopic dermatitis
Clobetasol
trials
Brenninkmeijer-2010-Excimer laser vs. clobetisol propionate 0.05% ointment on prurigo form of atopic dermatitis: a randomised controlled trial, a pilot
Sillevis Smitt-2000-Should children with constitutional eczema be treated with corticosteroids continuously or in pulse? A prospective, randomised, double blind study with clobetason butyrate
Fluocinonide
trials
del Rosso-2010-Daily application of fluocinonide 0.1% cream for the treatment of atopic dermatitis
Gupta-2006-Efficacy of fluocinonide 0.1% cream in the treatment of atopic dermatitis.
Fluticasone
trials
Berth-Jones-2003-Twice weekly fluticasone propionate added to emollient maintenance treatment to reduce risk of relapse in atopic dermatitis: randomised, double blind, parallel group study
Doss-2010-Efficacy of tacrolimus 0.03% ointment as second-line treatment for children with moderate-to-severe atopic dermatitis: evidence from a ramdomised, double-blind non-inferiority trial vs. fluticasone 0.005% ointment
Hanifin-2002-Intermittent dosing of fluticasone propionate cream for reducing the risk of relapse in atopic dermatitis patients
Hung-2007-Staphylococcus colonisation in atopic dermatitis treated with fluticasone or tacrolimus with or without antibiotics
Meurer-2010-Addition of pimecrolimus cream 1% to a topical corticosteroid treatment regimen in paediatric patients with severe atopic dermatitis: A randomized, double-blind trial
Valkova-2004-UVA/UVB phototherapy for atopic dermatitis revisited
Hydrocortisone
trials
Abramovits-2010-Hydrocortisone Butyrate 0.1% Lipocream in Pediatric Patients with Atopic Dermatitis
Caproni-2007-The comparative effects of tacrolimus and hydrocortisone in adult atopic dermatitis: an immunohistochemical study.
de Belilovsky-2010-Natural peroxisome proliferator activated-activated receptor-alpha agonist cream demonstrates similar therapeutic response to topical steroids in atopic dermatitis
Dolle-2010-Long-term reduction in local inflammation by a lipid raft molecule in atopic dermatitis
Fleisher-2006-Comparative efficacy and patient preference of 1% pramoxine lotion and 1% hydrocortisone cream in reducing pruritus in mild atopic dermatitis
Gong-2006-Skin colonisation by Staphylococcus aureus in patients with eczema and atopic dermatitis and relevant combined topical therapy: a double-blind multicentre randomized controlled trial
Griffiths-2002-Randomised comparison of the type 4 phosphodiesterase inhibitor cipamfylline cream, cream vehicle and hydrocortisone 17-butyrate cream for the treatment of atopic dermatitis.
Kaur-2007-Adherence to topical hydrocortisone 17-butyrate 0.1% using different vehicles in adults with atopic dermatitis
Mandelin-2010-One-year Treatment with 0.1% Tacrolimus Ointment versus a Corticosteroid regimen in Adults with Moderate to Severe Atopic Dermatitis: A Randomised, Double-blind, Comparative Trial
Meurer-2010-Addition of pimecrolimus cream 1% to a topical corticosteroid treatment regimen in paediatric patients with severe atopic dermatitis: A randomized, double-blind trial
Patzelt-Wenczler-2000-Proof of Efficacy of Kamillosan Cream in Atopic Eczema
Rahman-2006-Effectiveness of montelukast in the treatment of atopic dermatitis
Valkova-2004-UVA/UVB phototherapy for atopic dermatitis revisited
Methylpredesolone
trials
Bieber-2007-Efficacy and safety of methylprednisolone aceponate ointment 0.1% compared to tacrolimus 0.03% in children and adolescents with and acute flare of severe atopic dermatitis
Mometasone
trials
Capella-2001-A randomized trial of leukotriene receptor antagonist montelukast in moderate-to-severe atopic dermatitis of adults
Freeman-2006-A new treatment for atopic dermatitis: a randomized double-blind placebo-controlled study
Schnopp-2002-Topical Steroids under Wet-wrap Dressings in Atopic Dermatitis- A Vehicle-Controlled Trial
Prednicarbat
trials
Foelster-Holst-2006-Efficacy of Crisis Intervention Treatment with Topical Corticosteroid Prednicarbat with and without Partial Wet-Wrap Dressing in Atopic Dermatitis
Triamcinolone
trials
Cato-2001-Azone enhances clinical effectiveness of an optimized formulation of triamcinolone acetonide in atopic dermatitis.
Topical immunomodulatory agents
treatments
Pimecrolimus
trials
Barba-2003-Pimecrolimus cream 1% is effective, well tolerated and safe in infants/ children with atopic eczema of the face
Draelos-2005-Pharmacokinetics of topical calcineurin inhibitors in adult atopic dermatitis: A randomized, investigator-blind comparison
Eichenfield-2002-Safety and efficacy of pimecrolimus (ASM 981) cream 1% in the treatment of mild and moderate atopic dermatitis in children and adolescents.
Fowler-2007-Improvement in pruritis in Children with atopic dermatitis using pimecrolimus cream 1%
Ho-2003-Safety and efficacy of nonsteroid pimecrolimus cream 1% in the treatment of atopic dermatitis in infants
Kaufmann-2006-Onset of pruritus relief with pimecrolimus cream 1% in adult patients with atopic dermatitis: a randomized trial
Kaufmann-2004-Pimecrolimus Cream 1% Provides Long-Term Disease Management in Children with Severe Atopic Dermatitis
Leo-2004-Effect of pimecrolimus cream 1% on skin condition and sleep disturbance in children with atopic dermtitis
Luger-2001-SDZ ASM 981: an emerging safe and effective treatment for atopic dermatitis
Meurer-2010-Addition of pimecrolimus cream 1% to a topical corticosteroid treatment regimen in paediatric patients with severe atopic dermatitis: A randomized, double-blind trial
Salavec-2004-First experiences with 1% Pimecrolimus cream therapy in prevention of atopic eczema flares in children
Thaci-2005-Treatment effects of 1% pimecrolimus ointment formulations in adult patients with atopic dermatitis
Tzung-2006-Pimecrolimus and Narrowband UVB as Monotherapy or Combination Therapy in Children and Adolescents with Atopic Dermatitis
Wahn-2002-Efficacy and Safety of Pimecrolimus Cream in the Long Term Management of Atopic Dermatitis in Children
Zuberbier-2007-Steroid-Sparing Effect of Pimecrolimus Cream 1% in Children with Severe Atopic Dermatitis
Tacrolimus
trials
Bieber-2007-Efficacy and safety of methylprednisolone aceponate ointment 0.1% compared to tacrolimus 0.03% in children and adolescents with and acute flare of severe atopic dermatitis
Breneman-2008-Intermittent therapy for flare prevention and long-term disease control in stabilized atopic dermatitis: A randomized comparison of 3-times-weekly applications of tacrolimus ointment versus vehicle
Caproni-2007-The comparative effects of tacrolimus and hydrocortisone in adult atopic dermatitis: an immunohistochemical study.
Doss-2010-Efficacy of tacrolimus 0.03% ointment as second-line treatment for children with moderate-to-severe atopic dermatitis: evidence from a ramdomised, double-blind non-inferiority trial vs. fluticasone 0.005% ointment
Dou-2006-The impact of tacrolimus ointment on health-related quality of life of Chinese adult and pediatric patients with atopic dermatitis
Draelos-2005-Pharmacokinetics of topical calcineurin inhibitors in adult atopic dermatitis: A randomized, investigator-blind comparison
Hanifin-2001-Tacrolimus ointment for the treatment of atopic dermatitis in adult patients: Part I, Efficacy
Hung-2007-Staphylococcus colonisation in atopic dermatitis treated with fluticasone or tacrolimus with or without antibiotics
Levy-2005-Tacrolimus cream 0.03% is safe and effective in the treatment of mild to moderate atopic dermatitis in adults
Mandelin-2010-One-year Treatment with 0.1% Tacrolimus Ointment versus a Corticosteroid regimen in Adults with Moderate to Severe Atopic Dermatitis: A Randomised, Double-blind, Comparative Trial
Rahman-2008-Efficacy of topical tacrolimus in atopic dermatitis
Thaci-2008-Proactive disease management with 0.03% tacrolimus ointment for children with atopic dermatitis: results of randomized multicentre comparative study
Wollenburg-2008-Proactive treatment of atopic dermatitis in adults with 0.1% tacrolimus ointment
Wollenburg-2008-Proactive treatment of atopic dermatitis in adults with 0.1% tacrolimus ointment
Treatments
A to C
treatments
A to C
AN0128
trials
Beutner 2007 A randomised, double-blind, vehicle-controlled, multi-center study to evaluate the safety and efficacy of topically applied AN0128 cream, 1% for the treatment of mild to moderate atopic dermatitis.
Analogous blood therapy
trials
Kief 2007 A prospective, controlled study on the efficacy of the treatment with AHIT and treatment with Patient's blood in atopic dermatitis
Antihistamines
trials
Rahman 2006 Effectiveness of montelukast in the treatment of atopic dermatitis
Antioxidants
trials
Tripodi 2009 Lack of efficacy of topical furfuryl palmitate in pediatric atopic dermatitis: A randomized double-blind study.
Aromatherapy
trials
Anderson 2000 Evaluation of Massage with Essential Oils on Childhood Atopic Eczema
Bystron 2005 Assessment of a double blind, placebo controlled study using the medication JOALIS (Joalis BAMBI CUTIS, Joalis BAMBI IMUN, Joalis BAMBI ANALERG a COLA de CABALLO) on patients suffering from atopic eczema
Atopiclair
trials
Abramovits 2006 A multicenter, randomized, vehicle-controlled clinical study to examine the efficacy and safety of MAS063DP (Atopiclair) in the management of mild to moderate atopic dermatitis in adults
Belloni 2005 A Randomised, double-blind, vehicle-controlled study to evaluate the efficacy and safety of MAS063D (Atopiclair®), in the treatment of mild to moderate atopic dermatitis
Boguniewicz 2007 MAS063DP is effective monotherapy for mild to moderate atopic dermatitis in infants and children: A multicenter, randomized, vehicle-controlled study
Atorvastatin
trials
Kuznecovs 2010 Atopvastatin and polyprenol effect on atopic dermatitis: pathogenesis links in adult patients
Azathioprine
trials
Berth-Jones 2002 Azothiaprine in severe atopic dermatitis: a double-blind, placebo-controlled, crossover trial
Bacterial lysate
trials
Gueniche 2008 Effects of nonpathogenic gram-negative bacterium Vitreoscilla filiformis lysate on atopic dermatitis: a prospective, randomized, double-blind, placebo-controlled clinical study
Gueniche 2006 Improvement of atopic dermatitis skin symptoms by Vitreoscilla filiformis bacterial extract
Bath additives
trials
Shibagaki 2005 Clinical efficacy of bath additive containing a diamide derivative in patients with atopic dermatitis
Betamethasone
trials
Larsen 2007 An Efficient New Formulation of Fusidic Acid and Betamethasone 17-Valerate (Fucicort Lipid Cream) for Treatment of Clinically Infected Atopic Dermatitis
Luger 2001 SDZ ASM 981: an emerging safe and effective treatment for atopic dermatitis
Black seed oil
trials
Stern 2002 Black seed oil ointment - A new approach for the treatment of atopic dermatitis?
Borage oil
trials
Takwale 2003 Efficacy and tolerability of borage oil in adults and children with atopic eczema: randomised, double blind, placebo controlled, parallel group trial
Camellia oil
trials
Hamanda 2008 The usefulness of camellia oil spray for treatment of atopic dermatitis
Camomile extract
trials
Patzelt-Wenczler 2000 Proof of Efficacy of Kamillosan Cream in Atopic Eczema
Cetirizine
trials
Capella 2001 A randomized trial of leukotriene receptor antagonist montelukast in moderate-to-severe atopic dermatitis of adults
Diepgen 2002 Long-term treatment with cetirizine of infants with atopic dermatitis: A multi-country, double-blind, randomized, placebo-controlled trial (the ETAC trial) over 18 months
Chinese herbal medicine
trials
Henderson 2000 An open study comparing the efficacy of two different Chinese herbal therapy formulations in atopic eczema and their effects on circulating activated T-lymphocytes
Hon 2007 Efficacy and tolerability of a Chinese herbal medicine concoction for treatment of atopic dermatitis: a randomized, double-blind, placebo-controlled study
Klovekorn 2007 A randomized, double-blind, vehicle-controlled, half-side comparison with a herbal ointment containing Mahonia aquifolium, Viola tricolor and Centella asiatica for the treatment of mild-to-moderate atopic dermatitis
Kobayashi 2010 Efficacy and Safety of a traditional Herbal Medicine, Hochu-ekki-to in the Long Term Management of Kikyo (Delicate Constitution) Patients with Atopic Dermatitis: A 6-month, Multicentre, Double-blind, Randomised, Placebo-controlled Study
Shapira 2005 Treatment of atopic dermatitis with herbal combination of Eleuthercoccus, Achilla millefolium, and Lamium album had no advantage over placebo: A double blind, placebo-controlled, randomized trial
Shi 2008 Clinical study in treatment of atopic dermatitis by intergrated traditional chinese and western medicine.
Chlorpheniramine
trials
Munday 2002 Chlorpheniramine Is No More Effective than Placebo in Relieving the Symptoms of Childhood Atopic Dermatitis with a Nocturnal Itching and Scratching Component
Chymase Inhibitor
trials
Ger Rikken 2010 SUN13834 in the Treatment of Subjects with Atopic Dermatitis
Ciclopiroxolamine
trials
Mayser 2006 Treatment of Head and Neck Dermatitis with Ciclopiroxolamine Cream - Results of a Double-Blind, Placebo-Controlled Study
Cipamfylline
trials
Griffiths 2002 Randomised comparison of the type 4 phosphodiesterase inhibitor cipamfylline cream, cream vehicle and hydrocortisone 17-butyrate cream for the treatment of atopic dermatitis.
Clarythromycin
trials
Capella 2001 A randomized trial of leukotriene receptor antagonist montelukast in moderate-to-severe atopic dermatitis of adults
Clobetasol
trials
Brenninkmeijer 2010 Excimer laser vs. clobetisol propionate 0.05% ointment on prurigo form of atopic dermatitis: a randomised controlled trial, a pilot
Sillevis Smitt 2000 Should children with constitutional eczema be treated with corticosteroids continuously or in pulse? A prospective, randomised, double blind study with clobetason butyrate
Control
trials
Anderson 2000 Evaluation of Massage with Essential Oils on Childhood Atopic Eczema
Blessman Weber 2008 Improvement of pruritis and quality of life of children with atopic dermatitis and their families after joining support groups
Koller 2007 Action of a silk fabric treated with AEGIS in children with atopic dermatitis: A 3-month trial
Laumann 2006 The efficacy and safety of MimyX Cream in reducing the risk of relapse in atopic dermatitis
Licu 2002 Efficacy of thermal spring water in the treatment of mild atopic dermatitis.
Rahman 2008 Efficacy of topical tacrolimus in atopic dermatitis
Yokoyama 2009 Ethylene Vinyl Alcohol (EVOH) Fiber Compared to Cotton Underwear in the Treatment of Childhood Atopic Dermatitis: A Double-Blind Randomized Study
Cyclosporin
trials
Bemanian 2005 High Doses Intravenous Immunoglobulin versus Oral Cyclosporine in the Treatment of Severe Atopic Dermatitis
Czech 2000 A body-weight-independent dosing of regimen of cyclosporin microemulsion is effective in severe atopic dermatitis and improves the quality if life
Granlund 2001 Comparison of Cyclosporin and UVAB Phtotherapy for Intermittent One-year Treatment of Atopic Dermatitis
Schmitt 2010 Prednisolone vs. ciclosporin for severe adult. An investigator-initiated double-blind placebo-controlled multicentre trial
Treatments
D to H
treatments
D to H
Defensamide
trials
Kim 2010 Therapeutic efficacy of defensamide in atopic dermatitis
Dermatologist consulation
trials
Schuttelaar 2010 A randomised controlled trial in children with eczema: nurse practitioner vs. dermatologist
Dermatology nurse consultation
trials
Chinn 2002 Randomized controlled trial of a single dermatology nurse consultation in primary care on the quality of life of children with atopic eczema
Education
trials
Cooenraads 2001 Intensive patient education and treatment program for young adults with atopic eczema.
Grillo 2006 Pediatric Atopic Eczema: The Impact of an Educational Intervention
Shaw 2008 A Study of Targeted Enhanced Patient Care for Pediatric Atopic Dermatitis (STEP PAD)
Span 2001 Intensive daycare for young adults with atopic eczema
Staab 2006 Age related, structured educational programmes for the management of atopic dermatitis in children and adolescents: multicentre, randomised controlled trial
Staab 2002 Evaluation of a parental training program for the management of childhood atopic dermatitis
Emollients
trials
Berardesca 2001 Evaluation of efficacy of a skin lipid mixture in patients with irritant contact dermatitis, allergic contact dermatitis or atopic dermatitis: a multicenter study
Bissonette 2010 A double-blind study of tolerance and efficacy of a new urea-containing moisturiser in patients with atopic dermatitis
de Belilovsky 2010 Natural peroxisome proliferator activated-activated receptor-alpha agonist cream demonstrates similar therapeutic response to topical steroids in atopic dermatitis
Grimalt 2007 The steroid-sparing effect of an emollient therapy in infants with atopic dermatitis: A randomized controlled study
Loden 2001 Instrumental and dermatologist evaluation of the effect of glycerine and urea on dry skin in atopic dermatitis
Loden 2002 A Double-Blind Study Comparing the Effect of Glycerin and Urea on Dry, Eczematous Skin in Atopic Patients
Ramon 2006 Evaluation of the corticosteroid-sparing effect of a new emollient in 162 atopic infants
Tan 2010 A randomised double-blind controlled trial to compare a triclosan containing emollient with vehicle for the treatment of atopic dermatitis
Yang 2010 The adjuvant treatment of atopic dermatitis with medical skin preparation containing extracts from Portulaca oleracea and avocado
Excimer laser
trials
Brenninkmeijer 2010 Excimer laser vs. clobetisol propionate 0.05% ointment on prurigo form of atopic dermatitis: a randomised controlled trial, a pilot
Farnesol
trials
Masako 2005 A novel method to control the balance of skin microflora Part 2. A study to assess the effect of a cream containing faresol and xylitol on atopic dry skin
Fexofenadine
trials
Kawashima 2003 Addition of fexofenadine to a topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1-week randomized, multicentre, double-blind, placebo-controlled, parallel-group study
Nakagawa 2006 Efficacy and safety of fexofenadine hydrochloride in pediatric patients with atopic dermatitis in a phase III, randomized, double-blind, multi-center comparative study.
Fluocinonide
trials
del Rosso 2010 Daily application of fluocinonide 0.1% cream for the treatment of atopic dermatitis
Gupta 2006 Efficacy of fluocinonide 0.1% cream in the treatment of atopic dermatitis.
Fluticasone
trials
Berth-Jones 2003 Twice weekly fluticasone propionate added to emollient maintenance treatment to reduce risk of relapse in atopic dermatitis: randomised, double blind, parallel group study
Doss 2010 Efficacy of tacrolimus 0.03% ointment as second-line treatment for children with moderate-to-severe atopic dermatitis: evidence from a ramdomised, double-blind non-inferiority trial vs. fluticasone 0.005% ointment
Hanifin 2002 Intermittent dosing of fluticasone propionate cream for reducing the risk of relapse in atopic dermatitis patients
Hung 2007 Staphylococcus colonisation in atopic dermatitis treated with fluticasone or tacrolimus with or without antibiotics
Meurer 2010 Addition of pimecrolimus cream 1% to a topical corticosteroid treatment regimen in paediatric patients with severe atopic dermatitis: A randomized, double-blind trial
Valkova 2004 UVA/UVB phototherapy for atopic dermatitis revisited
Fusidic acid
trials
Hung 2007 Staphylococcus colonisation in atopic dermatitis treated with fluticasone or tacrolimus with or without antibiotics
Larsen 2007 An Efficient New Formulation of Fusidic Acid and Betamethasone 17-Valerate (Fucicort Lipid Cream) for Treatment of Clinically Infected Atopic Dermatitis
Ravenscroft 2003 Short-term effects of topical fusidic acid or mupirocin on the prevalence of fusidic acid resistant (FusR) Staphylococcus aureus in atopic eczema
Gold compound
trials
Freeman 2006 A new treatment for atopic dermatitis: a randomized double-blind placebo-controlled study
Hemp seed oil
trials
Callaway 2005 Efficacy of dietary hempseed oil in patients with atopic dermatitis
Heparin
trials
Arenberger 2010 Additive effect of Heparin and Levomenthol against Atopic Dermatitis
House dust mite desensitisation
trials
Pajno 2007 Sublingual immunotherapy in mite-sensitized children with atopic dermatitis: A randomized, double-blind, placebo-controlled study
Hydrocortisone
trials
Abramovits 2010 Hydrocortisone Butyrate 0.1% Lipocream in Pediatric Patients with Atopic Dermatitis
Caproni 2007 The comparative effects of tacrolimus and hydrocortisone in adult atopic dermatitis: an immunohistochemical study.
de Belilovsky 2010 Natural peroxisome proliferator activated-activated receptor-alpha agonist cream demonstrates similar therapeutic response to topical steroids in atopic dermatitis
Dolle 2010 Long-term reduction in local inflammation by a lipid raft molecule in atopic dermatitis
Fleisher 2006 Comparative efficacy and patient preference of 1% pramoxine lotion and 1% hydrocortisone cream in reducing pruritus in mild atopic dermatitis
Gong 2006 Skin colonisation by Staphylococcus aureus in patients with eczema and atopic dermatitis and relevant combined topical therapy: a double-blind multicentre randomized controlled trial
Griffiths 2002 Randomised comparison of the type 4 phosphodiesterase inhibitor cipamfylline cream, cream vehicle and hydrocortisone 17-butyrate cream for the treatment of atopic dermatitis.
Kaur 2007 Adherence to topical hydrocortisone 17-butyrate 0.1% using different vehicles in adults with atopic dermatitis
Mandelin 2010 One-year Treatment with 0.1% Tacrolimus Ointment versus a Corticosteroid regimen in Adults with Moderate to Severe Atopic Dermatitis: A Randomised, Double-blind, Comparative Trial
Meurer 2010 Addition of pimecrolimus cream 1% to a topical corticosteroid treatment regimen in paediatric patients with severe atopic dermatitis: A randomized, double-blind trial
Patzelt-Wenczler 2000 Proof of Efficacy of Kamillosan Cream in Atopic Eczema
Rahman 2006 Effectiveness of montelukast in the treatment of atopic dermatitis
Valkova 2004 UVA/UVB phototherapy for atopic dermatitis revisited
Hydrolysed infant formula
trials
Brouwer 2006 No effects of probiotics on atopic dermatitis in infancy: a randomised placebo-controlled trial
Isolauri 2000 Probiotics in the management of atopic eczema
Leung 2004 A randomized, single-blind and crossover study of an amino acid-based milk formula in treating young children with atopic dermatitis
van der Aa 2010 Effect of a new symbiotic mixture on atopic dermatitis in infants: a randomised - controlled trial
Hypnotherapy/biofeedback
trials
Senser 2004 Hypnotherapy in atopic dermatitis
Treatments
I to N
treatments
I to N
Immunoglobulin
trials
Bemanian 2005 High Doses Intravenous Immunoglobulin versus Oral Cyclosporine in the Treatment of Severe Atopic Dermatitis
Paul 2002 A randomized controlled evaluator-blinded trial of intravenous immunoglobin in adults with severe atopic dermatitis
Immunotherapy
trials
Silny 2006 Specific immunotherapy in the treatment of patients with atopic dermatitis--results of double blind placebo controlled study
Interferon gamma
trials
Jang 2000 Clinical improvement and immunohistochemical findings in severe atopic dermatitis treated with interferon gamma
Ketoconazole
trials
Back 2001 Systemic Ketoconazole for yeast allergic patients with atopic dermatitis
Lintu 2001 Systemic ketoconazole is an effective treatment of atopic dermatitis with IgE-mediated hypersensitivity to yeasts
Ketotifen
trials
Nakagawa 2006 Efficacy and safety of fexofenadine hydrochloride in pediatric patients with atopic dermatitis in a phase III, randomized, double-blind, multi-center comparative study.
Kiwi extract
trials
Mraz 2006 A multicenter, double-blind, placebo-controlled study of the effectiveness of kiwi fruit extract in adults with atopic dermatitis of moderate severity
Konjac ceramide
trials
Kimata 2006 Improvement of Atopic Dermatitis and Reduction of Skin Allergic Responses by Oral Intake of Kanjac Ceramide
Levocetirizine
trials
Kirkcik 2010 Management of pruritis with levocetirizine dihydrochloride in atopic dermatitis in a randomised, double blind, placebo controlled study - Interim analysis
Levomenol
trials
Arenberger 2010 Additive effect of Heparin and Levomenthol against Atopic Dermatitis
Licorice extract
trials
Saeedi 2003 The treatment of atopic dermatitis with licorice gel
Lipids
trials
Laumann 2006 The efficacy and safety of MimyX Cream in reducing the risk of relapse in atopic dermatitis
Loratadine
trials
Shi 2008 Clinical study in treatment of atopic dermatitis by intergrated traditional chinese and western medicine.
Massage therapy
trials
Anderson 2000 Evaluation of Massage with Essential Oils on Childhood Atopic Eczema
Mepolizumab
trials
Oldhoff 2005 Anti-IL-5 recombinant humanized monoclonal antibody (Mepolizumab) for the treatment of atopic dermatitis
Methylpredesolone
trials
Bieber 2007 Efficacy and safety of methylprednisolone aceponate ointment 0.1% compared to tacrolimus 0.03% in children and adolescents with and acute flare of severe atopic dermatitis
Miltefosine
trials
Dolle 2010 Long-term reduction in local inflammation by a lipid raft molecule in atopic dermatitis
Mometasone
trials
Capella 2001 A randomized trial of leukotriene receptor antagonist montelukast in moderate-to-severe atopic dermatitis of adults
Freeman 2006 A new treatment for atopic dermatitis: a randomized double-blind placebo-controlled study
Schnopp 2002 Topical Steroids under Wet-wrap Dressings in Atopic Dermatitis- A Vehicle-Controlled Trial
Montelukast
trials
Craig 2002 The effects of montelukast on atopic dermatitis (AD): A placebo controlled, double-blind, parallel study
Friedmann 2007 A double-blind, placebo-controlled trial of montelukast in adult atopic eczema.
Melamed 2010 The benefit of montelukast in atopic dermatitis induced by food allergies
Rahman 2006 Effectiveness of montelukast in the treatment of atopic dermatitis
Mupirocin
trials
Gong 2006 Skin colonisation by Staphylococcus aureus in patients with eczema and atopic dermatitis and relevant combined topical therapy: a double-blind multicentre randomized controlled trial
Ravenscroft 2003 Short-term effects of topical fusidic acid or mupirocin on the prevalence of fusidic acid resistant (FusR) Staphylococcus aureus in atopic eczema
Naltrexone cream
trials
Biglardi 2007 Treatment of pruritus with topically applied opiate receptor antagonist
Nanocrystalline silver
trials
Eichenfield 2007 A randomized, double-blind, placebo-controlled, parallel group study of nanocrystalline silver (NPI 32101) cream in pediatric atopic dermatitis (AD)
No treatment
trials
Byremo 2006 Effect of climatic change in children with atopic eczema
Chinn 2002 Randomized controlled trial of a single dermatology nurse consultation in primary care on the quality of life of children with atopic eczema
Cooenraads 2001 Intensive patient education and treatment program for young adults with atopic eczema.
Grimalt 2007 The steroid-sparing effect of an emollient therapy in infants with atopic dermatitis: A randomized controlled study
Kawana 2010 Efficacy of a 5-HT1a receptor agonist in atopic dermatitis
Paul 2002 A randomized controlled evaluator-blinded trial of intravenous immunoglobin in adults with severe atopic dermatitis
Ramon 2006 Evaluation of the corticosteroid-sparing effect of a new emollient in 162 atopic infants
Senser 2004 Hypnotherapy in atopic dermatitis
Staab 2006 Age related, structured educational programmes for the management of atopic dermatitis in children and adolescents: multicentre, randomised controlled trial
Staab 2002 Evaluation of a parental training program for the management of childhood atopic dermatitis
Yang 2010 The adjuvant treatment of atopic dermatitis with medical skin preparation containing extracts from Portulaca oleracea and avocado
Nurse Practitioner consultation
trials
Schuttelaar 2010 A randomised controlled trial in children with eczema: nurse practitioner vs. dermatologist
Treatments
O to S
treatments
O to S
Olive oil
trials
Callaway 2005 Efficacy of dietary hempseed oil in patients with atopic dermatitis
Takwale 2003 Efficacy and tolerability of borage oil in adults and children with atopic eczema: randomised, double blind, placebo controlled, parallel group trial
Omalizumab
trials
Heil 2010 Omalizumab therapy in atopic deratitis: depletion of IgE does not improve the clinical course - a randomised, placebo-controlled and double blind pilot study
Oral psoralen
trials
Tzaneva 2010 5-Methoxypsoralen plus ultraviolet (UV) A is superior to medium-dose UVA1 in the treatment of severe atopic dermatitis: a randomised crossover trial
Pale shale oil
trials
Korting 2010 Efficacy and tolerability of pale sulphonated shale oil cream 4% in the treatment of mid to moderate atopic eczema in children: a multicentre, randomised vehicle-controlled trial
Pimecrolimus
trials
Barba 2003 Pimecrolimus cream 1% is effective, well tolerated and safe in infants/ children with atopic eczema of the face
Draelos 2005 Pharmacokinetics of topical calcineurin inhibitors in adult atopic dermatitis: A randomized, investigator-blind comparison
Eichenfield 2002 Safety and efficacy of pimecrolimus (ASM 981) cream 1% in the treatment of mild and moderate atopic dermatitis in children and adolescents.
Fowler 2007 Improvement in pruritis in Children with atopic dermatitis using pimecrolimus cream 1%
Ho 2003 Safety and efficacy of nonsteroid pimecrolimus cream 1% in the treatment of atopic dermatitis in infants
Kaufmann 2006 Onset of pruritus relief with pimecrolimus cream 1% in adult patients with atopic dermatitis: a randomized trial
Kaufmann 2004 Pimecrolimus Cream 1% Provides Long-Term Disease Management in Children with Severe Atopic Dermatitis
Leo 2004 Effect of pimecrolimus cream 1% on skin condition and sleep disturbance in children with atopic dermtitis
Luger 2001 SDZ ASM 981: an emerging safe and effective treatment for atopic dermatitis
Meurer 2010 Addition of pimecrolimus cream 1% to a topical corticosteroid treatment regimen in paediatric patients with severe atopic dermatitis: A randomized, double-blind trial
Salavec 2004 First experiences with 1% Pimecrolimus cream therapy in prevention of atopic eczema flares in children
Thaci 2005 Treatment effects of 1% pimecrolimus ointment formulations in adult patients with atopic dermatitis
Tzung 2006 Pimecrolimus and Narrowband UVB as Monotherapy or Combination Therapy in Children and Adolescents with Atopic Dermatitis
Wahn 2002 Efficacy and Safety of Pimecrolimus Cream in the Long Term Management of Atopic Dermatitis in Children
Zuberbier 2007 Steroid-Sparing Effect of Pimecrolimus Cream 1% in Children with Severe Atopic Dermatitis
Placebo
trials
Back 2001 Systemic Ketoconazole for yeast allergic patients with atopic dermatitis
Berth-Jones 2003 Twice weekly fluticasone propionate added to emollient maintenance treatment to reduce risk of relapse in atopic dermatitis: randomised, double blind, parallel group study
Berth-Jones 2002 Azothiaprine in severe atopic dermatitis: a double-blind, placebo-controlled, crossover trial
Berth-Jones 2006 Killed Mycobacterium vaccae suspension in children with moderate-to-severe atopic dermatitis: a randomised, double-blind, placebo-controlled trial
Biglardi 2007 Treatment of pruritus with topically applied opiate receptor antagonist
Craig 2002 The effects of montelukast on atopic dermatitis (AD): A placebo controlled, double-blind, parallel study
Diepgen 2002 Long-term treatment with cetirizine of infants with atopic dermatitis: A multi-country, double-blind, randomized, placebo-controlled trial (the ETAC trial) over 18 months
Eichenfield 2006 Two randomized , double-blind, placebo-controlled studies of fluticasone propionate lotion 0.05% for the treatment of atopic dermatitis in subjects from 3 months of age
Folster Holst 2006 Prospective, randomized controlled trial on Lactobacillus rhamnosus in infants with moderate to severe atopic dermatitis.
Friedmann 2007 A double-blind, placebo-controlled trial of montelukast in adult atopic eczema.
Ger Rikken 2010 SUN13834 in the Treatment of Subjects with Atopic Dermatitis
Gerasimov 2010 Probiotic Supplement Reduces Atopic Dermatitis in Preschool Children. A Randomised, Double-Blind, Placebo-Controlled, Clinical Trial
Gobel 2010 Probiotics to young children with atopic dermatitis: a randomised palcebo-controlled trial
Gruber 2007 Randomized, placebo-controlled trial of Lactobacillus rhamnosus GG as treatment of atopic dermatitis in infancy
Guager 2005 Efficacy and functionality of silver-coated textiles in patients with atopic eczema.
Hamanda 2008 The usefulness of camellia oil spray for treatment of atopic dermatitis
Heil 2010 Omalizumab therapy in atopic deratitis: depletion of IgE does not improve the clinical course - a randomised, placebo-controlled and double blind pilot study
Hon 2007 Efficacy and tolerability of a Chinese herbal medicine concoction for treatment of atopic dermatitis: a randomized, double-blind, placebo-controlled study
Jang 2000 Clinical improvement and immunohistochemical findings in severe atopic dermatitis treated with interferon gamma
Januchowski 2009 Evaluation of Topical Vitamin B12 for the Treatment of Childhood Eczema
Kawashima 2003 Addition of fexofenadine to a topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1-week randomized, multicentre, double-blind, placebo-controlled, parallel-group study
Kirkcik 2010 Management of pruritis with levocetirizine dihydrochloride in atopic dermatitis in a randomised, double blind, placebo controlled study - Interim analysis
Kobayashi 2010 Efficacy and Safety of a traditional Herbal Medicine, Hochu-ekki-to in the Long Term Management of Kikyo (Delicate Constitution) Patients with Atopic Dermatitis: A 6-month, Multicentre, Double-blind, Randomised, Placebo-controlled Study
Kuznecovs 2010 Atopvastatin and polyprenol effect on atopic dermatitis: pathogenesis links in adult patients
Lintu 2001 Systemic ketoconazole is an effective treatment of atopic dermatitis with IgE-mediated hypersensitivity to yeasts
Loden 2002 A Double-Blind Study Comparing the Effect of Glycerin and Urea on Dry, Eczematous Skin in Atopic Patients
Melamed 2010 The benefit of montelukast in atopic dermatitis induced by food allergies
Moroi 2010 Beneficial effect of a diet containing heat-killed Lactobacillus paracasei K71 on adult type atopic dermatitis
Mraz 2006 A multicenter, double-blind, placebo-controlled study of the effectiveness of kiwi fruit extract in adults with atopic dermatitis of moderate severity
Munday 2002 Chlorpheniramine Is No More Effective than Placebo in Relieving the Symptoms of Childhood Atopic Dermatitis with a Nocturnal Itching and Scratching Component
Oldhoff 2005 Anti-IL-5 recombinant humanized monoclonal antibody (Mepolizumab) for the treatment of atopic dermatitis
Pajno 2007 Sublingual immunotherapy in mite-sensitized children with atopic dermatitis: A randomized, double-blind, placebo-controlled study
Rosenfeldt 2003 Effect of probiotic Lactobacillus strains in children with atopic dermatitis
Shapira 2005 Treatment of atopic dermatitis with herbal combination of Eleuthercoccus, Achilla millefolium, and Lamium album had no advantage over placebo: A double blind, placebo-controlled, randomized trial
Sidbury 2008 Randomised controlled trial of vitamin D supplementation for winter-related atopic dermatits in Boston: A pilot study
Silny 2006 Specific immunotherapy in the treatment of patients with atopic dermatitis--results of double blind placebo controlled study
Svejgaard 2004 Treatment of head and neck dermatitis comparing itraconazole 200 mg and 400 mg daily for 1 week with placebo
Takwale 2003 Efficacy and tolerability of borage oil in adults and children with atopic eczema: randomised, double blind, placebo controlled, parallel group trial
Viljanen 2005 Probiotics in the treatment of atopic eczema/dermatitis syndrome in infants: a double-blind placebo-controlled trial
Woo 2010 Effect of Lactobacillus sakei supplementation on children with atopic eczema-dermatitis syndrome
Yang 2000 Effect of dietary supplementation with sea buckthorn (Hippophae rhamnoides) seed and pulp oils on the fatty acid composition of skin glycerophospholipids of patients with atopic dermatitis
Yoshida 2010 Clinical Effects of Probiotic Bifidobacterium breve Supplementation in Adult Patients with Atopic Dermatitis
Polyprenol
trials
Kuznecovs 2010 Atopvastatin and polyprenol effect on atopic dermatitis: pathogenesis links in adult patients
Pramoxine
trials
Fleisher 2006 Comparative efficacy and patient preference of 1% pramoxine lotion and 1% hydrocortisone cream in reducing pruritus in mild atopic dermatitis
Prednicarbat
trials
Foelster-Holst 2006 Efficacy of Crisis Intervention Treatment with Topical Corticosteroid Prednicarbat with and without Partial Wet-Wrap Dressing in Atopic Dermatitis
Prednisolone
trials
Schmitt 2010 Prednisolone vs. ciclosporin for severe adult. An investigator-initiated double-blind placebo-controlled multicentre trial
Probiotics
trials
Brouwer 2006 No effects of probiotics on atopic dermatitis in infancy: a randomised placebo-controlled trial
Cukrowska 2008 The influence of probiotic Lactobacillus casei and paracasei strains on clinical status of atopic eczema in children with food allergy on cow's milk proteins.
Folster Holst 2006 Prospective, randomized controlled trial on Lactobacillus rhamnosus in infants with moderate to severe atopic dermatitis.
Gerasimov 2010 Probiotic Supplement Reduces Atopic Dermatitis in Preschool Children. A Randomised, Double-Blind, Placebo-Controlled, Clinical Trial
Gobel 2010 Probiotics to young children with atopic dermatitis: a randomised palcebo-controlled trial
Gruber 2007 Randomized, placebo-controlled trial of Lactobacillus rhamnosus GG as treatment of atopic dermatitis in infancy
Hattori 2003 Effects of administration of bifidobacteria on fecal microflora and clinical symptoms in infants with atopic dermatitis.
Isolauri 2000 Probiotics in the management of atopic eczema
Moroi 2010 Beneficial effect of a diet containing heat-killed Lactobacillus paracasei K71 on adult type atopic dermatitis
Murosaki 2006 Effects of intake of syrup supplemented with nigerooligosaccharides and heat-killed Lactobacillus plantarum L-137 on skin symptom and immune function in patients with atopic dermatitis
Rosenfeldt 2003 Effect of probiotic Lactobacillus strains in children with atopic dermatitis
Viljanen 2005 Probiotics in the treatment of atopic eczema/dermatitis syndrome in infants: a double-blind placebo-controlled trial
Woo 2010 Effect of Lactobacillus sakei supplementation on children with atopic eczema-dermatitis syndrome
Yoshida 2010 Clinical Effects of Probiotic Bifidobacterium breve Supplementation in Adult Patients with Atopic Dermatitis
Protease inhibitor
trials
Foelster Holst 2010 The novel protease inhibitor SRD441 ointment is not effective in the treatment of adult subjects with atopic dermatitis: results of a randomised, vehicle-controlled study
Rosmarinic acid
trials
Lee 2008 Effect of rosmarinic acid on atopic dermatitis
Saccharides
trials
Murosaki 2006 Effects of intake of syrup supplemented with nigerooligosaccharides and heat-killed Lactobacillus plantarum L-137 on skin symptom and immune function in patients with atopic dermatitis
Palombo 2004 A special pill-mask to rehydrate the skin affected by atopic dermatitis
Shibata 2009 Clinical effects of kestose, a prebiotic oligosaccharide, on the treatment of atopic dermatitis in infants.
Sea buckthorn cream
trials
Thumm 2000 Randomized trial to study efficacy of a 20% and 10% Hippophae rhamnoides containing creme used by patients with mild to intermediate atopic dermatitis
Yang 2000 Effect of dietary supplementation with sea buckthorn (Hippophae rhamnoides) seed and pulp oils on the fatty acid composition of skin glycerophospholipids of patients with atopic dermatitis
Sodium cromoglycate
trials
Stainer 2005 Efficacy and acceptability of a new topical skin lotion of sodium cromoglicate (Altoderm) in atopic dermatitis in children aged 2-12 years: a double-blind, randomized, placebo-controlled trial
Specialised clothing
trials
Guager 2005 Efficacy and functionality of silver-coated textiles in patients with atopic eczema.
Koller 2007 Action of a silk fabric treated with AEGIS in children with atopic dermatitis: A 3-month trial
Ozawa 2008 Effect of underwear made from MEDIELE on skin barrier function of atopic dermatitis patients in winter season.
Stinco 2008 A Randomized Double-Blind Study to Investigate the Clinical Efficacy of Adding a Non-Migrating Antimicrobial to a Special Silk Fabric in the Treatment of Atopic Dermatitis
Yokoyama 2009 Ethylene Vinyl Alcohol (EVOH) Fiber Compared to Cotton Underwear in the Treatment of Childhood Atopic Dermatitis: A Double-Blind Randomized Study
St John's Wort
trials
Schempp 2003 Topical treatment of atopic dermatitis with St. John's wort cream - a randomized, placebo controlled, double blind half-side comparison
Standard treatment
trials
Grillo 2006 Pediatric Atopic Eczema: The Impact of an Educational Intervention
Hindley 2006 A randomised study of "wet wraps" versus conventional treatment for atopic eczema.
Leung 2004 A randomized, single-blind and crossover study of an amino acid-based milk formula in treating young children with atopic dermatitis
Shaw 2008 A Study of Targeted Enhanced Patient Care for Pediatric Atopic Dermatitis (STEP PAD)
Span 2001 Intensive daycare for young adults with atopic eczema
Thomas 2011 A multicentre randomized controlled trial of ion-exchange water softeners for the treatment of eczema in children: protocol for the Softened Water Eczema Trial (SWET) (ISRCTN: 71423189)
Staying in a different climate
trials
Byremo 2006 Effect of climatic change in children with atopic eczema
Support group
trials
Blessman Weber 2008 Improvement of pruritis and quality of life of children with atopic dermatitis and their families after joining support groups
Synbiotics
trials
van der Aa 2010 Effect of a new symbiotic mixture on atopic dermatitis in infants: a randomised - controlled trial
Treatments
T to Z
treatments
T to Z
Tacrolimus
trials
Bieber 2007 Efficacy and safety of methylprednisolone aceponate ointment 0.1% compared to tacrolimus 0.03% in children and adolescents with and acute flare of severe atopic dermatitis
Breneman 2008 Intermittent therapy for flare prevention and long-term disease control in stabilized atopic dermatitis: A randomized comparison of 3-times-weekly applications of tacrolimus ointment versus vehicle
Caproni 2007 The comparative effects of tacrolimus and hydrocortisone in adult atopic dermatitis: an immunohistochemical study.
Doss 2010 Efficacy of tacrolimus 0.03% ointment as second-line treatment for children with moderate-to-severe atopic dermatitis: evidence from a ramdomised, double-blind non-inferiority trial vs. fluticasone 0.005% ointment
Dou 2006 The impact of tacrolimus ointment on health-related quality of life of Chinese adult and pediatric patients with atopic dermatitis
Draelos 2005 Pharmacokinetics of topical calcineurin inhibitors in adult atopic dermatitis: A randomized, investigator-blind comparison
Hanifin 2001 Tacrolimus ointment for the treatment of atopic dermatitis in adult patients: Part I, Efficacy
Hung 2007 Staphylococcus colonisation in atopic dermatitis treated with fluticasone or tacrolimus with or without antibiotics
Levy 2005 Tacrolimus cream 0.03% is safe and effective in the treatment of mild to moderate atopic dermatitis in adults
Mandelin 2010 One-year Treatment with 0.1% Tacrolimus Ointment versus a Corticosteroid regimen in Adults with Moderate to Severe Atopic Dermatitis: A Randomised, Double-blind, Comparative Trial
Rahman 2008 Efficacy of topical tacrolimus in atopic dermatitis
Thaci 2008 Proactive disease management with 0.03% tacrolimus ointment for children with atopic dermatitis: results of randomized multicentre comparative study
Wollenburg 2008 Proactive treatment of atopic dermatitis in adults with 0.1% tacrolimus ointment
Wollenburg 2008 Proactive treatment of atopic dermatitis in adults with 0.1% tacrolimus ointment
Tandospirone citrate
trials
Kawana 2010 Efficacy of a 5-HT1a receptor agonist in atopic dermatitis
Tetracycline
Thermal spring water
trials
Licu 2002 Efficacy of thermal spring water in the treatment of mild atopic dermatitis.
Topical corticosteroids
trials
Berardesca 2001 Evaluation of efficacy of a skin lipid mixture in patients with irritant contact dermatitis, allergic contact dermatitis or atopic dermatitis: a multicenter study
Topical doxepin
trials
Lee 2006 The antipruritic effect of topical doxepin cream in patients with atopic dermatitis
Topical vitamin B12
trials
Januchowski 2009 Evaluation of Topical Vitamin B12 for the Treatment of Childhood Eczema
Triamcinolone
trials
Cato 2001 Azone enhances clinical effectiveness of an optimized formulation of triamcinolone acetonide in atopic dermatitis.
Triclosan
trials
Tan 2010 A randomised double-blind controlled trial to compare a triclosan containing emollient with vehicle for the treatment of atopic dermatitis
Ultraviolet light
trials
Der Petrossian 2000 Half-side comparison study on the efficacy of 8-methoxypsoralen bath-PUVA versus narrow-band ultraviolet B phototherapy in patients with severe chronic atopic dermatitis.
Dittmar 2001 UVA1 Therapy Dose-Finding Study in Patients with Acute Exacerbated Atopic Dermatitis
Gambichler 2009 Medium-dose ultraviolet (UV) A1 vs. Narrowband UVB phototherapy in atopic eczema: a randomized crossover study
Granlund 2001 Comparison of Cyclosporin and UVAB Phtotherapy for Intermittent One-year Treatment of Atopic Dermatitis
Hoey 2006 Fixed low dose versus increasing dose of ultraviolet B-TLoâ‚ in the treatment of atopic eczema.
Majoie 2009 Narrowband ultraviolet B and medium-dose ultraviolet A1 are equally effective in the treatment of moderate to severe atopic dermatitis
Reynolds 2001 Narrow-band ultraviolet B and broad-band ultraviolet A phototherapy in adult atopic eczema: a randomised controlled trial
Selvaag 2005 Optimized UVB Treatment of Atopic Dermatitis Using Skin Reflectance Measurements. A Controlled, Left-Right Comparison Trial
Tzaneva 2010 5-Methoxypsoralen plus ultraviolet (UV) A is superior to medium-dose UVA1 in the treatment of severe atopic dermatitis: a randomised crossover trial
Tzung 2006 Pimecrolimus and Narrowband UVB as Monotherapy or Combination Therapy in Children and Adolescents with Atopic Dermatitis
Valkova 2004 UVA/UVB phototherapy for atopic dermatitis revisited
Urea
trials
Bissonette 2010 A double-blind study of tolerance and efficacy of a new urea-containing moisturiser in patients with atopic dermatitis
Vaccine
trials
Arkwright 2001 Intradermal administration of a killed Mycobacterium vaccae suspension (SRL 172) is associated with improvement in atopic dermatitis in children with moderate-to-severe disease.
Arkwright 2003 Effect of Mycobacterium vaccae on atopic dermatitis in children of different ages
Berth-Jones 2006 Killed Mycobacterium vaccae suspension in children with moderate-to-severe atopic dermatitis: a randomised, double-blind, placebo-controlled trial
Vehicle
trials
Abramovits 2010 Hydrocortisone Butyrate 0.1% Lipocream in Pediatric Patients with Atopic Dermatitis
Abramovits 2006 A multicenter, randomized, vehicle-controlled clinical study to examine the efficacy and safety of MAS063DP (Atopiclair) in the management of mild to moderate atopic dermatitis in adults
Arkwright 2003 Effect of Mycobacterium vaccae on atopic dermatitis in children of different ages
Arkwright 2001 Intradermal administration of a killed Mycobacterium vaccae suspension (SRL 172) is associated with improvement in atopic dermatitis in children with moderate-to-severe disease.
Barba 2003 Pimecrolimus cream 1% is effective, well tolerated and safe in infants/ children with atopic eczema of the face
Belloni 2005 A Randomised, double-blind, vehicle-controlled study to evaluate the efficacy and safety of MAS063D (Atopiclair®), in the treatment of mild to moderate atopic dermatitis
Beutner 2007 A randomised, double-blind, vehicle-controlled, multi-center study to evaluate the safety and efficacy of topically applied AN0128 cream, 1% for the treatment of mild to moderate atopic dermatitis.
Boguniewicz 2007 MAS063DP is effective monotherapy for mild to moderate atopic dermatitis in infants and children: A multicenter, randomized, vehicle-controlled study
Breneman 2008 Intermittent therapy for flare prevention and long-term disease control in stabilized atopic dermatitis: A randomized comparison of 3-times-weekly applications of tacrolimus ointment versus vehicle
Brouwer 2006 No effects of probiotics on atopic dermatitis in infancy: a randomised placebo-controlled trial
Cato 2001 Azone enhances clinical effectiveness of an optimized formulation of triamcinolone acetonide in atopic dermatitis.
Cukrowska 2008 The influence of probiotic Lactobacillus casei and paracasei strains on clinical status of atopic eczema in children with food allergy on cow's milk proteins.
del Rosso 2010 Daily application of fluocinonide 0.1% cream for the treatment of atopic dermatitis
Dou 2006 The impact of tacrolimus ointment on health-related quality of life of Chinese adult and pediatric patients with atopic dermatitis
Eichenfield 2002 Safety and efficacy of pimecrolimus (ASM 981) cream 1% in the treatment of mild and moderate atopic dermatitis in children and adolescents.
Eichenfield 2007 A randomized, double-blind, placebo-controlled, parallel group study of nanocrystalline silver (NPI 32101) cream in pediatric atopic dermatitis (AD)
Foelster Holst 2010 The novel protease inhibitor SRD441 ointment is not effective in the treatment of adult subjects with atopic dermatitis: results of a randomised, vehicle-controlled study
Fowler 2007 Improvement in pruritis in Children with atopic dermatitis using pimecrolimus cream 1%
Gong 2006 Skin colonisation by Staphylococcus aureus in patients with eczema and atopic dermatitis and relevant combined topical therapy: a double-blind multicentre randomized controlled trial
Griffiths 2002 Randomised comparison of the type 4 phosphodiesterase inhibitor cipamfylline cream, cream vehicle and hydrocortisone 17-butyrate cream for the treatment of atopic dermatitis.
Gueniche 2008 Effects of nonpathogenic gram-negative bacterium Vitreoscilla filiformis lysate on atopic dermatitis: a prospective, randomized, double-blind, placebo-controlled clinical study
Gueniche 2006 Improvement of atopic dermatitis skin symptoms by Vitreoscilla filiformis bacterial extract
Gupta 2006 Efficacy of fluocinonide 0.1% cream in the treatment of atopic dermatitis.
Hanifin 2002 Intermittent dosing of fluticasone propionate cream for reducing the risk of relapse in atopic dermatitis patients
Hanifin 2001 Tacrolimus ointment for the treatment of atopic dermatitis in adult patients: Part I, Efficacy
Hattori 2003 Effects of administration of bifidobacteria on fecal microflora and clinical symptoms in infants with atopic dermatitis.
Ho 2003 Safety and efficacy of nonsteroid pimecrolimus cream 1% in the treatment of atopic dermatitis in infants
Kaufmann 2006 Onset of pruritus relief with pimecrolimus cream 1% in adult patients with atopic dermatitis: a randomized trial
Kaufmann 2004 Pimecrolimus Cream 1% Provides Long-Term Disease Management in Children with Severe Atopic Dermatitis
Kim 2010 Therapeutic efficacy of defensamide in atopic dermatitis
Kimata 2006 Improvement of Atopic Dermatitis and Reduction of Skin Allergic Responses by Oral Intake of Kanjac Ceramide
Klovekorn 2007 A randomized, double-blind, vehicle-controlled, half-side comparison with a herbal ointment containing Mahonia aquifolium, Viola tricolor and Centella asiatica for the treatment of mild-to-moderate atopic dermatitis
Korting 2010 Efficacy and tolerability of pale sulphonated shale oil cream 4% in the treatment of mid to moderate atopic eczema in children: a multicentre, randomised vehicle-controlled trial
Larsen 2007 An Efficient New Formulation of Fusidic Acid and Betamethasone 17-Valerate (Fucicort Lipid Cream) for Treatment of Clinically Infected Atopic Dermatitis
Lee 2008 Effect of rosmarinic acid on atopic dermatitis
Lee 2006 The antipruritic effect of topical doxepin cream in patients with atopic dermatitis
Leo 2004 Effect of pimecrolimus cream 1% on skin condition and sleep disturbance in children with atopic dermtitis
Levy 2005 Tacrolimus cream 0.03% is safe and effective in the treatment of mild to moderate atopic dermatitis in adults
Loden 2001 Instrumental and dermatologist evaluation of the effect of glycerine and urea on dry skin in atopic dermatitis
Luger 2001 SDZ ASM 981: an emerging safe and effective treatment for atopic dermatitis
Masako 2005 A novel method to control the balance of skin microflora Part 2. A study to assess the effect of a cream containing faresol and xylitol on atopic dry skin
Mayser 2006 Treatment of Head and Neck Dermatitis with Ciclopiroxolamine Cream - Results of a Double-Blind, Placebo-Controlled Study
Murosaki 2006 Effects of intake of syrup supplemented with nigerooligosaccharides and heat-killed Lactobacillus plantarum L-137 on skin symptom and immune function in patients with atopic dermatitis
Palombo 2004 A special pill-mask to rehydrate the skin affected by atopic dermatitis
Patzelt-Wenczler 2000 Proof of Efficacy of Kamillosan Cream in Atopic Eczema
Saeedi 2003 The treatment of atopic dermatitis with licorice gel
Salavec 2004 First experiences with 1% Pimecrolimus cream therapy in prevention of atopic eczema flares in children
Schempp 2003 Topical treatment of atopic dermatitis with St. John's wort cream - a randomized, placebo controlled, double blind half-side comparison
Schnopp 2002 Topical Steroids under Wet-wrap Dressings in Atopic Dermatitis- A Vehicle-Controlled Trial
Shibagaki 2005 Clinical efficacy of bath additive containing a diamide derivative in patients with atopic dermatitis
Stainer 2005 Efficacy and acceptability of a new topical skin lotion of sodium cromoglicate (Altoderm) in atopic dermatitis in children aged 2-12 years: a double-blind, randomized, placebo-controlled trial
Stern 2002 Black seed oil ointment - A new approach for the treatment of atopic dermatitis?
Tan 2010 A randomised double-blind controlled trial to compare a triclosan containing emollient with vehicle for the treatment of atopic dermatitis
Thaci 2008 Proactive disease management with 0.03% tacrolimus ointment for children with atopic dermatitis: results of randomized multicentre comparative study
Thaci 2005 Treatment effects of 1% pimecrolimus ointment formulations in adult patients with atopic dermatitis
Wahn 2002 Efficacy and Safety of Pimecrolimus Cream in the Long Term Management of Atopic Dermatitis in Children
Wollenburg 2008 Proactive treatment of atopic dermatitis in adults with 0.1% tacrolimus ointment
Wollenburg 2008 Proactive treatment of atopic dermatitis in adults with 0.1% tacrolimus ointment
Zuberbier 2007 Steroid-Sparing Effect of Pimecrolimus Cream 1% in Children with Severe Atopic Dermatitis
Vitamin D
trials
Sidbury 2008 Randomised controlled trial of vitamin D supplementation for winter-related atopic dermatits in Boston: A pilot study
Wash cloth
trials
Hosokawa 2008 Evaluation of a low-irritant washcloth for patients with atopic dermatitis
Water softener
trials
Thomas 2011 A multicentre randomized controlled trial of ion-exchange water softeners for the treatment of eczema in children: protocol for the Softened Water Eczema Trial (SWET) (ISRCTN: 71423189)
Wet wraps
trials
Foelster-Holst 2006 Efficacy of Crisis Intervention Treatment with Topical Corticosteroid Prednicarbat with and without Partial Wet-Wrap Dressing in Atopic Dermatitis
Hindley 2006 A randomised study of "wet wraps" versus conventional treatment for atopic eczema.
Schnopp 2002 Topical Steroids under Wet-wrap Dressings in Atopic Dermatitis- A Vehicle-Controlled Trial
Xylitol
trials
Masako 2005 A novel method to control the balance of skin microflora Part 2. A study to assess the effect of a cream containing faresol and xylitol on atopic dry skin
Trials
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