New Reports and Guidelines

25 May 2006

MHRA - Final report on TGN1412 clinical trial

Medicines and Healthcare products Regulatory Agency (MHRA) has published Investigation Into Adverse Incidents During Clinical Trials Of TGN1412 The report concludes that the investigation indicates that the adverse incidents did not involve errors in the manufacture of TGN1412 or in its formulation, dilution or administration to trial participants. The MHRA therefore concludes that an unpredicted biological action of the drug in humans is the most likely cause of the adverse reactions in the trial participants
BBC News Report

25 May 2006

Map of health research funding

The UK Clinical Research Collaboration has published the first ever analysis detailing the distribution of spending on all types of health research across all areas of health and disease in the UK. The UK Health Research Analysis report focuses on the directly funded peer reviewed research of the eleven largest government and charity organisations funding health research in the UK. It includes projects, programmes and training awards.
BBC News Report

25 May 2006

NICE - appraisal consultation document on hormonal treatments for early breast cancer

The National Institute for Health and Clincal Excellence has published Breast cancer (early)- hormonal treatments (appraisal consultation document) The preliminary recommendations state that the aromatase inhibitors anastrozole, exemestane and letrozole, within their licensed indications, are recommended as options for the adjuvant treatment of early oestrogen-receptor-positive invasive breast cancer in post-menopausal women.
BBC News Report

25 May 2006

NICE guidance on Percutaneous disc decompression using coblation for lower back pain

The National Institute for Health and Clinical Excellence has published Percutaneous disc decompression using coblation for lower back pain The guidance concludes that current evidence suggests that there are no major safety concerns associated with the use of the procedure. There is some evidence of short-term efficacy; however, this is not sufficient to support the use of this procedure without special arrangements for consent and for audit or research.

24 May 2006

NICE guidance on Living donor lung transplantation for end-stage lung disease

The National Institute for Health and Clinical Excellence has published Living donor lung transplantation for end-stage lung disease The guidance concludes that current evidence on the efficacy of the procedure and its safety profile for suitable recipients appears adeqaute to support its use. However, the procedure should only be used in selected patients who would otherwise die. Additionally, limited evidence suggests that the procedure carries a significant risk of morbidity for donors. Therefore clinicians wishing to undertake this procedure should inform the clinical governance leads in their Trusts and ensure that donors receive thorough physical and psychological screening, and counselling about the morbidity associated with this
procedure.

24 May 2006

NICE gudiance on Laparoscopic helium plasma coagulation for endometriosis

The National Institute for Health and Clinical excellence has published Laparoscopic helium plasma coagulation for endometriosis The guidance concludes that current evidence suggests there are no major safety concerns associated with laparoscopic helium plasma coagulation for the treatment of endometriosis. However, evidence on efficacy does not appear adequate for this procedure to be used without special arrangements for consent and for audit or research.

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